LOCUS       NM_001370767           15221 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ligand dependent nuclear receptor corepressor (Lcor),
            transcript variant 1, mRNA.
ACCESSION   NM_001370767 XM_011247215
VERSION     NM_001370767.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 15221)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   2  (bases 1 to 15221)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 15221)
  AUTHORS   Wang,Y., Liu,W., Liu,Y., Cui,J., Zhao,Z., Cao,H., Fu,Z. and Liu,B.
  TITLE     Long noncoding RNA H19 mediates LCoR to impact the osteogenic and
            adipogenic differentiation of mBMSCs in mice through sponging
            miR-188
  JOURNAL   J Cell Physiol 233 (9), 7435-7446 (2018)
   PUBMED   29663375
  REMARK    GeneRIF: Long noncoding RNA H19 mediates LCoR to regulate the
            balance between osteogenic and adipogenic differentiation of mBMSCs
            in mice through sponging miR-188.
REFERENCE   4  (bases 1 to 15221)
  AUTHORS   Conway,E., Jerman,E., Healy,E., Ito,S., Holoch,D., Oliviero,G.,
            Deevy,O., Glancy,E., Fitzpatrick,D.J., Mucha,M., Watson,A.,
            Rice,A.M., Chammas,P., Huang,C., Pratt-Kelly,I., Koseki,Y.,
            Nakayama,M., Ishikura,T., Streubel,G., Wynne,K., Hokamp,K.,
            McLysaght,A., Ciferri,C., Di Croce,L., Cagney,G., Margueron,R.,
            Koseki,H. and Bracken,A.P.
  TITLE     A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL
            Genes Balance PRC2 Subtype Activities
  JOURNAL   Mol Cell 70 (3), 408-421 (2018)
   PUBMED   29628311
REFERENCE   5  (bases 1 to 15221)
  AUTHORS   Shalom-Barak,T., Liersemann,J., Memari,B., Flechner,L., Devor,C.E.,
            Bernardo,T.M., Kim,S., Matsumoto,N., Friedman,S.L., Evans,R.M.,
            White,J.H. and Barak,Y.
  TITLE     Ligand-Dependent Corepressor (LCoR) Is a Rexinoid-Inhibited
            Peroxisome Proliferator-Activated Receptor gamma-Retinoid X
            Receptor alpha Coactivator
  JOURNAL   Mol Cell Biol 38 (9), e00107-17 (2018)
   PUBMED   29463649
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 15221)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 15221)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 15221)
  AUTHORS   Kunieda,T., Park,J.M., Takeuchi,H. and Kubo,T.
  TITLE     Identification and characterization of Mlr1,2: two mouse homologues
            of Mblk-1, a transcription factor from the honeybee brain(1)
  JOURNAL   FEBS Lett 535 (1-3), 61-65 (2003)
   PUBMED   12560079
  REMARK    GeneRIF: identification and characterization of Mlr2 a homolog of
            Mblk-1, a transcription factor from the honeybee brain; expressed
            in various tissues other than testis
REFERENCE   9  (bases 1 to 15221)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 15221)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112271.4 and AC132303.3.
            
            On May 29, 2019 this sequence version replaced XM_011247215.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.237566.1,
                                           SRR7345562.1305336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC112271.4         59346-59447         c
            103-176             AC112271.4         58529-58602         c
            177-242             AC112271.4         14043-14108         c
            243-322             AC112271.4         13489-13568         c
            323-455             AC132303.3         82377-82509         c
            456-743             AC132303.3         75648-75935         c
            744-837             AC132303.3         72683-72776         c
