LOCUS       NM_001379059            3554 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus lymphoid enhancer binding factor 1 (Lef1), transcript
            variant 4, mRNA.
ACCESSION   NM_001379059 XM_006501068
VERSION     NM_001379059.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3554)
  AUTHORS   Leybova,L., Biswas,A., Sharan,R., Trejo,B.M., Kim,K.,
            Soto-Muniz,Y., Jones,R.A., Phillips,B.K. and Devenport,D.
  TITLE     Radially patterned morphogenesis of murine hair follicle placodes
            ensures robust epithelial budding
  JOURNAL   Dev Cell 59 (24), 3272-3289 (2024)
   PUBMED   39413781
REFERENCE   2  (bases 1 to 3554)
  AUTHORS   Oh,S.A., Jeon,J., Je,S.Y., Kim,S., Jung,J. and Ko,H.W.
  TITLE     TMEM132A regulates Wnt/beta-catenin signaling through stabilizing
            LRP6 during mouse embryonic development
  JOURNAL   Cell Commun Signal 22 (1), 482 (2024)
   PUBMED   39385148
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3554)
  AUTHORS   Bugacov,H., Der,B., Briantseva,B.M., Guo,Q., Kim,S., Lindstrom,N.O.
            and McMahon,A.P.
  TITLE     Dose-dependent responses to canonical Wnt transcriptional complexes
            in the regulation of mammalian nephron progenitors
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39250420
REFERENCE   4  (bases 1 to 3554)
  AUTHORS   Paramore,S.V., Goodwin,K., Fowler,E.W., Devenport,D. and
            Nelson,C.M.
  TITLE     Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and
            widening independently of the planar cell polarity complex
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39225402
REFERENCE   5  (bases 1 to 3554)
  AUTHORS   Shao,F., Phan,A.V., Yu,W., Guo,Y., Thompson,J., Coppinger,C.,
            Venugopalan,S.R., Amendt,B.A., Van Otterloo,E. and Cao,H.
  TITLE     Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling
            lineage specification of mandibular epithelium during tooth
            initiation
  JOURNAL   PLoS Genet 20 (7), e1011364 (2024)
   PUBMED   39052671
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3554)
  AUTHORS   Love,J.J., Li,X., Case,D.A., Giese,K., Grosschedl,R. and
            Wright,P.E.
  TITLE     Structural basis for DNA bending by the architectural transcription
            factor LEF-1
  JOURNAL   Nature 376 (6543), 791-795 (1995)
   PUBMED   7651541
REFERENCE   7  (bases 1 to 3554)
  AUTHORS   Zhou,P., Byrne,C., Jacobs,J. and Fuchs,E.
  TITLE     Lymphoid enhancer factor 1 directs hair follicle patterning and
            epithelial cell fate
  JOURNAL   Genes Dev 9 (6), 700-713 (1995)
   PUBMED   7537238
REFERENCE   8  (bases 1 to 3554)
  AUTHORS   Milatovich,A., Travis,A., Grosschedl,R. and Francke,U.
  TITLE     Gene for lymphoid enhancer-binding factor 1 (LEF1) mapped to human
            chromosome 4 (q23-q25) and mouse chromosome 3 near Egf
  JOURNAL   Genomics 11 (4), 1040-1048 (1991)
   PUBMED   1783375
REFERENCE   9  (bases 1 to 3554)
  AUTHORS   Travis,A., Amsterdam,A., Belanger,C. and Grosschedl,R.
  TITLE     LEF-1, a gene encoding a lymphoid-specific protein with an HMG
            domain, regulates T-cell receptor alpha enhancer function
            [corrected]
  JOURNAL   Genes Dev 5 (5), 880-894 (1991)
   PUBMED   1827423
  REMARK    Erratum:[Genes Dev 1991 Jun;5(6):following 1113]
REFERENCE   10 (bases 1 to 3554)
  AUTHORS   Mattei,M.G., Simon-Chazottes,D., Hirai,S., Ryseck,R.P.,
            Galcheva-Gargova,Z., Guenet,J.L., Mattei,J.F., Bravo,R. and
            Yaniv,M.
  TITLE     Chromosomal localization of the three members of the jun
            proto-oncogene family in mouse and man
  JOURNAL   Oncogene 5 (1), 151-156 (1990)
   PUBMED   2108401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114668.12 and AC123634.10.
