LOCUS       NM_008879               3748 bp    mRNA    linear   ROD 16-DEC-2022
DEFINITION  Mus musculus lymphocyte cytosolic protein 1 (Lcp1), transcript
            variant 2, mRNA.
ACCESSION   NM_008879 XR_105628 XR_106872
VERSION     NM_008879.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3748)
  AUTHORS   Joshi H, Almgren-Bell A, Anaya EP, Todd EM, Van Dyken SJ, Seth A,
            McIntire KM, Singamaneni S, Sutterwala F and Morley SC.
  TITLE     L-plastin enhances NLRP3 inflammasome assembly and
            bleomycin-induced lung fibrosis
  JOURNAL   Cell Rep 38 (11), 110507 (2022)
   PUBMED   35294888
  REMARK    GeneRIF: L-plastin enhances NLRP3 inflammasome assembly and
            bleomycin-induced lung fibrosis.
REFERENCE   2  (bases 1 to 3748)
  AUTHORS   Anaya EP, Lin X, Todd EM, Szasz TP and Morley SC.
  TITLE     Novel Mouse Model Reveals That Serine Phosphorylation of L-Plastin
            Is Essential for Effective Splenic Clearance of Pneumococcus
  JOURNAL   J Immunol 206 (9), 2135-2145 (2021)
   PUBMED   33858961
REFERENCE   3  (bases 1 to 3748)
  AUTHORS   Kao CS, van Bruggen R, Kim JR, Chen XXL, Chan C, Lee J, Cho WI,
            Zhao M, Arndt C, Maksimovic K, Khan M, Tan Q, Wilson MD and Park J.
  TITLE     Selective neuronal degeneration in MATR3 S85C knock-in mouse model
            of early-stage ALS
  JOURNAL   Nat Commun 11 (1), 5304 (2020)
   PUBMED   33082323
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3748)
  AUTHORS   Lu X, Kugadas A, Smith-Page K, Lamb J, Lin T, Ru Y, Morley SC,
            Fichorova R, Mittal SK, Chauhan SK, Littleton S, Saban D and
            Gadjeva M.
  TITLE     Neutrophil L-Plastin Controls Ocular Paucibacteriality and
            Susceptibility to Keratitis
  JOURNAL   Front Immunol 11, 547 (2020)
   PUBMED   32318063
  REMARK    GeneRIF: Neutrophil L-Plastin Controls Ocular Paucibacteriality and
            Susceptibility to Keratitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3748)
  AUTHORS   Hussein NJ, Mbimba T, Al-Adlaan AA, Ansari MY, Jaber FA, McDermott
            S, Kasumov T and Safadi FF.
  TITLE     A novel regulatory role of TRAPPC9 in L-plastin-mediated osteoclast
            actin ring formation
  JOURNAL   J Cell Biochem 121 (1), 284-298 (2020)
   PUBMED   31453638
  REMARK    GeneRIF: A novel regulatory role of TRAPPC9 in L-plastin-mediated
            osteoclast actin ring formation.
REFERENCE   6  (bases 1 to 3748)
  AUTHORS   Lin CS, Chang CH and Huynh T.
  TITLE     The murine L-plastin gene promoter: identification and comparison
            with the human L-plastin gene promoter
  JOURNAL   DNA Cell Biol 16 (1), 9-16 (1997)
   PUBMED   9022040
REFERENCE   7  (bases 1 to 3748)
  AUTHORS   Chafel MM, Shen W and Matsudaira P.
  TITLE     Sequential expression and differential localization of I-, L-, and
            T-fimbrin during differentiation of the mouse intestine and yolk
            sac
  JOURNAL   Dev Dyn 203 (2), 141-151 (1995)
   PUBMED   7655078
REFERENCE   8  (bases 1 to 3748)
  AUTHORS   Shinomiya H, Hagi A, Fukuzumi M, Mizobuchi M, Hirata H and Utsumi
            S.