            838-15221           AC132303.3         32223-46606         c
FEATURES             Location/Qualifiers
     source          1..15221
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.97 cM"
     gene            1..15221
                     /gene="Lcor"
                     /gene_synonym="3110023F06Rik; A630025C20Rik; Gm340;
                     mKIAA1795; Mlr2"
                     /note="ligand dependent nuclear receptor corepressor"
                     /db_xref="GeneID:212391"
                     /db_xref="MGI:MGI:2443930"
     exon            1..102
                     /gene="Lcor"
                     /gene_synonym="3110023F06Rik; A630025C20Rik; Gm340;
                     mKIAA1795; Mlr2"
                     /inference="alignment:Splign:2.1.0"
     exon            103..176
                     /gene="Lcor"
                     /gene_synonym="3110023F06Rik; A630025C20Rik; Gm340;
                     mKIAA1795; Mlr2"
                     /inference="alignment:Splign:2.1.0"
     exon            177..242
                     /gene="Lcor"
                     /gene_synonym="3110023F06Rik; A630025C20Rik; Gm340;
                     mKIAA1795; Mlr2"
                     /inference="alignment:Splign:2.1.0"
     exon            243..322
                     /gene="Lcor"
                     /gene_synonym="3110023F06Rik; A630025C20Rik; Gm340;
                     mKIAA1795; Mlr2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..455
                     /gene="Lcor"
                     /gene_synonym="3110023F06Rik; A630025C20Rik; Gm340;
                     mKIAA1795; Mlr2"
                     /inference="alignment:Splign:2.1.0"
     exon            456..743
                     /gene="Lcor"
                     /gene_synonym="3110023F06Rik; A630025C20Rik; Gm340;
                     mKIAA1795; Mlr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             506..5596
                     /gene="Lcor"
                     /gene_synonym="3110023F06Rik; A630025C20Rik; Gm340;
                     mKIAA1795; Mlr2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor MLR2; ligand-dependent corepressor;
                     mblk1-related protein 2; Mblk1-related protein-2"
                     /codon_start=1
                     /product="ligand-dependent corepressor isoform 1"
                     /protein_id="NP_001357696.1"
                     /db_xref="CCDS:CCDS89392.1"
                     /db_xref="GeneID:212391"
                     /db_xref="MGI:MGI:2443930"
                     /translation="MQRMIQQFAAEYTSKTSSTQDPSQPNSTKNQSLPKASPVTTSPT
                     AATTQNPVLSKLLMADQDSPLDLTVRKSQSEPSEQDGVLDLSTKKSPCASSTSLSHSP
                     GCSSTQGNGEESAEAPVADPNRQSKSPLEKFMVKLCNHHQKQFIRVLSDLYTESQPGS
                     EALQPLDSTVMDVSACDSGCAQLSGRENEKDDCLEESSPASVKLFLDSSGSPSSLNVT
                     EETMKEPPPETDSVDGRDSAASSSAVQKGSSEPPDAQHNPTGSADSSTMGCLGTLDAF
                     SSNSPHSAKSLEGQTTGQEQDTDMKPCEDAEDSAPAPVQSLAAVEEVAENTEEGGSCI
                     VSQRNSFKALSEETWDSGFMGNSSSTADKENALQSSSKSSFHQDLETDEQDARPKQEN
                     HLHSLGRNKVGFQTYPRDKGHFDHSRGGWLAPSPTPTVHRASNGHSQTKMMSASIKTA
                     RKSKRASGLRINDYDNQCDVVYISQPITECHFENQRSILSSRKTARKSTRGYFFNGDC
                     CELPTVRTLARNLCSQDKGSCSQVASEAVMTPKQTLTVPTSKHTVGVQLPTVGAQLPT
                     TDVQPPTAGTQLPTADVQSPTVGAQLPTADVQSPTVGAQLPTADVQPPTVDVQLPTAD
                     VQPPTGGVQLPTADVQPPTVGAQLPRVDVQLSSVGTQLPTADVQPPTVGAQLPAADVQ
                     LPTVDVQISTVDTQLSTVGEQPLEDICDDPRKERTSLEGGDEDTSSAKKHQEAEVCLS
                     LREQDPSSSPRPGETTTSSPACLLPTLLPNDNMSEVPEGSIVVSPPTESVLSFQEQDQ
