LOCUS       NM_001081193            4754 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus LEM domain containing 3 (Lemd3), mRNA.
ACCESSION   NM_001081193 XM_354566
VERSION     NM_001081193.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4754)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4754)
  AUTHORS   Bourgeois,B., Gilquin,B., Tellier-Lebegue,C., Ostlund,C., Wu,W.,
            Perez,J., El Hage,P., Lallemand,F., Worman,H.J. and Zinn-Justin,S.
  TITLE     Inhibition of TGF-beta signaling at the nuclear envelope:
            characterization of interactions between MAN1, Smad2 and Smad3, and
            PPM1A
  JOURNAL   Sci Signal 6 (280), ra49 (2013)
   PUBMED   23779087
  REMARK    GeneRIF: a nuclear envelope-localized mechanism of inactivating
            TGF-beta signaling in which MAN1 competes with transcription
            factors for binding to Smad2 and Smad3 and facilitates their
            dephosphorylation by PPM1A.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4754)
  AUTHORS   Dheedene,A., Deleye,S., Hellemans,J., Staelens,S., Vandenberghe,S.
            and Mortier,G.
  TITLE     The heterozygous Lemd3 +/GT mouse is not a murine model for
            osteopoikilosis in humans
  JOURNAL   Calcif Tissue Int 85 (6), 546-551 (2009)
   PUBMED   19862465
  REMARK    GeneRIF: the heterozygous Lemd3 gene-trapped mouse is not a good
            model to study osteopoikilosis and the Buschke-Ollendorff syndrome.
REFERENCE   4  (bases 1 to 4754)
  AUTHORS   Huber,M.D., Guan,T. and Gerace,L.
  TITLE     Overlapping functions of nuclear envelope proteins NET25 (Lem2) and
            emerin in regulation of extracellular signal-regulated kinase
            signaling in myoblast differentiation
  JOURNAL   Mol Cell Biol 29 (21), 5718-5728 (2009)
   PUBMED   19720741
REFERENCE   5  (bases 1 to 4754)
  AUTHORS   Ishimura,A., Chida,S. and Osada,S.
  TITLE     Man1, an inner nuclear membrane protein, regulates left-right axis
            formation by controlling nodal signaling in a node-independent
            manner
  JOURNAL   Dev Dyn 237 (12), 3565-3576 (2008)
   PUBMED   18697220
  REMARK    GeneRIF: Man1 regulates left-right asymmetry by controlling Nodal
            signaling in a node-independent manner
REFERENCE   6  (bases 1 to 4754)
  AUTHORS   Ishimura,A., Ng,J.K., Taira,M., Young,S.G. and Osada,S.
  TITLE     Man1, an inner nuclear membrane protein, regulates vascular
            remodeling by modulating transforming growth factor beta signaling
  JOURNAL   Development 133 (19), 3919-3928 (2006)
   PUBMED   16943282
  REMARK    GeneRIF: In Man1-deficient embryos, the expression of Tgfb1 is
            upregulated and Smad2/3 signaling is abnormally activated,
            resulting in increased extracellular matrix deposition, a hallmark
            of the resolution phase of angiogenesis.
REFERENCE   7  (bases 1 to 4754)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   8  (bases 1 to 4754)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4754)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4754)
  AUTHORS   Lin,F., Blake,D.L., Callebaut,I., Skerjanc,I.S., Holmer,L.,
            McBurney,M.W., Paulin-Levasseur,M. and Worman,H.J.
  TITLE     MAN1, an inner nuclear membrane protein that shares the LEM domain
            with lamina-associated polypeptide 2 and emerin
  JOURNAL   J Biol Chem 275 (7), 4840-4847 (2000)
   PUBMED   10671519
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF112300.1, AC140381.3, AK140538.1, BC082610.1, BF458366.1 and
            AI842096.1.
