LOCUS       NM_001247984            4007 bp    mRNA    linear   ROD 16-DEC-2022
DEFINITION  Mus musculus lymphocyte cytosolic protein 1 (Lcp1), transcript
            variant 1, mRNA.
ACCESSION   NM_001247984
VERSION     NM_001247984.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4007)
  AUTHORS   Joshi H, Almgren-Bell A, Anaya EP, Todd EM, Van Dyken SJ, Seth A,
            McIntire KM, Singamaneni S, Sutterwala F and Morley SC.
  TITLE     L-plastin enhances NLRP3 inflammasome assembly and
            bleomycin-induced lung fibrosis
  JOURNAL   Cell Rep 38 (11), 110507 (2022)
   PUBMED   35294888
  REMARK    GeneRIF: L-plastin enhances NLRP3 inflammasome assembly and
            bleomycin-induced lung fibrosis.
REFERENCE   2  (bases 1 to 4007)
  AUTHORS   Anaya EP, Lin X, Todd EM, Szasz TP and Morley SC.
  TITLE     Novel Mouse Model Reveals That Serine Phosphorylation of L-Plastin
            Is Essential for Effective Splenic Clearance of Pneumococcus
  JOURNAL   J Immunol 206 (9), 2135-2145 (2021)
   PUBMED   33858961
REFERENCE   3  (bases 1 to 4007)
  AUTHORS   Kao CS, van Bruggen R, Kim JR, Chen XXL, Chan C, Lee J, Cho WI,
            Zhao M, Arndt C, Maksimovic K, Khan M, Tan Q, Wilson MD and Park J.
  TITLE     Selective neuronal degeneration in MATR3 S85C knock-in mouse model
            of early-stage ALS
  JOURNAL   Nat Commun 11 (1), 5304 (2020)
   PUBMED   33082323
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4007)
  AUTHORS   Lu X, Kugadas A, Smith-Page K, Lamb J, Lin T, Ru Y, Morley SC,
            Fichorova R, Mittal SK, Chauhan SK, Littleton S, Saban D and
            Gadjeva M.
  TITLE     Neutrophil L-Plastin Controls Ocular Paucibacteriality and
            Susceptibility to Keratitis
  JOURNAL   Front Immunol 11, 547 (2020)
   PUBMED   32318063
  REMARK    GeneRIF: Neutrophil L-Plastin Controls Ocular Paucibacteriality and
            Susceptibility to Keratitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4007)
  AUTHORS   Hussein NJ, Mbimba T, Al-Adlaan AA, Ansari MY, Jaber FA, McDermott
            S, Kasumov T and Safadi FF.
  TITLE     A novel regulatory role of TRAPPC9 in L-plastin-mediated osteoclast
            actin ring formation
  JOURNAL   J Cell Biochem 121 (1), 284-298 (2020)
   PUBMED   31453638
  REMARK    GeneRIF: A novel regulatory role of TRAPPC9 in L-plastin-mediated
            osteoclast actin ring formation.
REFERENCE   6  (bases 1 to 4007)
  AUTHORS   Lin CS, Chang CH and Huynh T.
  TITLE     The murine L-plastin gene promoter: identification and comparison
            with the human L-plastin gene promoter
  JOURNAL   DNA Cell Biol 16 (1), 9-16 (1997)
   PUBMED   9022040
REFERENCE   7  (bases 1 to 4007)
  AUTHORS   Chafel MM, Shen W and Matsudaira P.
  TITLE     Sequential expression and differential localization of I-, L-, and
            T-fimbrin during differentiation of the mouse intestine and yolk
            sac
  JOURNAL   Dev Dyn 203 (2), 141-151 (1995)
   PUBMED   7655078
REFERENCE   8  (bases 1 to 4007)
  AUTHORS   Shinomiya H, Hagi A, Fukuzumi M, Mizobuchi M, Hirata H and Utsumi
            S.
  TITLE     Complete primary structure and phosphorylation site of the 65-kDa
            macrophage protein phosphorylated by stimulation with bacterial
            lipopolysaccharide
  JOURNAL   J Immunol 154 (7), 3471-3478 (1995)
   PUBMED   7897227
REFERENCE   9  (bases 1 to 4007)
  AUTHORS   Shinomiya H, Hirata H, Saito S, Yagisawa H and Nakano M.
