LOCUS       NM_145835               2157 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus lactase-like (Lctl), mRNA.
ACCESSION   NM_145835
VERSION     NM_145835.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2157)
  AUTHORS   Paidi,S.K., Zhang,Q., Yang,Y., Xia,C.H., Ji,N. and Gong,X.
  TITLE     Adaptive Optical Two-Photon Fluorescence Microscopy Probes Cellular
            Organization of Ocular Lenses In Vivo
  JOURNAL   Invest Ophthalmol Vis Sci 64 (7), 20 (2023)
   PUBMED   37306987
REFERENCE   2  (bases 1 to 2157)
  AUTHORS   Fan,J., Lerner,J., Wyatt,M.K., Cai,P., Peterson,K., Dong,L. and
            Wistow,G.
  TITLE     The klotho-related protein KLPH (lctl) has preferred expression in
            lens and is essential for expression of clic5 and normal lens
            suture formation
  JOURNAL   Exp Eye Res 169, 111-121 (2018)
   PUBMED   29425878
  REMARK    GeneRIF: These results suggest that KLPH is required for
            lens-specific expression of Clic5 and that Clic5 has an important
            role in the machinery that controls lens fiber cell extension and
            organization.
REFERENCE   3  (bases 1 to 2157)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   4  (bases 1 to 2157)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   5  (bases 1 to 2157)
  AUTHORS   Ito,S., Fujimori,T., Hayashizaki,Y. and Nabeshima,Y.
  TITLE     Identification of a novel mouse membrane-bound family 1
            glycosidase-like protein, which carries an atypical active site
            structure
  JOURNAL   Biochim Biophys Acta 1576 (3), 341-345 (2002)
   PUBMED   12084582
  REMARK    GeneRIF: Results describe a novel mouse gene klph that encodes a
            novel mammalian family 1 glycosidase-like protein.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114674.10.
            
            On Feb 2, 2022 this sequence version replaced NM_145835.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF309072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AC114674.10        163617-163756
            141-374             AC114674.10        164071-164304
            375-538             AC114674.10        165236-165399
            539-626             AC114674.10        165884-165971
            627-736             AC114674.10        166195-166304
            737-865             AC114674.10        168562-168690
            866-961             AC114674.10        168779-168874
            962-1016            AC114674.10        173157-173211
            1017-1178           AC114674.10        173294-173455
            1179-1453           AC114674.10        178006-178280
            1454-1580           AC114674.10        179259-179385
            1581-1780           AC114674.10        179554-179753
            1781-1844           AC114674.10        181308-181371
            1845-2157           AC114674.10        184262-184574
FEATURES             Location/Qualifiers
     source          1..2157
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 34.5 cM"
     gene            1..2157
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /note="lactase-like"
                     /db_xref="GeneID:235435"
                     /db_xref="MGI:MGI:2183549"
     exon            1..140
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /inference="alignment:Splign:2.1.0"
     exon            141..374
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1960
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /note="lactase-like protein; klotho/lactase-phlorizin
                     hydrolase-related protein; Klotho-LPH related"
                     /codon_start=1
                     /product="lactase-like protein precursor"
                     /protein_id="NP_665834.1"
                     /db_xref="CCDS:CCDS23274.1"
                     /db_xref="GeneID:235435"
                     /db_xref="MGI:MGI:2183549"
                     /translation="MKPVWVIILGWILLVPRVGTAWRGPPEEASFYYGTFPPGFSWGV
                     GSSAYQTEGAWDEDGKGPSIWDAFTHGRKEQVLGGDTADTACDSYYKVQEDIALLKEL
                     QVSHYRFSLSWPRLLPTGVRAEQVNKRGIKFYSDFIDALLKSNITPVVTLHHWDLPQM
                     LQVAYGGWQNVSMTRYFSDYADLCFEVFGDRVKHWLTFSDPRTMVEKGYETGLHAPGL
                     RLQGTGLYVAAHHIIKAHAQAWHSYNNTWRSKQHGLVGISLNCDWGEPVDIDNPDDIE
                     AAERYLQFCLGWFANPIYAGDYPQVMKDHIGTKSAEQGLEMSRLPTFSLQEKSYLKGT
                     SDFLGLGHFTTRYITQRKYPSHQGPSYQNDRDLVELVDPNWPEMGSPWLYSVPWGFRR
                     LLNFAQTQYGDPPIYVTESGAPQKLHCTQFCDEWRIQYLKGYINEMLKAIKDGVDIKG