            
            On Apr 26, 2007 this sequence version replaced NM_001081193.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.43975.1, AK140538.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AF112300.1         1-117
            118-1517            AC140381.3         158001-159400
            1518-2405           AK140538.1         1-888
            2406-2511           BC082610.1         1170-1275
            2512-2577           AK140538.1         995-1060
            2578-4302           BC082610.1         1341-3065
            4303-4741           BF458366.1         14-452              c
            4742-4754           AI842096.1         1-13                c
FEATURES             Location/Qualifiers
     source          1..4754
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 68.88 cM"
     gene            1..4754
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /note="LEM domain containing 3"
                     /db_xref="GeneID:380664"
                     /db_xref="MGI:MGI:3580376"
     exon            1..1547
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..2761
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /note="integral inner nuclear membrane protein MAN1; LEM
                     domain-containing protein 3"
                     /codon_start=1
                     /product="inner nuclear membrane protein Man1"
                     /protein_id="NP_001074662.2"
                     /db_xref="CCDS:CCDS48703.1"
                     /db_xref="GeneID:380664"
                     /db_xref="MGI:MGI:3580376"
                     /translation="MAAATAAAAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKL
                     KKLREEEQQQQQQQQQQQHRAGGRGNKTRNSNNNNTATAMGGRPGSGDLAYLRSPAGL
                     GRLSASAAESPVAGGSGGAAAVPAAGSKVLLGFSSDESDVEASPREQAGGGGARRDRA
                     ALQYRGLRAPPAPPAAGEVTGGHPGERRKPHSWWGARRPAGPEPQPPAAGSDGAAEDA
                     DEELADGEDRDPEAEEPLWASRTVNGSRLLPYSSCREHYSDSEEEEEEGEEDGDVAPA
                     RQVLKDDSLARHRPRRSHSKPFSALTAKSGGSRQETSVQGGGALAMNDRAAAAGSLDR
                     SRNLEEAAAEPGGGGGGGCGCDPVDSIPRYRAGAKKLAPLLSPPSPDGDSTLESPTGP
                     LLKTNNHIGGGAFGVDSPGLYANSLPPGATAAAAPGTLRINHANHTGSNHTYLKTAYG
                     KPKLCEPEEELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGV
                     PEDGGLIKNPFDETFGKIQESEKNLLMSTLYKLHDRLAQIAGDHECGSSSQRMLSVQE
                     AAAYLKNLGPEYEDVFNTSLLWIFKNGKDVGIRCVGYGPEEDLTNITDVQFLQSTRPQ
                     MPFWCRFRRAFITVTHRLLLLCLGVVLVCVALRYMRYRWTKEEEETRQMYDMVVKIID
                     VLRSHNEACQETKDLQPYMPLPHVRDSLIQPQDRKKMKKVWDRAVDFLAANESRVRTE
                     TRRVGGADFLVWRWIQPSASCDKTLVIPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNM
                     FDPVMEIGDHWHLAIQEAILEKCSDNDGIVHIAVDRNSREGCVYVKCLSPEYAGKAFK
                     ALHGSWFDGKLVTVKYLRLDRYHHRFPQALTCNTPLKPANKHMNSLSHLRLRTGLANS
                     QGSS"
     exon            1548..1585
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1652
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1720
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1800
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1946
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2048
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2151
