LOCUS       NM_001286348            2667 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus LIM domain binding 2 (Ldb2), transcript variant 3,
            mRNA.
ACCESSION   NM_001286348
VERSION     NM_001286348.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2667)
  AUTHORS   Galazo,M.J., Sweetser,D.A. and Macklis,J.D.
  TITLE     Tle4 controls both developmental acquisition and early post-natal
            maturation of corticothalamic projection neuron identity
  JOURNAL   Cell Rep 42 (8), 112957 (2023)
   PUBMED   37561632
REFERENCE   2  (bases 1 to 2667)
  AUTHORS   Lu,Y., Mu,Y., Chen,J., Guan,X., Guo,L. and Wu,C.
  TITLE     CLP36 promotes p53 deficient sarcoma progression through
            suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent
            degradation of YAP1
  JOURNAL   Theranostics 12 (11), 5051-5068 (2022)
   PUBMED   35836803
  REMARK    GeneRIF: CLP36 promotes p53 deficient sarcoma progression through
            suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent
            degradation of YAP1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2667)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2667)
  AUTHORS   Tsyporin,J., Tastad,D., Ma,X., Nehme,A., Finn,T., Huebner,L.,
            Liu,G., Gallardo,D., Makhamreh,A., Roberts,J.M., Katzman,S.,
            Sestan,N., McConnell,S.K., Yang,Z., Qiu,S. and Chen,B.
  TITLE     Transcriptional repression by FEZF2 restricts alternative
            identities of cortical projection neurons
  JOURNAL   Cell Rep 35 (12), 109269 (2021)
   PUBMED   34161768
REFERENCE   5  (bases 1 to 2667)
  AUTHORS   Ohnishi,T., Kiyama,Y., Arima-Yoshida,F., Kadota,M., Ichikawa,T.,
            Yamada,K., Watanabe,A., Ohba,H., Tanaka,K., Nakaya,A., Horiuchi,Y.,
            Iwayama,Y., Toyoshima,M., Ogawa,I., Shimamoto-Mitsuyama,C.,
            Maekawa,M., Balan,S., Arai,M., Miyashita,M., Toriumi,K., Nozaki,Y.,
            Kurokawa,R., Suzuki,K., Yoshikawa,A., Toyota,T., Hosoya,T.,
            Okuno,H., Bito,H., Itokawa,M., Kuraku,S., Manabe,T. and
            Yoshikawa,T.
  TITLE     Cooperation of LIM domain-binding 2 (LDB2) with EGR in the
            pathogenesis of schizophrenia
  JOURNAL   EMBO Mol Med 13 (4), e12574 (2021)
   PUBMED   33656268
  REMARK    GeneRIF: Cooperation of LIM domain-binding 2 (LDB2) with EGR in the
            pathogenesis of schizophrenia.
REFERENCE   6  (bases 1 to 2667)
  AUTHORS   Bach,I., Rodriguez-Esteban,C., Carriere,C., Bhushan,A., Krones,A.,
            Rose,D.W., Glass,C.K., Andersen,B., Izpisua Belmonte,J.C. and
            Rosenfeld,M.G.
  TITLE     RLIM inhibits functional activity of LIM homeodomain transcription
            factors via recruitment of the histone deacetylase complex
  JOURNAL   Nat Genet 22 (4), 394-399 (1999)
   PUBMED   10431247
REFERENCE   7  (bases 1 to 2667)
  AUTHORS   Sugihara,T.M., Bach,I., Kioussi,C., Rosenfeld,M.G. and Andersen,B.
  TITLE     Mouse deformed epidermal autoregulatory factor 1 recruits a LIM
            domain factor, LMO-4, and CLIM coregulators
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15418-15423 (1998)
   PUBMED   9860983
REFERENCE   8  (bases 1 to 2667)
  AUTHORS   Semina,E.V., Altherr,M.R. and Murray,J.C.
  TITLE     Cloning and chromosomal localization of two novel human genes
            encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI
  JOURNAL   Mamm Genome 9 (11), 921-924 (1998)
   PUBMED   9799849
REFERENCE   9  (bases 1 to 2667)
  AUTHORS   Bach,I., Carriere,C., Ostendorff,H.P., Andersen,B. and
            Rosenfeld,M.G.