                     PPASQLGPEEMQAQECHLVPTAGSTPFTSREDSEDLLCRPQSSPKTSIREESSPCSED
                     EGSTVALDPPLGLELSEHDQSTSTEAETRDIPGETLLLDDSLPLLESSIVTDENPSEM
                     EEGEATSGTGHLEAHDNDTKYSAENDPSEPNSDSPEENVDKKKKARKFPEASDRCLRS
                     QLGDPSSSDRYPGSQGLDSSAACSEIKVSKNPAVKHSKREGDSGRVTSEGPVIDSIHP
                     DNLEDPEDSGVSEHSSDEETKQETEGVGVITRQTVKNMLAKEIKREEGGTYPNSDPAT
                     VGQPLPGDNLETHVWSKIDERDAHVPSESIPCKRDPEQVKENPGHLAIQDTEAAAMSE
                     VDPEDTHHKDDAGLAPCSSSGISASHSDGADGPPKSVTRPKRLPSSTYNLRHAHCSNA
                     LDTAKMTSEKQGTQVNPAAKEGGASESAEPLDEEDEDSVVEEQPKFIGWCAEEENQEL
                     IASFNAHYLRVQKGWIQLEKEAQPTARARSKSDKLKEIWKSKKRARKCRGSLEVQKFS
                     PVQMLFMTNFKLSNICKWFLETTETRSLVIVKKLNTRLPGDIPLVKHPLQKFPPSTMY
                     PSSLQAERLKKHLKKFPGAIPARNNWKTQKLWAKLRENPDLIESEDGSDISFGPSSED
                     SVEEVREGRHSHPPTNLPTPASTRILRKYSNIRGKLRAQRLDSSLCGASEMKQGRKSV
                     CINPLMSPKLALQVGADGFPVNPKRAERSKGRRGKQMPETLLKVEGQNKRKRAEGSGT
                     QDGKDKGPATKVSRGLSAKKLAAKDRANQLSKKMTLKANKVRVCRKGPGRSCLSSRKE
                     KENANRRPGHPAAASEALTKPSKQRGAREASSKPPKVRRRNRKLSSGRGHARPLAKSP
                     ENRTAPRKRKLKAKLDSSQGKRRRLEAK"
     exon            744..837
                     /gene="Lcor"
                     /gene_synonym="3110023F06Rik; A630025C20Rik; Gm340;
                     mKIAA1795; Mlr2"
                     /inference="alignment:Splign:2.1.0"
     exon            838..15221
                     /gene="Lcor"
                     /gene_synonym="3110023F06Rik; A630025C20Rik; Gm340;
                     mKIAA1795; Mlr2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8041..8046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lcor"
                     /gene_synonym="3110023F06Rik; A630025C20Rik; Gm340;
                     mKIAA1795; Mlr2"
                     /note="hexamer: AATAGA"
     polyA_site      8061
                     /gene="Lcor"
                     /gene_synonym="3110023F06Rik; A630025C20Rik; Gm340;
                     mKIAA1795; Mlr2"
                     /note="major polyA site"
     regulatory      15200..15205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lcor"
                     /gene_synonym="3110023F06Rik; A630025C20Rik; Gm340;
                     mKIAA1795; Mlr2"
                     /note="hexamer: ATTAAA"
     polyA_site      15221
                     /gene="Lcor"
                     /gene_synonym="3110023F06Rik; A630025C20Rik; Gm340;
                     mKIAA1795; Mlr2"
                     /note="major polyA site"
ORIGIN      
        1 agaagatggc gagggtgtgt aggcggcagc aatgctccgt tgagagacgc ggctttcggc
       61 aagaactgga ctcgtggcgc cacaagctca tccactgtgt aggtcccgtt tccctctgtg
      121 cggcggccgg cgggaccata agggcttaac tcacatattt aacccccctc caaaaagatt
      181 tgaaagtatt cttgaagggc tgtttggacc tgcgttatta aaagatctca gtttatttaa
      241 agagtgtgac cctgaaagca tttctgattg ggcgtttgat gaaaattgtc tgttctgttg
      301 cttgaaaaga gataaagtaa agggacattt agtcggtctg gatgaaccag cttccggagc
      361 tgggcaagaa gctttgctta agcaagagca cgcaaaaatc attcgactcc agagacaagc
      421 agaagagttc ctcaatgcag tcttttatag aaaagacagt ccctgggtct ccgaccccaa
      481 tattccctta gtggcccgtg agatcatgca gcgaatgatc caacaatttg ctgctgaata
      541 tacctcaaaa actagctcta ctcaggaccc cagccagccc aatagcacaa agaaccaaag
      601 cctgccgaaa gcatctccag tcaccacctc tcccacggct gcaactactc agaaccccgt
      661 gctcagcaaa ctgctcatgg ctgaccaaga ctcacctctg gaccttactg tcagaaagtc
      721 tcagtcagaa cctagtgaac aagacggtgt acttgactta tctactaaga aaagtccatg
