LOCUS       NM_010696               3622 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus lymphocyte cytosolic protein 2 (Lcp2), mRNA.
ACCESSION   NM_010696
VERSION     NM_010696.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3622)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3622)
  AUTHORS   Yan,Z., Luo,H., Xie,B., Tian,T., Li,S., Chen,Z., Liu,J., Zhao,X.,
            Zhang,L., Deng,Y., Billiar,T.R. and Jiang,Y.
  TITLE     Targeting adaptor protein SLP76 of RAGE as a therapeutic approach
            for lethal sepsis
  JOURNAL   Nat Commun 12 (1), 308 (2021)
   PUBMED   33436632
  REMARK    GeneRIF: Targeting adaptor protein SLP76 of RAGE as a therapeutic
            approach for lethal sepsis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3622)
  AUTHORS   Utley,A., Chavel,C., Lightman,S., Holling,G.A., Cooper,J., Peng,P.,
            Liu,W., Barwick,B.G., Gavile,C.M., Maguire,O., Murray-Dupuis,M.,
            Rozanski,C., Jordan,M.S., Kambayashi,T., Olejniczak,S.H.,
            Boise,L.H. and Lee,K.P.
  TITLE     CD28 Regulates Metabolic Fitness for Long-Lived Plasma Cell
            Survival
  JOURNAL   Cell Rep 31 (12), 107815 (2020)
   PUBMED   32579940
REFERENCE   4  (bases 1 to 3622)
  AUTHORS   Raynor,J., Lin,A., Hummel,S.A., Lampe,K., Jordan,M., Hoebe,K. and
            Hildeman,D.A.
  TITLE     The Variable Genomic NK Cell Receptor Locus Is a Key Determinant of
            CD4+ T Cell Responses During Viral Infection
  JOURNAL   Front Immunol 11, 197 (2020)
   PUBMED   32153566
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3622)
  AUTHORS   Voisinne,G., Kersse,K., Chaoui,K., Lu,L., Chaix,J., Zhang,L.,
            Goncalves Menoita,M., Girard,L., Ounoughene,Y., Wang,H.,
            Burlet-Schiltz,O., Luche,H., Fiore,F., Malissen,M., Gonzalez de
            Peredo,A., Liang,Y., Roncagalli,R. and Malissen,B.
  TITLE     Quantitative interactomics in primary T cells unveils TCR signal
            diversification extent and dynamics
  JOURNAL   Nat Immunol 20 (11), 1530-1541 (2019)
   PUBMED   31591574
REFERENCE   6  (bases 1 to 3622)
  AUTHORS   Pivniouk,V.I., Martin,T.R., Lu-Kuo,J.M., Katz,H.R., Oettgen,H.C.
            and Geha,R.S.
  TITLE     SLP-76 deficiency impairs signaling via the high-affinity IgE
            receptor in mast cells
  JOURNAL   J Clin Invest 103 (12), 1737-1743 (1999)
   PUBMED   10377180
REFERENCE   7  (bases 1 to 3622)
  AUTHORS   Clements,J.L., Lee,J.R., Gross,B., Yang,B., Olson,J.D., Sandra,A.,
            Watson,S.P., Lentz,S.R. and Koretzky,G.A.
  TITLE     Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice
  JOURNAL   J Clin Invest 103 (1), 19-25 (1999)
   PUBMED   9884330
REFERENCE   8  (bases 1 to 3622)
  AUTHORS   Pivniouk,V., Tsitsikov,E., Swinton,P., Rathbun,G., Alt,F.W. and
            Geha,R.S.
  TITLE     Impaired viability and profound block in thymocyte development in
            mice lacking the adaptor protein SLP-76
  JOURNAL   Cell 94 (2), 229-238 (1998)
   PUBMED   9695951
REFERENCE   9  (bases 1 to 3622)
  AUTHORS   Clements,J.L., Yang,B., Ross-Barta,S.E., Eliason,S.L., Hrstka,R.F.,
            Williamson,R.A. and Koretzky,G.A.
  TITLE     Requirement for the leukocyte-specific adapter protein SLP-76 for
            normal T cell development
  JOURNAL   Science 281 (5375), 416-419 (1998)
   PUBMED   9665885
REFERENCE   10 (bases 1 to 3622)
  AUTHORS   Jackman,J.K., Motto,D.G., Sun,Q., Tanemoto,M., Turck,C.W.,
            Peltz,G.A., Koretzky,G.A. and Findell,P.R.
  TITLE     Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein
            associated with Grb2 in T cells
  JOURNAL   J Biol Chem 270 (13), 7029-7032 (1995)
   PUBMED   7706237
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645909.11.
