LOCUS       NM_001163073            4970 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus ligand dependent nuclear receptor corepressor-like
            (Lcorl), transcript variant 1, mRNA.
ACCESSION   NM_001163073
VERSION     NM_001163073.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4970)
  AUTHORS   Takayanagi-Kiya S, Misawa-Hojo K, Kiya T, Kunieda T and Kubo T.
  TITLE     Splicing variants of NOL4 differentially regulate the transcription
            activity of Mlr1 and Mlr2 in cultured cells
  JOURNAL   Zoolog Sci 31 (11), 735-740 (2014)
   PUBMED   25366156
  REMARK    GeneRIF: These findings suggest that transactivation activities of
            Mlr1 and Mlr2 are differentially regulated by splicing variants of
            NOL4, which are expressed in a tissue-selective manner.
REFERENCE   2  (bases 1 to 4970)
  AUTHORS   Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND and Robson P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   3  (bases 1 to 4970)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 4970)
  AUTHORS   Nishimura M, Yokoi N, Miki T, Horikawa Y, Yoshioka H, Takeda J,
            Ohara O and Seino S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   5  (bases 1 to 4970)
  AUTHORS   Kunieda T, Park JM, Takeuchi H and Kubo T.
  TITLE     Identification and characterization of Mlr1,2: two mouse homologues
            of Mblk-1, a transcription factor from the honeybee brain(1)
  JOURNAL   FEBS Lett 535 (1-3), 61-65 (2003)
   PUBMED   12560079
  REMARK    GeneRIF: identification and characterization of Mlr2 a homolog of
            Mblk-1, a transcription factor from the honeybee brain; expressed
            predominantly in the spermatocytes of the testis
REFERENCE   6  (bases 1 to 4970)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158786.8, AK041987.1 and AC093341.5.
            
            [WARNING] On Mar 12, 2024 this sequence was replaced by
            NM_001163073.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155421.1, AK154398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC158786.8         79469-79510
            43-1222             AK041987.1         2-1181
            1223-4970           AC093341.5         168582-172329       c
FEATURES             Location/Qualifiers
     source          1..4970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 25.27 cM"
     gene            1..4970
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /note="ligand dependent nuclear receptor corepressor-like"
                     /db_xref="GeneID:209707"
                     /db_xref="MGI:MGI:2651932"
     exon            1..194
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1846
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor MLR1; ligand-dependent nuclear
                     receptor corepressor-like protein; mblk1-related protein
                     1; LCoR-like protein; Mblk1-related protein-1"
                     /codon_start=1
                     /product="ligand-dependent nuclear receptor
                     corepressor-like protein isoform 1"
                     /protein_id="NP_001156545.1"
                     /db_xref="CCDS:CCDS51499.1"
                     /db_xref="GeneID:209707"
                     /db_xref="MGI:MGI:2651932"
                     /translation="MDKGRERMAAAAAAAAAAAAAQCRSPRCAAERRGFRRELDSWRH
                     RLMHCVGFESILEGLYGPRLRRDLSLFEDCEPEELTDWSMDEKCSFCNLQREAVSDCI
                     PSLDSSQSTPTEELSSQGQSHTDKIECQAESYLNALFRKKDLPQNCDPNIPLVAQELM
                     KKMIRQFAIEYISKSGKIQENRNGSIGASLVCKSIQMNQADNCLQDEQEGPLDLTVTR
                     TQEQTAQQGDGVLDLSTKKTSIKSEESSISDPSSENAVAGRLHRNREDYVERSAEFAD
