LOCUS       NM_001018087            1390 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus regulator of NFKB signaling (Ldoc1), mRNA.
ACCESSION   NM_001018087 XM_486688
VERSION     NM_001018087.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1390)
  AUTHORS   Walentin,K., Hinze,C., Werth,M., Haase,N., Varma,S., Morell,R.,
            Aue,A., Potschke,E., Warburton,D., Qiu,A., Barasch,J., Purfurst,B.,
            Dieterich,C., Popova,E., Bader,M., Dechend,R., Staff,A.C.,
            Yurtdas,Z.Y., Kilic,E. and Schmidt-Ott,K.M.
  TITLE     A Grhl2-dependent gene network controls trophoblast branching
            morphogenesis
  JOURNAL   Development 142 (6), 1125-1136 (2015)
   PUBMED   25758223
REFERENCE   2  (bases 1 to 1390)
  AUTHORS   Naruse,M., Ono,R., Irie,M., Nakamura,K., Furuse,T., Hino,T.,
            Oda,K., Kashimura,M., Yamada,I., Wakana,S., Yokoyama,M., Ishino,F.
            and Kaneko-Ishino,T.
  TITLE     Sirh7/Ldoc1 knockout mice exhibit placental P4 overproduction and
            delayed parturition
  JOURNAL   Development 141 (24), 4763-4771 (2014)
   PUBMED   25468940
REFERENCE   3  (bases 1 to 1390)
  AUTHORS   Astrom,P., Pirila,E., Lithovius,R., Heikkola,H., Korpi,J.T.,
            Hernandez,M., Sorsa,T. and Salo,T.
  TITLE     Matrix metalloproteinase-8 regulates transforming growth
            factor-beta1 levels in mouse tongue wounds and fibroblasts in vitro
  JOURNAL   Exp Cell Res 328 (1), 217-227 (2014)
   PUBMED   25036555
REFERENCE   4  (bases 1 to 1390)
  AUTHORS   Brandt,J., Schrauth,S., Veith,A.M., Froschauer,A., Haneke,T.,
            Schultheis,C., Gessler,M., Leimeister,C. and Volff,J.N.
  TITLE     Transposable elements as a source of genetic innovation: expression
            and evolution of a family of retrotransposon-derived neogenes in
            mammals
  JOURNAL   Gene 345 (1), 101-111 (2005)
   PUBMED   15716091
REFERENCE   5  (bases 1 to 1390)
  AUTHORS   Brandt,J., Veith,A.M. and Volff,J.N.
  TITLE     A family of neofunctionalized Ty3/gypsy retrotransposon genes in
            mammalian genomes
  JOURNAL   Cytogenet Genome Res 110 (1-4), 307-317 (2005)
   PUBMED   16093683
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672025.8 and BC052689.1.
            
            On Aug 14, 2018 this sequence version replaced NM_001018087.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC052689.1, AK137057.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-788               AL672025.8         139122-139909
            789-1390            BC052689.1         794-1395
FEATURES             Location/Qualifiers
     source          1..1390
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 34.57 cM"
     gene            1..1390
                     /gene="Ldoc1"
                     /gene_synonym="Gm366; Mar7; Mart7; Rtl7; Sirh7"
                     /note="regulator of NFKB signaling"
                     /db_xref="GeneID:434784"
                     /db_xref="MGI:MGI:2685212"
     exon            1..1340
                     /gene="Ldoc1"
                     /gene_synonym="Gm366; Mar7; Mart7; Rtl7; Sirh7"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..555
                     /gene="Ldoc1"
                     /gene_synonym="Gm366; Mar7; Mart7; Rtl7; Sirh7"
                     /note="breast cancer, up-regulated 1; leucine zipper,
                     down-regulated in cancer 1"
                     /codon_start=1
                     /product="protein LDOC1"
                     /protein_id="NP_001018097.1"
                     /db_xref="CCDS:CCDS30163.1"
                     /db_xref="GeneID:434784"
                     /db_xref="MGI:MGI:2685212"
                     /translation="MVEELLSLLHALLDRHQALCMENHQLLKQLRLLVCERARLLRQV
                     CPPSCPVPYPSRFSGESGRLPEFIMQTMSYMLANEEHFCNDAMKVAFLISLLSGEAEE
                     WVMPYIESNSYVLGDYQAFVDEMKQYFGWGTDDEDDGDDDEEEEMEEDH"
     regulatory      1315..1320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ldoc1"
                     /gene_synonym="Gm366; Mar7; Mart7; Rtl7; Sirh7"
                     /note="hexamer: AATAAA"
     polyA_site      1340
                     /gene="Ldoc1"
                     /gene_synonym="Gm366; Mar7; Mart7; Rtl7; Sirh7"
                     /note="major polyA site"
ORIGIN      
        1 gaggacccgc acttcctgct cagcctctct gtgcagctcc gtggagccga tccgagactg
       61 agaccgagac cgagaccgag accgtccaag cagttaacca tggtggaaga gctgctgtcg
      121 cttctgcacg cgcttctgga taggcaccaa gccctgtgca tggagaacca ccagctcctg
      181 aagcagctgc gactgttggt gtgtgagcgg gccaggctgc tgcgccaggt atgtccaccg
      241 agctgtccgg tgccctaccc ctcacggttt agcggcgaga gtggtcggct ccctgagttt
      301 atcatgcaga ccatgtctta catgcttgcg aatgaggagc acttctgcaa tgatgccatg
      361 aaagtggcat tcttgatcag cctcctctcc ggggaagctg aggagtgggt gatgccttac
      421 atcgagtcaa atagctacgt cctcggtgat tatcaggcct ttgttgatga gatgaagcag
      481 tattttggct ggggtaccga cgacgaagat gatggtgatg atgatgaaga ggaagaaatg
      541 gaggaagatc actaggccgg agccccctta ggcctagagg tgggggcctt cacgcctttt
      601 cattccaacc ccccacccgc cattcctgct gcctcaatct ctccctttgc atggccatcc
      661 tcttccccgc cagtctgttt gctccatcat tcccttcagg acttgtcttt gttccagtta
      721 cctgctgtga gttgggcctg gaccttgctc tgaaactcac tttggcctca ggcacttatc
      781 ctaatctgaa ctctgttcgg agttccagcg attttccagg tccctattag aactggtcag
      841 accacctgca ttcctgctgc tgacatccac tggaactcag gccagtccgc catctgccca
      901 gaagcagatt cctgacattt cacctccact caccgaattt catctgaagc acttttcaag
      961 ataaggacca agaagatgat ggagttgcta ctccacccat tcagactctg ttttggacta
     1021 ctcaccaaac cttgaagggg ccagccagtc tttaccgact ggttagttct gtacgtacta
     1081 ccaggttcca catctgcctg accagaacag gaacctgatg tgcctgccgg acagttaaaa
     1141 tgttgacatg tcttttctcc tatgcatcag ttttgcacag cacgtttcct ttcagaactg
     1201 cagcagcctc acagatgtgt ccatgtggac aaggactact aaaataaaag caaacggaca
     1261 ggcattcagc ccagatcctc tctagtactt gaaaaaagca atgtaattct ttgcaataaa
     1321 tatcaagcac tgcaaaacta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1381 aaaaaaaaaa
//