  TITLE     Identification of the 65-kDa phosphoprotein in murine macrophages
            as a novel protein: homology with human L-plastin
  JOURNAL   Biochem Biophys Res Commun 202 (3), 1631-1638 (1994)
   PUBMED   8060349
REFERENCE   10 (bases 1 to 4007)
  AUTHORS   Ezzell RM, Chafel MM and Matsudaira PT.
  TITLE     Differential localization of villin and fimbrin during development
            of the mouse visceral endoderm and intestinal epithelium
  JOURNAL   Development 106 (2), 407-419 (1989)
   PUBMED   2686960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF728368.1, AK149790.1, AK152891.1 and BF149038.1.
            
            [WARNING] On Sep 27, 2023 this sequence was replaced by
            NM_001247984.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-431               CF728368.1         1-431
            432-2715            AK149790.1         2-2285
            2716-3974           AK152891.1         2183-3441
            3975-4007           BF149038.1         1-33                c
FEATURES             Location/Qualifiers
     source          1..4007
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 39.63 cM"
     gene            1..4007
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /note="lymphocyte cytosolic protein 1"
                     /db_xref="GeneID:18826"
                     /db_xref="MGI:MGI:104808"
     exon            1..589
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            590..676
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            677..840
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            841..970
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1103
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1185
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1351
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1494
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1590
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1786
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1865
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1980
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2114
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2238
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2363
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..4000
                     /gene="Lcp1"
                     /gene_synonym="D14Ertd310e; LCP-1; Pls2; pp65"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcccctaat tctgctgcgg gcagcgcagg atgcccggag gctgaagtgg tggagccggg
       61 aggagtggct ccacgtgtag ctgtacggaa ggctgtggtg acaatcgtta ttactattct
      121 tactcttaaa acagtggcca ctattattta cttacttttc tccatgactt gacaccggtg
      181 tctggagact gggttggcat tttctaatac ggctacactt ttgggcagct ggccaccgtt
      241 actcattttg cagtaaaacc cttgtctcca aatcgcacgt tctgttttcc ttcttgtctc
      301 ttgggtgcaa cctggtttgt ctttctgttt ttaaagttct tggtggaagt ggaactgtgt
      361 gggaaccgag agctgtaagg cagtgagtgg ttccaaagct ctttaaaagg acacccaggt
      421 ctcactgtca cggtggttgg ctgtgattac cggtgttggt gctgtctcca tgttcagtgg
      481 tagatatacc gcgcttgttt gcctgtatgt gcttgcttct ctggagattt gagaacgaaa
      541 actggaaaga acctattaca gagacgggaa aatccaactg agaattcaag tctgtcacct
      601 aaagcagtga aaatggccag aggatccgtg tctgacgaag aaatgatgga gctcagagag
      661 gcttttgcca aagttgatac cgatggcaac ggatacatca gctgcaatga gctaaatgac
      721 ttgttcaagg ccgcctgcct gcctctgcct gggtaccgag tgagagaaat cacagaaaac
      781 ctgatggcca caggtgatct ggaccaagat ggaaagatca gctttgatga gtttatcaag
      841 gtcttccatg gcttaaaaag caccgaggtt gccaaaacct tccgaaaagc tatcaacaag
      901 aaggaaggga tctgtgcgat tggcggcacc tctgagcagt ccagcgttgg tacccagcac
      961 tcttactcag aggaagaaaa gtatgccttt gtcaactgga taaacaaagc cctggagaat
