LOCUS       NM_153069                497 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus liver-expressed antimicrobial peptide 2 (Leap2), mRNA.
ACCESSION   NM_153069
VERSION     NM_153069.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Hewawasam,N., Sarkar,D., Bolton,O., Delishaj,B., Almutairi,M.,
            King,A.J.F., Dereli,A.S., Despontin,C., Gilon,P., Reeves,S.,
            Patterson,M. and Hauge-Evans,A.C.
  TITLE     The GHSR1a antagonist LEAP2 regulates islet hormone release in a
            sex-specific manner
  JOURNAL   J Endocrinol 263 (2), e240135 (2024)
   PUBMED   39292603
  REMARK    GeneRIF: The GHSR1a antagonist LEAP2 regulates islet hormone
            release in a sex-specific manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Islam,M.N., Nabekura,H., Ueno,H., Nishida,T., Nanashima,A.,
            Sakoda,H., Zhang,W. and Nakazato,M.
  TITLE     Liver-expressed antimicrobial peptide 2 is a hepatokine regulated
            by ghrelin, nutrients, and body weight
  JOURNAL   Sci Rep 14 (1), 24782 (2024)
   PUBMED   39433849
  REMARK    GeneRIF: Liver-expressed antimicrobial peptide 2 is a hepatokine
            regulated by ghrelin, nutrients, and body weight.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 497)
  AUTHORS   Varshney,S., Shankar,K., Kerr,H.L., Anderson,L.J., Gupta,D.,
            Metzger,N.P., Singh,O., Ogden,S.B., Paul,S., Pinon,F.,
            Osborne-Lawrence,S., Richard,C.P., Lawrence,C., Mani,B.K.,
            Garcia,J.M. and Zigman,J.M.
  TITLE     The LEAP2 Response to Cancer-Related Anorexia-Cachexia Syndrome in
            Male Mice and Patients
  JOURNAL   Endocrinology 165 (11) (2024)
   PUBMED   39331742
  REMARK    GeneRIF: The LEAP2 Response to Cancer-Related Anorexia-Cachexia
            Syndrome in Male Mice and Patients.
REFERENCE   4  (bases 1 to 497)
  AUTHORS   Tufvesson-Alm,M., Zhang,Q., Aranas,C., Blid Skoldheden,S.,
            Edvardsson,C.E. and Jerlhag,E.
  TITLE     Decoding the influence of central LEAP2 on food intake and its
            effect on accumbal dopamine release
  JOURNAL   Prog Neurobiol 236, 102615 (2024)
   PUBMED   38641041
  REMARK    GeneRIF: Decoding the influence of central LEAP2 on food intake and
            its effect on accumbal dopamine release.
REFERENCE   5  (bases 1 to 497)
  AUTHORS   Lang,Y., Liu,Y., Ye,C., Tang,X., Cheng,Z., Xie,L., Feng,L. and
            Liu,Y.
  TITLE     Loss of LEAP-2 alleviates obesity-induced myocardial injury by
            regulating macrophage polarization
  JOURNAL   Exp Cell Res 430 (2), 113702 (2023)
   PUBMED   37414204
  REMARK    GeneRIF: Loss of LEAP-2 alleviates obesity-induced myocardial
            injury by regulating macrophage polarization.
REFERENCE   6  (bases 1 to 497)
  AUTHORS   Cornejo,M.P., Castrogiovanni,D., Schioth,H.B., Reynaldo,M.,
            Marie,J., Fehrentz,J.A. and Perello,M.
  TITLE     Growth hormone secretagogue receptor signalling affects high-fat
            intake independently of plasma levels of ghrelin and LEAP2, in a
            4-day binge eating model
  JOURNAL   J Neuroendocrinol 31 (10), e12785 (2019)
   PUBMED   31469195
  REMARK    GeneRIF: Growth hormone secretagogue receptor signalling affects
            high-fat intake independently of plasma levels of ghrelin and
            LEAP2, in a 4-day binge eating model.
REFERENCE   7  (bases 1 to 497)
  AUTHORS   Mani,B.K., Puzziferri,N., He,Z., Rodriguez,J.A.,
            Osborne-Lawrence,S., Metzger,N.P., Chhina,N., Gaylinn,B.,
            Thorner,M.O., Thomas,E.L., Bell,J.D., Williams,K.W., Goldstone,A.P.
            and Zigman,J.M.
