LOCUS       NM_001034872            2208 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus leucine decarboxylase 1 (Ldc1), mRNA.
ACCESSION   NM_001034872 XM_886991 XM_910837
VERSION     NM_001034872.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2208)
  AUTHORS   Lambertos A, Ramos-Molina B, Cerezo D, Lopez-Contreras AJ and
            Penafiel R.
  TITLE     The mouse Gm853 gene encodes a novel enzyme: Leucine decarboxylase
  JOURNAL   Biochim Biophys Acta Gen Subj 1862 (3), 365-376 (2018)
   PUBMED   29108956
  REMARK    GeneRIF: GM853 is a stable protein that was not able to
            decarboxylate l-ornithine or l-lysine or act as an antizyme
            inhibitor. GM853 showed leucine decarboxylase activity, an activity
            never described in animal cells. By acting on l-leucine it produced
            isopentylamine, of unknown function. L-valine and l-isoleucine were
            poor substrates. Expression was mainly detected in the kidney, and
            it was stimulated by testosterone.
REFERENCE   2  (bases 1 to 2208)
  AUTHORS   Silander KM, Pihlajamaa P, Sahu B, Janne OA and Andersson LC.
  TITLE     Characterization of an androgen-responsive, ornithine
            decarboxylase-related protein in mouse kidney
  JOURNAL   Biosci Rep 37 (4) (2017)
   PUBMED   28607032
  REMARK    GeneRIF: Characterization of an androgen-responsive, ornithine
            decarboxylase-related protein in mouse kidney.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143920.1.
            
            On Apr 6, 2007 this sequence version replaced NM_001034872.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2208              AK143920.1         2-2209
FEATURES             Location/Qualifiers
     source          1..2208
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.43 cM"
     gene            1..2208
                     /gene="Ldc1"
                     /gene_synonym="Gm853"
                     /note="leucine decarboxylase 1"
                     /db_xref="GeneID:332942"
                     /db_xref="MGI:MGI:2685699"
     exon            1..132
                     /gene="Ldc1"
                     /gene_synonym="Gm853"
                     /inference="alignment:Splign:2.1.0"
     exon            133..308
                     /gene="Ldc1"
                     /gene_synonym="Gm853"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1448
                     /gene="Ldc1"
                     /gene_synonym="Gm853"
                     /codon_start=1
                     /product="ornithine decarboxylase-like"
                     /protein_id="NP_001030044.1"
                     /db_xref="CCDS:CCDS38890.1"
                     /db_xref="GeneID:332942"
                     /db_xref="MGI:MGI:2685699"
                     /translation="MNTPSEVKKDLLGVAEHLRPSEPITLGPGASAWQLVLKKIKELS
                     ISGRQDAFMVADLDVLVSRHRTFLQALPRVQPFYAVKCNSNPWVLLVLAALGTGFDCA
                     SQGELEQVLGLGVAPSRIIFANPCKAVSHIQFAARCGVQLLTFDNEEELIKLARYHPR
                     ARLVLRIQTLDSQSTFPLHTKFGAHLEACGHLLQVARELGLAVVGASFHVGSDCHTPE
                     SYRQAIADCHRVFEMGCKAGHHMSLLDLGGGFPGVKGSEAKFEEVARVINTALAQYFP
                     EETGIEVIAEPGRFYAGSVCTAAVNIIVKKSSLDPGGHRKLAYYLNEGHYGVFRLFLR
                     DPVPRIPIVVKEFPSEPPLFPCTLYGPTCDAYDRLFSTEVQLPELDVGDWLIFPDMGA
                     YSSSMSSTFNGFPIATVYDAMSPQLRSLLETVP"
     exon            309..482
                     /gene="Ldc1"
                     /gene_synonym="Gm853"
                     /inference="alignment:Splign:2.1.0"
     exon            483..655
                     /gene="Ldc1"
                     /gene_synonym="Gm853"
