LOCUS       NM_178886               3910 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus low density lipoprotein receptor class A domain
            containing 3 (Ldlrad3), transcript variant 1, mRNA.
ACCESSION   NM_178886 XM_158875
VERSION     NM_178886.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3910)
  AUTHORS   Kafai,N.M., Janova,H., Cain,M.D., Alippe,Y., Muraro,S., Sariol,A.,
            Elam-Noll,M., Klein,R.S. and Diamond,M.S.
  TITLE     Entry receptor LDLRAD3 is required for Venezuelan equine
            encephalitis virus peripheral infection and neurotropism leading to
            pathogenesis in mice
  JOURNAL   Cell Rep 42 (8), 112946 (2023)
   PUBMED   37556325
  REMARK    GeneRIF: Entry receptor LDLRAD3 is required for Venezuelan equine
            encephalitis virus peripheral infection and neurotropism leading to
            pathogenesis in mice.
REFERENCE   2  (bases 1 to 3910)
  AUTHORS   Ma,H., Kim,A.S., Kafai,N.M., Earnest,J.T., Shah,A.P., Case,J.B.,
            Basore,K., Gilliland,T.C., Sun,C., Nelson,C.A., Thackray,L.B.,
            Klimstra,W.B., Fremont,D.H. and Diamond,M.S.
  TITLE     LDLRAD3 is a receptor for Venezuelan equine encephalitis virus
  JOURNAL   Nature 588 (7837), 308-314 (2020)
   PUBMED   33208938
  REMARK    GeneRIF: LDLRAD3 is a receptor for Venezuelan equine encephalitis
            virus.
REFERENCE   3  (bases 1 to 3910)
  AUTHORS   Noyes,N.C., Hampton,B., Migliorini,M. and Strickland,D.K.
  TITLE     Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by
            LRAD3
  JOURNAL   Biochemistry 55 (8), 1204-1213 (2016)
   PUBMED   26854353
REFERENCE   4  (bases 1 to 3910)
  AUTHORS   Ranganathan,S., Noyes,N.C., Migliorini,M., Winkles,J.A.,
            Battey,F.D., Hyman,B.T., Smith,E., Yepes,M., Mikhailenko,I. and
            Strickland,D.K.
  TITLE     LRAD3, a novel low-density lipoprotein receptor family member that
            modulates amyloid precursor protein trafficking
  JOURNAL   J Neurosci 31 (30), 10836-10846 (2011)
   PUBMED   21795536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX571894.9, AK032208.1, BX322585.4 and BB349367.1.
            
            On Mar 20, 2014 this sequence version replaced NM_178886.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138177.1, AK032208.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849386,
                                           SAMN01164133 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               BX571894.9         11670-11784         c
            116-2058            AK032208.1         2-1944
            2059-3876           BX322585.4         9385-11202          c
            3877-3910           BB349367.1         264-297
FEATURES             Location/Qualifiers
     source          1..3910
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.11 cM"
     gene            1..3910
                     /gene="Ldlrad3"
                     /gene_synonym="6430500P08; Lrad3"
                     /note="low density lipoprotein receptor class A domain
                     containing 3"
                     /db_xref="GeneID:241576"
                     /db_xref="MGI:MGI:2138856"
     exon            1..181
                     /gene="Ldlrad3"
                     /gene_synonym="6430500P08; Lrad3"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1173
                     /gene="Ldlrad3"
                     /gene_synonym="6430500P08; Lrad3"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; low-density lipoprotein receptor class A
                     domain-containing protein 3"
                     /codon_start=1
                     /product="low-density lipoprotein receptor class A
