LOCUS       NM_001081078            6174 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus lactase (Lct), mRNA.
ACCESSION   NM_001081078 XM_129479
VERSION     NM_001081078.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6174)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6174)
  AUTHORS   Rattner,A., Terrillion,C.E., Jou,C., Kleven,T., Hu,S.F.,
            Williams,J., Hou,Z., Aggarwal,M., Mori,S., Shin,G., Goff,L.A.,
            Witter,M.P., Pletnikov,M., Fenton,A.A. and Nathans,J.
  TITLE     Developmental, cellular, and behavioral phenotypes in a mouse model
            of congenital hypoplasia of the dentate gyrus
  JOURNAL   Elife 9, e62766 (2020)
   PUBMED   33084572
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6174)
  AUTHORS   Chen,L., Toke,N.H., Luo,S., Vasoya,R.P., Aita,R., Parthasarathy,A.,
            Tsai,Y.H., Spence,J.R. and Verzi,M.P.
  TITLE     HNF4 factors control chromatin accessibility and are redundantly
            required for maturation of the fetal intestine
  JOURNAL   Development 146 (19) (2019)
   PUBMED   31345929
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6174)
  AUTHORS   Srivillibhuthur,M., Warder,B.N., Toke,N.H., Shah,P.P., Feng,Q.,
            Gao,N., Bonder,E.M. and Verzi,M.P.
  TITLE     TFAM is required for maturation of the fetal and adult intestinal
            epithelium
  JOURNAL   Dev Biol 439 (2), 92-101 (2018)
   PUBMED   29684311
REFERENCE   5  (bases 1 to 6174)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   6  (bases 1 to 6174)
  AUTHORS   Delacour,D., Koch,A., Ackermann,W., Eude-Le Parco,I.,
            Elsasser,H.P., Poirier,F. and Jacob,R.
  TITLE     Loss of galectin-3 impairs membrane polarisation of mouse
            enterocytes in vivo
  JOURNAL   J Cell Sci 121 (Pt 4), 458-465 (2008)
   PUBMED   18211959
  REMARK    GeneRIF: Data found transport defects of the intestinal brush
            border hydrolases lactase-phlorizin hydrolase (LPH) in
            galectin-3-null mutant mice, showing that it directly interact with
            galectin-3 and transit through non-raft-dependent apical transport
            platforms.
REFERENCE   7  (bases 1 to 6174)
  AUTHORS   Bosse,T., Fialkovich,J.J., Piaseckyj,C.M., Beuling,E., Broekman,H.,
            Grand,R.J., Montgomery,R.K. and Krasinski,S.D.
  TITLE     Gata4 and Hnf1alpha are partially required for the expression of
            specific intestinal genes during development
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 292 (5), G1302-G1314 (2007)
   PUBMED   17272516
  REMARK    GeneRIF: Inactivation of Gata4 had no effect on LPH gene
            expression, whereas inactivation of Hnf1alpha resulted in a 50%
            reduction in LPH gene expression during either cytodifferentiation
            or suckling.
REFERENCE   8  (bases 1 to 6174)
  AUTHORS   Wang,Z., Maravelias,C. and Sibley,E.
  TITLE     Lactase gene promoter fragments mediate differential spatial and
            temporal expression patterns in transgenic mice
  JOURNAL   DNA Cell Biol 25 (4), 215-222 (2006)
   PUBMED   16629594
  REMARK    GeneRIF: Lactase gene promoter fragments mediate differential
            spatial and temporal expression patterns in transgenic mice.
REFERENCE   9  (bases 1 to 6174)
  AUTHORS   Wang,C.C., Biben,C., Robb,L., Nassir,F., Barnett,L., Davidson,N.O.,
            Koentgen,F., Tarlinton,D. and Harvey,R.P.
  TITLE     Homeodomain factor Nkx2-3 controls regional expression of leukocyte
            homing coreceptor MAdCAM-1 in specialized endothelial cells of the
            viscera
  JOURNAL   Dev Biol 224 (2), 152-167 (2000)
   PUBMED   10926756
REFERENCE   10 (bases 1 to 6174)
  AUTHORS   Oesterreicher,T.J., Leeper,L.L., Finegold,M.J., Darlington,G.J. and
            Henning,S.J.
  TITLE     Intestinal maturation in mice lacking CCAAT/enhancer-binding
            protein alpha (C/EPBalpha)
  JOURNAL   Biochem J 330 (Pt 3) (Pt 3), 1165-1171 (1998)
   PUBMED   9494081
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161809.3.
