LOCUS       NM_013580               1310 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus lactate dehydrogenase C (Ldhc), transcript variant 1,
            mRNA.
ACCESSION   NM_013580
VERSION     NM_013580.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1310)
  AUTHORS   Iida-Norita,R., Miyata,H., Kaneda,Y., Emori,C., Noda,T.,
            Nakagawa,T., Matzuk,M.M. and Ikawa,M.
  TITLE     Generation of humanized LDHC knock-in mice as a tool to assess
            human LDHC-targeting contraceptive drugs
  JOURNAL   Andrology 11 (5), 840-848 (2023)
   PUBMED   36464740
REFERENCE   2  (bases 1 to 1310)
  AUTHORS   Mrowiec,K., Chadalski,M., Paszek,A., Vydra,N., Janus,P.,
            Pietrowska,M., Toma-Jonik,A., Gramatyka,M. and Widlak,W.
  TITLE     The periphilin 1-like BFAR isoform 3 is highly expressed in
            transcriptionally silent oocytes and involved in RNA metabolism
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (10), 119086 (2021)
   PUBMED   34175335
REFERENCE   3  (bases 1 to 1310)
  AUTHORS   Dodo,M., Kitamura,H., Shima,H., Saigusa,D., Wati,S.M., Ota,N.,
            Katsuoka,F., Chiba,H., Okae,H., Arima,T., Igarashi,K., Koseki,T.,
            Sekine,H. and Motohashi,H.
  TITLE     Lactate dehydrogenase C is required for the protein expression of a
            sperm-specific isoform of lactate dehydrogenase A
  JOURNAL   J Biochem 165 (4), 323-334 (2019)
   PUBMED   30590713
  REMARK    GeneRIF: the LDHA protein level was remarkably decreased in
            Ldhc-deficient sperm, indicating that LDHC is required for LDHA
            expression in the sperm.
REFERENCE   4  (bases 1 to 1310)
  AUTHORS   Tung,K.S., Harakal,J., Qiao,H., Rival,C., Li,J.C., Paul,A.G.,
            Wheeler,K., Pramoonjago,P., Grafer,C.M., Sun,W., Sampson,R.D.,
            Wong,E.W., Reddi,P.P., Deshmukh,U.S., Hardy,D.M., Tang,H.,
            Cheng,C.Y. and Goldberg,E.
  TITLE     Egress of sperm autoantigen from seminiferous tubules maintains
            systemic tolerance
  JOURNAL   J Clin Invest 127 (3), 1046-1060 (2017)
   PUBMED   28218625
REFERENCE   5  (bases 1 to 1310)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   6  (bases 1 to 1310)
  AUTHORS   Thomas,K., Del Mazo,J., Eversole,P., Bellve,A., Hiraoka,Y., Li,S.S.
            and Simon,M.
  TITLE     Developmental regulation of expression of the lactate dehydrogenase
            (LDH) multigene family during mouse spermatogenesis
  JOURNAL   Development 109 (2), 483-493 (1990)
   PUBMED   2401207
REFERENCE   7  (bases 1 to 1310)
  AUTHORS   Wu,K.C., Chan,K., Lee,C.Y. and Lau,Y.F.
  TITLE     Molecular isolation and sequence determination of the cDNA for the
            mouse sperm-specific lactate dehydrogenase-X gene
  JOURNAL   Biochem Biophys Res Commun 146 (3), 964-970 (1987)
   PUBMED   3619944
REFERENCE   8  (bases 1 to 1310)
  AUTHORS   Sakai,I., Sharief,F.S. and Li,S.S.
  TITLE     Molecular cloning and nucleotide sequence of the cDNA for
            sperm-specific lactate dehydrogenase-C from mouse
  JOURNAL   Biochem J 242 (2), 619-622 (1987)
   PUBMED   2439071
REFERENCE   9  (bases 1 to 1310)
  AUTHORS   Musick,W.D. and Rossmann,M.G.
  TITLE     The tentative amino acid sequencing of lactate dehydrogenase C4 by
            X-ray diffraction analysis
  JOURNAL   J Biol Chem 254 (16), 7621-7623 (1979)
   PUBMED   468774
REFERENCE   10 (bases 1 to 1310)
  AUTHORS   Musick,W.D. and Rossmann,M.G.
  TITLE     The structure of mouse testicular lactate dehydrogenase isoenzyme
            C4 at 2.9 A resolution
  JOURNAL   J Biol Chem 254 (16), 7611-7620 (1979)
   PUBMED   468772
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090123.68.
