LOCUS       NM_001113408            2123 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus LIM domain binding 1 (Ldb1), transcript variant 1,
            mRNA.
ACCESSION   NM_001113408
VERSION     NM_001113408.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2123)
  AUTHORS   Cheffer,A., Garcia-Miralles,M., Maier,E., Akol,I., Franz,H.,
            Srinivasan,V.S.V. and Vogel,T.
  TITLE     DOT1L deletion impairs the development of cortical
            parvalbumin-expressing interneurons
  JOURNAL   Cereb Cortex 33 (19), 10272-10285 (2023)
   PUBMED   37566909
REFERENCE   2  (bases 1 to 2123)
  AUTHORS   Liu,Y., Kepple,J.D., Shalev,A. and S Hunter,C.
  TITLE     LDB1-mediated transcriptional complexes are sensitive to islet
            stress
  JOURNAL   Islets 14 (1), 58-68 (2022)
   PUBMED   34968409
  REMARK    GeneRIF: LDB1-mediated transcriptional complexes are sensitive to
            islet stress.
REFERENCE   3  (bases 1 to 2123)
  AUTHORS   Liu,G., Wang,L., Wess,J. and Dean,A.
  TITLE     Enhancer looping protein LDB1 regulates hepatocyte gene expression
            by cooperating with liver transcription factors
  JOURNAL   Nucleic Acids Res 50 (16), 9195-9211 (2022)
   PUBMED   36018801
  REMARK    GeneRIF: Enhancer looping protein LDB1 regulates hepatocyte gene
            expression by cooperating with liver transcription factors.
REFERENCE   4  (bases 1 to 2123)
  AUTHORS   Love,P.E., Warzecha,C. and Li,L.
  TITLE     Ldb1 complexes: the new master regulators of erythroid gene
            transcription
  JOURNAL   Trends Genet 30 (1), 1-9 (2014)
   PUBMED   24290192
  REMARK    Review article
REFERENCE   5  (bases 1 to 2123)
  AUTHORS   Tran,Y.H., Xu,Z., Kato,A., Mistry,A.C., Goya,Y., Taira,M.,
            Brandt,S.J. and Hirose,S.
  TITLE     Spliced isoforms of LIM-domain-binding protein (CLIM/NLI/Ldb)
            lacking the LIM-interaction domain
  JOURNAL   J Biochem 140 (1), 105-119 (2006)
   PUBMED   16815859
  REMARK    GeneRIF: mouse Ldb1b lacks the ability to activate protein 4.2
            promoter, which is stimulated by LMO2 and Ldb1. These findings
            suggest that splice isoforms of Ldb lacking LID are potential
            regulators of Ldb function.[lbd1]
REFERENCE   6  (bases 1 to 2123)
  AUTHORS   Matthews,J.M. and Visvader,J.E.
  TITLE     LIM-domain-binding protein 1: a multifunctional cofactor that
            interacts with diverse proteins
  JOURNAL   EMBO Rep 4 (12), 1132-1137 (2003)
   PUBMED   14647207
  REMARK    Review article
REFERENCE   7  (bases 1 to 2123)
  AUTHORS   Yamashita,T., Agulnick,A.D., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Westphal,H.
  TITLE     Genomic structure and chromosomal localization of the mouse LIM
            domain-binding protein 1 gene, Ldb1
  JOURNAL   Genomics 48 (1), 87-92 (1998)
   PUBMED   9503020
REFERENCE   8  (bases 1 to 2123)
  AUTHORS   Bach,I., Carriere,C., Ostendorff,H.P., Andersen,B. and
            Rosenfeld,M.G.
  TITLE     A family of LIM domain-associated cofactors confer transcriptional
            synergism between LIM and Otx homeodomain proteins
  JOURNAL   Genes Dev 11 (11), 1370-1380 (1997)
   PUBMED   9192866
REFERENCE   9  (bases 1 to 2123)
  AUTHORS   Agulnick,A.D., Taira,M., Breen,J.J., Tanaka,T., Dawid,I.B. and
            Westphal,H.
  TITLE     Interactions of the LIM-domain-binding factor Ldb1 with LIM
            homeodomain proteins
  JOURNAL   Nature 384 (6606), 270-272 (1996)
   PUBMED   8918878
REFERENCE   10 (bases 1 to 2123)
  AUTHORS   Jurata,L.W., Kenny,D.A. and Gill,G.N.
  TITLE     Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting
            protein, is expressed early in neuronal development
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11693-11698 (1996)
   PUBMED   8876198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140233.3.