            
            On Sep 1, 2015 this sequence version replaced NM_001081078.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-661               AC161809.3         4927-5587
            662-741             AC161809.3         14107-14186
            742-825             AC161809.3         20107-20190
            826-928             AC161809.3         21608-21710
            929-1007            AC161809.3         22650-22728
            1008-1728           AC161809.3         24969-25689
            1729-2374           AC161809.3         28848-29493
            2375-3931           AC161809.3         31850-33406
            3932-4200           AC161809.3         34511-34779
            4201-4491           AC161809.3         37882-38172
            4492-4690           AC161809.3         38921-39119
            4691-4893           AC161809.3         39416-39618
            4894-5003           AC161809.3         41213-41322
            5004-5138           AC161809.3         44160-44294
            5139-5362           AC161809.3         45531-45754
            5363-5593           AC161809.3         46559-46789
            5594-6174           AC161809.3         47909-48489
FEATURES             Location/Qualifiers
     source          1..6174
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 55.8 cM"
     gene            1..6174
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /note="lactase"
                     /db_xref="GeneID:226413"
                     /db_xref="MGI:MGI:104576"
     exon            1..661
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..5811
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /note="lactase-phlorizin hydrolase"
                     /codon_start=1
                     /product="lactase/phlorizin hydrolase preproprotein"
                     /protein_id="NP_001074547.1"
                     /db_xref="CCDS:CCDS35698.1"
                     /db_xref="GeneID:226413"
                     /db_xref="MGI:MGI:104576"
                     /translation="MELPWTALFLSTFLLGLSCQGNDWESDRNFISAAGPLTNDLVHN
                     LNHPLGKQGSDLVAGDTDIYVCQQPLPSFLPQYFSSLRASQVTHYKVLLSWAQLLPKG
                     SSKNPDQEAVQCYRQLLQSLKDAQLQPMVVLFHQMPPTSTIQRDGGFADLFADYATLA
                     FQSFGDLVEIWFTFSDLEKVIMGLPHQHLKASGLQTLSDAHRKAFDVYHRKYSSQGGK
                     LSVVLKAEDLPKLLPDPSSAALVKGSVDFLSLDLSYDCQSISTLPQKLSELQNLEPKV
                     KVFVYTLKPQDCPSTGMSPASLLFRLLEAINKDQVQTVGFDVSAFLSCTSSSEESPSC
                     SLTYSSLALQSEQQHETVVSSFPGSAYQRVWAALANQSREERDAFLQDVFPEGFLWGV
                     STGAFNVEGGWAEGGRGPSIWDHYSNLNAAESQATAKVASDSYHKPVSDVALLRGLRA
                     DVYKFSISWSRIFPFGQRTSPNLQGVAYYNKLIDSLLDSQVEPMATLFHWDLPQALQE
                     QGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTFHEPWVISYAGYGTGQHAPAISDPG
                     VASFKVAHLILKAHARTWHHYNYHHRQKQQGRVGIVLNSDWAEPLDGKSPQDLAAAER
                     YLHFMLGWFAHPIFIDGDYPAALRAQIQHTNQQCGRPLAQLPEFTEAEKRLLKGSADF
                     LGLSHYTSRLISKAGQQTCIPSYDNIGGFSQHVDPKWPQTASPWIRVVPWGIRRLLRF
                     ASLEYTKGKLPIFLAGNGMPIGEGSDLFDDSMRVNYLNLYINEVLKAVKEDSVDVRSY
                     IARSLIDGYEGPLGYSQRFGLYHVNFNDSSRPRTPRKSAYFFTSIIEKNGFPAKKVKR
                     NPLPLKADFSSRARAAFSFPSEVPSKAKVVWEKFSRQPKFERDLFYHGTFRDDFLWGV
                     SSSAYQIEGGWDADGKGPSIWDNFTHTPGNGVKDNATGDIACDSYHQLDADINILRTL
                     KVKSYRFSISWPRIFPTGRNSSINKQGVDYYNKLIDRLLESNIFPMVTLFHWDLPQAL
                     QDIGGWENPSLIELFDSYADFCFKTFGDRVKFWMTFNEPWCSAVLGYSSGIFPPNVQD