            
            On Mar 19, 2020 this sequence version replaced XM_006501068.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.8735.1,
                                           SRR7652917.448311.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1356              AC114668.12        145131-146486
            1357-1423           AC114668.12        148664-148730
            1424-1557           AC114668.12        150221-150354
            1558-1690           AC123634.10        115081-115213       c
            1691-1781           AC123634.10        110431-110521       c
            1782-1865           AC123634.10        108750-108833       c
            1866-1988           AC123634.10        106605-106727       c
            1989-2151           AC123634.10        105069-105231       c
            2152-2259           AC123634.10        99454-99561         c
            2260-2308           AC123634.10        95552-95600         c
            2309-3554           AC123634.10        75535-76780         c
FEATURES             Location/Qualifiers
     source          1..3554
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 60.78 cM"
     gene            1..3554
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /note="lymphoid enhancer binding factor 1"
                     /db_xref="GeneID:16842"
                     /db_xref="MGI:MGI:96770"
     exon            1..1356
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1150..2388
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /note="isoform d is encoded by transcript variant 4"
                     /codon_start=1
                     /product="lymphoid enhancer-binding factor 1 isoform d"
                     /protein_id="NP_001365988.1"
                     /db_xref="GeneID:16842"
                     /db_xref="MGI:MGI:96770"
                     /translation="MPQLSGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEE
                     EGDLADIKSSLVNESEIIPASNGHEVVRQAPSSQEPYHDKAREHPDEGKHPDGGLYNK
                     GPSYSSYSGYIMMPNMNSDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSD
                     EHFSPGSHPSHIPSDVNSKQGMSRHPPAPEIPTFYPLSPGGVGQITPPIGWQGQPVYP
                     ITGGFRQPYPSSLSGDTSMSRFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSD
                     LMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRR
                     WHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESTSGGKRSS
                     FPTCKAKAATPGPLLEMEAC"
     exon            1357..1423
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1557
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1690
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1781
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1865
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1988
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2151
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2259
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2308
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..3554
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2988..2993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /note="hexamer: AATAAA"
     polyA_site      3009
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
     regulatory      3532..3537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /note="hexamer: AATAAA"
     polyA_site      3554
                     /gene="Lef1"
                     /gene_synonym="3000002B05; Lef-1"
                     /note="major polyA site"
ORIGIN      
        1 gaggagaagc ggtgggaagg cgcaaccgct cacctgcggg gcagcgcgca ccggagggac
       61 cgggctgcgc tttcgtgggc cctggcattc ggacattccc ggagccttgc aagcggctac
      121 gctccgggtg ttccccggcc ggtctgcccg gaggagccga ggggccaccg gcagctcttt
      181 gctttgaccg aggggaggcg gggagagagg cgagccaggc agaaactcga gccgggaaca
      241 aagagggatc gggctcgagt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtaagtgt
      301 gtgtatcggc ccgagctgcg ggctggaaca tttgggcccg aagctcctgc tgtgactccc