                     YTSWSLLDKFEWEKGYADKYGFYYVEFNVRNKPRYPKASVQYYKEIITASGFPNPQEV
                     ESWRLKALETCSINNQMLATEPLLRHMHVASEIVVPTVCALSILTAALMLTLLLRRRG
                     "
     exon            375..538
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /inference="alignment:Splign:2.1.0"
     exon            539..626
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /inference="alignment:Splign:2.1.0"
     exon            627..736
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /inference="alignment:Splign:2.1.0"
     exon            737..865
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /inference="alignment:Splign:2.1.0"
     exon            866..961
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1016
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1178
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1453
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1580
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1780
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1844
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..2157
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2119..2124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /note="hexamer: AATAAG"
     regulatory      2129..2134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /note="hexamer: AATAAA"
     regulatory      2139..2144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /note="hexamer: AAGAAA"
     polyA_site      2140
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /note="major polyA site"
     polyA_site      2150
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /note="major polyA site"
     polyA_site      2157
                     /gene="Lctl"
                     /gene_synonym="E130104I05Rik; KLPH"
                     /note="major polyA site"
ORIGIN      
        1 acagatcaca cccctgacta gaggattcca tgcctgtagg ttctgctttg gtggggagtg
       61 tggggcccag gagtcattca gagagactgg taactgacaa cagtggccct gggggtgtcg
      121 agggctgaac accatcttgg ggtcccacac acagctgctg tgtgcccaag caagccgctc
      181 tgtggcccct ttcctttccc tcctggcctg tgtccctgag ctgacagggg ctcttaggca
      241 tggaggaagg tgaggtgtca tgaagccagt gtgggtcatc atccttgggt ggatcctgct
      301 ggtgcccagg gtagggactg cctggagagg acccccagaa gaggcatcct tctactatgg
      361 aacctttcca cccggcttct cctggggcgt gggcagttct gcctaccaga cagaaggtgc
      421 atgggacgag gatgggaaag ggcccagcat ctgggatgcc ttcacacatg gcagaaagga
      481 acaggtgcta ggaggtgaca cagcagacac agcctgtgac agctactata aagttcagga
      541 ggacattgcc ctgctgaagg aactacaagt cagccactac cgattttccc tgtcttggcc
      601 gcggctcctg cccacggggg tcagagctga acaggtgaac aagagaggaa tcaaattcta
      661 cagcgatttc attgacgctc tcctgaagag caacatcacc cccgttgtga ccttgcacca
      721 ctgggaccta ccacagatgc tccaggtagc atacggcggg tggcagaatg tgagtatgac
      781 ccgatacttc agtgactatg ctgacctatg ctttgaggtc tttggggacc gagtgaagca
      841 ttggctcaca ttcagtgatc ctcggacaat ggtagaaaaa ggttatgaga ccggtctcca
      901 cgcaccaggc ctgaggctcc agggcactgg cctatatgtg gctgcacacc atatcattaa
      961 ggcccacgcc caggcttggc attcttataa taacacgtgg cgcagcaaac agcacggcct
     1021 agtagggatc tcactgaact gtgactgggg ggaacctgtg gacatcgaca accccgacga
     1081 tattgaggct gctgagcgat acctacagtt ctgtctcggt tggtttgcca accctattta
     1141 cgctggtgac tacccccaag tcatgaaaga ccacattgga acaaagagtg ccgagcaagg
     1201 cctggagatg tcgaggttgc ccacgttctc cctgcaggag aagagctacc ttaaaggcac
     1261 atctgacttc ctgggcctgg gccattttac cactcgatac atcactcaaa ggaaatatcc
     1321 ctcccaccag gggcccagct accagaatga ccgtgactta gtggagcttg tggaccccaa
     1381 ctggccagaa atgggatccc catggctcta ttctgtgccg tggggattca ggaggcttct
     1441 caactttgcc cagactcagt acggtgaccc tcccatatat gtgacagaaa gtggagcgcc
     1501 ccaaaagtta cattgcactc agttctgcga tgagtggaga atccagtacc tcaaaggata
     1561 catcaatgaa atgttaaaag ctataaaaga tggcgtggat ataaaagggt atacttcctg
     1621 gtctctgttg gataagtttg aatgggagaa aggctatgca gataaatatg gattctacta
     1681 tgttgaattc aatgtgagaa acaagcctcg ctatcccaag gcttctgtgc agtattacaa
     1741 ggagatcatc acagccagtg ggttcccaaa cccacaagag gtggaaagtt ggcgtctcaa
     1801 agccttggaa acttgctcca tcaacaacca gatgcttgcc acagagccct tgcttaggca
     1861 catgcacgtg gcttcagaga ttgtggtccc cacagtctgc gccctctcca tcctcactgc
     1921 tgccctgatg ctgacacttc tcctcaggag acgtggctga gacgggatct cctctccacc
     1981 ttcatctgtc aaagcatctc ttcaggatca ctcttctttt ctgctgcaga agttcacgtg
     2041 atgtctattt ttcaggctct gaaaattaac tcactctttt cccccttttt gttttgtgct
     2101 gtgatttaag aaaataaaaa taagcataaa taaaatgaaa gaaacctgta gtctcaa
//