                     PGSLSYKVSHVIIKAHARVYHTYDEKYRQEQKGVISLSLNTHWVEPKDPGVQRDVEAA
                     DRMLQFNLGWFAHPIFKNGDYPDVMKWNVGNRSELQHLASSRLPSFTEEEKNYIRGTA
                     DVFCINTYTSVFAQHVTPRLNPPSYDNDMELKASDMNSSALISMMHQDVPWGMRRLLN
                     WIKEEYGNIPIYITENGQGLTNPTLDDTERIFYHKTYINEALKAYRLDGVDLRGYSAW
                     ALMDNFEWLHGYTMRFGLYHVDFDHVNRPRTARASARYYTEVITNNGMPLAKEDEFLY
                     GEFPKGFIWSAASASYQVEGAWRADGKGLSIWDTFSHTPLKIGNDDNGDVACDSYHKI
                     AEDVVALQNLGVSHYRFSISWPRILPDGTTKFINEAGLNYYVRFIDALLAAGITPQVT
                     MYHWDLPQALQDVGGWENETVVQRFKDYADVLFRRLGDKVKFWITLNEPFVIAAHGYG
                     SGVSAPGISFRPGTAPYTAGHNLIKAHAEAWHLYNSTYRNSQGGVISITISSDWAEPR
                     DPSNQEDVEAARRYVQFMGGWFAHPIFKNGDYPEVMKTRIRDRSLAAGLNKSRLPEFT
                     ESEKKKIQGTFDFFGFNHYTTVLAYNLNYAAAVSSFDADRGVASITDRSWPDSGSFWL
                     KMTPFGFRRILNWLKEEYNNPLIYVTENGVSRRGDPELNDTDRIYYLRSYINEALKAV
                     RDKVDLRGYTVWSIMDNFEWATGFAERFGVHFVNRSDPSLPRIPKASAKVYASIVRCN
                     GFPDPAQGPHPCLQQPEDAGPTASPVKSEVPFLGLMLGTAEAQTALYVLFALVLLGVC
                     SVAFLLYKYCKRSKQGTTQPGHHGLSQISSF"
     exon            662..741
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     exon            742..825
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     exon            826..928
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1007
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1728
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..2374
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..3931
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     exon            3932..4200
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     exon            4201..4491
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     exon            4492..4690
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     exon            4691..4893
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     exon            4894..5003
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     exon            5004..5138
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     exon            5139..5362
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     exon            5363..5593
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     exon            5594..6174
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6157..6162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /note="hexamer: AATAAA"
     polyA_site      6174
                     /gene="Lct"
                     /gene_synonym="Gm100; LAC; LPH; Lphl"
                     /note="major polyA site"
ORIGIN      
        1 agcagttcct tgaccatgga gctgccttgg acagcactct tcctcagtac cttcctcctg
       61 ggtctttcat gccaggggaa tgactgggaa tctgacagaa attttatttc agctgctggt
      121 cctctaacaa atgacttagt gcacaatctg aaccatccgc tgggaaagca gggctctgat
      181 ttggtagctg gtgatactga catctatgtc tgccagcagc cactgccctc cttcttgcct
      241 cagtacttca gcagtcttcg ggccagccag gttacccatt acaaagtact tctgtcatgg
      301 gcacaacttc tcccaaaagg aagctccaag aatccagacc aggaagcagt gcagtgctac
      361 cgacaactcc tccagtccct gaaggatgcc cagcttcagc ccatggtggt cctgttccac
      421 cagatgccac ctaccagcac catccagaga gacgggggct ttgctgacct ctttgctgat
      481 tatgccacat tggcttttca gtcctttggg gaccttgttg agatctggtt caccttcagt
      541 gacttggaga aagtgatcat gggtcttccc caccagcatt tgaaagcttc tggtctccaa
      601 accctcagcg atgcccacag gaaagccttt gacgtttacc acagaaagta ctcttctcag