      781 tgctagcagc acttccctga gccattctcc aggctgctcc agtactcaag ggaacggaga
      841 ggagtcagca gaggcacccg tagctgatcc taaccgtcaa tcaaagtctc cactggagaa
      901 gtttatggtc aagttgtgca atcatcatca gaagcaattc atccgcgtcc tgagtgacct
      961 gtacaccgag tcccagccag gttctgaggc cctgcagcct ctggattcca ccgtgatgga
     1021 cgtctccgct tgcgattcgg gctgtgccca gctgagcggc agagagaatg aaaaggatga
     1081 ttgtctcgag gagagttctc ctgcctctgt aaagttgttc ttagactcat ccggttctcc
     1141 tagctccctg aatgtgactg aagaaaccat gaaggaacca cctcctgaga cagactctgt
     1201 agatgggaga gacagtgccg cgagctcgag cgctgtccag aaaggttcct ctgaacctcc
     1261 agacgctcag cataacccca caggttctgc agacagttcc accatgggat gcctcggtac
     1321 actggacgct ttctcttcta actctcccca cagtgctaaa agcttagagg ggcaaaccac
     1381 tggccaggag caagacacag acatgaaacc ctgtgaggat gctgaagaca gtgccccagc
     1441 gccagtccaa agtctggctg cagtggaaga ggtggctgag aatactgaag agggtggtag
     1501 ctgtattgtg tctcaaagaa actcattcaa agctttatca gaagagacgt gggactcagg
     1561 gtttatggga aactcatcta gtactgcaga caaagagaat gctttacagt ctagctcaaa
     1621 atcatccttc caccaggatt tagagacaga tgagcaagat gcaaggccaa agcaagagaa
     1681 ccatcttcat tcattaggta gaaacaaggt aggtttccag acatatccca gagacaaggg
     1741 ccattttgat cattccagag gtggttggtt agctcccagc cccacgccaa ctgtacacag
     1801 agcatccaat ggtcactcac aaaccaagat gatgtcagcc tccatcaaga ctgctcggaa
     1861 aagtaagagg gcatcagggt tgaggataaa cgattatgac aaccagtgtg atgttgttta
     1921 tatcagccaa ccaataacag aatgccactt tgagaatcaa agatccatac tgtcttctcg
     1981 gaaaacagcc cgaaagagta cccggggata tttcttcaat ggtgactgct gtgagctgcc
     2041 aactgttcgc acactggcca gaaatttatg ctcccaagac aaaggaagct gctcacaagt
     2101 agcatcagag gcagtgatga ctcccaagca gactcttaca gttcccacct caaagcacac
     2161 agtaggtgtg cagcttccca cagtaggtgc acaacttcct acaacagatg tacagcctcc
     2221 cacagcaggt acacaacttc ctacagcaga tgtgcagtcc cccacagtag gtgcacaact
     2281 tcctacagca gatgtgcagt cccccacagt aggtgcacaa cttcctacag cagatgtgca
     2341 gcctcccaca gtagatgtac aacttcctac agcagatgtg cagcctccca caggaggtgt
     2401 acaacttcct acagcagatg tgcagcctcc cacagtaggt gcacaacttc ctagagtaga
     2461 tgtccagctt tcctcagtag gtacacaact tcctacagca gatgtgcagc ctcccacagt
     2521 aggtgcacaa cttcctgcag cggatgtaca acttcccaca gtggatgtgc agatttccac
     2581 agttgatacg cagctttcca cagtaggtga gcagcctcta gaagatatct gtgacgatcc
     2641 taggaaagag agaacctccc ttgagggagg ggacgaagac acatcctcag cgaaaaagca
     2701 tcaggaggca gaggtttgcc tcagcttgag ggaacaggat cctagtagct cccctaggcc
     2761 gggagagacc acaacctcta gcccagcatg cctcctgcct actctcctcc ctaatgacaa
     2821 tatgtctgag gtgccagaag gcagcattgt ggtctcacct cccacagaaa gtgtactgtc
     2881 tttccaggag caagaccagc caccagcctc tcagctaggt ccagaggaaa tgcaggcaca
     2941 ggagtgccac ttggttccga cagctggaag cacccccttt acctcccgag aggacagtga
     3001 agacctcctc tgtagacctc agtcttctcc taaaacatcc atcagagagg agagctctcc
     3061 atgctcggaa gatgaaggtt ccactgtggc tttagatccc cccctgggcc tagaactgtc
     3121 tgaacatgac caaagcacca gcactgaggc ggagaccaga gacatccccg gggagacact
     3181 gttgctagat gactccctgc ccctcctgga gagcagcatt gtcactgatg agaacccaag
     3241 cgagatggaa gaaggtgagg ccacaagtgg aacaggacac ctggaggcgc atgacaatga
     3301 tacaaaatac tcagcagaaa atgatcccag tgagccaaac tccgactcac ctgaagagaa
     3361 tgtggataag aagaaaaagg ctagaaagtt ccccgaggcc tctgataggt gcctaagaag
     3421 tcagcttgga gatccttcct cttctgacag gtacccagga agccagggtt tggattcatc
     3481 cgctgcttgc tctgaaatca aggtttctaa aaatcctgct gtaaagcatt ctaaaagaga
     3541 aggggactct ggtagggtga catccgaggg accagtgatt gacagcatcc atccagacaa
     3601 tctggaagac cctgaagact ctggtgttag tgagcattcc tctgatgaag agaccaagca