  TITLE     Complete primary structure and phosphorylation site of the 65-kDa
            macrophage protein phosphorylated by stimulation with bacterial
            lipopolysaccharide
  JOURNAL   J Immunol 154 (7), 3471-3478 (1995)
   PUBMED   7897227
REFERENCE   9  (bases 1 to 3748)
  AUTHORS   Shinomiya H, Hirata H, Saito S, Yagisawa H and Nakano M.
  TITLE     Identification of the 65-kDa phosphoprotein in murine macrophages
            as a novel protein: homology with human L-plastin
  JOURNAL   Biochem Biophys Res Commun 202 (3), 1631-1638 (1994)
   PUBMED   8060349
REFERENCE   10 (bases 1 to 3748)
  AUTHORS   Ezzell RM, Chafel MM and Matsudaira PT.
  TITLE     Differential localization of villin and fimbrin during development
            of the mouse visceral endoderm and intestinal epithelium
  JOURNAL   Development 106 (2), 407-419 (1989)
   PUBMED   2686960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129591.4 and AC161877.5.
            
            [WARNING] On Sep 27, 2023 this sequence was replaced by
            NM_008879.5.
            
            On or before Oct 13, 2011 this sequence version replaced
            XR_106872.1, XR_105628.1, NM_008879.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022943.1, SRR7345562.2367023.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AC129591.4         85216-85433         c
            219-337             AC129591.4         44925-45043         c
            338-424             AC129591.4         23695-23781         c
            425-588             AC129591.4         22415-22578         c
            589-718             AC129591.4         21349-21478         c
            719-851             AC129591.4         19090-19222         c
            852-933             AC129591.4         17212-17293         c
            934-1099            AC129591.4         15574-15739         c
            1100-1242           AC129591.4         13296-13438         c
            1243-1338           AC129591.4         11324-11419         c
            1339-1534           AC129591.4         9332-9527           c
            1535-1613           AC129591.4         7295-7373           c
            1614-1728           AC129591.4         6635-6749           c
            1729-1862           AC129591.4         5397-5530           c
            1863-1986           AC161877.5         46383-46506
            1987-2111           AC161877.5         49279-49403
            2112-3748           AC161877.5         51518-53154
FEATURES             Location/Qualifiers
     source          1..3748
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 39.63 cM"
     gene            1..3748
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /note="lymphocyte cytosolic protein 1"
                     /db_xref="GeneID:18826"
                     /db_xref="MGI:MGI:104808"
     exon            1..218
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            219..337
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            338..424
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..2244
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /note="65 kDa macrophage protein; plastin 2, L; L-plastin
                     (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa
                     macrophage protein) (PP65); L-fimbrin"
                     /codon_start=1