  TITLE     A family of LIM domain-associated cofactors confer transcriptional
            synergism between LIM and Otx homeodomain proteins
  JOURNAL   Genes Dev 11 (11), 1370-1380 (1997)
   PUBMED   9192866
REFERENCE   10 (bases 1 to 2667)
  AUTHORS   Agulnick,A.D., Taira,M., Breen,J.J., Tanaka,T., Dawid,I.B. and
            Westphal,H.
  TITLE     Interactions of the LIM-domain-binding factor Ldb1 with LIM
            homeodomain proteins
  JOURNAL   Nature 384 (6606), 270-272 (1996)
   PUBMED   8918878
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY068608.1, AK147160.1, BC079611.1 and BB679977.1.
            
            Transcript Variant: This variant (3) contains an alternate exon in
            the 3' coding region and differs in the 3' UTR, compared to variant
            1. It encodes isoform 3, which is shorter and has a distinct
            C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U89489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                BY068608.1         2-92
            92-1138             AK147160.1         2-1048
            1139-1144           BC079611.1         1032-1037
            1145-2415           AK147160.1         1049-2319
            2416-2667           BB679977.1         166-417
FEATURES             Location/Qualifiers
     source          1..2667
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 24.24 cM"
     gene            1..2667
                     /gene="Ldb2"
                     /gene_synonym="CLIM1; CLP-36; Ldb3"
                     /note="LIM domain binding 2"
                     /db_xref="GeneID:16826"
                     /db_xref="MGI:MGI:894670"
     exon            1..385
                     /gene="Ldb2"
                     /gene_synonym="CLIM1; CLP-36; Ldb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1249
                     /gene="Ldb2"
                     /gene_synonym="CLIM1; CLP-36; Ldb3"
                     /note="isoform 3 is encoded by transcript variant 3; LIM
                     domain-binding protein 2; LIM domain-binding factor CLIM1;
                     carboxyl-terminal LIM domain-binding protein 1"
                     /codon_start=1
                     /product="LIM domain-binding protein 2 isoform 3"
                     /protein_id="NP_001273277.1"
                     /db_xref="CCDS:CCDS80276.1"
                     /db_xref="GeneID:16826"
                     /db_xref="MGI:MGI:894670"
                     /translation="MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTE
                     DSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYY
                     ILKHSKESYHNSSITVDCDQCAMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHF
                     TIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMS
                     RHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNTT
                     NSAGSKKKTPAASLSLATQVPGLGAIPNCSLNPGRDGDLCHSTAVTPSGQFKEKH"
     exon            386..488
                     /gene="Ldb2"
                     /gene_synonym="CLIM1; CLP-36; Ldb3"
                     /inference="alignment:Splign:2.1.0"
     exon            489..661
                     /gene="Ldb2"
                     /gene_synonym="CLIM1; CLP-36; Ldb3"
                     /inference="alignment:Splign:2.1.0"
     exon            662..784
                     /gene="Ldb2"
                     /gene_synonym="CLIM1; CLP-36; Ldb3"
                     /inference="alignment:Splign:2.1.0"
     exon            785..868
                     /gene="Ldb2"
                     /gene_synonym="CLIM1; CLP-36; Ldb3"
                     /inference="alignment:Splign:2.1.0"
     exon            869..992
                     /gene="Ldb2"
                     /gene_synonym="CLIM1; CLP-36; Ldb3"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1144
                     /gene="Ldb2"
                     /gene_synonym="CLIM1; CLP-36; Ldb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1287