      361 caagactccg ccgtgccagc caccgccgat tcccagcgct catcatcaca aactttattc
      421 ttggcaaact tctctttttc tcccctcctc ctccgcccct ccccctccag cagattaaat
      481 gctcctccag aaggaaaacc gaagcgaaag ggaaggaaag aagctctaac gcggacgtct
      541 gcagcccggt ggctctttat tgtttactct gaaggaagtg gacttttcgg tattttctga
      601 ttcttctcgt acctccgctg gggcaaaggg agcctcttgg cccagctctc ctcttctcaa
      661 aaacaaaaca aaacaaaacc ccaaatcacc gaaatcagca tccgaggaat ccgtggagag
      721 gttttgcacg gtgacgcacc acgggaccct cgtttgcact ttggcaagtc gtgtcccctc
      781 cggaaccggt gtcctcgaag cacagacccc agcaacgagt gcggcgtggg gtggccaccc
      841 agccctggca gcctagccta gtgcacgcgg agcggcgtag acgctctcag aggcgccggc
      901 ggctgccgcc ctcgcagtct ggtgcccttc gccccagggc cgggcgccgg cgtccttcta
      961 agtgggaaag cgcggcaatc gcagaggctc ctgcagctgc tccagccgtg ggcccctcgc
     1021 ttgcccaccc ggcttccatt cacagtcctc ccgcactcag tcttccaact cccccacctc
     1081 acatcgaccc tcccttcttg ctgtctcgga gtgctcccgc agcggagcgg agattacaca
     1141 gccgccggga tgccccaact ttccggagga ggcggcgggg gggacccgga actctgcgcc
     1201 accgatgaga tgatcccctt caaggacgaa ggcgatcccc agaaggagaa gatcttcgcc
     1261 gagatcagtc atcccgaaga ggagggcgac ttagccgaca tcaagtcatc tttggttaac
     1321 gagtccgaaa tcatcccagc cagcaacggg catgaggtgg tcagacaagc cccgtcctct
     1381 caggagccct accacgacaa ggccagagaa caccctgatg aaggaaagca tccagacgga
     1441 ggcctgtaca acaagggacc ctcctactcc agttactctg gctacataat gatgcccaat
     1501 atgaacagcg acccgtacat gtcaaatggg tccctttctc cacccatccc gaggacatca
     1561 aataaagtgc ccgtggtgca gccctctcac gcggtccacc cgctcacccc cctcatcacc
     1621 tacagcgacg agcacttttc tccgggatcc cacccgtcac acatcccgtc agatgtcaac
     1681 tccaagcaag gcatgtccag acaccctcca gctcctgaaa tccccacctt ctaccccctg
     1741 tctccgggcg gcgttggaca gatcacccca cccattggct ggcaaggtca gcctgtttat
     1801 cccatcacgg gtggattcag gcaaccctac ccatcctcac tgtcaggcga cacttccatg
     1861 tccaggtttt cccatcatat gattcctggt ccccctggcc cccacacaac tggcatccct
     1921 catccagcta ttgtaacacc tcaggtcaaa caggagcacc cccacacgga cagtgaccta
     1981 atgcacgtga agcctcaaca cgaacagaga aaggagcagg agcccaaaag acctcatatt
     2041 aagaagcctc tgaatgcttt catgttatat atgaaagaaa tgagagcgaa tgtcgtagct
     2101 gagtgcacgc taaaggagag tgcagctatc aaccagatcc tgggcagaag atggcacgcc
     2161 ctctcccggg aagagcaggc caaatactat gaactagcac ggaaagagag acagctacac
     2221 atgcagcttt atccaggctg gtcagcgcga gacaattatg gcaagaagaa gaagaggaag
     2281 agagagaagc tacaggagtc gacttcaggt ggtaagagaa gctccttccc aacgtgcaaa
     2341 gccaaggcag cgaccccagg ccctcttctg gagatggaag cttgttgaaa ccccagactg
     2401 tctccacagc ttgcccggct gaccccaagg aacactgaca gcaaccttac cctgaggtca
     2461 ctgctagcgc tgacccgaag acacagtcac tgccacctct tccttctgtc gtctactgca
     2521 agcgccgact tccaaaaaga aagccgaaaa cggttgtttc ggaaaaagaa aaaaaaattt
     2581 ttttttcagc ccgtgagaag gctagcaggc cctgcccact gagcggcact gcctccggtc
     2641 tctgtgcgat cctccagcat cttctgtgct gacctgtcac ccttccgcaa ggacagacag
     2701 gaccttggct gtgtttgcct tgtcacgtgc aactagaaag ccagcgacca gagcgggtat
     2761 cctggtgtga gaattgtgga agactcctct cgctcctgtc ttcattttcc tatccaaatt
     2821 tttatttaac agtacaaaag gatcaagtgt gtgtttgctt cttcttcttc ttcttttttt
     2881 ttaacttgga atttttaaat ttactttttt tttaattttt attttccttg tatatttttg
     2941 ctagctctga gcttttaagt gaaattcata ggtctgaaag agtttgaaat aaaaacaaga
     3001 tgaaaagaag ccttttacgt ttttttcttt tttcttttct ttcttttttt tttccttttt
     3061 tcttttgtcc tgagagatct tgtccagtaa atggcttctc tgtgacacac agtggcctct
     3121 gccctgtgaa gtgtctgatg aagctaaaga gatagccaaa cccactcctg ttggtggtca
     3181 catttggcag cccgtctcac ttagtttctg attttttttt aaataacaac agatcttaac
     3241 atctcctttg agcgaacccg tttgcagttc atttttttaa tctctttctt ttcactcctg
     3301 taaaaagccc agcacttgaa ttgttctttc tttaaatgtt ctgtgtttgt atctgttttt
     3361 attagccgat tagtgggaat ttatgccagt tgttaaaatg agcattgacg cacctgttat
     3421 tttttttttt ttaaatagca aggcacagcc tctgccccaa acttgtcatc ttaacgtttg
     3481 tcattccagt ttgagttaac gtgctgagca ttttttaaaa agaagctttg taataaaaca
     3541 tttttttaaa agtg
//
