LOCUS       NM_145554               2671 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus low density lipoprotein receptor adaptor protein 1
            (Ldlrap1), mRNA.
ACCESSION   NM_145554
VERSION     NM_145554.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2671)
  AUTHORS   Li,S., Teegarden,A., Bauer,E.M., Choi,J., Messaddeq,N.,
            Hendrix,D.A., Ganguli-Indra,G., Leid,M. and Indra,A.K.
  TITLE     Transcription Factor CTIP1/ BCL11A Regulates Epidermal
            Differentiation and Lipid Metabolism During Skin Development
  JOURNAL   Sci Rep 7 (1), 13427 (2017)
   PUBMED   29044125
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2671)
  AUTHORS   Tao,W., Moore,R., Meng,Y., Smith,E.R. and Xu,X.X.
  TITLE     Endocytic adaptors Arh and Dab2 control homeostasis of circulatory
            cholesterol
  JOURNAL   J Lipid Res 57 (5), 809-817 (2016)
   PUBMED   27005486
  REMARK    GeneRIF: The combination of Arh and Dab2 is responsible for the
            majority of adaptor function in LDLR endocytosis and LDLR-mediated
            cholesterol homeostasis.
REFERENCE   3  (bases 1 to 2671)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   4  (bases 1 to 2671)
  AUTHORS   Moore,R., Cai,K.Q., Tao,W., Smith,E.R. and Xu,X.X.
  TITLE     Differential requirement for Dab2 in the development of embryonic
            and extra-embryonic tissues
  JOURNAL   BMC Dev Biol 13, 39 (2013)
   PUBMED   24168030
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2671)
  AUTHORS   Shah,M., Baterina,O.Y. Jr., Taupin,V. and Farquhar,M.G.
  TITLE     ARH directs megalin to the endocytic recycling compartment to
            regulate its proteolysis and gene expression
  JOURNAL   J Cell Biol 202 (1), 113-127 (2013)
   PUBMED   23836931
REFERENCE   6  (bases 1 to 2671)
  AUTHORS   Maurer,M.E. and Cooper,J.A.
  TITLE     Endocytosis of megalin by visceral endoderm cells requires the Dab2
            adaptor protein
  JOURNAL   J Cell Sci 118 (Pt 22), 5345-5355 (2005)
   PUBMED   16263760
REFERENCE   7  (bases 1 to 2671)
  AUTHORS   Harada-Shiba,M., Takagi,A., Marutsuka,K., Moriguchi,S., Yagyu,H.,
            Ishibashi,S., Asada,Y. and Yokoyama,S.
  TITLE     Disruption of autosomal recessive hypercholesterolemia gene shows
            different phenotype in vitro and in vivo
  JOURNAL   Circ Res 95 (9), 945-952 (2004)
   PUBMED   15472122
  REMARK    GeneRIF: Hepatocytes do not take-up LDL in vivo without ARH
            protein, but they normally catabolize LDL in vitro. Thus, the
            requirement of ARH protein for proper functioning of the LDLR is
            not cell-specific, but rather may depend on the cellular
            environment.
REFERENCE   8  (bases 1 to 2671)
  AUTHORS   Michaely,P., Li,W.P., Anderson,R.G., Cohen,J.C. and Hobbs,H.H.
  TITLE     The modular adaptor protein ARH is required for low density
            lipoprotein (LDL) binding and internalization but not for LDL
            receptor clustering in coated pits
  JOURNAL   J Biol Chem 279 (32), 34023-34031 (2004)
   PUBMED   15166224
REFERENCE   9  (bases 1 to 2671)
  AUTHORS   Jones,C., Hammer,R.E., Li,W.P., Cohen,J.C., Hobbs,H.H. and Herz,J.
  TITLE     Normal sorting but defective endocytosis of the low density
            lipoprotein receptor in mice with autosomal recessive
            hypercholesterolemia
  JOURNAL   J Biol Chem 278 (31), 29024-29030 (2003)
   PUBMED   12746448
  REMARK    GeneRIF: results are consistent with LDL receptor adaptor
            protein(ARH) playing a critical and specific role in low density
            lipoprotein receptor endocytosis in the liver
REFERENCE   10 (bases 1 to 2671)
  AUTHORS   He,G., Gupta,S., Yi,M., Michaely,P., Hobbs,H.H. and Cohen,J.C.
  TITLE     ARH is a modular adaptor protein that interacts with the LDL
            receptor, clathrin, and AP-2
  JOURNAL   J Biol Chem 277 (46), 44044-44049 (2002)
   PUBMED   12221107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY124598.1, AK148340.1, AK167290.1 and BY435601.1.