      661 ggaggaaagc tgtctgtggt cctgaaggct gaagacctcc ccaagcttct gccagaccca
      721 tcctcagcgg ctctcgtcaa gggctccgtg gatttcctct ctcttgattt gtcttatgac
      781 tgccaaagta tatcgactct accacagaag ctgagtgaat tgcagaacct tgagcccaaa
      841 gtgaaagttt tcgtctacac cctaaaacct caggactgcc catcgactgg aatgagcccc
      901 gcctcactgc tcttcagact cctggaagcc ataaataaag accaagtcca gactgttggg
      961 tttgatgtca gtgccttcct gagctgtacg tccagttctg aggagagccc atcttgttct
     1021 ttaacctaca gtagcctggc ccttcagagc gagcagcagc atgagacagt tgtgtcctca
     1081 ttccctgggt cggcctacca gagagtctgg gcagccttgg ctaaccagtc tagggaggaa
     1141 agggacgctt tcctgcaaga tgtatttcca gaagggttcc tctggggcgt atccacggga
     1201 gcctttaacg tggaaggagg ctgggccgaa ggtggcagag ggccaagcat ctgggaccac
     1261 tacagtaacc tgaatgctgc ggagagccaa gcgacagcaa aggtggccag tgacagttac
     1321 cacaaaccag tttctgatgt ggccctcctc cgaggcctca gggctgacgt gtacaaattc
     1381 tccatctcct ggtcccgcat cttccctttc gggcagagga ccagccccaa cctccaaggt
     1441 gttgcctact acaacaaact gattgacagc ctgctggact cccaggtgga gcccatggct
     1501 acgctgttcc actgggacct cccccaggcc ctgcaggagc aaggcgggtg gcagaacgag
     1561 agtgtggtgg atgccttcct ggactacgcc gccttctgct tctccacctt tggggaccgt
     1621 gtgaagctgt gggtgacctt ccatgagccc tgggtgataa gctatgcagg ctacggcacc
     1681 gggcagcatg cgccagccat ctctgaccca ggagtggctt cctttaaggt ggctcacctg
     1741 atcctcaagg cgcatgccag aacttggcat cactacaact atcaccatcg ccaaaagcag
     1801 cagggacgcg tgggcattgt gctcaattca gactgggcgg agcccctgga cgggaagagc
     1861 ccgcaggacc ttgctgctgc cgagcgctac ctgcacttca tgctaggctg gtttgcacac
     1921 cccatcttca tagatgggga ctaccctgct gcccttcggg cccagatcca gcacacaaac
     1981 cagcagtgtg gccgtcctct ggcccaactc ccagagttca ctgaagcaga gaagcggctc
     2041 ctgaaaggct ctgcggattt cctaggtctg tctcattaca catcccgcct catcagcaag
     2101 gccgggcagc agacctgcat ccccagctat gataacatcg gaggcttctc ccagcacgta
     2161 gatcccaagt ggccccagac cgcatcgccc tggatccgag tggtgccctg gggcataagg
     2221 aggctgcttc ggttcgcttc cctggaatac acgaaaggaa aacttccaat cttcttggct
     2281 ggaaatggca tgccaatagg ggaagggtcg gatctgtttg atgactcaat gagagtaaac
     2341 tacttaaact tgtacatcaa cgaggtgctc aaggctgtca aagaggattc agtggatgtc
     2401 cgttcataca ttgctcgttc cctcattgat ggctatgaag gacccctggg ctatagccag
     2461 aggtttgggc tataccatgt caacttcaat gacagcagca ggccacgaac tcccaggaaa
     2521 tctgcctact tcttcaccag catcattgaa aagaacggtt ttcctgccaa gaaagtcaaa
     2581 agaaacccac tacccttgaa agcagacttc agctccagag ccagggctgc cttcagcttt
     2641 ccatcggagg tgccctccaa ggctaaagta gtgtgggaga agttctccag gcagcccaag
     2701 tttgaaagag acttattcta tcatggcaca ttccgggatg acttcctgtg gggcgtatcc
     2761 tcttcagcct atcaaatcga aggaggttgg gatgctgatg gcaaaggccc cagcatctgg
     2821 gataacttca cgcacacccc agggaacggt gtgaaagaca atgccacggg agacatagcg
     2881 tgtgacagct atcatcaact ggacgctgac ataaacatcc ttcgaactct gaaggtcaag
     2941 tcctatcgat tttccatctc ctggcctcga attttcccaa cgggaagaaa cagttccatc
     3001 aacaaacaag gtgttgatta ttacaacaaa ctgattgaca gattgttgga gagcaacatc
     3061 ttccccatgg tgacactctt tcactgggac ctgccccagg ccctccagga tattggaggt
     3121 tgggagaacc cttctttgat tgagttgttc gatagctatg cggacttctg ttttaagacc
     3181 tttggtgaca gagtcaagtt ctggatgacc tttaatgagc cttggtgttc tgcagtgtta
     3241 ggctacagtt cagggatatt ccccccaaat gtgcaggacc cgggctcact atcttacaag
     3301 gttagccatg taatcattaa ggcacacgcc agagtctacc atacttatga tgagaagtac
     3361 aggcaggagc agaagggggt catctctctg agcctcaaca ctcactgggt cgaacccaag