                     domain-containing protein 3 isoform a precursor"
                     /protein_id="NP_849217.2"
                     /db_xref="CCDS:CCDS38187.1"
                     /db_xref="GeneID:241576"
                     /db_xref="MGI:MGI:2138856"
                     /translation="MWLLGPLCLLLSSTAESQLLPGNNFTNECNIPGNFMCSNGRCIP
                     GAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSD
                     EENCTANPLLCSTARYHCRNGLCIDKSFICDGQNNCQDNSDEESCESSLEPGSGQVFV
                     TSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLS
                     RLVVLDHPHHCNVTYNVNNGVQYVATQAEQNASEVGSPPSYSEALLDQRPAWYDLPPP
                     PYSSDTESLNQADLPPYRSRSGSAYSASSQAASSLLSVEASSHNPEQPGSPEGSAEPR
                     DSVPSQGTEEV"
     exon            182..328
                     /gene="Ldlrad3"
                     /gene_synonym="6430500P08; Lrad3"
                     /inference="alignment:Splign:2.1.0"
     exon            329..454
                     /gene="Ldlrad3"
                     /gene_synonym="6430500P08; Lrad3"
                     /inference="alignment:Splign:2.1.0"
     exon            455..589
                     /gene="Ldlrad3"
                     /gene_synonym="6430500P08; Lrad3"
                     /inference="alignment:Splign:2.1.0"
     exon            590..935
                     /gene="Ldlrad3"
                     /gene_synonym="6430500P08; Lrad3"
                     /inference="alignment:Splign:2.1.0"
     exon            936..3910
                     /gene="Ldlrad3"
                     /gene_synonym="6430500P08; Lrad3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3763..3768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ldlrad3"
                     /gene_synonym="6430500P08; Lrad3"
                     /note="hexamer: AATAAA"
     polyA_site      3790
                     /gene="Ldlrad3"
                     /gene_synonym="6430500P08; Lrad3"
     regulatory      3886..3891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ldlrad3"
                     /gene_synonym="6430500P08; Lrad3"
                     /note="hexamer: AATAAA"
     polyA_site      3908
                     /gene="Ldlrad3"
                     /gene_synonym="6430500P08; Lrad3"
                     /note="major polyA site"
ORIGIN      
        1 ttggctgagc tctctggcct gggagggcgg gggcgtggct gggccggcga gagggcgtgg
       61 ccggcgccga gaggcggggt ctgaccgagg ccgcggggca gcaacgtcgc tgggcagcgg
      121 agcggcggcc gcgccatgtg gctgctgggg ccgctgtgcc tgctgctgag cagcactgcg
      181 gagagccagc tgctccctgg gaacaacttc accaacgagt gcaacatccc aggtaacttc
      241 atgtgcagca acgggcggtg catcccgggc gcctggcagt gtgacgggct gcctgactgc
      301 ttcgacaaga gtgacgagaa ggaatgcccc aaagcaaaat caaaatgtgg cccgaccttc
      361 ttcccctgcg ccagtggcat ccactgtatc atcggccgct tccgctgcaa tggatttgag
      421 gactgtcccg acggcagcga cgaggagaac tgcacagcga accccctgct ttgctccacg
      481 gctcgctacc actgcaggaa cggcctgtgc atcgacaaga gcttcatctg cgatggtcag
      541 aataactgtc aagacaacag tgacgaggag agctgcgaga gttctctaga accaggcagc
      601 gggcaggtgt ttgtgacctc ggagaaccag cttgtgtact accccagcat cacgtacgcc
      661 atcatcggca gctctgtcat cttcgtgctg gtggtggccc tgctcgcact ggtcctgcat
      721 catcagcgaa agcgaaacaa cctcatgacc ctccctgtgc accggctgca gcatcctgtg
      781 ctgctctctc gcctggtggt cctggaccac cctcaccact gcaacgtcac ctacaatgtc
      841 aataatggtg ttcagtatgt ggctacccag gctgaacaaa atgcctcgga agtaggctct
      901 ccaccctcct attcagaggc cctgctggac caaagacctg catggtacga ccttcctcca
      961 ccaccctatt catctgacac cgagtctctg aaccaagctg acctgcctcc ttaccgctcc