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2330
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2412
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2518
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2597
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..4743
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4713..4718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /note="hexamer: ATTAAA"
     polyA_site      4741
                     /gene="Lemd3"
                     /gene_synonym="Man1"
                     /note="major polyA site"
ORIGIN      
        1 gaaaatggcg gcggcgacgg cggcggcggc gcctcagcag ctctcggatg aggagctttt
       61 ctctcagctc cgccgttacg gcttatctcc gggtcccgtg acggagagca cccggcccgt
      121 ctacctcaag aagctgaaga agcttcgcga ggaagagcag cagcaacagc agcaacagca
      181 gcagcagcag caccgggcgg ggggccgcgg caacaagacg cggaacagta ataacaataa
      241 cacggcgacg gcgatggggg gccggccggg ctccggggac ctcgcgtact tacggagccc
      301 cgcgggcctc ggccgcctgt cggcctcggc tgccgagagc cccgtggcag gaggctccgg
      361 gggcgcggcg gccgtccccg cggcgggcag caaagtgctg ctgggcttca gctcggacga
      421 gtcggacgtg gaggccagcc cgcgggagca ggcgggcggc ggcggcgcgc ggagggaccg
      481 ggctgcgctc cagtaccgcg ggctcagagc cccaccggcg cccccggccg cgggcgaggt
      541 gacgggcggc cacccgggcg agcggaggaa gccgcactcg tggtgggggg cgcggaggcc
      601 ggcgggcccc gagccgcagc ccccggcggc ggggagcgac ggggccgcgg aggacgcgga
      661 cgaggagctg gcggacggtg aggaccgcga ccccgaggcc gaggagccgc tgtgggccag
      721 ccgaacggtg aacggcagcc ggcttctccc ctacagcagc tgccgggagc actactcgga
      781 ctcggaggag gaggaggagg agggggagga ggacggcgac gtggccccgg ccagacaggt
      841 attaaaggac gactccctcg cccggcatcg acccagacgg agccatagta agccgttctc
      901 ggcgctgact gctaaatctg gcggcagccg gcaggagact tcggttcagg gagggggagc
      961 actcgcgatg aatgacaggg cggcggccgc ggggagtcta gacaggagcc gaaacctcga
     1021 ggaggcggcg gccgagccgg gaggaggagg aggaggaggg tgcgggtgcg atccagtgga
     1081 ctccattcct cgataccgtg ccggcgcgaa gaagctggcc ccgctgctgt cgcctccgag
     1141 tcccgatggg gactccacct tggagtcgcc cacggggccc ctcctcaaaa ccaataatca
     1201 cataggcggc ggggccttcg gcgtggattc ccccggtctg tatgccaaca gcctccctcc
     1261 cggggccacc gccgcggccg cccctggcac actcaggatc aaccacgcca accatactgg
     1321 ctccaatcac acctacctga aaaccgccta cggcaagccg aagctctgcg agcccgaaga
     1381 ggaacttctc cagcagttta aacgggagga ggtgtccccg acggggagtt tcagcgctca
     1441 ctacttgtcg atgttcctcc taaccgctgc ctgcttgttt ttcctaatac tgggactgac
     1501 ttacctagga atgagaggga cgggagtacc cgaggacgga ggactcataa aaaacccctt
     1561 tgatgaaaca tttggaaaaa tacaagaaag tgaaaaaaat cttttgatga gcacattgta
     1621 caaacttcat gatcgattgg cccagattgc aggagaccat gaatgtggca gttctagtca
     1681 aaggatgctt tctgtccaag aagcagctgc atatttaaaa aatttaggtc ctgagtatga
     1741 agatgtattt aatacttcat tgctgtggat ttttaaaaat gggaaagatg ttggaataag
     1801 gtgtgttggt tacgggcctg aggaagactt gacaaacata actgatgtgc agtttttaca
     1861 gtccaccagg ccccagatgc ccttctggtg ccgtttccgg cgtgctttca ttactgtgac
     1921 ccataggtta ttgttgttat gtttaggtgt agtgctggtg tgcgttgctc tccggtacat
     1981 gagataccgc tggactaagg aggaggagga gacgaggcag atgtatgaca tggtggtaaa
     2041 gattatagat gttttgcgaa gtcataatga agcttgccag gagactaaag acttacagcc
     2101 ttacatgcct cttccacatg tccgcgattc cctaatacag ccgcaggaca ggaaaaagat
