LOCUS       NM_027570               2888 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus lactate dehydrogenase D (Ldhd), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_027570
VERSION     NM_027570.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2888)
  AUTHORS   Drabkin,M., Yogev,Y., Zeller,L., Zarivach,R., Zalk,R., Halperin,D.,
            Wormser,O., Gurevich,E., Landau,D., Kadir,R., Perez,Y. and
            Birk,O.S.
  TITLE     Hyperuricemia and gout caused by missense mutation in d-lactate
            dehydrogenase
  JOURNAL   J Clin Invest 129 (12), 5163-5168 (2019)
   PUBMED   31638601
  REMARK    GeneRIF: gout can be caused by a mutation in LDHD within the
            putative catalytic site of the encoded d-lactate dehydrogenase,
            resulting in augmented blood levels of d-lactate, a stereoisomer of
            l-lactate
REFERENCE   2  (bases 1 to 2888)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 2888)
  AUTHORS   Willmroth,F. and Beaudet,A.L.
  TITLE     Structure of the murine E-selectin ligand 1 (ESL-1) gene and
            assignment to Chromosome 8
  JOURNAL   Mamm Genome 10 (11), 1085-1088 (1999)
   PUBMED   10556428
REFERENCE   4  (bases 1 to 2888)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122364.4.
            
            On Apr 4, 2022 this sequence version replaced NM_027570.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055443.1, ERR3835354.262797.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC122364.4         133754-133851
            99-211              AC122364.4         134035-134147
            212-353             AC122364.4         134343-134484
            354-495             AC122364.4         134668-134809
            496-655             AC122364.4         134945-135104
            656-855             AC122364.4         135370-135569
            856-984             AC122364.4         135652-135780
            985-1112            AC122364.4         135864-135991
            1113-1203           AC122364.4         136512-136602
            1204-1315           AC122364.4         136701-136812
            1316-2888           AC122364.4         136900-138472
FEATURES             Location/Qualifiers
     source          1..2888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.98 cM"
     gene            1..2888
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /note="lactate dehydrogenase D"
                     /db_xref="GeneID:52815"
                     /db_xref="MGI:MGI:106428"
     exon            1..98
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1481
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /EC_number="1.1.2.4"
                     /codon_start=1
                     /product="probable D-lactate dehydrogenase, mitochondrial"
                     /protein_id="NP_081846.3"
                     /db_xref="CCDS:CCDS22677.1"
                     /db_xref="GeneID:52815"
                     /db_xref="MGI:MGI:106428"
                     /translation="MAMLLRVATQRLSPWRSFCSRGSQGGLSQDFVEALKAVVGSPHV
                     STASAVREQHGHDESMHRCQPPDAVVWPQNVDQVSRVASLCYNQGVPIIPFGTGTGVE
                     GGVCAVQGGVCINLTHMDQITELNTEDFSVVVEPGVTRKALNTHLRDSGLWFPVDPGA
                     DASLCGMAATGASGTNAVRYGTMRDNVINLEVVLPDGRLLHTAGRGRHYRKSAAGYNL
                     TGLFVGSEGTLGIITSTTLRLHPAPEATVAATCAFPSVQAAVDSTVQILQAAVPVARI
                     EFLDDVMMDACNRHSKLNCPVAPTLFLEFHGSQQTLAEQLQRTEAITQDNGGSHFSWA
                     KEAEKRNELWAARHNAWYAALALSPGSKAYSTDVCVPISRLPEILVETKEEIKASKLT
                     GAIVGHVGDGNFHCILLVDPDDAEEQRRVKAFAENLGRRALALGGTCTGEHGIGLGKR
                     QLLQEEVGPVGVETMRQLKNTLDPRGLMNPGKVL"
     exon            99..211
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /inference="alignment:Splign:2.1.0"
     exon            212..353
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /inference="alignment:Splign:2.1.0"
     exon            354..495
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /inference="alignment:Splign:2.1.0"
     exon            496..655
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /inference="alignment:Splign:2.1.0"
     exon            656..855
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /inference="alignment:Splign:2.1.0"
     exon            856..984
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1112