     3661 ggagactgaa ggagttggtg tcattacaag gcagactgtt aaaaatatgc tggcaaagga
     3721 aattaaaagg gaagagggag ggacttaccc aaacagtgac ccagccactg ttggccagcc
     3781 attgcctggg gacaatctgg aaacccatgt ctggtccaag atagatgaga gagatgccca
     3841 tgtgccctca gaaagcattc cttgcaagag ggatccagag caggtaaaag agaacccggg
     3901 acaccttgcc atacaggaca cagaggctgc cgctatgagt gaggtagacc ctgaggatac
     3961 ccaccataaa gatgatgctg gcctcgctcc atgtagctca tctgggatat cagccagtca
     4021 tagtgacggt gctgatgggc caccaaaatc agtaacaagg cctaagagac tgccttcttc
     4081 tacctacaac ctgagacatg ctcattgttc gaatgccttg gacactgcaa aaatgacttc
     4141 agaaaagcaa ggcacacagg taaacccagc agccaaggaa ggcggagctt ccgagagtgc
     4201 agagccctta gatgaggaag atgaggactc ggtggtggag gagcagccca agttcatagg
     4261 atggtgtgca gaggaggaga accaggagct gatcgccagc ttcaacgccc actacctgcg
     4321 ggtccagaag ggctggatcc agttggagaa ggaagctcag ccaacggcaa gagcaaggag
     4381 caagtctgac aagctgaagg agatttggaa gagcaagaag cgggcacgga agtgtagggg
     4441 gtcgttggag gtgcaaaagt tttctcccgt tcagatgctg tttatgacca actttaagct
     4501 gtctaacatc tgtaagtggt tcttagagac aacagaaact cgatctctgg tcattgtgaa
     4561 gaaactcaat actcgtcttc caggagacat cccccttgtt aaacaccctc ttcagaagtt
     4621 tcctccttcc accatgtacc ctagttcact acaggcagaa cgcttgaaaa aacatttaaa
     4681 gaaattccct ggagccattc ctgctaggaa taattggaag acacagaagc tatgggctaa
     4741 actacgagag aatcctgacc tgatagagtc agaggatggc agtgacatca gctttggccc
     4801 tagcagtgaa gacagcgtgg aggaagtcag ggaaggcaga catagccatc ctcccaccaa
     4861 cttgcctact ccagccagca cccggatcct tagaaagtat tccaatattc gaggaaagct
     4921 cagagcacag cgcctggaca gctcactgtg tggggcttct gaaatgaagc agggccgcaa
     4981 gagcgtgtgc attaacccgc tcatgtcccc aaagctcgcc ctccaggtgg gtgcagatgg
     5041 gtttcccgtc aaccccaaga gggctgaaag aagcaagggg agaagaggga agcagatgcc
     5101 ggaaactttg cttaaagtgg aaggtcagaa caagcgcaag agagcagaag gctctggtac
     5161 tcaagatggt aaggacaagg ggccggcaac aaaagtcagc agaggccttt ctgccaagaa
     5221 gctagctgca aaggacagag ccaaccaact ctccaagaag atgaccttga aagcgaataa
     5281 agtgagagtc tgtagaaagg gtcctggaag gagctgcctg tcatccagga aagaaaaaga
     5341 gaatgccaac agaagacctg gccatcctgc ggcagcctcc gaagcgctga caaagccttc
     5401 aaaacaaagg ggcgcaagag aagcctcttc aaagccccca aaagtgagga ggagaaaccg
     5461 gaagctgagc agtggtaggg gccatgccag acccttagca aaaagcccag agaaccggac
     5521 tgccccaaga aaaagaaagc tcaaggccaa actggactct tcccagggca aacggaggcg
     5581 gttagaagcc aagtgatagt ggatagccac tgagagcaac gggcccatga gagcaacctt
     5641 tcattttgca ttaacagaat ctggttttct gagcctctca agcctttcac ggtgtagtta
     5701 cggggaacgc cagtttgaga tgccagaaac tggagaagag aactggcaga gttcttctct
     5761 ggggctaagg gaagtggtag gttattttct ggttgttcct tgggttttat acttggaatc
     5821 aagcagtttc tgttttaaga agtacagtgc cttatttatc cttttttgtt taaaaattta
     5881 caaaagctaa gaagctgatg tatgtgacta aaggcttgta ttttatactt gacgcacaag
     5941 cacttgttct gtcactgaag aggccgccgc cgccacacat gcacgagcgg gcgaggagcc
     6001 gtcagcagct gcctgtgcgc ctggacaggt gcaccttgca gaccgcagca caactccctc
     6061 tctgtcttgt ttggttttta tttgattgat atttgaaagc tgaaccaaat catttctatg
     6121 gtatgtggag aatgcagggg atttataatt attatgaaag attaatattt ctgttatgtt
     6181 tcttccaaaa ctcatattgt tgatcacccc ttcatctttt tattttttaa aataatttca
     6241 gatcatgttc tcaaatttgt gtgcccatgg gacaaagatg tgctacactt ccttttgttg
     6301 ttgtgttttg ttttttgttt tgttttgttt tgttttgttt tttgtcccaa actatgttac
     6361 tactaacatg ctggtcattt ggtcattagg atgagtgact cttgttttca ttcttacaca
     6421 atgtatttcc ctgcgcatca gaagttcttt ccggcagtgg aaaagcttag ctgtgtgcat
     6481 atgcgtctta tgtgctcatg gctgctaccc gcaagtgtct tctggtactg gtttcacagt
     6541 aaagttcctc cttccccacg cagtgcatct gtgagctgcg tagttagcaa tgaccggaat
