LOCUS       NM_010702                889 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus leukocyte cell-derived chemotaxin 2 (Lect2), mRNA.
ACCESSION   NM_010702
VERSION     NM_010702.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 889)
  AUTHORS   Liu,Z., Jiang,X., Zhao,K., Ruan,H., Ma,Y., Ma,Y., Zhou,Q.,
            Zhang,J., Sun,X., Ma,W. and Xu,S.
  TITLE     Role of LECT2 in exacerbating atopic dermatitis: insight from in
            vivo and in vitro models via NF-kappaB signaling pathway
  JOURNAL   Front Immunol 15, 1439367 (2024)
   PUBMED   39206203
  REMARK    GeneRIF: Role of LECT2 in exacerbating atopic dermatitis: insight
            from in vivo and in vitro models via NF-kappaB signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 889)
  AUTHORS   Tanida,R., Goto,H., Takayama,H., Nakano,Y., Oo,H.K.,
            Galicia-Medina,C.M., Takahashi,K., Ishii,K.A., Goli,A.S.,
            Matsuzaka,T., Harada,K. and Takamura,T.
  TITLE     LECT2 Deletion Exacerbates Liver Steatosis and Macrophage
            Infiltration in a Male Mouse Model of LPS-mediated NASH
  JOURNAL   Endocrinology 165 (7) (2024)
   PUBMED   38781447
  REMARK    GeneRIF: LECT2 Deletion Exacerbates Liver Steatosis and Macrophage
            Infiltration in a Male Mouse Model of LPS-mediated NASH.
REFERENCE   3  (bases 1 to 889)
  AUTHORS   Zhang,X., Sun,K., Tang,C., Cen,L., Li,S., Zhu,W., Liu,P., Chen,Y.,
            Yu,C. and Li,L.
  TITLE     LECT2 modulates dendritic cell function after Helicobacter pylori
            infection via the CD209a receptor
  JOURNAL   J Gastroenterol Hepatol 38 (4), 625-633 (2023)
   PUBMED   36740832
  REMARK    GeneRIF: LECT2 modulates dendritic cell function after Helicobacter
            pylori infection via the CD209a receptor.
REFERENCE   4  (bases 1 to 889)
  AUTHORS   Xie,Y., Zhong,K.B., Hu,Y., Xi,Y.L., Guan,S.X., Xu,M., Lin,Y.,
            Liu,F.Y., Zhou,W.J. and Gao,Y.
  TITLE     Liver infiltration of multiple immune cells during the process of
            acute liver injury and repair
  JOURNAL   World J Gastroenterol 28 (46), 6537-6550 (2022)
   PUBMED   36569272
  REMARK    GeneRIF: Liver infiltration of multiple immune cells during the
            process of acute liver injury and repair.
REFERENCE   5  (bases 1 to 889)
  AUTHORS   Shirasaki,T., Yamagoe,S., Shimakami,T., Murai,K., Imamura,R.,
            Ishii,K.A., Takayama,H., Matsumoto,Y., Tajima-Shirasaki,N.,
            Nagata,N., Shimizu,R., Yamanaka,S., Abe,A., Omura,H., Kawaguchi,K.,
            Okada,H., Yamashita,T., Yoshikawa,T., Takimoto,K., Taharaguchi,M.,
            Takatsuka,S., Miyazaki,Y., Tamai,T., Tanabe,Y., Kurachi,M.,
            Yamamoto,Y., Kaneko,S., Matsumoto,K., Takamura,T. and Honda,M.
  TITLE     Leukocyte cell-derived chemotaxin 2 is an antiviral regulator
            acting through the proto-oncogene MET
  JOURNAL   Nat Commun 13 (1), 3176 (2022)
   PUBMED   35676290
  REMARK    GeneRIF: Leukocyte cell-derived chemotaxin 2 is an antiviral
            regulator acting through the proto-oncogene MET.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 889)
  AUTHORS   Saito,T., Okumura,A., Watanabe,H., Asano,M., Ishida-Okawara,A.,
            Sakagami,J., Sudo,K., Hatano-Yokoe,Y., Bezbradica,J.S., Joyce,S.,
            Abo,T., Iwakura,Y., Suzuki,K. and Yamagoe,S.
  TITLE     Increase in hepatic NKT cells in leukocyte cell-derived chemotaxin
            2-deficient mice contributes to severe concanavalin A-induced
            hepatitis
  JOURNAL   J Immunol 173 (1), 579-585 (2004)
   PUBMED   15210819
REFERENCE   7  (bases 1 to 889)
  AUTHORS   Juriloff,D.M., Gunn,T.M., Harris,M.J., Mah,D.G., Wu,M.K. and
            Dewell,S.L.