            
            On Aug 18, 2022 this sequence version replaced NM_001113408.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF030333.1, SRR14777530.64231.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-404               AC140233.3         72052-72455         c
            405-507             AC140233.3         63485-63587         c
            508-552             AC140233.3         63329-63373         c
            553-628             AC140233.3         63146-63221         c
            629-731             AC140233.3         62957-63059         c
            732-904             AC140233.3         62643-62815         c
            905-1027            AC140233.3         62046-62168         c
            1028-1111           AC140233.3         61833-61916         c
            1112-1235           AC140233.3         61611-61734         c
            1236-1384           AC140233.3         61254-61402         c
            1385-2123           AC140233.3         59825-60563         c
FEATURES             Location/Qualifiers
     source          1..2123
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.75 cM"
     gene            1..2123
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
                     /note="LIM domain binding 1"
                     /db_xref="GeneID:16825"
                     /db_xref="MGI:MGI:894762"
     exon            1..404
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
                     /inference="alignment:Splign:2.1.0"
     CDS             380..1615
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
                     /note="isoform 1 is encoded by transcript variant 1;
                     carboxyl-terminal LIM domain-binding protein 2; LIM
                     domain-binding protein 1; nuclear LIM interactor; LIM
                     domain-binding factor CLIM2"
                     /codon_start=1
                     /product="LIM domain-binding protein 1 isoform 1"
                     /protein_id="NP_001106879.1"
                     /db_xref="CCDS:CCDS50455.1"
                     /db_xref="GeneID:16825"
                     /db_xref="MGI:MGI:894762"
                     /translation="MSVGCACPGCSSKSFKLYSPKEPPNGNAFPPFHPGTMLDRDVGP
                     TPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDA
                     MLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKEAFHSNFVSLDCD
                     QGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQ
                     DPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQ
                     KWQRMVAPPAEPARQQPSKRRKRKMSGGSTMSSGGGNTNNSNSKKKSPASTFALSSQV
                     PDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDEDSFNNSPALGANSPWNS
                     KPPSSQESKSENPTSQASQ"
     exon            405..507
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            508..552
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            553..628
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            629..731
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            732..904
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1027
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1111
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1235
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1384
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..2123
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1683..1688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
                     /note="hexamer: AATAAA"
     polyA_site      1706
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
     polyA_site      2109
                     /gene="Ldb1"
                     /gene_synonym="CLIM2; NLI"
                     /note="major polyA site"
ORIGIN      
        1 ggagagccgg cgcttgcgag agggagagga cgcgcgaacg aacgggagcg agcgcgaggg
       61 cggcggcggg gagggcggcg ggagcgcaca gacacgcaca cgcacacgcg cacacacgga
      121 cacacactcc ggggacgcac acccgcgcgt acacacgcag aggcagctcg ccttcctgcc
      181 tggcttcctt cctgtctgct ccgcgcctga caggcccctc gctgcaggca ggggcggccc
      241 gcaccgggca gaggccgggc cgggccggcg gcgcgggcat cgggggccgc gggcggcggc
      301 agcggctcat gcccggcctg tccctgcgag gggcgggcat cgtgactcgg ctgggccccc
      361 agcggcgggc gatgtgaaga tgtcagtggg ctgtgcctgt cctggttgtt cctcaaagtc
      421 attcaagctg tactcgccga aggagccccc gaacggcaac gccttccctc ccttccaccc
      481 cggcaccatg ctggatcggg atgtgggccc aactcccatg tacccaccta catacctgga
      541 gcctgggatc gggaggcaca caccatatgg taaccaaacc gactatagaa tatttgagct
      601 taacaaacgg ctacagaact ggacagagga gtgtgacaat ctctggtggg atgctttcac
      661 aactgagttc tttgaagatg acgccatgct gaccatcact ttctgcttgg aggatggacc
      721 aaagagatat accattggcc ggaccctgat accacgctac ttccgaagca tttttgaggg
      781 gggtgccaca gagctgtact acgtgctcaa gcaccccaag gaggcattcc acagcaactt
      841 cgtgtccctc gactgtgacc agggcagcat ggtgacccag cacggcaaac ccatgtttac
      901 ccaggtgtgt gtggaaggcc ggttgtacct ggagttcatg tttgacgaca tgatgcggat
      961 aaagacgtgg cacttcagca tccggcaaca cagagagctc atccccagaa gtatcctggc
     1021 catgcacgcc caggaccccc agatgctgga tcagctgtcc aaaaacatta cccggtgtgg
     1081 gctgtccaat tccactctca actacctccg actctgtgtg atactagagc ccatgcagga
     1141 acttatgtcc cgccacaaga cctacagcct cagcccccga gactgcctca agacctgcct
     1201 cttccagaag tggcagcgaa tggtagcgcc tcccgcggag cccgcacgac agcagcccag
     1261 caaacggagg aaacggaaga tgtcaggggg tagcaccatg agctcggggg gtggcaacac
     1321 caacaacagc aacagcaaga agaagagccc agccagcacc ttcgctctct ccagccaggt
     1381 acctgatgtg atggtggtgg gggagcccac cctgatgggc ggggagttcg gggacgagga
     1441 cgagaggctc atcacccggc tggagaacac ccagtttgac gcggccaacg gcattgacga
     1501 cgaggacagc tttaacaact cccccgcact gggcgccaac agcccctgga acagcaagcc
     1561 tccatccagc caagagagca aatcggagaa tcccacgtca caggcttccc agtgaaggcc
     1621 ctaccacggc cacccagcgc tctgcctgcc tacccctcac agctccaggg agcagaagac
     1681 ggaataaaga gactgggcgt ctgaaatggg cagcctccat ccacccactt cagggaggga
     1741 ctggactcgc tgggggcagg tgccaagatt tgccccccag ttgccctggg ctgggcctgg
     1801 cccctgcaga gccttttggg ggaagggggt actcatgtgg atgcctgtgt ggaccctggg
     1861 cctctgagaa atgtcccgac cctcctctcc ccagggcatt tgccctcgtt cttaccccag
     1921 gttctgggtg ccccatcttc ctgatttctc ccttggatcc tggggtttat acctacagcc
     1981 cttaggggct aaatgttggg gctgtggttg aacgcccttc ccctaggtgg ctgtcaacag
     2041 agggtaaaat tctgggctcc tcccttttgc cacttaccca gctccaagtt tttaaaaaaa
     2101 taatattatt aaaaatgtaa att
//