     1021 gaccccgact gccggcatgt catccccatg aaccccaaca ccgacgatct cttcaatgct
     1081 gtaggcgatg gcatagttct ttgtaaaatg atcaacctgt ctgtgccaga cacgattgac
     1141 gagagaacga tcaacaagaa aaagctcaca ccattcacca ttcaggaaaa cttgaacttg
     1201 gctctgaact ctgcctctgc cattgggtgc cacgtggtta atataggggc cgaggacctg
     1261 aaggagggca agccttacct ggtcctggga cttttgtggc aagtcatcaa gattgggttg
     1321 tttgctgaca ttgaactcag cagaaatgaa gctctgattg ctcttttgag agaaggagag
     1381 agcctagagg atttgatgaa gttgtctcct gaagaactcc tgctgcggtg ggctaactac
     1441 cacctagaaa acgcaggctg caccaaaatc accaacttca gcaccgacat caaggactcc
     1501 aaagcttatt accacctgct cgagcaagtg gctccaaaag gagatgaaga agggatcccg
     1561 gcggttgtga ttgacatgtc aggactgagg gagaaggatg acatccagag ggcagagtgc
     1621 atgctgcaac aggcggagag gctgggctgc cggcagtttg tcacagctac tgatgttgtc
     1681 cgagggaacc ccaagttgaa cctggccttc attgccaacc tcttcaacaa ataccctgcc
     1741 ttacacaaac cagagaacca ggacattgac tggggggctc tcgaaggtga gacgagggaa
     1801 gagcggacct tcaggaattg gatgaactcc ctgggcgtta acccgcgcgt caatcacttg
     1861 tacagcgact tatcggatgc cttagtcatc ttccagctct atgagaagat caaagtccct
     1921 gttgattgga acagagtaaa caagcctcca taccccaagc tggggggcaa tatgaaaaag
     1981 ctggagaact gtaattatgc agtggacctg gggaagaatc aagctaaatt ctccctggtt
     2041 ggcatcgcag gacaagacct caatgaagga aaccgaactc tcacgctggc attggtttgg
     2101 cagctcatga gaaggtacac actgaatatc ctggaagata tcggaggtgg acagaaggtc
     2161 aatgatgaca ttattgtcaa ctgggtgaat acgaccttga aggaggcaca gaaaagctca
     2221 tccattgcta gcttcaagga cccaaagatc agtaccagcc tcccggttct ggatctcatt
     2281 gacgccattc agccaggttc cataaactat gaccttctaa agacagaaaa cctggatgat
     2341 gaagagaaac tcaacaatgc aaagtatgcc atctctatgg ccagaaaaat cggagcaagg
     2401 gtgtacgccc tcccagaaga cctggttgaa gtgaacccca aaatggtcat gacagtgttt
     2461 gcctgcctca tggggaaagg gatgaagagg gtgtaagtcc cagaggagta agccagaaat
     2521 cgacacagac aagcctgagg gggtcagcac atggtgctcc caggatgcag aggaccattc
     2581 aagccattgc aaagtcctga accttggaga cattatttga aattcacaca tttcttcagc
     2641 caagtagctt ctgctataat tagcaatacg tgcttctctt ttgttgttgt tttttcagaa
     2701 gatgtactcg cctacaaatt ttttttttat tctttgaaag tctaccagga aaaaaaaaag
     2761 agttaaaaag ttatttccag atgctcaccc ctcccctccc cccatgcttt cactggtagt
     2821 caaggatata aactacagta tgcttaaggg tcacctgatc tcttgagcca gcttgatcta
     2881 gctgctcttg gccttgttca gactgaagac ctagaagaga tcatcaaact tgccttaaat
     2941 aaaccctctc aactagatgg tcacagcccc tccttgcatc ttcttctccc agtctgtctc
     3001 cctgtgagtc tgtgagtttg ctccattccc ctcagaacca tacctgtggt ccccatttgt
     3061 tttttgtttt ttaccagcct tgctactgga gtatctgaca aatcagtcaa ggtctcaaga
     3121 gtctctcagg gagactgcaa cactggggac tcaaggaaag tgtaataaag agtagaacca
     3181 ctagggggca gcatggtggg accacagagc atctaccttt ctgagtgcct ttaaccccac
     3241 ttgtgagaga gctgcttatc ttggtgttga caaaatgcct gacgattgtt gaaagcaatc
     3301 ctgctcaact tcatttgctt ttagacatgg gcatatctga ttgctgccca gccatattac
     3361 caagcctcac tttgctggta ctacggaagc tttttgccac cctaaaattc ctggaattgg
     3421 ggcattgata tgtgccaata atctatgtcc ctgcctcacc caaatgctta cacgggccca
     3481 tacacacatg tagctggatg tcaagagtag aatgttgact aggaactgcc tggaattcag
     3541 aacaaagagg acagtatgaa tttgaatagc tcccactaga taagcaattt ccacgagaac
     3601 ctaccaaaag ctaaaaagcc acagagcttc gtgaaccaaa gcaagactcc ctctgcatta
     3661 gtgaaaggct taccgccata gcatcttcct taggggtaga aggatgtaat ggaactttgt
     3721 tgtcttccaa accaatgcaa atgcagggct tctcagctcc ctcccctgac agtaggctca
     3781 ggaaaccaat agatgactgt ttccagctcc caagcagtat tcccgctgca tcagacgcaa
     3841 ggtgtttggc tgtgacttta gtctgaactt cgtgtagcct tggatgatgt ttgtccatct
     3901 gcctccgtga aggaaggata ttattattgc cttaatgtaa aatgaaaata aatcatgtta
     3961 aaaaaatctt tccgaataaa atgtccccca attctggtta aaaaaaa
//
