LOCUS       NM_172631               2577 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus low density lipoprotein receptor class A domain
            containing 4 (Ldlrad4), transcript variant 1, mRNA.
ACCESSION   NM_172631
VERSION     NM_172631.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2577)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2577)
  AUTHORS   Youlten,S.E., Kemp,J.P., Logan,J.G., Ghirardello,E.J., Sergio,C.M.,
            Dack,M.R.G., Guilfoyle,S.E., Leitch,V.D., Butterfield,N.C.,
            Komla-Ebri,D., Chai,R.C., Corr,A.P., Smith,J.T., Mohanty,S.T.,
            Morris,J.A., McDonald,M.M., Quinn,J.M.W., McGlade,A.R.,
            Bartonicek,N., Jansson,M., Hatzikotoulas,K., Irving,M.D.,
            Beleza-Meireles,A., Rivadeneira,F., Duncan,E., Richards,J.B.,
            Adams,D.J., Lelliott,C.J., Brink,R., Phan,T.G., Eisman,J.A.,
            Evans,D.M., Zeggini,E., Baldock,P.A., Bassett,J.H.D., Williams,G.R.
            and Croucher,P.I.
  TITLE     Osteocyte transcriptome mapping identifies a molecular landscape
            controlling skeletal homeostasis and susceptibility to skeletal
            disease
  JOURNAL   Nat Commun 12 (1), 2444 (2021)
   PUBMED   33953184
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2577)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2577)
  AUTHORS   Liu,Z., Huo,X., Zhao,S., Yang,J., Shi,W., Jing,L., Li,W., Li,Y.,
            Ma,L., Gao,Y. and Diao,A.
  TITLE     Low density lipoprotein receptor class A domain containing 4
            (LDLRAD4) promotes tumorigenesis of hepatic cancer cells
  JOURNAL   Exp Cell Res 360 (2), 189-198 (2017)
   PUBMED   28888937
  REMARK    GeneRIF: Depletion of LDLRAD4 in HepG2 liver cancer cells inhibited
            tumorigenesis in nude mice. These results reveal an oncogenic role
            of LDLRAD4 in tumorigenesis through its association with Nedd4.
REFERENCE   5  (bases 1 to 2577)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2577)
  AUTHORS   Nakano,N., Maeyama,K., Sakata,N., Itoh,F., Akatsu,R., Nakata,M.,
            Katsu,Y., Ikeno,S., Togawa,Y., Vo Nguyen,T.T., Watanabe,Y., Kato,M.
            and Itoh,S.
  TITLE     C18 ORF1, a novel negative regulator of transforming growth
            factor-beta signaling
  JOURNAL   J Biol Chem 289 (18), 12680-12692 (2014)
   PUBMED   24627487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127236.3, BE987654.1 and AK052338.1.