     3421 gacccggggg tccaaaggga cgtggaagcc gctgaccgga tgctgcagtt taacctgggc
     3481 tggtttgccc accctatttt taaaaacggg gactatccag atgtcatgaa atggaatgtg
     3541 gggaacagga gtgagctgca gcacctggcc agctcccgcc tgcccagctt cacagaagag
     3601 gagaagaatt acatcagagg caccgccgat gtcttctgca tcaacaccta cacctctgta
     3661 tttgcacagc atgtcactcc tagactgaac ccacccagct atgataatga catggagtta
     3721 aaggccagtg acatgaactc ttcagccttg atctccatga tgcaccaaga cgtgccctgg
     3781 gggatgagga ggttgctgaa ctggatcaag gaggagtatg gcaacattcc catttacatc
     3841 actgagaatg gacaggggct gacaaacccc acgctggatg acacggaaag gatattctac
     3901 cacaaaacct atattaatga ggctctgaaa gcctacaggc tggatggtgt tgaccttcga
     3961 ggctactctg cctgggcgct gatggacaac ttcgagtggc tgcacggcta caccatgaga
     4021 tttggattgt atcacgtcga ctttgatcat gtgaacagac ctcgaacagc aagagcctca
     4081 gccagatact atacagaggt cattaccaac aatggcatgc ccctagccaa ggaggatgag
     4141 ttcctgtatg gagagtttcc caagggcttc atctggagtg cagcgtctgc ttcctatcag
     4201 gttgaaggtg cgtggagagc agatggcaaa ggacttagta tctgggacac attttcccac
     4261 actccactga agattgggaa tgacgacaac ggggacgtgg catgtgacag ttaccacaag
     4321 attgctgagg atgtggtggc ccttcagaac ctgggcgtgt cccactaccg cttctccatc
     4381 tcctggccta gaatcctccc cgacggaacc accaagttca tcaacgaagc aggcctcaac
     4441 tactatgttc gattcataga tgcgctgctg gctgctggca tcacaccaca ggtgaccatg
     4501 tatcactggg acctgcccca ggcactgcag gacgttgggg gctgggagaa cgagacagtt
     4561 gtacagcggt ttaaggacta tgccgatgtg ctcttccgga ggttggggga caaggtcaag
     4621 ttctggatca cactgaatga gccctttgtc attgcggccc acggctacgg cagtggggtg
     4681 tctgctccag ggatctcttt cagacctggc acagctccgt acactgctgg acacaaccta
     4741 ataaaggctc acgctgaggc ttggcatctc tacaacagca cataccgtaa cagccaggga
     4801 ggtgtgatct ctatcaccat cagcagcgac tgggccgagc ccagagatcc ttccaaccag
     4861 gaggatgtgg aggcggccag gagatacgta cagtttatgg ggggctggtt tgcacacccc
     4921 atcttcaaaa acggagacta ccctgaggtg atgaagacac ggattcgtga cagaagcctg
     4981 gcggcaggcc tcaacaagtc caggctccct gaatttacag agagcgagaa gaagaagatc
     5041 cagggcacct ttgacttttt tgggttcaac cactacacca ctgtcctagc ctacaacctc
     5101 aactacgccg ctgctgtttc gtcttttgat gccgataggg gagttgcttc cattacagac
     5161 cgctcctggc cagactctgg ctccttctgg ctgaagatga ccccttttgg cttccggagg
     5221 atcttgaact ggttgaagga ggagtacaac aaccctctaa tttatgtcac agagaatgga
     5281 gtgtcccgac gaggagaccc agaactcaat gacaccgaca ggatctacta cctccgcagc
     5341 tacattaatg aagccctcaa agctgtacga gataaggtgg accttcgagg gtacacggtc
     5401 tggagcatca tggacaactt tgaatgggcc acaggcttcg cagagaggtt cggcgtgcac
     5461 tttgtgaacc gctctgaccc ttctttgcca aggatcccca aggcgtcagc caaggtctac
     5521 gcctccatag tccgctgcaa tggctttcct gaccctgcac aaggacctca tccttgtctc
     5581 cagcaaccag aagatgctgg gcccactgcc agccctgtga agtcagaggt gcccttcctg
     5641 gggctgatgc tgggcacggc agaagcacag acggctctgt atgtcctctt cgctcttgtg
     5701 ctgcttggag tttgcagcgt ggcatttctg ttatacaaat actgcaagcg ctccaagcaa
     5761 gggacaacac agccaggcca ccacggtctg agtcaaattt cttccttctg acaagtcacc
     5821 acctcaagtt gcagagaagc ctggctggcc accatactag caccagactc ctgcctgcag
     5881 tgagcggctt cctcatggct ttatgcaccg ctggaggtaa tttccatctt gaagcgtctc
     5941 aagtttccaa ttgaaatgaa aacatctttg gcgctgggaa tttttctgcg gactctgaga
     6001 agcctgcaag gcacccccat ggaaatgcag aggctgaact gcctcgtggt tctctgtcct
     6061 catttcaggg tttgatggta gactcaagag cacggacttc ctttagtaag aaccagtctt
     6121 gccccctctt gcagttcttt ccataaacct atgtagaata aaatggaaaa taga
//
