LOCUS       NM_010700               4549 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus low density lipoprotein receptor (Ldlr), transcript
            variant 1, mRNA.
ACCESSION   NM_010700 XM_979020 XM_979059 XM_979100 XM_979131 XM_979172
            XM_979210 XM_979251
VERSION     NM_010700.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4549)
  AUTHORS   Gengatharan,J.M., Handzlik,M.K., Chih,Z.Y., Ruchhoeft,M.L.,
            Secrest,P., Ashley,E.L., Green,C.R., Wallace,M., Gordts,P.L.S.M.
            and Metallo,C.M.
  TITLE     Altered sphingolipid biosynthetic flux and lipoprotein trafficking
            contribute to trans-fat-induced atherosclerosis
  JOURNAL   Cell Metab 37 (1), 274-290 (2025)
   PUBMED   39547233
REFERENCE   2  (bases 1 to 4549)
  AUTHORS   Alcicek,F.C., Dybas,J., Bulat,K., Mohaissen,T.,
            Szczesny-Malysiak,E., Franczyk-Zarow,M. and Marzec,K.M.
  TITLE     Hypoxia induces robust ATP release from erythrocytes in ApoE-LDLR
            double-deficient mice
  JOURNAL   Front Physiol 15, 1497346 (2024)
   PUBMED   39678689
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4549)
  AUTHORS   Hong,N.E., Chaplin,A., Di,L., Ravodina,A., Bevan,G.H., Gao,H.,
            Asase,C., Gangwar,R.S., Cameron,M.J., Mignery,M., Cherepanova,O.,
            Finn,A.V., Nayak,L., Pieper,A.A. and Maiseyeu,A.
  TITLE     Nanoparticle-based itaconate treatment recapitulates
            low-cholesterol/low-fat diet-induced atherosclerotic plaque
            resolution
  JOURNAL   Cell Rep 43 (11), 114911 (2024)
   PUBMED   39466775
REFERENCE   4  (bases 1 to 4549)
  AUTHORS   Gallerand,A., Dolfi,B., Stunault,M.I., Caillot,Z., Castiglione,A.,
            Strazzulla,A., Chen,C., Heo,G.S., Luehmann,H., Batoul,F.,
            Vaillant,N., Dumont,A., Pilot,T., Merlin,J., Zair,F.N.,
            Gilleron,J., Bertola,A., Carmeliet,P., Williams,J.W.,
            Arguello,R.J., Masson,D., Dombrowicz,D., Yvan-Charvet,L., Doyen,D.,
            Haschemi,A., Liu,Y., Guinamard,R.R. and Ivanov,S.
  TITLE     Glucose metabolism controls monocyte homeostasis and migration but
            has no impact on atherosclerosis development in mice
  JOURNAL   Nat Commun 15 (1), 9027 (2024)
   PUBMED   39424804
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4549)
  AUTHORS   Busnelli,M., Manzini,S., Colombo,A., Franchi,E., Laaperi,M.,
            Laaksonen,R. and Chiesa,G.
  TITLE     Effect of diet and genotype on the lipidome of mice with altered
            lipoprotein metabolism
  JOURNAL   iScience 27 (10), 111051 (2024)
   PUBMED   39568621
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4549)
  AUTHORS   Nett,M.A., Cerretti,D.P., Berson,D.R., Seavitt,J., Gilbert,D.J.,
            Jenkins,N.A., Copeland,N.G., Black,R.A. and Chaplin,D.D.
  TITLE     Molecular cloning of the murine IL-1 beta converting enzyme cDNA
  JOURNAL   J Immunol 149 (10), 3254-3259 (1992)
   PUBMED   1431103
REFERENCE   7  (bases 1 to 4549)
  AUTHORS   Herz,J., Clouthier,D.E. and Hammer,R.E.
  TITLE     LDL receptor-related protein internalizes and degrades uPA-PAI-1
            complexes and is essential for embryo implantation
  JOURNAL   Cell 71 (3), 411-421 (1992)
   PUBMED   1423604
  REMARK    Erratum:[Cell. 1993 May 7;73(3):428. doi:
            10.1016/0092-8674(93)90130-i. PMID: 8490961]
REFERENCE   8  (bases 1 to 4549)
  AUTHORS   Polvino,W.J., Dichek,D.A., Mason,J. and Anderson,W.F.
  TITLE     Molecular cloning and nucleotide sequence of cDNA encoding a
            functional murine low-density-lipoprotein receptor
  JOURNAL   Somat Cell Mol Genet 18 (5), 443-450 (1992)
   PUBMED   1475710
REFERENCE   9  (bases 1 to 4549)
  AUTHORS   Shapiro,S.D., Griffin,G.L., Gilbert,D.J., Jenkins,N.A.,
            Copeland,N.G., Welgus,H.G., Senior,R.M. and Ley,T.J.