     6601 gtcggaaagt aattccaagt ctccgtgtgc atttctaatc cgacttccac atcagccttg
     6661 ggagaggtgt gagcagtggc cctgaaagac caggcgcgca ggcaactgag agcttctgct
     6721 ctgagtctta gcggggccac atccccacag atgagtgacg ttcagtgggg ctctctgatg
     6781 ggagttgtct gtgcctggag taggtgtctt ttcaaactga tggttccgtt ctcgtggctg
     6841 aacgcttgca gagttgcccc tcccctccca tgtcattctg tcccatggct cagaaatgag
     6901 aaacgcaata attgaaagtg acgtttgcct ttccttggtg gagcctgaca cggccccatt
     6961 ggctttactt ggtgcctaca gcattgctcc attataagtg tgtacttgac atttccattg
     7021 ggccagtcag caaaccttgg gtcgctaaag cctccatcgg ctttgacctg tcctgtcacc
     7081 aaaatagctt gcatggacag ctgctgccct gttcttctga ttaagtttct acttaggttg
     7141 attcagattt ttttttttag atcaacccgg atgggcttct tttatatgca aatcatgata
     7201 aaacaggcct tctacctatt ttgctattgt caaaggtttg ctgcagatga tggaaacttc
     7261 tgataattgg gtaggactgg agtatttgac tcttgagaag ttaagacttg tgttgaattt
     7321 cacagacaat gaaagtcacc agtttctttt tttttttctt ttttgggtgt gtgtcacctc
     7381 tgttccatga gcttcctccc tttccccatt ccctgttttg ttttgttttg ttttgtttta
     7441 ttattattat ctttgacctt gaccattcac aagctaccta tggtaatgag cctgctgagc
     7501 gagtgccggc aactctttct tagcattagg ttgcacagga gcattaatgt gttttaaata
     7561 ggttcattta atcctaaagg atggttttaa ggcttaaaaa acttttgcta tagttgtcgc
     7621 tggatagtct tgttgtagtg acttaaacag ctgaggctta ctaatgtccg ctctgccgat
     7681 gcctgtatat atgaggagcc cttggctacc tggagatttc cttgtagggt gcttggatta
     7741 ggttaggggg aggagtgagt ggtaagctgg tgggatgctt ccagttccca ccagtttata
     7801 attcattccg ttacttttct ggtggtgttt tcagttttca aagttcactt ggaggtaggc
     7861 tgcatttgaa gaagctatgt ggaagtgttt attctataac cacctaatga tgatgtaagc
     7921 atcttgaaaa tcagcttaca cttgatgata gtaactgcat ttatttatat ttgtacagtc
     7981 tacaaaatta gcacgttcaa attaagtaat ctcatttttg ctgatctggt taattttgtt
     8041 aatagaagaa gagaaacaaa agcaaaacgt gacggtagct ctacgccttt ctatgcccag
     8101 agcgtgctgg gaggttatcc cctccgcatc tccagattgg gcattgactg cagtctcttt
     8161 gttttcctcc cctcctgtag ccattttcaa atatgacttg ccaccatctg cagtgcactc
     8221 tgtcccacgg ttttgatgct aagtctgaaa ggcattctgc ttctgccctg gctgtcacag
     8281 gctggagctg gacttgatgc cagaggactg gtgctctctg ttcaggagct ggaagacgcc
     8341 ccagaagcta tcagagcagc tctgggtagc ttccctagag cacagccttc ctcgggagat
     8401 ccgttttcgt attgggctcc ctgggatggg cctgctctct tgatgggggt tcacagtttt
     8461 attctgacac ctcctagata tgttaatctc tcagtgcatt gggaaggccc caaacctttc
     8521 tctgttctgg gaacttcctg cataggaatg ttacctgagg ctgttgatcc acagttgcta
     8581 gtccctggga ttccttgctg ggttgttttt tttttttttt tttttttttt ttggaggggg
     8641 gaagtggggg gttccctgtc cattctaaac cgcagttgag ctgtggggtc tgtaccccat
     8701 cattctgtaa tggcttagag agaagagctc ttcatccctt gccccagggc ctcagtgcat
     8761 cacccagcac aggtgcatct ctccccctgc acctaggtca tcagcaagta tcactgcgag
     8821 acagatgctg taagccaaga tctggcctgc gtccagcctt gtgatggcct ctgtcgtgag
     8881 gccacagctg ccactcattg atccgtagac ctgaatccct tgggaaatga caccgtgctc
     8941 tgtgacgcaa actggagatg cttcggtgtt gccatcagca agcctgtgct tgtcacaata
     9001 tcagaaacaa actgaatcat ccaagaagct gcccagtagc caggtagcca cctccgtccc
     9061 tgtggcttca gatcagtcag ctcaggcctc ctcttagctt aaacaagcag tcacagccat
     9121 gcagaatgga ctgtgtaaat tacactcctg tgtaaatttt atgggcacac aacctcgccc
     9181 ttttgcttac cgattgtcca tgaagtagat taaatactta gagaaaccca caaagcctaa
     9241 aataactaaa tttacatctt tgaagaaacc cgctgacccc tgcttgagaa aataaccact
     9301 tttaggaatt aatcctctcc attccccttc tgcctcgtgc ctcccatctc agttctgtcc
     9361 tgtgcacaca ttcgtgtgct cttgctgtaa gaggcatgcc attgagacag ctcctatgta
     9421 ggctttgaac aagaagtgca tctcccttta aatactttac cccagcccct ccatgaaggc