                     /gene="Ldb2"
                     /gene_synonym="CLIM1; CLP-36; Ldb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..2667
                     /gene="Ldb2"
                     /gene_synonym="CLIM1; CLP-36; Ldb3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2638..2643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ldb2"
                     /gene_synonym="CLIM1; CLP-36; Ldb3"
                     /note="hexamer: AATAAA"
     polyA_site      2660
                     /gene="Ldb2"
                     /gene_synonym="CLIM1; CLP-36; Ldb3"
                     /note="major polyA site"
ORIGIN      
        1 agtgctccct cccctcccgc gctccctccc tccctctccc tcctcgttcc ctctcctctc
       61 tcgctataga gggctcccac agcacttccc agccagtgtg ctcagcctgc ctgcctgcct
      121 gcctctgtgt gtgtctgtgt gtgtgtgagc gtgtgtgcgt gcgtctactt tgtactgtga
      181 agaacacagc ccatgtgctc tgcatggacg ttcctgatac tctattaagc ttgattttcg
      241 acaagcaggc aagatgtcca gcacaccaca tgaccccttc tattcttctc ctttcggccc
      301 attttatagg agacatacac catacatggt acagccagag taccgaatct atgagatgaa
      361 caagagactg cagtctcgta cagaggacag tgacaacctc tggtgggatg cgtttgccac
      421 tgaatttttt gaagatgatg ccacattaac actttcattt tgtttggaag acggaccaaa
      481 gcgatacact atcggcagga ccctcattcc ccgttatttt agcaccgtat ttgaaggagg
      541 ggtgacagac ctgtactaca tccttaaaca ctcaaaggag tcatatcaca actcatccat
      601 cacagtagac tgcgaccagt gtgccatggt cacacagcat gggaagccca tgtttaccaa
      661 ggtatgcaca gaaggcaggc tgatcttgga attcacattt gatgacctca tgagaataaa
      721 aacgtggcac tttaccatta gacagtacag ggagctggtc cccagaagca tactagccat
      781 gcacgcacaa gatcctcagg tcctggatca gctgtccaaa aatatcacca ggatgggtct
      841 cacaaacttc accctcaact acctcaggtt gtgtgtaata ctggagccaa tgcaggaact
      901 gatgtcgaga cacaaaacct acaacctcag tccccgagac tgcctgaaga cctgtctgtt
      961 tcagaagtgg cagcggatgg tggccccgcc agcagaaccc acaaggcaac cgacaaccaa
     1021 aaggagaaaa cgaaaaaact ccacaagcag cacgtccaat agcagtgccg ggaacacgac
     1081 caacagtgcc ggcagcaaga agaagacccc ggcggcaagc ctgagcctgg ccactcaggt
     1141 acctgggcta ggagccatcc cgaactgcag cctcaaccct gggagggatg gagacctgtg
     1201 tcattcaaca gcagtgaccc cttctggcca atttaaggag aagcattgag gggccctgaa
     1261 aggagtcact tccagtcctc ctcagaggat gtgatggtgg taggagagcc aactctgatg
     1321 ggaggtgagt ttggggacga ggacgaaagg ctaatcacta gattagaaaa cacgcagtat
     1381 gatgcggcca acggcatgga cgacgaagaa gacttcaaca attcacctgc cctggggaac
     1441 aacagcccgt ggaacagtaa acctcccgcc acgcaagaga ccaaatcaga aaacgcccca
     1501 ccccaggctt cccagtaaga tgggctactg gcacctgatt acgctgtcca taggcccgtg
     1561 gggtagaatt ccattcgcaa atctctacta tcaggagaga aaagagatga aatttaaaac
     1621 acacaagcaa aacgtttcca tgtaaacatc tatttctaaa cttatataat gacctgattt
     1681 tctttcttgc aatttttccc cctttttaat tgagaggatc gttcgaatga gcctctgtgg
     1741 cctctcctta gaggccttca caagaagcat agacactgtc cctgacggta attagaagaa
     1801 gcagaggctc acacatctcc tggcacggtc ttatctccct cgtgtgttga acttgctgtc
     1861 cgtccatgca ccctacgaag gccatgctgt gcaaacgtgc tcaggatctc agtaacgggc
     1921 caacccccaa ctacagatga ctttttaata ttgtaaaata ttttctgctt ttttgacttg
     1981 catttgagag tttcttgttt cagtaaaaaa agaaaagaaa agaaaaatat ccgttttgga
     2041 aaaataactt aaatgcccct ccccggccgc ctccaatttc cattggtttc catgtggcaa
     2101 gatccccgag aaaacacagc taggtgactt tctgacaagc tgaagctaat tggttcttga
     2161 atctgagttg tttcaattta ggccaagtac tagaacaagg aatcatcaaa gatatatggg
     2221 tagattttat tatgtacaca aagacaaatg gaccctgaga aatgtatgcg tttgtaaact
     2281 tgccatgggt ccgaatattt tcaagccatg taatccatta attttgtggg aagcttaata
     2341 aatcagaagc ttttatttct tcttatttta attgtatctt agttgactga attttggtga
     2401 agtttttttt tttttatgct atatttcctg tgtaatattt tgtaaatcct tcacctgttt
     2461 cttttatggg gacttttctt ttggggcaag ttcagtgtat ttatgtgaaa ctttataaga
     2521 gaactaattt ttccatttgc atattaatat gttcctctat acatgtaaag acacagtggc
     2581 tctgtgtgtc atcaagcagc tgtattttat gtatgcttta ctggtaagtg tgccaataat
     2641 aaactgtgtt aatgaccaaa gtaagtg
//