            
            On Nov 15, 2007 this sequence version replaced NM_145554.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167290.1, BC067411.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BY124598.1         22-60
            40-550              AK148340.1         2-512
            551-2664            AK167290.1         500-2613
            2665-2668           AK148340.1         2626-2629
            2669-2671           BY435601.1         424-426
FEATURES             Location/Qualifiers
     source          1..2671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 67.09 cM"
     gene            1..2671
                     /gene="Ldlrap1"
                     /gene_synonym="Arh; Arh1; ARH2; FHCB1; FHCB2"
                     /note="low density lipoprotein receptor adaptor protein 1"
                     /db_xref="GeneID:100017"
                     /db_xref="MGI:MGI:2140175"
     exon            1..189
                     /gene="Ldlrap1"
                     /gene_synonym="Arh; Arh1; ARH2; FHCB1; FHCB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1031
                     /gene="Ldlrap1"
                     /gene_synonym="Arh; Arh1; ARH2; FHCB1; FHCB2"
                     /note="LDL receptor adaptor protein; autosomal recessive
                     hypercholesterolemia protein homolog"
                     /codon_start=1
                     /product="low density lipoprotein receptor adapter protein
                     1"
                     /protein_id="NP_663529.2"
                     /db_xref="CCDS:CCDS51327.1"
                     /db_xref="GeneID:100017"
                     /db_xref="MGI:MGI:2140175"
                     /translation="MDALKSAGRALIRSPSLAKQSWAGGRHRKLPENWTDTRETLLEG
                     MVFSLKYLGMTLVERPKGEELSAAAVKRIVATAKASGKKLQKVTLKVSPRGIILTDSL
                     TSQLIENVSIYRISYCTADKMHDKVFAYIAQSQQNESLECHAFLCTKRKVAQAVTLTV
                     AQAFKVAFEFWQVSKEEKEKREKANQEGGDVPGTRRDSTPSLKTLVATGNLLDLEEVA
                     KAPLSTVSANTNNVDETPRPQVLGNNSVVWELDDGLDEAFSRLAQSRTNPQVLDTGLS
                     AQDIHYAQCLSPTDWDKPDSSGIDQDDDVFTF"
     exon            190..332
                     /gene="Ldlrap1"
                     /gene_synonym="Arh; Arh1; ARH2; FHCB1; FHCB2"
                     /inference="alignment:Splign:2.1.0"
     exon            333..445
                     /gene="Ldlrap1"
                     /gene_synonym="Arh; Arh1; ARH2; FHCB1; FHCB2"
                     /inference="alignment:Splign:2.1.0"
     exon            446..560
                     /gene="Ldlrap1"
                     /gene_synonym="Arh; Arh1; ARH2; FHCB1; FHCB2"
                     /inference="alignment:Splign:2.1.0"
     exon            561..633
                     /gene="Ldlrap1"
                     /gene_synonym="Arh; Arh1; ARH2; FHCB1; FHCB2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..717
                     /gene="Ldlrap1"
                     /gene_synonym="Arh; Arh1; ARH2; FHCB1; FHCB2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..848
                     /gene="Ldlrap1"
                     /gene_synonym="Arh; Arh1; ARH2; FHCB1; FHCB2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..883
                     /gene="Ldlrap1"
                     /gene_synonym="Arh; Arh1; ARH2; FHCB1; FHCB2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..2671
                     /gene="Ldlrap1"
                     /gene_synonym="Arh; Arh1; ARH2; FHCB1; FHCB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2641..2646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ldlrap1"
                     /gene_synonym="Arh; Arh1; ARH2; FHCB1; FHCB2"