            
            On Oct 27, 2017 this sequence version replaced NM_172631.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052338.1, SRR7345562.415003.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC127236.3         148428-148439
            13-84               BE987654.1         1-72
            85-2577             AK052338.1         2-2494
FEATURES             Location/Qualifiers
     source          1..2577
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 40.14 cM"
     gene            1..2577
                     /gene="Ldlrad4"
                     /gene_synonym="8230401C20Rik; A430083H02; A430108L08Rik;
                     C18orf1; D18Ertd653e; D330030L18Rik"
                     /note="low density lipoprotein receptor class A domain
                     containing 4"
                     /db_xref="GeneID:52662"
                     /db_xref="MGI:MGI:1277150"
     exon            1..216
                     /gene="Ldlrad4"
                     /gene_synonym="8230401C20Rik; A430083H02; A430108L08Rik;
                     C18orf1; D18Ertd653e; D330030L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            217..686
                     /gene="Ldlrad4"
                     /gene_synonym="8230401C20Rik; A430083H02; A430108L08Rik;
                     C18orf1; D18Ertd653e; D330030L18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             647..1567
                     /gene="Ldlrad4"
                     /gene_synonym="8230401C20Rik; A430083H02; A430108L08Rik;
                     C18orf1; D18Ertd653e; D330030L18Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     low-density lipoprotein receptor class A domain-containing
                     protein 4"
                     /codon_start=1
                     /product="low-density lipoprotein receptor class A
                     domain-containing protein 4 isoform 1"
                     /protein_id="NP_766219.2"
                     /db_xref="CCDS:CCDS29325.1"
                     /db_xref="GeneID:52662"
                     /db_xref="MGI:MGI:1277150"
                     /translation="MPEAGFQATNAFTECKFTCTSGKCLYLGSLVCNQQNDCGDNSDE
                     ENCLLVTEHPPPGIFNSELEFAQILIIVVVVTVMVVVVVCLLNHYKVSTRSFINRPNQ
                     SQRQEDGLQPEGSLWPSDSSVQRPGASEIMCAPRGRDRFTTPSFIQRDPFSRFQPTYP
                     YVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTVFDSDL
                     IDISMYNGGPCPPSSHSGISAATCSSNGRMEGPPPTYSEVMGHYPGTSFFHHQHSNTH
                     RGSRPQFQPNNSEGTIVPIKGKDRKPGDLV"
     exon            687..827
                     /gene="Ldlrad4"
                     /gene_synonym="8230401C20Rik; A430083H02; A430108L08Rik;
                     C18orf1; D18Ertd653e; D330030L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            828..982
                     /gene="Ldlrad4"
                     /gene_synonym="8230401C20Rik; A430083H02; A430108L08Rik;
                     C18orf1; D18Ertd653e; D330030L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1036
                     /gene="Ldlrad4"
                     /gene_synonym="8230401C20Rik; A430083H02; A430108L08Rik;
                     C18orf1; D18Ertd653e; D330030L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..2577
                     /gene="Ldlrad4"
                     /gene_synonym="8230401C20Rik; A430083H02; A430108L08Rik;
                     C18orf1; D18Ertd653e; D330030L18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1672..1677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ldlrad4"
                     /gene_synonym="8230401C20Rik; A430083H02; A430108L08Rik;
                     C18orf1; D18Ertd653e; D330030L18Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      1687
                     /gene="Ldlrad4"
                     /gene_synonym="8230401C20Rik; A430083H02; A430108L08Rik;