  TITLE     Multifactorial genetics of exencephaly in SELH/Bc mice
  JOURNAL   Teratology 64 (4), 189-200 (2001)
   PUBMED   11598925
REFERENCE   8  (bases 1 to 889)
  AUTHORS   Juriloff,D.M., Harris,M.J. and Brown,C.J.
  TITLE     Unravelling the complex genetics of cleft lip in the mouse model
  JOURNAL   Mamm Genome 12 (6), 426-435 (2001)
   PUBMED   11353389
REFERENCE   9  (bases 1 to 889)
  AUTHORS   Shukunami,C., Kondo,J., Wakai,H., Takahashi,K., Inoue,H.,
            Kamizono,A. and Hiraki,Y.
  TITLE     Molecular cloning of mouse and bovine chondromodulin-II cDNAs and
            the growth-promoting actions of bovine recombinant protein
  JOURNAL   J Biochem 125 (3), 436-442 (1999)
   PUBMED   10050029
REFERENCE   10 (bases 1 to 889)
  AUTHORS   Yamagoe,S., Watanabe,T., Mizuno,S. and Suzuki,K.
  TITLE     The mouse Lect2 gene: cloning of cDNA and genomic DNA, structural
            characterization and chromosomal localization
  JOURNAL   Gene 216 (1), 171-178 (1998)
   PUBMED   9714793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132901.11, AK131971.1 and AI173435.1.
            
            On Aug 12, 2009 this sequence version replaced NM_010702.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI327554.1, BC027753.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC132901.11        115045-115134       c
            91-870              AK131971.1         2-781
            871-889             AI173435.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..889
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.08 cM"
     gene            1..889
                     /gene="Lect2"
                     /note="leukocyte cell-derived chemotaxin 2"
                     /db_xref="GeneID:16841"
                     /db_xref="MGI:MGI:1278342"
     exon            1..222
                     /gene="Lect2"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..632
                     /gene="Lect2"
                     /note="LECT-2; chM-II; chondromodulin II"
                     /codon_start=1
                     /product="leukocyte cell-derived chemotaxin-2 precursor"
                     /protein_id="NP_034832.2"
                     /db_xref="CCDS:CCDS26564.1"
                     /db_xref="GeneID:16841"
                     /db_xref="MGI:MGI:1278342"
                     /translation="MIPTTILISAALLSSALAGPWANICASKSSNEIRTCDSYGCGQY
                     SAQRTQRHHPGVDVLCSDGSVVYAPFTGKIVGQEKPYRNKNAINDGIRLSGRGFCVKI
                     FYIKPIKYKGSIKKGEKLGTLLPLQKVYPGIQSHVHVENCDSSDPTAYL"
     exon            223..319
                     /gene="Lect2"
                     /inference="alignment:Splign:2.1.0"
     exon            320..465
                     /gene="Lect2"
                     /inference="alignment:Splign:2.1.0"
     exon            466..877
                     /gene="Lect2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      858..863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lect2"
                     /note="hexamer: AATGAA"
     polyA_site      873
                     /gene="Lect2"
                     /note="major polyA site"
ORIGIN      
        1 ggatcagaca gctctccacg gaatgttaca gtttaacccg actcatcttg ctttctgtgt
       61 ctcttactag atctcggaga gacataaatt accagagaag attcactcat tccgggggtg
      121 accctgtgtg catggagcag gtctaactag aggaagaaac aagaagcaga acctagatga
      181 ttcccacaac aatcctcatt tcagctgctt tgctttcctc tgccctagca ggaccatggg
      241 ctaacatatg tgccagcaaa tcttccaacg agatccggac gtgtgacagc tatggctgtg
      301 gacagtactc tgctcaaaga acccaaaggc atcacccagg tgtggacgtc ctgtgctcgg
      361 atggatctgt ggtgtatgca ccattcactg ggaagatagt gggccaggag aaaccctata
      421 gaaacaaaaa tgccatcaat gatggcattc gactgtctgg aagaggtttt tgtgtcaaaa
      481 ttttctacat taagccaatt aagtataaag gttctatcaa aaagggggag aagctgggca
      541 ccttgctgcc cctgcagaaa gtttacccgg gcatccagtc gcatgtacac gttgaaaact
      601 gcgactccag tgaccccaca gcatacctgt aagcagagac aaaggccaga tcttctaaat
      661 tcaaagccat ctcagaaact gggacatgcc ctgctcccga agaaacgtgc attctaacag
      721 aaacataaat ctgtgtaaac actcacaacc ctgattccaa gtcatcaccg ctctgacggg
      781 tgggctctgg tcggcctgcc acctcaaggg ccagggagtt tgacattttc gatttttagg
      841 ttctggtgac tgagataaat gaatgacctc tcatgtgaaa aaaaaaaaa
//