                     /note="hexamer: AATAAA"
     polyA_site      2666
                     /gene="Ldlrap1"
                     /gene_synonym="Arh; Arh1; ARH2; FHCB1; FHCB2"
                     /note="major polyA site"
ORIGIN      
        1 ggagcgcagc gggcgcgcgc cgcctggccc ggcggaaagt tttcctggag gagttttggc
       61 ggcggtagcg gcgtcagtgg cggcggcgac aaccggagcg ggccatggac gcgctcaagt
      121 cggcggggcg cgcgctaatc cggagcccca gtctggccaa gcagagctgg gcgggcggcc
      181 ggcaccgcaa gttgccagag aactggacgg acacgcggga gacactgctg gagggcatgg
      241 ttttcagcct caagtacctt ggtatgacgc tggtggagcg gcccaagggc gaggagctgt
      301 ctgcagctgc tgtcaagagg atcgtagcta cagccaaggc cagcgggaag aagctgcaga
      361 aggtgacact caaggtgtca ccccggggga tcatcctgac cgacagcctc actagccagc
      421 tcatcgagaa cgtgtccatt tacaggatct cctactgcac tgcagacaag atgcacgaca
      481 aggtgttcgc ctacatcgcc cagagccagc agaacgagag cctcgagtgc cacgccttcc
      541 tctgcaccaa gcggaaagtg gcccaagccg tcaccctgac tgtagcccaa gccttcaaag
      601 ttgcctttga gttttggcag gtgtccaagg aagagaaaga gaaaagggag aaagccaacc
      661 aggaaggagg agacgtccca gggacccgac gggacagcac cccctcactg aaaaccttgg
      721 tcgctaccgg gaacctgctg gatttggaag aggtggctaa ggccccgtta tctacagtca
      781 gcgctaatac caacaacgtg gacgagacac cacggcctca ggtcttgggc aacaacagcg
      841 tcgtctggga gctggatgac ggcctggacg aagcattttc aaggctggcg cagtcccgga
      901 caaaccctca agtcctggac actggactgt cagcacagga catccattat gcacagtgct
      961 tatcgcccac cgactgggac aagcctgaca gcagtggcat tgatcaagat gatgacgtct
     1021 tcaccttctg aggacccgag gctggcaata cactactggc ctagacatgg gacggaccat
     1081 aagccaccag cagcaggcag ccaacttcag gagccatcag ctgcctttgg ccaggggcgt
     1141 cagagcctac agattcaggt tgcacagtca ctcggggaga gggggagaaa gatgcctgcg
     1201 gtatccagtt ggtgactcct ggtttatgct cggaaaccag tttgattcag gtgctcatgt
     1261 gtgtggggca gggcctggcc tcctggagcc agtgccccct cctgctgtgg gcgtcaggac
     1321 aatgaccaaa gccgttgatg ttccttttct ctgggcatcc tcactcctga agcagtaaga
     1381 gcctgccgtt ctttgtgtac tggatgggac gtggctttca ggaaagttgg ggctcctcaa
     1441 gctctgcttc ctcggggccg agtaactgag gctctcagag aggcagcccc tgaccaaaga
     1501 cacatttaac tctgcacttt aactctcccg tagtggccat ggttcgaggt ccatgatggt
     1561 gctttgggag tagagcttgc ctcctgccct ccctccacaa gggggcccca gtccctgacg
     1621 tggcccatac agtgctagga cctagtgtac cagctgccca tgactcccag agtcactgca
     1681 accatggtga tcacctctgt ggctcctggg agtgcccccc acccccaccg ccaacagaca
     1741 aagctgggcc tgcttttctg ttttgtctgt ttgtccttgt gtgtgctcca ttttctgctt
     1801 ccccacaatt cctgggatga taccaaagcc tagcactagg ctgtggcagg cgattcttgc
     1861 atccatttta cagataaaga aactgaggcg acacacgtgt tgaggggtgg agttgagaac
     1921 agaacccaga tctgatacca aagctgccgt ctgtgctgcc acctcccagc ccacgcctct
     1981 ttctctgtgg ctttgttgtc ctcccaggaa ccaaaactcc ccagctattt tctgaccaaa
     2041 atgtgtttca taacaaacca tctggtgcct tttcacacag cgctggcgca ggccgccatg
     2101 ccctgctagc tgctatgccg ctgacttctg ggcagatgtg ttttgaagtc tgttaattcc
     2161 atgggtgaaa cggtatctca ctctagaaac atcttgctgt ccttttctga cctgcagccg
     2221 tagtggtccc tcgaccctag ctggtggtcg gggcggtcca gtggtgagct tctcttaatc
     2281 tcttttctcc cttcgctggt cccgtgggct ctggcatcct gaatctcagc caaactaaca
     2341 acatctttcc atcgcttgtg aaagctggtc tcagtgtccc caggaaaaca cacttttcct
     2401 gagtggctga gtcggaccct tgccttgggg gttggggggc acttggagaa ttcttgctag
     2461 aataaaggtt gccagctccc tttccctggc cagctccaag gcccctgctc cttagcccaa
     2521 gtggccaggg tacgggcgcg agggggactg tgtggtgttg ggtgatgctg tagtcttgct
     2581 tcctgtgcct gctgccaatg ctgctgtgtg aagctggaaa ggcagttctg agcaggaaac
     2641 aataaatgtt ccctttctga gtgtgagcat c
//