     1021 cggtcaggaa gtgcctacag tgccagctcc caggcagcca gcagcctcct gagtgtggaa
     1081 gccagcagcc acaacccaga gcagcctggc tctccagagg gctctgctga gcccagagac
     1141 tctgtgccca gtcagggcac cgaagaagta taaaatccag cgattccaaa gtccatatgg
     1201 gtagatcctc tccaacttgt tgaattctat cagactgtgc tcatgggaca ctctttgagc
     1261 tccttttgag gatgtctcca gttgaaattt tggggtgctc actatacctt ctcctccaga
     1321 tttcagggat gttctttgga atgacctggc actcctccag ccacttagtt aacaggatgc
     1381 attgccgtct ttctctgcac agtcactgtt ccttcagggc ctgtgattaa cagactccta
     1441 cttcagatga ctgtgcgatt gttggtccat tccagtagtc ttatgactgg acaggcggcc
     1501 gggtgaagcc atgtatgtaa atagtctttg gcagggttct agggccatgt cacacattca
     1561 ggaggtcaga agacatcaga ccagagtctc tactgagctg ccaacttata gatacatttg
     1621 gagacttagt ttggaggatt cttacaaaaa ggccattact ggatggccac tcaaaaaagt
     1681 gtccaggaga acatcaaatc ccgttttgta ctctcctatg catcgatctt actccagcag
     1741 aggccaaaga aaatctctgg catgagcaac agctttcaac tctccaaact ctagtttggt
     1801 tttatgaaag actcagaaac ctccaccctg gccttacaga cttgcccaag agtcctcatt
     1861 ctgagatctt tctagaaggg cagagcctca gcaacgtcct tgaataagta ggaagcccct
     1921 ggcatgagtt cctagctgct aatgtgtagg ttaccagagt ctgctcctgc cttggcccca
     1981 tcatcctttt cctgccttct ggattgtccc cttccaagat gacctgccat agctaaggat
     2041 aaggacccaa attaagccgg tcaaaattct gatctaaccg tttgccccag gaaaacagac
     2101 ccagtctggc atgttcatcc atgcaacttc cttgataggc tcctaagttc tatgaacact
     2161 tgggagccta ttgtccatgt gcatttggac ataaggacac gtttttctct aacttacatg
     2221 agaaccacat tcaataccat ccatgagaat tctcaggtcc ctgtactaca cacacaaccc
     2281 ccaggacagt gcaccaagtc agggttaggg ttagagtgag ggtcaggcct ggccagacat
     2341 ctggcagttt ctcctgagag aagtgggcaa cagataaatc ttggagtcaa gatttcccat
     2401 tggattttgt ttttttaaag tctcttagaa atgcatttga aacagtgtgt ttgtcttttc
     2461 ccttctagtt aagggactat ttatatgtgt ataggaaagc tatctctttg cttttcttat
     2521 ttctctttca gtgaggtcca aagaaagatg caaaaagaaa tgctgccttt cccatcccat
     2581 cccataatgt cacctcagac tcacatacac gctgagcatc tacactgggt catcgtggag
     2641 tcattattta ttgagttact gagacacgca gagacaagtc caccatccac tgtttgtttg
     2701 gattaccttt cctcctcctt gatgcccagc cagtcctagt gcatgccacc accacgcacc
     2761 cccaccaacc aggcaataat gggtaaacca tactaactag ggacaaaact ggaaccagat
     2821 ggtgccacct caggcagctg ccacccattc aaagcatttt tccactgcta acaaaagttt
     2881 caataacctg ttcgatgcta attaaaaggg agcctgcagg gagcagggat gaagtggcct
     2941 tcagtgatgt tgtactgact tcctttttaa ccaaatccaa agtagactgc aggaaaggta
     3001 actagccact tggggttttg tttggttttg gttttgtgta aataagccta gctgtttgct
     3061 tttttcattg ttaaaataga aattgagttg gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3121 gtgtgtgtgt gtaacccaat gaagaaagaa cctgggtggc agacagagct tttctggctg
     3181 cacatctcat cccagtgagt cagagtcgct cttcccttcc tttgatgggt ccccgcttct
     3241 ttttggtgct ctgaaagttg tctggaggaa aggattctaa ttttaattaa ttgtgcagtg
     3301 agctaatctc aggagctttt ctgcttcaag gcattttagg gaaaacaaat ggttttagta
     3361 gataaggaga gcctattaat gttggggttt tgttttgttt ccaaacaaac acaggaacat
     3421 ttttttacta tagatttggt ttttaatgga tttttttaaa ataataatca taagatagca
     3481 aagctcgggg acatggggtt ttttccccct gattttttca agataccaag taagtggcta
     3541 acaatatttt ttttaattcg ttccagtcag gattttttaa atactatatt gcctaattta
     3601 caccagccaa aaaactgcct cttctccatt gtctctcctc ctgtaagatc aacacttcat
     3661 ttttaacact acactagatt cactgtggtt ggaactcact gcctaactta actccctcta
     3721 ccttgtaatt gatgattgtt tttgaaatgc aactaagata ttaataaata gcgtgtgata
     3781 ttcaaagtta tataaactgg aaggttgtat gtggttgctt cttgtttttt tgtttgtttt
     3841 gttttttgaa ttggcccatt ttttaaaaaa aattttatac tctcaaataa actttcagtt
     3901 tcattctttc
//