  TITLE     Molecular cloning, chromosomal localization, and bacterial
            expression of a murine macrophage metalloelastase
  JOURNAL   J Biol Chem 267 (7), 4664-4671 (1992)
   PUBMED   1537850
REFERENCE   10 (bases 1 to 4549)
  AUTHORS   Seldin,M.F., Saunders,A.M., Rochelle,J.M. and Howard,T.A.
  TITLE     A proximal mouse chromosome 9 linkage map that further defines
            linkage groups homologous with segments of human chromosomes 11,
            15, and 19
  JOURNAL   Genomics 9 (4), 678-685 (1991)
   PUBMED   1674729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161371.4 and BC053041.1.
            
            On Nov 24, 2011 this sequence version replaced NM_010700.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053041.1, X64414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC161371.4         85298-85352         c
            56-4549             BC053041.1         1-4494
FEATURES             Location/Qualifiers
     source          1..4549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.87 cM"
     gene            1..4549
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /note="low density lipoprotein receptor"
                     /db_xref="GeneID:16835"
                     /db_xref="MGI:MGI:96765"
     exon            1..269
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            270..392
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            393..515
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            516..899
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1022
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1145
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1265
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1391
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1563
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1788
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1907
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2047
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2189
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2345
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2519
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2597
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2755
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..4534
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4515..4520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /note="hexamer: ATTAAA"
     polyA_site      4534
                     /gene="Ldlr"
                     /gene_synonym="Hlb301"
                     /note="major polyA site"
ORIGIN      
        1 gcagactcct cccccgcctg gaaacctcgc ccctagtact gggaatgact ctgggcgtgc
       61 ggcgtagttt gcagccggga caccgtgagg cttgcgagcc cagattcgca gccgagacac
      121 cgtggggccc gcgatccagt gtttgcagcg ggaacatttc ggggtctgtg atccgagtga
      181 ggacgcaacg cagaagctaa ggatgagcac cgcggatctg atgcgtcgct gggtcatcgc
      241 cctgctcctg gctgctgccg gagttgcagc agaagactca tgcagcagga acgagttcca
      301 gtgtagagac ggaaaatgca tcgctagcaa gtgggtgtgc gatggcagcc ccgagtgccc
      361 ggatggctcc gatgagtccc cagagacatg catgtctgtc acctgtcagt ccaatcaatt
      421 cagctgtgga ggccgtgtca gccgatgcat tcctgactcc tggagatgtg atggacaggt
      481 agactgtgaa aatgactcag acgaacaagg ctgtcccccc aagacgtgct cccaggatga
      541 cttccgatgc caggatggca agtgcatctc cccgcagttt gtgtgtgatg gagaccgaga
      601 ttgcctagat ggctctgatg aggcccactg ccaggccacc acttgtggcc ccgcccactt
      661 ccgctgcaac tcatccatat gcatccccag tctttgggcc tgcgacgggg atgtcgactg
      721 tgttgacggc tccgatgagt ggccacagaa ctgccagggc cgagacacgg cctccaaagg
      781 cgttagcagc ccctgctcct ccctggagtt ccactgtggt agcagtgagt gtatccatcg
      841 cagctgggtc tgtgacggcg aggcagactg caaggacaag tcagatgagg agcactgcgc
      901 ggtggccacc tgccgacctg atgaattcca gtgtgcagat ggctcctgca ttcacggtag
      961 ccgccagtgt gaccgtgaac atgactgcaa ggacatgagc gacgagctcg gctgcgtcaa
     1021 tgtgacacag tgtgatggcc ccaacaagtt caagtgtcac agtggggagt gcatcagctt
     1081 ggacaaggtg tgcgactccg cccgcgactg ccaggactgg tcggatgagc ccatcaagga
     1141 gtgcaagacc aacgagtgtt tggacaacaa tggtggctgt tcccacatct gcaaggacct
     1201 caagattggc tctgagtgcc tgtgtcccag cggcttccgg ttggtggacc tccacaggtg