                     GLLSKALKDIQSGALDINKAGILYGIPQKTLLLHLEALPAGKPASFKNKTRDFNDSYS
                     YNESKETCAVLQKVALWARAQTERTEKSKLNLLETSEFKFPTASSYLHQLTLQKMVTQ
                     FKEKNESLQYETSNPPVQLKIPQLRVNSVSKSQADGSGLLDVMYQVSKTSSVLEGSAL
                     QKLKNILPKQNKLDCSGPVTHSSVDSYFLHGDLSPLCLNSKNGTVDGTSENTEDGLDR
                     KDNKQPRKKRGRYRQYDHEIMEEAIAMVMSGKMSVSKAQGIYGVPHSTLEYKVKERSG
                     TLKTPPKKKLRLPDTGLYMTDSGTGSCRNSSKPV"
     exon            195..260
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /inference="alignment:Splign:2.1.0"
     exon            261..340
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /inference="alignment:Splign:2.1.0"
     exon            341..470
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..722
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..816
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /inference="alignment:Splign:2.1.0"
     exon            817..4970
                     /gene="Lcorl"
                     /gene_synonym="Mlr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgccgctcg tatgtaaatg agggcgcgtg acgcgggacg cagatggaca agggaagaga
       61 gagaatggcc gctgccgccg ctgctgccgc cgccgccgct gccgctcagt gccggagccc
      121 tcggtgcgcg gcggagagga gaggattccg gcgggaactc gactcttggc gccaccgcct
      181 catgcactgt gtaggttttg agagtatttt agaagggctt tatggaccac ggctacgaag
      241 agacctcagt ttatttgaag actgtgaacc agaagagctg actgactggt ctatggatga
      301 aaaatgttca ttttgtaacc tacagagaga agcagtcagt gattgtatac catctcttga
      361 ttcttcacag tcaacgccaa cagaggagct atcatctcag ggccagtccc acactgataa
      421 gattgaatgc caagcagaaa gttacctaaa tgcactcttt cgaaagaaag atcttcctca
      481 gaactgtgat cctaacattc ccttagttgc tcaggaatta atgaaaaaaa tgatacgtca
      541 gtttgcaatt gagtacatct caaaaagcgg taaaattcaa gaaaatagaa atggttcaat
      601 tggagcaagt ctcgtgtgta aaagtatcca aatgaaccaa gcagacaact gccttcagga
      661 tgagcaagaa ggccccttag acctcactgt gactcgaacg caagagcaaa ctgctcagca
      721 aggggatgga gtgttagatc tctctacaaa gaaaaccagc ataaagtctg aagagtcatc
      781 cataagtgat ccttcttctg aaaatgcagt ggctgggaga ctacacagaa acagagagga
      841 ctatgtggaa agaagtgctg agtttgcaga tggtttgctc tcaaaagctt tgaaagacat
      901 tcagtctgga gcactggaca taaataaagc aggcatactt tatggcatac ctcaaaaaac
      961 tttacttctc cacttagaag ccttaccagc agggaagcct gcatctttta aaaacaaaac
     1021 tcgagatttc aatgatagtt actcatataa cgaaagtaaa gaaacttgtg ctgtgctgca
     1081 aaaagtagcc ttgtgggcaa gagctcaaac agagcgcaca gaaaaaagta aactcaacct
     1141 acttgaaacc tcagaattca aattcccaac agcttccagt tacctccatc agttaactct
     1201 acagaaaatg gttactcagt ttaaagaaaa aaatgaaagc cttcaatatg aaacttcaaa
     1261 tcctcctgta cagttaaaaa ttcctcagct acgagtaaat tcggtttcaa aatcacaagc
     1321 tgatggttct ggtctgctgg atgtcatgta tcaagtttcc aaaacctctt cagtccttga
     1381 aggatcagct ctccaaaaac tgaaaaatat actccctaaa cagaacaaac tagactgttc
     1441 tgggcctgta actcactcaa gtgttgactc ttactttcta catggggacc tctctccttt
     1501 gtgtcttaat tctaaaaatg gaacagttga tggaacctct gagaacactg aagatggact
     1561 ggaccggaaa gataataagc agcccaggaa aaaacgtggc cgctatcgac agtatgatca
     1621 tgaaataatg gaagaggcca ttgcaatggt aatgagtggg aaaatgagtg tttccaaagc
     1681 acaaggaatc tatggggtac ctcacagcac tttagaatac aaggtaaagg aaagatctgg
     1741 aacactgaag actcctccga agaagaaact acgattacca gacactgggt tatatatgac
     1801 agattcaggg actggcagct gcagaaacag cagcaagcct gtgtagatta ctgttagaga
     1861 acatgtgcga gactgtgtgt gtgtgtgtgt gtgagagtgt gtgtgcgcgc gtgtgcgtgc
     1921 aggaatgtat gtgtacaggg gtatgtgagt ctttgtgtgt gtgtatctac atacacatgt
     1981 ggaaattaca aatgctcact ctgacaggag acatgaaatt ttacagttca aaaaccactt
