LOCUS       NM_172153               4983 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus ligand dependent nuclear receptor corepressor-like
            (Lcorl), transcript variant 2, mRNA.
ACCESSION   NM_172153
VERSION     NM_172153.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4983)
  AUTHORS   Takayanagi-Kiya S, Misawa-Hojo K, Kiya T, Kunieda T and Kubo T.
  TITLE     Splicing variants of NOL4 differentially regulate the transcription
            activity of Mlr1 and Mlr2 in cultured cells
  JOURNAL   Zoolog Sci 31 (11), 735-740 (2014)
   PUBMED   25366156
  REMARK    GeneRIF: These findings suggest that transactivation activities of
            Mlr1 and Mlr2 are differentially regulated by splicing variants of
            NOL4, which are expressed in a tissue-selective manner.
REFERENCE   2  (bases 1 to 4983)
  AUTHORS   Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND and Robson P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   3  (bases 1 to 4983)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 4983)
  AUTHORS   Nishimura M, Yokoi N, Miki T, Horikawa Y, Yoshioka H, Takeda J,
            Ohara O and Seino S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   5  (bases 1 to 4983)
  AUTHORS   Kunieda T, Park JM, Takeuchi H and Kubo T.
  TITLE     Identification and characterization of Mlr1,2: two mouse homologues
            of Mblk-1, a transcription factor from the honeybee brain(1)
  JOURNAL   FEBS Lett 535 (1-3), 61-65 (2003)
   PUBMED   12560079
  REMARK    GeneRIF: identification and characterization of Mlr2 a homolog of
            Mblk-1, a transcription factor from the honeybee brain; expressed
            predominantly in the spermatocytes of the testis
REFERENCE   6  (bases 1 to 4983)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158786.8 and AC093341.5.
            
            [WARNING] On Mar 12, 2024 this sequence was replaced by
            NM_172153.4.
            
            On Jul 10, 2009 this sequence version replaced NM_172153.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (2) has a shorter N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB076078.1, SRR9219381.302191.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               AC158786.8         80457-80663
            208-273             AC158786.8         141651-141716
            274-353             AC093341.5         214670-214749       c
            354-483             AC093341.5         213642-213771       c
            484-735             AC093341.5         185306-185557       c
            736-829             AC093341.5         173981-174074       c
            830-4983            AC093341.5         168582-172735       c
FEATURES             Location/Qualifiers
     source          1..4983
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 25.27 cM"
     gene            1..4983
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /note="ligand dependent nuclear receptor corepressor-like"
                     /db_xref="GeneID:209707"
                     /db_xref="MGI:MGI:2651932"
     exon            1..207
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..273
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..353
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..1859
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcription factor MLR1; ligand-dependent nuclear
                     receptor corepressor-like protein; mblk1-related protein
                     1; LCoR-like protein; Mblk1-related protein-1"
                     /codon_start=1
                     /product="ligand-dependent nuclear receptor
                     corepressor-like protein isoform 2"
                     /protein_id="NP_742165.1"