     2161 gaagaaagtc tgggatagag ctgttgactt ccttgctgct aacgaatcta gagtccgtac
     2221 ggagactcga agagtaggcg gtgcagactt tctagtctgg cggtggatcc agccctctgc
     2281 gtcttgtgac aagacattag ttataccctc taaagtatgg caaggtcaag catttcattt
     2341 agatagaaga aattcaccac caaatagttt gactccatgt ttaaagattc gaaatatgtt
     2401 tgacccggtt atggaaatag gagatcactg gcacctggcg atccaagaag cgattttaga
     2461 gaagtgcagt gacaatgacg gcatcgttca tattgccgta gacaggaact cgcgggaggg
     2521 ctgtgtctat gttaaatgtt tgtctccgga atatgctggg aaggctttta aagcattgca
     2581 tggctcttgg tttgatggaa aattggttac agtaaaatac ttacgactag atagatacca
     2641 ccatcgcttt ccccaggccc tcacttgcaa cactcccttg aagccagcaa ataaacatat
     2701 gaactctctg tctcacctgc gcctgcggac tggcctagct aattctcaag gaagttcctg
     2761 aaaagatgtc ttcactccta ggactgttaa tttaaatagg aaattcccat ttggcttcct
     2821 gtcttccttt gaaaatgctt tttgtatgta atatttttat tgctgaagac agctgtttga
     2881 gagttctgca aatcttcagg ttccgaaggc tttggcagtg aggcaggcag tgcctaggag
     2941 gcagagaagg acgtctcact cagtttgtgc ggctcaggta tgccaggctg cacatgagga
     3001 gcaccggctt gacagcaagc ggttccgaga tggtgcttgt aggcgtgcac caagagtgtt
     3061 agagaaccac ggacaagcat ggcaaagcag cttgttttgt atttccataa tttgtgaact
     3121 aatgtgaatt tttgtataca gtaagccgca tcgttcctta caggccactg tggtaaaacc
     3181 attcacttcc cactttaacc ttaggttcct attgcttgta aaaggttcat ttgctgcagc
     3241 tggaatatgg ggaaatttat ttggttttaa tggttacata catgtaagag ggtgtacatg
     3301 tacttacatt ggcttttgta tatatgtata aatgctgatg atagcgaaag tcttgttttg
     3361 tgagaatgtc tgcattagca gtaaaataag ctttctattt tactcataat ctaatctgta
     3421 tatatataca tatatatata tgtatatgtg cgtagctgtg tgtctatgta catatgtagc
     3481 tgcacatatg tacatatcca cacagatata tacatatggc tgtacagtca tagatgatca
     3541 aacagccaaa tacctggaag tattagatac atgtttaaaa tatcttttat agattttata
     3601 taaaaatatc cgagtatggt tttgtgtaga agttctggca ccagctgtaa tgagttcaaa
     3661 tttatgtgag caataaagaa gcaattggca gatactggaa aatattttgt gaaaagctgt
     3721 atttattata aatactggga ctgtgacaga actaaaggga ttatgtcatt tcccagtctg
     3781 tttatagctt aaagaactgt tagctcctgt tctgtgtcca gtgtaaaaca gggtgcattg
     3841 ttgcagcaaa atgtactaga caaatttcct tggaatgttg ggccatgcaa gtttgcagtg
     3901 tagatcgtgc acgaatgacc attggtttgt gcctcagtgt ttatttcagt atgatttcag
     3961 atcagaatag ttactgatca aggtttactt gtaacctaaa aattggcttt ttgaaaaata
     4021 acctgctgga tagatcattg ttggtccaag ggaagatgtg aaacagctgg aattacatga
     4081 atcttaattt ttacgttaag ttcagttttc tttttgttgt gtatgtgttt ggtttgcagc
     4141 atgaacttgc acagataatg cacgttttct ggttaagtaa acatgatgca cactattctg
     4201 taacagaaaa cccttgtgcc ttacctgtgt gcttttgtgg gcaccatgtt tatgaagaat
     4261 aaatgatttg ttatcagaag agaataaatt ttaaattctc aatctatgtc tcagatgcta
     4321 atgtgttaaa atatatatat ataatatata aagtaaccaa tctttctgta ttttatgtgc
     4381 atcatagtga tttatttgag cttagtgaca caatcttgta acctgttgca agagtgaatg
     4441 taaaataata tagttgtggc atttaaacag gtcacctttt gatgcagatg catccttttc
     4501 ttgcttctaa gatatatttc atgtaaacat tgtacattta ttattgtaat atatactatt
     4561 atgcagctta ttttacctgg aactcttaag ccgaccaaga gtcctccctg taagacagat
     4621 gggaatgtgt ataataatta ggtatttgaa aagttctgct ttgatgtaat ttgtttcttg
     4681 ttctgtttta aaaaaagaag gaaaacattc taattaaaaa tttattaggt ttttttaaaa
     4741 acaaaaaaaa aaaa
//