     2041 acatgccttt tgaaaaagtt ttattcaggg ttttcactgt ggacagaatt atagagttgc
     2101 ttattaattc tgatagtttg tatttaatcc ttgtataaat aggtgaaaaa gattcaggtt
     2161 ttctttagta gtcaatagca taaatgtggg gaaacaagta accgtcaagt gagacatttt
     2221 tttattggta aaaagattgt agccattcag ttgaaccatc tcataatgga aacatgatat
     2281 taatagtttg tgaacacttt tatgtaacat acctacaatg attgtgagta tgtcaaagaa
     2341 ccaatcaaag ttaaatagtt acctctgtac caagagtaac taatagatac agtattaata
     2401 cactacagtg cattctttga aatacagaat gcactaaagt gcatccgcca ggatagaaga
     2461 gaaaacctta aaggatatgt atagtaaaat ttaatattta tcatttaatt gttgagttag
     2521 caggaagttg gggttattac gtatataatt taaattttaa aaaagctgac atagttaatt
     2581 aaccccagaa gctatagaat cctttaatat aagatggaat actaaaagca aaaagtaatt
     2641 taaatttaat tattaaagta acttaatttt gtttttcatt tgaaaactaa gctaatgtgt
     2701 aaggttagga aagaagttgg aatgccactt agagcatgtt tataatgtgc gcaggacaag
     2761 cttgagaatg gtcattgtgg ttaatgtgct ggttagttga cgttatgact actttaagga
     2821 ttgtgacaca ctcctactga aaaacctcag tgtaacttta atatatttgc tgctgtgaca
     2881 tttcaaaaca ttttcagttt atcaagatga attacagatt tcattttggt gggtgataca
     2941 ttatcatttt gctaataacc aaacttgcag tttgttcagg gtcttgaata gatttacaga
     3001 tatttaacac tgacgctgtt ttgaattttc agtaatgtaa actctttact acttggatat
     3061 ttagaagctg ggcagtgcat tttaactttt actagactca tatgaaacca gtgattttta
     3121 taaaacagtt ttaaaaatat gggtcagagt attcatgtgg gtttatgaag tatgcagttt
     3181 tggtagtaga aatgtaataa agcatgtacc tccgtgtaaa gacaggagat ctgctttata
     3241 gatgagactc ctcctctatg cccttttctc tgttagaatt caggttctgg tcatgttcct
     3301 aagccacttt ttataaatcc aaaaggaatt cttacagctg aatttaaata taagtgcacc
     3361 ttgtcaaata cttgtgttgc tacacttgtg tttgtgtgta tttagtaatc acatgaactt
     3421 gtgattgttc agctactaaa ctttaaaact gcttgcatgt atttaaagaa actgaagaat
     3481 gagaaaatat atgaccaggt aatcgcttgg tctctcagat ctgtactgaa cattttcagc
     3541 tgttaacatt acctgcatac tggggtatga atcctcttta tctttttctt cccccaagaa
     3601 aatatactta atagattaca agacagcatt tgtcagggtc atctttcttt ttaaagaatt
     3661 aagccatatt ttgtgaggac cggaacatgg attatttatt atatttcccc ctcctcccat
     3721 tgaaaaacaa agttaaaaag taaatgcttc aaaaaacaat tttcttgacc tctttataca
     3781 gaattttact tgcaaaactt tgggagctcg aatgcattac ataatattta tattgtattg
     3841 agctttttta ttcctcacac tatatttaca ttgataaatt gattgagaag tttatagtaa
     3901 agggaaactt acagaacact tttctatcat ttaaaagatg acctgaccaa aaactttaca
     3961 gcattcataa atcagggatc attttgctat tgacttcaca gtgaccagta gttttatagg
     4021 taatattaaa gttaatttgc agcattttag tacttattat ttatttttgg tcaaatagta
     4081 aattaaaata ttttttgata gtttataggt aatgatccac ccataacttt taaaagaaac
     4141 ataacgtttg tattactgag ttgacttttt aattatacaa actaggaaag gcagggaagt
     4201 ttatgggttc ccctctcccc actggttcta ttaaaacgtg ctttatgtta aactttcaaa
     4261 atcctttaaa aatttaatta ccagttacta cttaattgac agtttctgaa aaatccaatt
     4321 tcagctgact tttaatgaat atgaaagcaa cccttatgcg ctttctactt atttgaatgt
     4381 tcctcaagta ttttatattt aaaataaaaa aagaaggaaa agaaaaaaac agtgcctctg
     4441 tttttagaaa actactgctc agtaaagttg tttaaaccat ttctgatagc tgatgacaat
     4501 tttatattaa actgtatact gactttagtg aaactgattt cttttttagt tgtttacagt
     4561 gcagatactt gtgggttttt tttttaattg cagtatttcc attgtcgcag taatttagta
     4621 aaactctgtg gctgccttga ttttgacaga ttttgttaat ataaactgat tgttaggcaa
     4681 ttagttatat ttatgcataa atcaattgca ctataattca tgaattattt attacaatat
     4741 tttctaatga attcatgtat ctgtcttgtg ttgtacatgt actgtaattt tgttcctact
     4801 ttgtgttgtt atatatctaa atctgattgt atgaatttta attgttcagt taacgtgttt
     4861 ctaggttgta atttgtagta aagcacttca atgcttttgc acttaaattt acaacactgt
     4921 cggtgtgtgg ttaatttact cattcagtaa aggaaaagaa aagtaaactt
//
