LOCUS       NP_001156545             600 aa            linear   ROD 02-MAY-2024
DEFINITION  ligand-dependent nuclear receptor corepressor-like protein isoform
            1 [Mus musculus].
ACCESSION   NP_001156545
VERSION     NP_001156545.1
DBSOURCE    REFSEQ: accession NM_001163073.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 600)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 600)
  AUTHORS   Takayanagi-Kiya,S., Misawa-Hojo,K., Kiya,T., Kunieda,T. and Kubo,T.
  TITLE     Splicing variants of NOL4 differentially regulate the transcription
            activity of Mlr1 and Mlr2 in cultured cells
  JOURNAL   Zoolog Sci 31 (11), 735-740 (2014)
   PUBMED   25366156
  REMARK    GeneRIF: These findings suggest that transactivation activities of
            Mlr1 and Mlr2 are differentially regulated by splicing variants of
            NOL4, which are expressed in a tissue-selective manner.
REFERENCE   3  (residues 1 to 600)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   4  (residues 1 to 600)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (residues 1 to 600)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   6  (residues 1 to 600)
  AUTHORS   Kunieda,T., Park,J.M., Takeuchi,H. and Kubo,T.
  TITLE     Identification and characterization of Mlr1,2: two mouse homologues
            of Mblk-1, a transcription factor from the honeybee brain(1)
  JOURNAL   FEBS Lett 535 (1-3), 61-65 (2003)
   PUBMED   12560079
  REMARK    GeneRIF: identification and characterization of Mlr2 a homolog of
            Mblk-1, a transcription factor from the honeybee brain; expressed
            predominantly in the spermatocytes of the testis
REFERENCE   7  (residues 1 to 600)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158786.8 and AC093341.5.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155421.1, AK154398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 25.31 cM"
     Protein         1..600
                     /product="ligand-dependent nuclear receptor
                     corepressor-like protein isoform 1"
                     /note="transcription factor MLR1; ligand-dependent nuclear
                     receptor corepressor-like protein; mblk1-related protein
                     1; LCoR-like protein; Mblk1-related protein-1"
                     /calculated_mol_wt=66564
     Region          279..312
                     /region_name="HTH_psq"
                     /note="helix-turn-helix, Psq domain; pfam05225"
                     /db_xref="CDD:283007"
     Region          525..570
                     /region_name="HTH_psq"
                     /note="helix-turn-helix, Psq domain; pfam05225"
                     /db_xref="CDD:283007"
     CDS             1..600
                     /gene="Lcorl"
                     /gene_synonym="Gm3414; Mlr1"
                     /coded_by="NM_001163073.2:5..1807"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS51499.1"
                     /db_xref="GeneID:209707"
                     /db_xref="MGI:MGI:2651932"
ORIGIN      
        1 mdkgrermaa aaaaaaaaaa aqcrsprcaa errgfrreld swrhrlmhcv gfesilegly
       61 gprlrrdlsl fedcepeelt dwsmdekcsf cnlqreavsd cipsldssqs tpteelssqg
      121 qshtdkiecq aesylnalfr kkdlpqncdp niplvaqelm kkmirqfaie yisksgkiqe
      181 nrngsigasl vcksiqmnqa dnclqdeqeg pldltvtrtq eqtaqqgdgv ldlstkktsi
      241 kseessisdp ssenavagrl hrnredyver saefadglls kalkdiqsga ldinkagily
      301 gipqktlllh lealpagkpa sfknktrdfn dsysyneske tcavlqkval waraqterte
      361 ksklnllets efkfptassy lhqltlqkmv tqfkeknesl qyetsnppvq lkipqlrvns
      421 vsksqadgsg lldvmyqvsk tssvlegsal qklknilpkq nkldcsgpvt hssvdsyflh
      481 gdlsplclns kngtvdgtse ntedgldrkd nkqprkkrgr yrqydheime eaiamvmsgk
      541 msvskaqgiy gvphstleyk vkersgtlkt ppkkklrlpd tglymtdsgt gscrnsskpv
//