            
            On Apr 28, 2007 this sequence version replaced NM_013580.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007058.1, BC049602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC090123.68        116121-116159       c
            40-172              AC090123.68        115527-115659       c
            173-290             AC090123.68        110896-111013       c
            291-464             AC090123.68        107650-107823       c
            465-638             AC090123.68        104337-104510       c
            639-756             AC090123.68        101629-101746       c
            757-880             AC090123.68        100825-100948       c
            881-1310            AC090123.68        99280-99709         c
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.6 cM"
     gene            1..1310
                     /gene="Ldhc"
                     /gene_synonym="Ldh-3; LDH-C4; Ldh-x; Ldh3; Ldhc4"
                     /note="lactate dehydrogenase C"
                     /db_xref="GeneID:16833"
                     /db_xref="MGI:MGI:96764"
     exon            1..39
                     /gene="Ldhc"
                     /gene_synonym="Ldh-3; LDH-C4; Ldh-x; Ldh3; Ldhc4"
                     /inference="alignment:Splign:2.1.0"
     exon            40..172
                     /gene="Ldhc"
                     /gene_synonym="Ldh-3; LDH-C4; Ldh-x; Ldh3; Ldhc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1045
                     /gene="Ldhc"
                     /gene_synonym="Ldh-3; LDH-C4; Ldh-x; Ldh3; Ldhc4"
                     /EC_number="1.1.1.27"
                     /note="LDH testis subunit; lactate dehydrogenase-X; LDH-C;
                     lactate dehydrogenase 3, C chain, sperm specific"
                     /codon_start=1
                     /product="L-lactate dehydrogenase C chain"
                     /protein_id="NP_038608.1"
                     /db_xref="CCDS:CCDS21290.1"
                     /db_xref="GeneID:16833"
                     /db_xref="MGI:MGI:96764"
                     /translation="MSTVKEQLIQNLVPEDKLSRCKITVVGVGNVGMACAISILLKGL
                     ADELALVDADTNKLRGEALDLLHGSLFLSTPKIVFGKDYNVSANSKLVIITAGARMVS
                     GETRLDLLQRNVAIMKAIVPGIVQNSPDCKIIIVTNPVDILTYVVWKISGFPVGRVIG
                     SGCNLDSARFRYLIGEKLGVNPTSCHGWVLGEHGDSSVPIWSGVNVAGVTLKSLNPAI
                     GTDSDKEHWKNVHKQVVEGGYEVLNMKGYTSWAIGLSVTDLARSILKNLKRVHPVTTL
                     VKGFHGIKEEVFLSIPCVLGQSGITDFVKVNMTAEEEGLLKKSADTLWNMQKDLQL"
     exon            173..290
                     /gene="Ldhc"
                     /gene_synonym="Ldh-3; LDH-C4; Ldh-x; Ldh3; Ldhc4"
                     /inference="alignment:Splign:2.1.0"
     exon            291..464
                     /gene="Ldhc"
                     /gene_synonym="Ldh-3; LDH-C4; Ldh-x; Ldh3; Ldhc4"
                     /inference="alignment:Splign:2.1.0"
     exon            465..638
                     /gene="Ldhc"
                     /gene_synonym="Ldh-3; LDH-C4; Ldh-x; Ldh3; Ldhc4"
                     /inference="alignment:Splign:2.1.0"
     exon            639..756
                     /gene="Ldhc"
                     /gene_synonym="Ldh-3; LDH-C4; Ldh-x; Ldh3; Ldhc4"
                     /inference="alignment:Splign:2.1.0"
     exon            757..880
                     /gene="Ldhc"
                     /gene_synonym="Ldh-3; LDH-C4; Ldh-x; Ldh3; Ldhc4"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1310
                     /gene="Ldhc"
                     /gene_synonym="Ldh-3; LDH-C4; Ldh-x; Ldh3; Ldhc4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1137..1142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ldhc"
                     /gene_synonym="Ldh-3; LDH-C4; Ldh-x; Ldh3; Ldhc4"
                     /note="hexamer: AATAAA"
     polyA_site      1160
                     /gene="Ldhc"
                     /gene_synonym="Ldh-3; LDH-C4; Ldh-x; Ldh3; Ldhc4"
                     /note="major polyA site"
ORIGIN      
        1 atcctggttt cttacctgtg ctgcggagtc agcagtaagg ctcaacatgt ccaccgtcaa
       61 ggagcagctg attcagaacc tagttccgga agataaactt tcccggtgta agattactgt
      121 ggtcggagtt ggaaatgtgg gcatggcgtg tgctattagt attttactga agggtttggc
      181 tgatgaactt gcccttgttg acgctgatac gaacaaactg aggggagagg cactggatct
      241 tctgcacggc agtcttttcc ttagcactcc aaaaatcgtc tttggaaaag attacaatgt
      301 atctgccaac tccaaactgg ttattatcac agctggtgca agaatggtgt ctggagaaac
      361 tcgccttgac ctgctccaac gtaatgtcgc tatcatgaaa gccattgttc cgggcattgt
      421 ccaaaacagt ccggactgta aaataattat cgtcactaac ccagtggata ttttgacata
      481 cgtggtttgg aagataagcg gcttccctgt aggccgtgtg atcggaagtg gctgtaacct
      541 agactcagca cgttttcgtt acctgattgg ggagaagctg ggtgtcaacc ctacaagctg
      601 ccacggctgg gttcttggag aacatgggga ctccagtgtg cccatatgga gtggtgtaaa
      661 cgttgctggc gtaactctga agtcactgaa cccagcaata ggaactgact cagataagga
      721 acactggaaa aatgttcaca agcaggtggt ggaaggcggc tatgaggtcc ttaacatgaa
      781 gggctatacc tcttgggcta tcgggctgtc tgtgactgat ctggcgcgat ccatcttgaa
      841 gaatcttaag agagtgcatc ctgttaccac gctggttaag ggcttccatg ggataaagga
      901 agaggtcttc ctcagtatcc cttgtgtctt gggacaaagt ggtatcacag actttgtgaa
      961 agtcaacatg accgctgagg aggagggtct cctcaagaag agtgcggaca cactctggaa
     1021 tatgcagaag gatctgcagt tataaactcg ccaccttcga ccgtgtgaca gatgcctgat
     1081 cacatcactg atcacggcag tcccactgaa agtgtttcca catcataaca aagttcaata
     1141 aaattttgga aacctgttaa gatcaatctc aaggctagaa agattaatgc caaaggcatc
     1201 tccctccccc tttttttgag acagggtctc actttatagc cttagctgac ctcaaacgga
     1261 aatctgctag cctcccagtg tattaaaggc aaccaccacc aggcccagct
//