     9481 actacatcct gtagaccaga cttgggagca aggtgtcttt ggattctaaa attctgtggc
     9541 ctgacccctg tcccgttccc atagtttgtg atcatagaac tgcctctggc tgtacttgtt
     9601 tactgaaata agccaagacc tctctgatga gcttagctgg gggtgcttct ggggggcatt
     9661 tagttgtggg aaagtcaaac agcacggaaa caaaagccta gtggcaacca aagcactgtt
     9721 tataatgtgt tcccattgat ctgtttttaa tcgcacacct tcaaaataat tttattaaag
     9781 gcaagctaac aataaaatgg cagtttgtac atcacactta cacaagttcc aggctgtgag
     9841 tcctccctgg gcccccaact caaataagtt tctatttatt ctgcattcca gaaagaggtt
     9901 gtcgtgtcag acattttcaa aatggggacc ttgtccccta atgagtggac agtgctgaag
     9961 accgaactcc aggcctcatg gtagacaagg caggctttct accactgcac aacgtcccct
    10021 gcccaaatta ttttggacct tgcctattct ggttatccac tgaaacagga agtgtctata
    10081 cccaaagcag tcctcatatc cacacagcag gtacttcaac ctacatcctt caagaaaaag
    10141 atatttttgt taaaacttaa cacagcagac ctagggaagt agccttttga cactgctttc
    10201 aaaataattc cagtcttgaa aattctgaag actcctgtca tgtacaagag acacattgca
    10261 gggcttgtag caccccactg ttctgcaccc aaaggaccac cgatgacagt gtgcaaggtt
    10321 gtcgtcactc atgcctttct ttgtctttgg gtttgagcca gtggtggtca gttcctgatg
    10381 ttaccttctc cccacccgat tgccctttcc caggctttcc atgtgttggc ctcagcacat
    10441 cccctagcct gcagattggc agctgcacag gcacgtgagc aggagaccct gatgctttca
    10501 cgtccgatag gcccatcgtg tctgatcgga gtgcagttgt aagccacccg aaagcataga
    10561 ccacctgtct gaaacagcag cacagtgccc atggtactcg aatacgccag gggttggatg
    10621 agtgtgtttt cactatttga actggataag taggagtaac agaaccacag actgacagtg
    10681 atctacacta cctagaatac tcactgcctg accttttagg tcagtgtacc gatctttgca
    10741 aaagccatta tgaaattgtc tgggcagtta ggcacactcc ccaccccccg gcccccacct
    10801 aagtcaccat tgcagcagtc ctaggtttat ggcatcttgc atgtctgtcc gagcacacag
    10861 tagccatcgt acatcattcc tgatagtgct tgcagagaag acgactgtct ttgctcatta
    10921 gatacttgct gagttgtgga tatacagtac cggctagggt atagtttaaa gtgtggtttt
    10981 gtaacctaag aatgcagtca gtcatcgatc ttactcatca ccgtgaactt gactgataga
    11041 gacattccac cggcagtgtt tggcagacgc atgctgagct ccggtgatgg agcggtctcc
    11101 agcagtgcct ctctcaaagc acagggactg gttgtgttcg cactgatagc cctctgttct
    11161 ctcctgtaca tatgacgtat gcaggtttac agttctcaaa tttggtcagt atctgtgtgt
    11221 ttgaaccctg actctaggcc atgcttcttt tttacacgaa gagtgtgtta tccatgcacc
    11281 agcagcttta ggcccagcaa gtccagggcc ctctagcctg ccagggaagc ccaggcttgt
    11341 tcaagtctga agcagctcct cctctgggga gccattctcg gtacattgcc ttctcccctc
    11401 ctgactctgt cactggcctc cttccaggtg gcatcttctc tgggacctcc cccctgcccc
    11461 caagtgcttt gctgaacata tcacaagaga agaatttctc ccctcgttac tagattctca
    11521 gtgttagtgg accgggtctg aatgccattc atcgctcacc ttccccccac tccagttggt
    11581 actgtgatgt acagctcgtg ttgtgttgta gtcagagctg tatgttgtac tcggaagcgt
    11641 ttgtggtaaa gctaccacac agatgagatc tgcctaattt tgtatattta taccacaggt
    11701 ataaaggatt attactgcta gggccactgt atcttagggt aattgatttc acttgtggct
    11761 tctgcattct tagtagttct aggagactgt attagtgatt ggtttcaaat atatagagta
    11821 catatttata gacaccactg tggagtttat tttactgtgt aaatagtggt attttcctgt
    11881 tcaaatgctt ctatacaaag tatttatttt aacaaaagta gttagctgtc aaaagggctt
    11941 tccaaaaact gttcttgcca tctcttctcc cacgctcagc tatcagacgc ctaagcatca
    12001 cagtaaaggc aggaggttgc tgtacttggg cagacacaac atggattggg aaccggaatg
    12061 ctgccctgga tgctcctcgc cagaccaaag tggagcttga aggggtgtgg ctttgctcag
    12121 cctagcatcc tggcgtcccc catagccact tacctatgca ccattgatat attcagccat
    12181 tctcttccat ggtctgtgca tggaagtgac cttggttgta gtcctgtggc aagcagcctt
    12241 atgcccgtgc aatgaggaga aaccacggtg gttgccggta tgagcttctc atctggctct
    12301 cgggatttat gagagtcgcc cttcgacaca cctgtcacct tctgcacatt gacaaaactt