                     C18orf1; D18Ertd653e; D330030L18Rik"
                     /note="major polyA site"
     polyA_site      1691
                     /gene="Ldlrad4"
                     /gene_synonym="8230401C20Rik; A430083H02; A430108L08Rik;
                     C18orf1; D18Ertd653e; D330030L18Rik"
                     /note="major polyA site"
     polyA_site      1936
                     /gene="Ldlrad4"
                     /gene_synonym="8230401C20Rik; A430083H02; A430108L08Rik;
                     C18orf1; D18Ertd653e; D330030L18Rik"
ORIGIN      
        1 ggggaggagc tgcggccgcc gccagacagg ctgcaagtcc cgagaaggcg aaaggggggc
       61 ggggagctcc gagagcccgg tggcaggtcc ctcttaaaga gctacgccgc gccgtgtcgc
      121 gccacccgga gcgctgcccc tcccccgcag cccactgggc cggtggccga actgcgcggt
      181 gggcggtccc gctcgcccat ccaggggctg cggcagcaag aacagaagca gagcagagac
      241 cagcagatct gagcagactg agagcccttg gtgaggctga gcctgctccc tgtgtggaag
      301 atgccggccg ctgcaaggct gaggcgccct tcgttttgag gtgggagagc gggtttcggc
      361 aggacagctt ctccgttcct gacctcacca tggcttcaac tctctggctg gatggttgat
      421 gtgactgtgt gtccccacat gctgtcggac tgtgtgacat ccgggtagtg cctgctcaca
      481 gggtgtggga ggacagccag tgggcatcag atgctcccaa aagccggacc agcagagtga
      541 tggacttgga caggctaaga tggaagtgac ctgaggcctc gcccaggcag tttcttcaca
      601 acaggacagc tgaagaattg aaacacaggc ttgtctgggg agcagtatgc cggaagctgg
      661 ttttcaggcc acaaatgcgt tcacagagtg caaattcacc tgcaccagcg gtaaatgctt
      721 gtatcttggt tctctggtct gtaaccaaca gaacgactgt ggggacaaca gtgacgaaga
      781 gaactgcctc ctggtgaccg agcacccacc gccgggcatc ttcaactccg agctggaatt
      841 cgcgcagatc cttatcattg ttgtggtggt gacggtgatg gtggtggtcg ttgtctgcct
      901 actgaaccac tacaaagtct ccacacgctc cttcatcaac cgccccaacc agagccagag
      961 acaggaggac gggctgcagc cggaaggatc cctgtggcct tctgatagct ccgtgcagcg
     1021 cccaggggct tcagagatca tgtgtgcccc acggggcagg gataggttta ctaccccatc
     1081 tttcatccag agggatccat tcagtcgttt ccagcccacc tacccctatg tgcagcacga
     1141 gattgacttg cctcccacca tctccctgtc agacggggag gagccgcctc cttaccaagg
     1201 accctgcacg ctacagctcc gggacccaga gcagcagatg gaactcaacc gagagtccgt
     1261 gagggccccg cccaatcgaa ccgtttttga cagtgacttg atagacattt ctatgtacaa
     1321 cgggggacca tgcccaccaa gcagccactc gggcatcagc gcagctacct gtagcagtaa
     1381 cggaagaatg gaggggccac ccccgaccta cagcgaggtg atgggccact acccaggcac
     1441 ctcgttcttc catcaccagc acagcaacac acacaggggc agcagaccac agtttcagcc
     1501 gaacaactca gagggcacaa tagtacccat caagggcaaa gacaggaagc cgggggacct
     1561 ggtctgattc cctctagagt gcacttttca aggagagaga aaccgcggca gggagagaga
     1621 ggcccgctgg ccccactgcc acagtgttgt ccagctttac tggtacagcc aagtaaaacc
     1681 aaatgtgcaa acacggtctt cgtttctgct tcctttcacg ggaattgcat gcaaacaaga
     1741 tggaaacacg attcaaactt ccatccagtt tgaccacaga cagtgttcac cttggggcag
     1801 ggggtggatg gagacaaggg ctagagatgg tatgatcttg gctaagtggt gtgcagagaa
     1861 aactaaaaaa ggctgctttg aagacatcat gaaagtaaga cccacagagg tatttttgac
     1921 atatttgatt ccaaaaggag actgcggata aatgaggcca cagtggcctg ttttataatt
     1981 aactgaataa agagggaaga attattatat attatcatgg ggaagaatca gccagtttgc
     2041 tttttctcca aaggtgtgaa acttattttg ttttaaaaat atgagtcaaa actcctgttt
     2101 ggtgtgccaa ggttttaaag ttggagaagt tagacgagtg agaggaagtg atttgtgttg
     2161 tgatggtatg ttttaagagt tgcactatct caatgtttaa catatggatg agggaaccgt
     2221 gtcgtgtgaa gttctatatg ttgtcttgtc acctatggat ggctaccatg cccaaggaaa
     2281 cactcttgag tgtccacaga gtcatacaag aaaggtattt ggcaatgtac cctggtgttt
     2341 accaagttaa tgtacatttt taaaagtggt tatgttgcaa gaatttgcag ccagaagccg
     2401 tgtactactg aggtatttgg agaggttggt gaaaagagat gcttacactg tgtacggagt
     2461 gtcacgcaca gctagtcttt ttcccagcag ggtcagcagt tcagactttt tttccacagt
     2521 agcatgaaat atattcagat acatacccta ttttatgcaa taaatcgtct aaaatgc
//