            
            On Feb 15, 2018 this sequence version replaced NM_010696.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036727.1, AK170491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-504               AL645909.11        47193-47696
            505-567             AL645909.11        51162-51224
            568-614             AL645909.11        54571-54617
            615-680             AL645909.11        68679-68744
            681-712             AL645909.11        69203-69234
            713-750             AL645909.11        70133-70170
            751-949             AL645909.11        71235-71433
            950-1047            AL645909.11        73762-73859
            1048-1114           AL645909.11        75317-75383
            1115-1198           AL645909.11        75481-75564
            1199-1224           AL645909.11        78509-78534
            1225-1244           AL645909.11        78650-78669
            1245-1352           AL645909.11        78773-78880
            1353-1383           AL645909.11        80455-80485
            1384-1396           AL645909.11        81985-81997
            1397-1526           AL645909.11        82659-82788
            1527-1576           AL645909.11        83685-83734
            1577-1671           AL645909.11        87473-87567
            1672-1749           AL645909.11        88295-88372
            1750-1905           AL645909.11        89790-89945
            1906-3622           AL645909.11        90830-92546
FEATURES             Location/Qualifiers
     source          1..3622
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 19.43 cM"
     gene            1..3622
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /note="lymphocyte cytosolic protein 2"
                     /db_xref="GeneID:16822"
                     /db_xref="MGI:MGI:1321402"
     exon            1..504
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     CDS             427..2028
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /note="SLP-76 tyrosine phosphoprotein; SH2
                     domain-containing leukocyte protein of 76 kDa"
                     /codon_start=1
                     /product="lymphocyte cytosolic protein 2"
                     /protein_id="NP_034826.2"
                     /db_xref="CCDS:CCDS48768.1"
                     /db_xref="GeneID:16822"
                     /db_xref="MGI:MGI:1321402"
                     /translation="MALKNVPFRSEVLAWNSDNLADYFRKLNYRDCEKAVKKYHIDGA
                     RFLNLTENDIQKFPKLRMPLLSKLSQDINKNEERRSIFTRKPQIPRFLEETESHEEDD
                     GGWSSFEDDYESPNDDDPDGEDDGDYESPNEEEQALVDDAADYEPPPSNNEEALQSSI
                     LPPNSFHNTNSMYIDRPPTGKVSQQPPVPPLRPKPALPPLPTGRNHSPLSPPHPNHEE
                     PSRSGNNKTAKLPAPSIDRSTKPPLDRSLAPLDREPFILGKKPPFSDKPSAPLGREHL
                     PKIQKPPLPPAMDRHERNERLGPVTTRKPPVPRHGRGPDRRENDEDDVHQRPLPQPSL
                     PSMSSNTFPSRSVQPSSKNTFPLAHMPGAFSESNIGFQQSASLPPYFSQGPGNRPPLR
                     SEGRNLPLPVPNRPQPPSPGEEETPLDEEWYVSYITRPEAEAALRKINQDGTFLVRDS
                     SKKTANNPYVLMVLYKDKVYNIQIRYQEESQVYLLGTGLRGKEDFLSVSDIIDYFRKM
                     PLLLIDGKNRGSRYQCTLTHAAGCL"
     exon            505..567
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            568..614
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            615..680
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            681..712
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            713..750
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            751..949
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1047
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1114
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1198
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1224
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1244
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1352
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1383
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1396
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1526
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1576
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1671
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1749
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1905
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..3622
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /note="hexamer: ATTAAA"
     polyA_site      2597
                     /gene="Lcp2"
                     /gene_synonym="m1Khoe; SLP-76; SLP76; twm"