                     /inference="alignment:Splign:2.1.0"
     exon            656..790
                     /gene="Ldc1"
                     /gene_synonym="Gm853"
                     /inference="alignment:Splign:2.1.0"
     exon            791..956
                     /gene="Ldc1"
                     /gene_synonym="Gm853"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1104
                     /gene="Ldc1"
                     /gene_synonym="Gm853"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1205
                     /gene="Ldc1"
                     /gene_synonym="Gm853"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1423
                     /gene="Ldc1"
                     /gene_synonym="Gm853"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..2208
                     /gene="Ldc1"
                     /gene_synonym="Gm853"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagatctct gtggaaagtc tccagtacac aggcccacaa gaagccctgt ggctgctggg
       61 gaccccactt tagtctgagg gttctctggc tgttccaggg aaccccaggt gccaccaact
      121 actcaacctg aggactgtgc ccaacagaca cctcaactag agtctcaagg atgaacaccc
      181 cctctgaggt caagaaggat ctgctgggag ttgcagaaca cctgaggcca tcagagccca
      241 tcaccttggg gccaggggca tctgcctggc agctggtctt gaagaagatc aaggagttgt
      301 ccatctcggg ccgccaagat gccttcatgg tggctgacct ggatgtgctg gtcagccgcc
      361 atcggacctt cctccaggcc ctgcccagag tccagccctt ctatgcagtc aagtgtaaca
      421 gcaacccctg ggtgctgctc gtcttggctg ccctgggcac cggctttgac tgtgccagcc
      481 agggagagct ggaacaagtg ctgggcttgg gcgtggcccc ctccagaatc atcttcgcca
      541 acccctgcaa ggccgtctcc cacatccagt tcgcagcccg ctgtggggtg cagcttctga
      601 ccttcgacaa tgaggaggaa ctgattaagc tggcccggta ccacccgagg gctaggctgg
      661 ttctccggat acagaccctg gacagtcaaa gcaccttccc tctgcacacc aagtttggag
      721 cccatctgga ggcatgtgga cacctgctcc aggttgccag agagctgggg ttggctgtgg
      781 tgggggcctc cttccacgtg ggttccgact gccacacacc tgagagctac agacaggcca
      841 tcgctgactg ccatcgtgtg tttgagatgg gctgcaaggc tggccaccac atgagcctcc
      901 tggatcttgg agggggcttc ccaggagtta agggctctga agccaaattt gaggaggtgg
      961 cgagagtgat caacactgcc ctggcccagt actttccgga ggagaccggt atcgaggtca
     1021 ttgcagagcc tggccgcttc tatgcggggt ccgtgtgcac agctgctgtg aatatcatag
     1081 tcaagaagtc ttccctagat ccaggaggcc acaggaagct ggcatactac cttaatgagg
     1141 gccattatgg agtcttccga ctcttcctca gggaccctgt ccccaggata cccatagtgg
     1201 tgaaggagtt cccctcggag cccccactct tcccctgcac gctttatggc cccacctgcg
     1261 atgcctatga ccggcttttt tcgacagagg ttcagttgcc agagctggat gtaggtgact
     1321 ggctgatttt ccctgacatg ggtgcctaca gtagctccat gagttccacc ttcaatggct
     1381 tcccgatcgc aactgtctat gatgccatga gcccccaact caggagccta ctggagacag
     1441 taccttaggc caggacatgg ccagaatgaa gaggagtcag acacccagta tgatatgccc
     1501 actggggaaa gcttactgtg agaggcctat ggggttggtc cttgggggaa atgaggcctg
     1561 gcctcttctg cactgatgag acccttttat acgttgaaaa gagttttctt tttaaagtaa
     1621 gcttgaagta ccagatgact gtactgggta gcttggcatc ccttctggct ctcgatctcc
     1681 tagactatag gacccccatg gagaatgggt gagacaagga aggccagatt tgtgctgaca
     1741 catgagctag tcaccttaat ctcaaaaaag actgggtccc ctggggaagg atactaacaa
     1801 aagggtacct aggagtgctt caggatgaag tgaggtgggg agtgacccca gggggaaagc
     1861 cactaactcc tgtgtgcttt ctaaactttg cctgacgaag ctttctggga tgcacagtct
     1921 ctgccaaggc tttcaagacc tgtccagttg tgtcacagcc cagctctacc gtctgagcat
     1981 ccttgaacgg aagagaatcc cccaccatga gacatccagt ggaaggtgtg ggctgctgac
     2041 tccacccatg aatgtgggaa aggctcagtc ttcaagacag tgtggtgctc atttggcctc
     2101 tccacagctt gcaacttagg agtggaaata ttaatatcta tctatcaaag gggtttcaaa
     2161 atacaggtat attgggcttt ggcggaaaaa aaaactgtac ttagatgc
//