    12361 ggggacacct tgtctttcct cctctcccct tctcatcaag caccctgtgc agatgcagcc
    12421 cctcccactc atctgtaacc catggttcta aaatgcattt agctttgctt ctcaggagtc
    12481 ctggtctgca atccagagca cccttgatat catggaacca gtgctctgcg gtcatgcatg
    12541 gccccctttc ccctgtgctt cacccatgga caccccatct gtcacttagt cactcttctg
    12601 ggatggctgg gttggcctgc agctccagga ctctagggtc cttggaggcc aggtatgtag
    12661 gaattacagt catttatttg aactctagtt tgcatatttc cttatggcct ccctttgtct
    12721 tttctgaaca aggaaggcac gtgaatggtg atgctggaga aagtttttat aagatgctgt
    12781 ttgtaagcaa atctgattct gagatgaaat gtgaatgggt aactaggtgc cagggacttt
    12841 agcactgaac tagacagtca aaacttttta acctttgcag aaagtagatt ctgttctcat
    12901 ctaaatgttc acaagacgtg atgctgtaaa tagttttcta aaaaaaaata tttattacat
    12961 gttctgtata caaactcatg ttctgagtga tgttggtttg cattgtattg tagaagatta
    13021 tattttgaat agtggacttc tttcataata cagttcactc atggagaaag aaacaaaacc
    13081 agcaggttga gagctgtttg gggcatttga tctgtaatgg accacccaat ccaagcttta
    13141 accgcccccc tcttctcccc tggttgtgtt atatatatta tatatatata tatatatata
    13201 tatatatata tacaggtgta cagtacaggt cagtgcttgg gtctgcagag cagatttcca
    13261 ggtgtccttt ctgatgtgtt cccatagcaa tatgaccccg ggtgctgacc agtcctgtgg
    13321 tctcagagga tcaggttggg ggacagctct tgcaatgcct cttgcctttc ctaaggggtt
    13381 gctttacttg aatcgatgcc tctgtttctt ctgcatgctc cagtgtcgca aaactatagc
    13441 agggtgtggg gaactctccc aacaccagac acgtcaaaag tggacatgcc aaccacagct
    13501 tagccatttc ccaggaattt tactttccag aacagatgag gcaaagctca attggccata
    13561 gaataaatgt aaggaatttt taccagagaa acatatgtgg cctgttaaca ttccccctac
    13621 ccccgacccc cgtctgactc acctttggaa gccagcctat gtcctgcctt ctgcctctat
    13681 gcctaggctc aagatgtcca tggcccctag agtctggcta ggttcttaat gtgcccaact
    13741 ctagttgagc agccttttcc ctgtgaccgt cctaagctta atgaaaagga ataccccaca
    13801 cccaggaacc cattgttaga agtgatgtag ttttttaggc ttttggaata tgtcttcttt
    13861 tgtatttctg atggtgattg ggatttttca ctagtgtttt ttagattgaa gtgggtgcat
    13921 taaggtaaac tttccactgc tgagccccaa agcgtgcaga ggagaggact tgccctgcat
    13981 tgtgttgttg gggaggcgac tacttatggt gagggggtgg ggtgggggtc ttgtagatga
    14041 gatggggttg gaatagaaac tctggccaga ggtttcctga gtctttgata ttttgtaatg
    14101 aaactcccca cattaaccct gcttaatctc aatgtaagcc tgctgtttac cctcagggaa
    14161 caagtggttt tcaaaattga gctcctccaa ggtcctgggc cagtgcctgt gtgcgctggt
    14221 cctctccgtg atctcatggc attatttccc cgtatgcatt acgatagtaa gaagttccac
    14281 cccaccctgt atgaaaagca cagcccagtg ccctaattta ggcttgtgtc gttgccttcg
    14341 aggggcctgg ggggaggtcc taggaggtcc atgcagttta actgaagctc aggtgtgcat
    14401 tggattttgc ctctattagg ccacaaccct tcagaatgag tgtagggcag gggctacgga
    14461 tccggctcca gattcaggga gctgagtctc cactgttcct taagttttta ctggtccctc
    14521 ccggtggcgt tgccaaggtc aatcttgtag gtgtttggat gtgctccttt tttgctgtct
    14581 tgtgagtcgt agccagtgct ccaggagccc aagggcgggg cctctggagg gtccaccctc
    14641 ccttacccca gcgcctttca gactagtgga gcgaaaagac tctgcaaatg gccactggcc
    14701 ggacagcacg tgcctctggg cctggattcc actgttagtg agtgtaggaa aatactgtgt
    14761 ctttaatgga tgaaattcaa tgtatgctgt gaatttgttg gtttgaaaca ttgaaaaatt
    14821 ttcattagac aatgtttaca tacctcacct gaagaacctt tgagagtgta tatatgaaat
    14881 ttaaaaatat attaagttgc tttaaaacag tatgtatagc tataaaagtt ggagttattt
    14941 taactttgag tatgtaccaa gtctcttaaa tattggaatc tcgtagactt tctggcttct
    15001 gtgttttgct ttcctatgga ccacatagat aactgtgttt ttgttcttga taaagggggc
    15061 ccacaccgac gtccaggctt ggaaggattt tctggtttgg ttttgagggg aggggtgtgg
    15121 aactagaggg tgtgtgggag ggatttctct aaccttgaca tctgtgagct ttttcaaggc
    15181 gcttatttta ttgcagcata ttaaagttct ttgatattaa a
//