                     /note="major polyA site"
ORIGIN      
        1 tttgttcctc ttcctgcttg gctggggtgt ctgggccagt ggggaattaa caatctctct
       61 ctctctctct ctctctctct ctctctctct ctctctctct ctctctctcc cctctctctc
      121 tctctgcatt atgaaccccc agagctgtcc ttccttgttt acttatttag aagtcagcag
      181 aggaagtggt aaaggaaact agctgagtcg ttttctgaga agagaccata tttgttcaca
      241 ggggaagccg ctgcttttgg ggatctggct acagcagaaa agagtcctct tcaacaaggg
      301 tgttcctgag agcatctggg aatcagaaga gccaaggaca cctcagagct ctggatctgg
      361 gcttttcccc tgttcatggc tgcatcgcct ctcctcagtt tgtgagcctc tccctgtaga
      421 gcagccatgg ccttgaagaa tgtcccgttt cgctcagagg tcctagcctg gaactcagac
      481 aacctcgctg actatttcag gaagctgaac tacagggact gtgagaaggc tgtgaagaaa
      541 taccacattg atggtgctcg gtttttgaac ctgacagaaa atgacattca gaagttccct
      601 aagctgagga tgccacttct cagtaagttg agtcaagata tcaacaagaa cgaagagaga
      661 aggagcattt tcacacgcaa accccagatt ccacggtttc ttgaggagac agaaagccac
      721 gaagaagacg atggtggctg gtcatccttt gaagatgact atgaaagtcc caatgatgat
      781 gatccagatg gggaggacga tggtgactat gagtccccta atgaggagga acaggccctg
      841 gtggacgatg ctgctgacta tgagcctcca ccctccaaca acgaggaggc tctgcagagc
      901 tccatcctgc cccccaactc tttccacaac accaactcca tgtacatcga ccgacctccc
      961 actggcaagg tctcccagca gcctccagtg cccccactga gaccaaaacc tgccctccct
     1021 cccctgccaa caggcaggaa tcactcgcca ctgtctccac cccatcccaa ccacgaagag
     1081 cccagcagaa gtggaaacaa caagacagca aagttgcctg ctccatcaat agacagaagc
     1141 acaaaacctc ccctggaccg ctcactggcc cctcttgacc gagagccctt catactagga
     1201 aagaaaccac cattttctga taagccctca gccccattgg ggagggaaca tttacccaag
     1261 atacaaaagc ctcctttgcc accagccatg gacagacacg aaagaaatga aagactcgga
     1321 cccgtgacaa cgaggaagcc accagttcca aggcatggaa ggggaccaga cagaagagag
     1381 aatgatgaag atgatgtgca tcagagacct ttgccacagc cgtcactacc ttccatgagc
     1441 tccaacacat tcccttcgag atctgtccag cccagctcca agaacacatt cccattggcc
     1501 cacatgccgg gagccttctc agaaagcaac attggctttc agcagagtgc ctccctgccg
     1561 ccatacttct ctcaaggtcc aggcaacagg ccacctctca gaagtgaagg cagaaactta
     1621 cccttgccgg ttccaaacag gcctcagcct ccatctcctg gggaagaaga gacaccctta
     1681 gatgaagagt ggtatgtctc ttatatcacc cgaccagagg cagaagctgc tctgaggaag
     1741 ataaaccagg atggcacctt cctggttaga gacagctcta agaagacagc gaacaatccg
     1801 tatgtcctca tggtgctgta caaagacaaa gtttacaaca tccaaatccg ctaccaggag
     1861 gaaagtcaag tctacttgtt gggcactgga cttcgaggaa aagaggactt cctgtctgta
     1921 tcagatatta ttgactactt caggaaaatg ccgctgttgc tcattgatgg aaagaatcga
     1981 gggtccagat accagtgcac actaacacac gctgcaggct gtctgtagca agttagccaa
     2041 gaaatgagcc tttctgactt ggtggtcact gcggcgaaat cacgtgacct tagcaaatcg
     2101 ccgagcactt aggagtagac tgttaactcg ggcccagagt tctgccctgc ccttttaaag
     2161 tatctgaaga ttgttgaata ccacatgatt tatttatttt ctttgatgtt tatagagtat
     2221 agaagtgatc atgttcacat ttgaagtcta agagtgcatg gcagacatga gattttgaac
     2281 atccatccca aaatacagta cttgatacag tacagaaata atgtggagca agctgaaaaa
     2341 gtactgaaac tggtcatttt tgatatattt tataatgaat cttttgtcag gccgaggcat
     2401 gttctgtttt ttacacaact taaaatgatt aaaattcatt ttggagcagc aataacttaa
     2461 gaggctccaa aaaaaaaaaa tagaactcca tcgtttctta tttggtttta cagggtgtgt
     2521 ttttatgtgt tccctttcgt aatgagatta atgcatgtgg ggataacttc ctgggattaa
     2581 agttatcgtt tgctttactt ttttcgatcc ttaagacaac gttgtttggt ccttgctgtt
     2641 atatttttat tttaaagcaa atgtaagcta cctttctgaa catacaagaa gaaaataggc
     2701 ttaggttcag tgatgcagct ttgctgtcaa acatgctggg cttcttgttg cttctcttat
     2761 cacagaccct catgtctcca tccatggtgg cctccgttct agtactgaag gtctcctggg
     2821 aagacgagca atgcttggta aacacacaca cacgcacaca cacacacaca cacacacaca
     2881 cacacacact tcgagcctac cttcctacta gatgatactt gcattcgctg gccttcagtt
     2941 agacagtttg actttctggg atggtcgcct gttcctgttc ctttgggcct gcaacagttc
     3001 atagaggatc atgaagtgag aatgtgagga catccgttca cttcatggtg actgggaaac
     3061 aaaagaaagg acaagaagcg catttccctc catgtcttgc atcttctgcc taactgggct
     3121 tcatctccta agattccacc actgcccaat gctgccctgg tcgggggcag ggggccaagc
     3181 ttctaccatg tgggcctttg gagaattcta tccaaacctc tgctctggtt ttctgcttta
     3241 ttagcccaac aagtatgttg caaaactgct atcttgtcct cagattggct tttaaaccct
     3301 ttgaagcacc tcagatctcc ttcagttttg aaatcacact taacaaaagg tagagagaga
     3361 tttctggcct atgttggttt aacttgccat ttttgacttt atgatggcat ggaagtgatg
     3421 cttgttaagc acgaactgta cgtcaaagtt tgaattttgc ttttctgggg ctagcagcag
     3481 atgctatgaa atgtaagagt cttggctagc aggtgatcac cagggcaccc atcagtactt
     3541 tacatgtttt atgttgaagc tgattttttt ctttttgtgg aggggctgct atgaacgctc
     3601 aataaattaa ataatgcatt cc
//