                     /product="plastin-2"
                     /protein_id="NP_032905.2"
                     /db_xref="CCDS:CCDS27276.1"
                     /db_xref="GeneID:18826"
                     /db_xref="MGI:MGI:104808"
                     /translation="MARGSVSDEEMMELREAFAKVDTDGNGYISCNELNDLFKAACLP
                     LPGYRVREITENLMATGDLDQDGKISFDEFIKVFHGLKSTEVAKTFRKAINKKEGICA
                     IGGTSEQSSVGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFNAVGDG
                     IVLCKMINLSVPDTIDERTINKKKLTPFTIQENLNLALNSASAIGCHVVNIGAEDLKE
                     GKPYLVLGLLWQVIKIGLFADIELSRNEALIALLREGESLEDLMKLSPEELLLRWANY
                     HLENAGCTKITNFSTDIKDSKAYYHLLEQVAPKGDEEGIPAVVIDMSGLREKDDIQRA
                     ECMLQQAERLGCRQFVTATDVVRGNPKLNLAFIANLFNKYPALHKPENQDIDWGALEG
                     ETREERTFRNWMNSLGVNPRVNHLYSDLSDALVIFQLYEKIKVPVDWNRVNKPPYPKL
                     GGNMKKLENCNYAVDLGKNQAKFSLVGIAGQDLNEGNRTLTLALVWQLMRRYTLNILE
                     DIGGGQKVNDDIIVNWVNTTLKEAQKSSSIASFKDPKISTSLPVLDLIDAIQPGSINY
                     DLLKTENLDDEEKLNNAKYAISMARKIGARVYALPEDLVEVNPKMVMTVFACLMGKGM
                     KRV"
     exon            425..588
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            589..718
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            719..851
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            852..933
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1099
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1242
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1338
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1534
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1613
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1728
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1862
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1986
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2111
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..3748
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctgatggg gctttgaaag cttcaagagc ctcctcctat ggcggaggct gggatttgta
       61 aacaagctgt ccataggctg tggctaaagg aataaggaaa cttgaaggga aagggctcca
      121 gaggaagtag acaggaggcc ggaataatag acttctctca agtgacctcc accccgcaga
      181 aacaaatgtg caaagatcaa cagacgggct gattccagtt acttcctgcc ttgtgaccac
      241 acagccctgc ttgacaaggc tgctctgtag atctgaagga ctggggtttc tgaccacaca
      301 gcagtgctgc tgacacagag gacagtttct ctaccaggtc tgtcacctaa agcagtgaaa
      361 atggccagag gatccgtgtc tgacgaagaa atgatggagc tcagagaggc ttttgccaaa
      421 gttgataccg atggcaacgg atacatcagc tgcaatgagc taaatgactt gttcaaggcc
      481 gcctgcctgc ctctgcctgg gtaccgagtg agagaaatca cagaaaacct gatggccaca
      541 ggtgatctgg accaagatgg aaagatcagc tttgatgagt ttatcaaggt cttccatggc
      601 ttaaaaagca ccgaggttgc caaaaccttc cgaaaagcta tcaacaagaa ggaagggatc
      661 tgtgcgattg gcggcacctc tgagcagtcc agcgttggta cccagcactc ttactcagag
      721 gaagaaaagt atgcctttgt caactggata aacaaagccc tggagaatga ccccgactgc
      781 cggcatgtca tccccatgaa ccccaacacc gacgatctct tcaatgctgt aggcgatggc
      841 atagttcttt gtaaaatgat caacctgtct gtgccagaca cgattgacga gagaacgatc
      901 aacaagaaaa agctcacacc attcaccatt caggaaaact tgaacttggc tctgaactct
      961 gcctctgcca ttgggtgcca cgtggttaat ataggggccg aggacctgaa ggagggcaag
     1021 ccttacctgg tcctgggact tttgtggcaa gtcatcaaga ttgggttgtt tgctgacatt