     1261 tgaagatatt gacgagtgtc aggagccaga cacctgcagc cagctctgtg tgaacctgga
     1321 aggcagctac aagtgtgagt gccaggccgg cttccacatg gacccacaca ccagggtctg
     1381 caaggctgtg ggctccatag gctatctgct cttcaccaac cgccacgagg tccggaagat
     1441 gaccctggac cgcagcgagt acaccagtct gctccccaac ctgaagaatg tggtggctct
     1501 cgacacggag gtgaccaaca atagaatcta ctggtccgac ctgtcccaaa aaaagatcta
     1561 cagcgccctg atggaccagg cccctaactt gtcctacgac accatcatca gtgaggacct
     1621 gcatgcccct gacgggctgg cggtagactg gatccaccgc aacatctact ggacagattc
     1681 agtcccaggc agcgtatctg tggctgacac caagggcgta aagaggagga cactgttcca
     1741 agaggcaggg tccagaccca gagccatcgt agtggaccct gtgcatggct tcatgtactg
     1801 gacagattgg ggaacacccg ccaagatcaa gaaagggggt ttgaatggtg tggacatcca
     1861 ctcactggtg accgaaaaca tccagtggcc aaatggcatc acactagatc tttccagtgg
     1921 ccgtctctat tgggttgatt ccaaactcca ctctatctcc agcatcgatg tcaatggggg
     1981 caatcggaaa accattttgg aggatgagaa ccggctggcc caccccttct ccttggccat
     2041 ctatgaggac aaagtgtatt ggacagatgt cataaacgaa gccattttca gtgccaatcg
     2101 actcacgggt tcagatgtga atttggtggc tgaaaacctc ttgtccccgg aggacattgt
     2161 cctgttccac aaggtcacac agcctagagg ggtgaactgg tgtgagacaa cagccctcct
     2221 ccccaatggt ggttgccagt acctgtgcct gcccgcccca cagatcggtc cccactcgcc
     2281 caaattcacc tgcgcctgcc ctgatggcat gctgctggcc aaggacatgc ggagctgcct
     2341 cacagaagtc gacactgtac tgaccaccca ggggacatcc gccgtccggc ctgtggtcac
     2401 cgcatcagct accaggccac cgaagcacag tgaggatctc tcagctccca gtactcctag
     2461 gcagcctgtg gacaccccag ggctcagcac agtggcgtca gtgacagtgt cccaccaagt
     2521 ccagggtgac atggctggca gagggaatga ggagcagcca catggtatga ggttcctgtc
     2581 catcttcttc cctattgcac tggttgccct ccttgtcctt ggggccgtcc tgctgtggag
     2641 gaactggcgg ctgaagaaca tcaacagcat aaactttgac aacccagtct accagaagac
     2701 cacagaggac gagctccaca tttgccgaag ccaggatggc tatacctacc cctcaagaca
     2761 gatggtcagc ctggaggacg atgtggcatg agcagccggg agagccgtct ctttccggga
     2821 tccattgcca agcttaggca gaaaagacac tctctccaga cctccccatc cagcactggt
     2881 cctgccacct ccctgggctc tgtgttgctc aaagcaagat aagagcaaag ctgggctggg
     2941 ggccaagctc agctgcctgt ctgccccagg ttctgtttta tatatttatt gtctggggac
     3001 agaaaaggct actggctgtg cttgaaattc gaattctgcc tgggaatttt tttttttctc
     3061 ccatcttcat ttccttggaa gccaaatagg ctgtcccaga agcttctgaa ttctactctt
     3121 ttcaacacta acacggagga ggaagagacc cacccaggca gagagaagcc tgctggacat
     3181 gagacagcag gtactactga ccgggtcctg ggtaccatag ccagtcccta acctcaggac
     3241 ttcctgcatt gaccttcatc ccagagcctt cctgcctgac tctgccgccc ccatcagaag
     3301 ccaggaaagt gactcgtgac attcggtact gatcttgctg gatcttgagg ccggcagctg
     3361 ccagtgatgg atacccgctc atgcctttgc caaaacgtca cccgttcctg gagggacaag
     3421 cccaagtcgc cattctccct taatatttat caagtgcctg agacaactgg ttgccttgct
     3481 caggagtcct ggcctgctca gtgtcctgct gctcaggggt ggccggcagg acccctgtcc
     3541 tgtgcccagc ccccgagtct ccgagtgagg cttgcacttc tctctgcgca cttttcccgt
     3601 tctgtgctgg gcacccacgt ggtccacatt tgtactccta ggttgcactg accctggtgc
     3661 attggatggg acctcaggcc ggaagtggcc ccgaatcatt gaccacagaa gataattgcc
     3721 aggctccaag catccattgc cttcttcagt actgggggga actcagggcc tctgtctggt
     3781 gtttagttag tctgtttgtt tgtttgtttg tttgtttgtt tggtggtttc tggctctgca
     3841 cagcagagtt gtttagctcc tctggtaacg tcatcctctc tcacagagac atccagcctg
     3901 ctgaagggga gagatggggc gaggggaggg atacacgcat ggtttctcag gtgtggtggc
     3961 acttggcttt aatcctatgc tcaagaggaa gaggtgggca catgtctgag gtccaagcct
     4021 acatagtgag accttatata tctaaaaacc aaaagaaatc ccagactatt tggtgggact
     4081 tggaagaata cttagaaatt gccacagatt tgtcacatgg gtaacctaag aagacagtgg
     4141 tggccttact tggattcctg ggtagatcca cctgtccact actcaagaca caagggcaca
     4201 ctgcccagcc cactgggaca cttgtaaaga gctctgtaat gtgccgatgg cacctggctc
     4261 ggttttcatt ctgtatattc aaggatatca cacatatgta ttaaatctat ttatttttgc
     4321 aaaccctgat tgctgcacct ctctgcaatt tctccaggtt aggctggggt gatactctgg
     4381 gatgctctgt atacaaagat gatttgaatg ggctgatctc aggcctgtcc tgtgcgttgc
     4441 tttgagtggg tgggaactgc tttgaaaccc ttgttcagat gtttttatag gctgaaaata
     4501 tcatactgtg atggattaaa ttcttttttg gaaaaaaaaa aaaaaaaaa
//