                     /db_xref="CCDS:CCDS19278.1"
                     /db_xref="GeneID:209707"
                     /db_xref="MGI:MGI:2651932"
                     /translation="MDEKCSFCNLQREAVSDCIPSLDSSQSTPTEELSSQGQSHTDKI
                     ECQAESYLNALFRKKDLPQNCDPNIPLVAQELMKKMIRQFAIEYISKSGKIQENRNGS
                     IGASLVCKSIQMNQADNCLQDEQEGPLDLTVTRTQEQTAQQGDGVLDLSTKKTSIKSE
                     ESSISDPSSENAVAGRLHRNREDYVERSAEFADGLLSKALKDIQSGALDINKAGILYG
                     IPQKTLLLHLEALPAGKPASFKNKTRDFNDSYSYNESKETCAVLQKVALWARAQTERT
                     EKSKLNLLETSEFKFPTASSYLHQLTLQKMVTQFKEKNESLQYETSNPPVQLKIPQLR
                     VNSVSKSQADGSGLLDVMYQVSKTSSVLEGSALQKLKNILPKQNKLDCSGPVTHSSVD
                     SYFLHGDLSPLCLNSKNGTVDGTSENTEDGLDRKDNKQPRKKRGRYRQYDHEIMEEAI
                     AMVMSGKMSVSKAQGIYGVPHSTLEYKVKERSGTLKTPPKKKLRLPDTGLYMTDSGTG
                     SCRNSSKPV"
     exon            354..483
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..735
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..829
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..4983
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccccgcct cccattcctg ttcaaatgca gttcagtttt ccgtttcggt ggggtctgat
       61 cggttttgct tcaaacttgc gcgctcccgg ctgtcattca gtgggctgct ccgggtagcg
      121 ggaagtactg ggactccctt accttgttgc ggtcgctgct tttcctcact cagagtgcga
      181 cgtgtgccca cagctgttac ccagcaggtt ttgagagtat tttagaaggg ctttatggac
      241 cacggctacg aagagacctc agtttatttg aagactgtga accagaagag ctgactgact
      301 ggtctatgga tgaaaaatgt tcattttgta acctacagag agaagcagtc agtgattgta
      361 taccatctct tgattcttca cagtcaacgc caacagagga gctatcatct cagggccagt
      421 cccacactga taagattgaa tgccaagcag aaagttacct aaatgcactc tttcgaaaga
      481 aagatcttcc tcagaactgt gatcctaaca ttcccttagt tgctcaggaa ttaatgaaaa
      541 aaatgatacg tcagtttgca attgagtaca tctcaaaaag cggtaaaatt caagaaaata
      601 gaaatggttc aattggagca agtctcgtgt gtaaaagtat ccaaatgaac caagcagaca
      661 actgccttca ggatgagcaa gaaggcccct tagacctcac tgtgactcga acgcaagagc
      721 aaactgctca gcaaggggat ggagtgttag atctctctac aaagaaaacc agcataaagt
      781 ctgaagagtc atccataagt gatccttctt ctgaaaatgc agtggctggg agactacaca
      841 gaaacagaga ggactatgtg gaaagaagtg ctgagtttgc agatggtttg ctctcaaaag
      901 ctttgaaaga cattcagtct ggagcactgg acataaataa agcaggcata ctttatggca
      961 tacctcaaaa aactttactt ctccacttag aagccttacc agcagggaag cctgcatctt
     1021 ttaaaaacaa aactcgagat ttcaatgata gttactcata taacgaaagt aaagaaactt
     1081 gtgctgtgct gcaaaaagta gccttgtggg caagagctca aacagagcgc acagaaaaaa
     1141 gtaaactcaa cctacttgaa acctcagaat tcaaattccc aacagcttcc agttacctcc
     1201 atcagttaac tctacagaaa atggttactc agtttaaaga aaaaaatgaa agccttcaat
     1261 atgaaacttc aaatcctcct gtacagttaa aaattcctca gctacgagta aattcggttt
     1321 caaaatcaca agctgatggt tctggtctgc tggatgtcat gtatcaagtt tccaaaacct
     1381 cttcagtcct tgaaggatca gctctccaaa aactgaaaaa tatactccct aaacagaaca
     1441 aactagactg ttctgggcct gtaactcact caagtgttga ctcttacttt ctacatgggg
     1501 acctctctcc tttgtgtctt aattctaaaa atggaacagt tgatggaacc tctgagaaca
     1561 ctgaagatgg actggaccgg aaagataata agcagcccag gaaaaaacgt ggccgctatc
     1621 gacagtatga tcatgaaata atggaagagg ccattgcaat ggtaatgagt gggaaaatga
     1681 gtgtttccaa agcacaagga atctatgggg tacctcacag cactttagaa tacaaggtaa
     1741 aggaaagatc tggaacactg aagactcctc cgaagaagaa actacgatta ccagacactg
     1801 ggttatatat gacagattca gggactggca gctgcagaaa cagcagcaag cctgtgtaga
     1861 ttactgttag agaacatgtg cgagactgtg tgtgtgtgtg tgtgtgagag tgtgtgtgcg
     1921 cgcgtgtgcg tgcaggaatg tatgtgtaca ggggtatgtg agtctttgtg tgtgtgtatc
     1981 tacatacaca tgtggaaatt acaaatgctc actctgacag gagacatgaa attttacagt