     1081 gaactcagca gaaatgaagc tctgattgct cttttgagag aaggagagag cctagaggat
     1141 ttgatgaagt tgtctcctga agaactcctg ctgcggtggg ctaactacca cctagaaaac
     1201 gcaggctgca ccaaaatcac caacttcagc accgacatca aggactccaa agcttattac
     1261 cacctgctcg agcaagtggc tccaaaagga gatgaagaag ggatcccggc ggttgtgatt
     1321 gacatgtcag gactgaggga gaaggatgac atccagaggg cagagtgcat gctgcaacag
     1381 gcggagaggc tgggctgccg gcagtttgtc acagctactg atgttgtccg agggaacccc
     1441 aagttgaacc tggccttcat tgccaacctc ttcaacaaat accctgcctt acacaaacca
     1501 gagaaccagg acattgactg gggggctctc gaaggtgaga cgagggaaga gcggaccttc
     1561 aggaattgga tgaactccct gggcgttaac ccgcgcgtca atcacttgta cagcgactta
     1621 tcggatgcct tagtcatctt ccagctctat gagaagatca aagtccctgt tgattggaac
     1681 agagtaaaca agcctccata ccccaagctg gggggcaata tgaaaaagct ggagaactgt
     1741 aattatgcag tggacctggg gaagaatcaa gctaaattct ccctggttgg catcgcagga
     1801 caagacctca atgaaggaaa ccgaactctc acgctggcat tggtttggca gctcatgaga
     1861 aggtacacac tgaatatcct ggaagatatc ggaggtggac agaaggtcaa tgatgacatt
     1921 attgtcaact gggtgaatac gaccttgaag gaggcacaga aaagctcatc cattgctagc
     1981 ttcaaggacc caaagatcag taccagcctc ccggttctgg atctcattga cgccattcag
     2041 ccaggttcca taaactatga ccttctaaag acagaaaacc tggatgatga agagaaactc
     2101 aacaatgcaa agtatgccat ctctatggcc agaaaaatcg gagcaagggt gtacgccctc
     2161 ccagaagacc tggttgaagt gaaccccaaa atggtcatga cagtgtttgc ctgcctcatg
     2221 gggaaaggga tgaagagggt gtaagtccca gaggagtaag ccagaaatcg acacagacaa
     2281 gcctgagggg gtcagcacat ggtgctccca ggatgcagag gaccattcaa gccattgcaa
     2341 agtcctgaac cttggagaca ttatttgaaa ttcacacatt tcttcagcca agtagcttct
     2401 gctataatta gcaatacgtg cttctctttt gttgttgttt tttcagaaga tgtactcgcc
     2461 tacaaatttt ttttttattc tttgaaagtc taccaggaaa aaaaaaagag ttaaaaagtt
     2521 atttccagat gctcacccct cccctccccc catgctttca ctggtagtca aggatataaa
     2581 ctacagtatg cttaagggtc acctgatctc ttgagccagc ttgatctagc tgctcttggc
     2641 cttgttcaga ctgaagacct agaagagatc atcaaacttg ccttaaataa accctctcaa
     2701 ctagatggtc acagcccctc cttgcatctt cttctcccag tctgtctccc tgtgagtctg
     2761 tgagtttgct ccattcccct cagaaccata cctgtggtcc ccatttgttt tttgtttttt
     2821 accagccttg ctactggagt atctgacaaa tcagtcaagg tctcaagagt ctctcaggga
     2881 gactgcaaca ctggggactc aaggaaagtg taataaagag tagaaccact agggggcagc
     2941 atggtgggac cacagagcat ctacctttct gagtgccttt aaccccactt gtgagagagc
     3001 tgcttatctt ggtgttgaca aaatgcctga cgattgttga aagcaatcct gctcaacttc
     3061 atttgctttt agacatgggc atatctgatt gctgcccagc catattacca agcctcactt
     3121 tgctggtact acggaagctt tttgccaccc taaaattcct ggaattgggg cattgatatg
     3181 tgccaataat ctatgtccct gcctcaccca aatgcttaca cgggcccata cacacatgta
     3241 gctggatgtc aagagtagaa tgttgactag gaactgcctg gaattcagaa caaagaggac
     3301 agtatgaatt tgaatagctc ccactagata agcaatttcc acgagaacct accaaaagct
     3361 aaaaagccac agagcttcgt gaaccaaagc aagactccct ctgcattagt gaaaggctta
     3421 ccgccatagc atcttcctta ggggtagaag gatgtaatgg aactttgttg tcttccaaac
     3481 caatgcaaat gcagggcttc tcagctccct cccctgacag taggctcagg aaaccaatag
     3541 atgactgttt ccagctccca agcagtattc ccgctgcatc agacgcaagg tgtttggctg
     3601 tgactttagt ctgaacttcg tgtagccttg gatgatgttt gtccatctgc ctccgtgaag
     3661 gaaggatatt attattgcct taatgtaaaa tgaaaataaa tcatgttaaa aaaatctttc
     3721 cgaataaaat gtcccccaat tctggtta
//