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1203
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1315
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..2888
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2216..2221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /note="hexamer: AATACA"
     polyA_site      2236
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
     regulatory      2847..2852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /note="hexamer: AATACA"
     polyA_site      2888
                     /gene="Ldhd"
                     /gene_synonym="4733401P21Rik; D8Bwg1320e; DLD"
                     /note="major polyA site"
ORIGIN      
        1 attctcccct tagctgcggt ctggctatgg ccatgctcct tcgggtggcc acccagaggc
       61 tgtctccctg gaggagtttc tgctccaggg ggtcgcaggg tggactcagc caggactttg
      121 tggaggctct gaaggcagtt gtagggagcc cccacgtgtc cactgcttct gcagtcagag
      181 agcaacacgg gcatgatgaa tcgatgcaca ggtgtcaacc tcctgatgct gtggtttggc
      241 ctcagaatgt ggaccaggtc agccgagtgg caagcctgtg ctacaatcaa ggtgttccca
      301 tcatcccatt tggcacaggc accggtgttg aggggggagt ctgtgctgtg cagggtggag
      361 tgtgcatcaa cctgacccat atggaccaga tcacggagct gaatacagaa gacttctccg
      421 tggtggtgga gcctggagtc acccgtaaag ctctcaatac ccacctgcgt gacagtggcc
      481 tttggtttcc tgttgaccca ggcgcagatg cttctctgtg tggcatggca gccaccgggg
      541 cctcgggcac caatgctgtg cgctatggaa ccatgcggga caacgtgatt aacctggagg
      601 tagtgctgcc tgacggcagg ctgcttcaca ccgcaggccg gggccgccat tacaggaaga
      661 gtgcagctgg ctacaatctc acaggactct ttgtgggctc tgaggggacc ctgggcatca
      721 ttacatcaac caccctgcgc ctgcaccctg cgccggaagc aacggtggct gccacctgtg
      781 cgttccccag tgttcaagcg gctgtggaca gcacagttca gatcctccag gctgcagtgc
      841 ccgtggctcg cattgagttc ctagatgatg tcatgatgga tgcctgcaac agacacagca
      901 aacttaactg ccccgtggca cccacgcttt tcctggagtt ccacggttcc cagcagacac
      961 tggcggaaca gctgcagcgc acagaggcaa tcactcagga taatggtggc tctcacttct
     1021 cctgggccaa ggaggccgaa aagcgcaatg aactttgggc agcgcggcac aatgcttggt
     1081 atgcagcctt ggccctgagt ccaggaagta aggcctattc cacggacgtg tgtgtaccca
     1141 tctcccggct gccagagatc ttggtagaga ccaaggagga gattaaagct tcaaaactca
     1201 caggagccat cgttgggcat gtgggtgatg gcaactttca ctgcatcctc ctggtcgacc
     1261 cagatgatgc agaggagcag aggagggtca aggcctttgc agaaaatctg ggcaggcggg
     1321 ccctggcact cggtgggaca tgcactggag aacatggcat cggactgggc aagcgacagc
     1381 tgctccaaga ggaagtgggc cccgtgggcg tggagaccat gcggcagctc aaaaacacac
     1441 tggatccccg tggtctcatg aacccaggca aagtgctatg aggaatgtgt aacccttggc
     1501 tggcaatctc cagaacacaa agcccgcccc tgttctggtc ttttccttca tgccaacgat
     1561 cgagcacgaa atggaagggc tgatgctatc tatctatcta tctatctatc tatctatcta
     1621 tctatgcctg ccaggtagcc tctgtagctg gggctcaaga tgaaggtgag ggagctggac
     1681 tctctcacag aaagctgcta cccttgttct taggagcctt ttactccggt agaaaaccca
     1741 gggtgtttcc cagtggggtg tcttcctggc tggcagaggt ggtgtggatc tactccaagc
     1801 taagatcaga tcccagatcc gtctgtgggg gcctctcctc tgctggtgcc ctgcatcatg
     1861 actcaccctg tatatatgat gacaggagcg ttcctttcct tgcagaggga gggaggaccg
     1921 ttccatccgg cactgttggg ccggctcttt ggtcacgtga gccccgtttg cagctgcatc
     1981 ctttccccct ctaggtctct tgaccttggg ctaaaaagca tttgttttgg gcccatcccc
     2041 agactaactg tagcctgggg aggggatgga gttcaagttt tggaagaaag tcagtcccag
     2101 cccctctgct tttgcatacc tgaggcagga gacctgccag tggtggaggt cacctgacag
     2161 cttccccacc aggaaactga agcaccttct tcaagctgtt atggtggaca atagaaatac
     2221 agatgaacta acctactgtg tcccatccct atccatggta taaagctcta tccaccagcg
     2281 cttactttca aagtcagggt cttgcctact ttggggcctg gcagttttga gactccctgg
     2341 tcagagccct ggtctggagg tacttgcagt tgttccccag aagtccacga gagggcgcgc
     2401 aacaccagaa acctagcaga cacttttagg gtggccagtc tctaggcatt ttacccttgt
     2461 gggtcccagt caactgtagt accatcttct ctactgctag gtacttgggt tggaaaaaaa
     2521 aaaggaagaa gcagcctcct gccccccacc ctgacacttt cttagtccaa cttcaggtct
     2581 gtctcatgat tctttggctt gctcccaaac tacttcagga tgaagaaacc caaacaccag
     2641 tcccgaattc accattgaga aatatcgcca gtgaaccccc ctcaccccca gacagtctgt
     2701 tcacctcaag tcctcccaag ttgagttcca ctgggcaggg ctcctacata caccctccaa
     2761 taatgggaaa ctcaatacac agccatttcc ccacaatttc ttttattaaa gaaaatccca
     2821 aacatacaga aaaagttgaa agaacaaata cactatattc actgaaatat cagtcgttga
     2881 agattcaa
//