  TITLE     LEAP2 changes with body mass and food intake in humans and mice
  JOURNAL   J Clin Invest 129 (9), 3909-3923 (2019)
   PUBMED   31424424
  REMARK    GeneRIF: plasma LEAP2/acyl-ghrelin molar ratio may be a key
            determinant modulating acyl-ghrelin activity in response to body
            mass, feeding status, and blood glucose.
REFERENCE   8  (bases 1 to 497)
  AUTHORS   Ge,X., Yang,H., Bednarek,M.A., Galon-Tilleman,H., Chen,P., Chen,M.,
            Lichtman,J.S., Wang,Y., Dalmas,O., Yin,Y., Tian,H., Jermutus,L.,
            Grimsby,J., Rondinone,C.M., Konkar,A. and Kaplan,D.D.
  TITLE     LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor
  JOURNAL   Cell Metab 27 (2), 461-469 (2018)
   PUBMED   29233536
  REMARK    GeneRIF: liver-expressed antimicrobial peptide 2 (LEAP2) is an
            endogenous antagonist of GHSR.
REFERENCE   9  (bases 1 to 497)
  AUTHORS   Bensaid,M., Fruchon,S., Mazeres,C., Bahram,S., Roth,M.P. and
            Coppin,H.
  TITLE     Multigenic control of hepatic iron loading in a murine model of
            hemochromatosis
  JOURNAL   Gastroenterology 126 (5), 1400-1408 (2004)
   PUBMED   15131800
REFERENCE   10 (bases 1 to 497)
  AUTHORS   Krause,A., Sillard,R., Kleemeier,B., Kluver,E., Maronde,E.,
            Conejo-Garcia,J.R., Forssmann,W.G., Schulz-Knappe,P., Nehls,M.C.,
            Wattler,F., Wattler,S. and Adermann,K.
  TITLE     Isolation and biochemical characterization of LEAP-2, a novel blood
            peptide expressed in the liver
  JOURNAL   Protein Sci 12 (1), 143-152 (2003)
   PUBMED   12493837
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            W82161.1 and AA571276.1.
            
            On Aug 29, 2006 this sequence version replaced NM_153069.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089593.1, CJ236586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               W82161.1           35-317
            284-497             AA571276.1         37-250
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.94 cM"
     gene            1..497
                     /gene="Leap2"
                     /gene_synonym="leap-2"
                     /note="liver-expressed antimicrobial peptide 2"
                     /db_xref="GeneID:259301"
                     /db_xref="MGI:MGI:2672795"
     exon            1..91
                     /gene="Leap2"
                     /gene_synonym="leap-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..265
                     /gene="Leap2"
                     /gene_synonym="leap-2"
                     /codon_start=1
                     /product="liver-expressed antimicrobial peptide 2
                     precursor"
                     /protein_id="NP_694709.1"
                     /db_xref="CCDS:CCDS36150.1"
                     /db_xref="GeneID:259301"
                     /db_xref="MGI:MGI:2672795"
                     /translation="MLQLKLFAVLLTCLLLLGQVNSSPVPEVSSAKRSRRMTPFWRGV
                     SLRPIGASCRDDSECITRLCRKRRCSLSVAQE"
     exon            92..228
                     /gene="Leap2"
                     /gene_synonym="leap-2"
                     /inference="alignment:Splign:2.1.0"
     exon            229..497
                     /gene="Leap2"
                     /gene_synonym="leap-2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      397
                     /gene="Leap2"
                     /gene_synonym="leap-2"
                     /note="major polyA site"
     regulatory      478..483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Leap2"
                     /gene_synonym="leap-2"
                     /note="hexamer: ATTAAA"
     polyA_site      497
                     /gene="Leap2"
                     /gene_synonym="leap-2"
                     /note="major polyA site"
ORIGIN      
        1 ggctttcaga ctccaacatc attcttttgc caagatgcta cagctaaaac tctttgcagt
       61 gctcctgact tgcctgctgc tgctgggtca ggtcaatagt tccccagtac cagaagtgag
      121 ttcagcaaag agatcccgga gaatgacccc attttggaga ggggtttccc tcaggcccat
      181 tggtgcctcg tgccgggatg actctgagtg tatcacaaga ctatgcagaa aaagacgctg
      241 ttccctaagt gtggcccagg agtgatgtcc atactgggga agagtcacct ccaacagtga
      301 tctgttctgg ggaatattgt taacgacatt ttggttggag atagataagt gaagtagtct
      361 ttgtttttaa tatttaaaga cggatacttg ctttaaactg gtctccattt cttattagaa
      421 tgttgttgat ttgtacatag acataacttt gtcagagttt atttttctat aaatactatt
      481 aaatgtctca aatctaa
//