     2041 tcaaaaacca cttacatgcc ttttgaaaaa gttttattca gggttttcac tgtggacaga
     2101 attatagagt tgcttattaa ttctgatagt ttgtatttaa tccttgtata aataggtgaa
     2161 aaagattcag gttttcttta gtagtcaata gcataaatgt ggggaaacaa gtaaccgtca
     2221 agtgagacat ttttttattg gtaaaaagat tgtagccatt cagttgaacc atctcataat
     2281 ggaaacatga tattaatagt ttgtgaacac ttttatgtaa catacctaca atgattgtga
     2341 gtatgtcaaa gaaccaatca aagttaaata gttacctctg taccaagagt aactaataga
     2401 tacagtatta atacactaca gtgcattctt tgaaatacag aatgcactaa agtgcatccg
     2461 ccaggataga agagaaaacc ttaaaggata tgtatagtaa aatttaatat ttatcattta
     2521 attgttgagt tagcaggaag ttggggttat tacgtatata atttaaattt taaaaaagct
     2581 gacatagtta attaacccca gaagctatag aatcctttaa tataagatgg aatactaaaa
     2641 gcaaaaagta atttaaattt aattattaaa gtaacttaat tttgtttttc atttgaaaac
     2701 taagctaatg tgtaaggtta ggaaagaagt tggaatgcca cttagagcat gtttataatg
     2761 tgcgcaggac aagcttgaga atggtcattg tggttaatgt gctggttagt tgacgttatg
     2821 actactttaa ggattgtgac acactcctac tgaaaaacct cagtgtaact ttaatatatt
     2881 tgctgctgtg acatttcaaa acattttcag tttatcaaga tgaattacag atttcatttt
     2941 ggtgggtgat acattatcat tttgctaata accaaacttg cagtttgttc agggtcttga
     3001 atagatttac agatatttaa cactgacgct gttttgaatt ttcagtaatg taaactcttt
     3061 actacttgga tatttagaag ctgggcagtg cattttaact tttactagac tcatatgaaa
     3121 ccagtgattt ttataaaaca gttttaaaaa tatgggtcag agtattcatg tgggtttatg
     3181 aagtatgcag ttttggtagt agaaatgtaa taaagcatgt acctccgtgt aaagacagga
     3241 gatctgcttt atagatgaga ctcctcctct atgccctttt ctctgttaga attcaggttc
     3301 tggtcatgtt cctaagccac tttttataaa tccaaaagga attcttacag ctgaatttaa
     3361 atataagtgc accttgtcaa atacttgtgt tgctacactt gtgtttgtgt gtatttagta
     3421 atcacatgaa cttgtgattg ttcagctact aaactttaaa actgcttgca tgtatttaaa
     3481 gaaactgaag aatgagaaaa tatatgacca ggtaatcgct tggtctctca gatctgtact
     3541 gaacattttc agctgttaac attacctgca tactggggta tgaatcctct ttatcttttt
     3601 cttcccccaa gaaaatatac ttaatagatt acaagacagc atttgtcagg gtcatctttc
     3661 tttttaaaga attaagccat attttgtgag gaccggaaca tggattattt attatatttc
     3721 cccctcctcc cattgaaaaa caaagttaaa aagtaaatgc ttcaaaaaac aattttcttg
     3781 acctctttat acagaatttt acttgcaaaa ctttgggagc tcgaatgcat tacataatat
     3841 ttatattgta ttgagctttt ttattcctca cactatattt acattgataa attgattgag
     3901 aagtttatag taaagggaaa cttacagaac acttttctat catttaaaag atgacctgac
     3961 caaaaacttt acagcattca taaatcaggg atcattttgc tattgacttc acagtgacca
     4021 gtagttttat aggtaatatt aaagttaatt tgcagcattt tagtacttat tatttatttt
     4081 tggtcaaata gtaaattaaa atattttttg atagtttata ggtaatgatc cacccataac
     4141 ttttaaaaga aacataacgt ttgtattact gagttgactt tttaattata caaactagga
     4201 aaggcaggga agtttatggg ttcccctctc cccactggtt ctattaaaac gtgctttatg
     4261 ttaaactttc aaaatccttt aaaaatttaa ttaccagtta ctacttaatt gacagtttct
     4321 gaaaaatcca atttcagctg acttttaatg aatatgaaag caacccttat gcgctttcta
     4381 cttatttgaa tgttcctcaa gtattttata tttaaaataa aaaaagaagg aaaagaaaaa
     4441 aacagtgcct ctgtttttag aaaactactg ctcagtaaag ttgtttaaac catttctgat
     4501 agctgatgac aattttatat taaactgtat actgacttta gtgaaactga tttctttttt
     4561 agttgtttac agtgcagata cttgtgggtt ttttttttaa ttgcagtatt tccattgtcg
     4621 cagtaattta gtaaaactct gtggctgcct tgattttgac agattttgtt aatataaact
     4681 gattgttagg caattagtta tatttatgca taaatcaatt gcactataat tcatgaatta
     4741 tttattacaa tattttctaa tgaattcatg tatctgtctt gtgttgtaca tgtactgtaa
     4801 ttttgttcct actttgtgtt gttatatatc taaatctgat tgtatgaatt ttaattgttc
     4861 agttaacgtg tttctaggtt gtaatttgta gtaaagcact tcaatgcttt tgcacttaaa
     4921 tttacaacac tgtcggtgtg tggttaattt actcattcag taaaggaaaa gaaaagtaaa
     4981 ctt
//
