LOCUS       NP_001357696            1696 aa            linear   ROD 28-APR-2025
DEFINITION  ligand-dependent corepressor isoform 1 [Mus musculus].
ACCESSION   NP_001357696 XP_011245517
VERSION     NP_001357696.1
DBSOURCE    REFSEQ: accession NM_001370767.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1696)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   2  (residues 1 to 1696)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1696)
  AUTHORS   Wang,Y., Liu,W., Liu,Y., Cui,J., Zhao,Z., Cao,H., Fu,Z. and Liu,B.
  TITLE     Long noncoding RNA H19 mediates LCoR to impact the osteogenic and
            adipogenic differentiation of mBMSCs in mice through sponging
            miR-188
  JOURNAL   J Cell Physiol 233 (9), 7435-7446 (2018)
   PUBMED   29663375
  REMARK    GeneRIF: Long noncoding RNA H19 mediates LCoR to regulate the
            balance between osteogenic and adipogenic differentiation of mBMSCs
            in mice through sponging miR-188.
REFERENCE   4  (residues 1 to 1696)
  AUTHORS   Conway,E., Jerman,E., Healy,E., Ito,S., Holoch,D., Oliviero,G.,
            Deevy,O., Glancy,E., Fitzpatrick,D.J., Mucha,M., Watson,A.,
            Rice,A.M., Chammas,P., Huang,C., Pratt-Kelly,I., Koseki,Y.,
            Nakayama,M., Ishikura,T., Streubel,G., Wynne,K., Hokamp,K.,
            McLysaght,A., Ciferri,C., Di Croce,L., Cagney,G., Margueron,R.,
            Koseki,H. and Bracken,A.P.
  TITLE     A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL
            Genes Balance PRC2 Subtype Activities
  JOURNAL   Mol Cell 70 (3), 408-421 (2018)
   PUBMED   29628311
REFERENCE   5  (residues 1 to 1696)
  AUTHORS   Shalom-Barak,T., Liersemann,J., Memari,B., Flechner,L., Devor,C.E.,
            Bernardo,T.M., Kim,S., Matsumoto,N., Friedman,S.L., Evans,R.M.,
            White,J.H. and Barak,Y.
  TITLE     Ligand-Dependent Corepressor (LCoR) Is a Rexinoid-Inhibited
            Peroxisome Proliferator-Activated Receptor gamma-Retinoid X
            Receptor alpha Coactivator
  JOURNAL   Mol Cell Biol 38 (9), e00107-17 (2018)
   PUBMED   29463649
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1696)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 1696)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (residues 1 to 1696)
  AUTHORS   Kunieda,T., Park,J.M., Takeuchi,H. and Kubo,T.
  TITLE     Identification and characterization of Mlr1,2: two mouse homologues
            of Mblk-1, a transcription factor from the honeybee brain(1)
  JOURNAL   FEBS Lett 535 (1-3), 61-65 (2003)
   PUBMED   12560079
  REMARK    GeneRIF: identification and characterization of Mlr2 a homolog of
            Mblk-1, a transcription factor from the honeybee brain; expressed
            in various tissues other than testis
REFERENCE   9  (residues 1 to 1696)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 1696)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112271.4 and AC132303.3.
            
            On May 29, 2019 this sequence version replaced XP_011245517.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.237566.1,
                                           SRR7345562.1305336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1696
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.97 cM"
     Protein         1..1696
                     /product="ligand-dependent corepressor isoform 1"
                     /note="transcription factor MLR2; ligand-dependent
                     corepressor; mblk1-related protein 2; Mblk1-related
                     protein-2"
                     /calculated_mol_wt=183168
     Site            42
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96JN0; propagated from
                     UniProtKB/Swiss-Prot (Q6ZPI3.2)"
     Region          53..57
                     /region_name="Interaction with nuclear receptors.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZPI3.2)"
     Site            63
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96JN0; propagated from
                     UniProtKB/Swiss-Prot (Q6ZPI3.2)"
     Region          <558..823
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          <726..959
                     /region_name="PTZ00441"
                     /note="sporozoite surface protein 2 (SSP2); Provisional"
                     /db_xref="CDD:240420"
     Region          1247..1695
                     /region_name="DUF4553"
                     /note="Domain of unknown function (DUF4553); pfam15090"
                     /db_xref="CDD:464496"
     CDS             1..1696
                     /gene="Lcor"
                     /gene_synonym="3110023F06Rik; A630025C20Rik; Gm340;
                     mKIAA1795; Mlr2"
                     /coded_by="NM_001370767.1:506..5596"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS89392.1"
                     /db_xref="GeneID:212391"
                     /db_xref="MGI:MGI:2443930"
ORIGIN      
        1 mqrmiqqfaa eytsktsstq dpsqpnstkn qslpkaspvt tsptaattqn pvlskllmad
       61 qdspldltvr ksqsepseqd gvldlstkks pcasstslsh spgcsstqgn geesaeapva
      121 dpnrqskspl ekfmvklcnh hqkqfirvls dlytesqpgs ealqpldstv mdvsacdsgc
      181 aqlsgrenek ddcleesspa svklfldssg spsslnvtee tmkepppetd svdgrdsaas
      241 ssavqkgsse ppdaqhnptg sadsstmgcl gtldafssns phsakslegq ttgqeqdtdm
      301 kpcedaedsa papvqslaav eevaenteeg gscivsqrns fkalseetwd sgfmgnssst
      361 adkenalqss skssfhqdle tdeqdarpkq enhlhslgrn kvgfqtyprd kghfdhsrgg
      421 wlapsptptv hrasnghsqt kmmsasikta rkskrasglr indydnqcdv vyisqpitec
      481 hfenqrsils srktarkstr gyffngdcce lptvrtlarn lcsqdkgscs qvaseavmtp
      541 kqtltvptsk htvgvqlptv gaqlpttdvq pptagtqlpt advqsptvga qlptadvqsp
      601 tvgaqlptad vqpptvdvql ptadvqpptg gvqlptadvq pptvgaqlpr vdvqlssvgt
      661 qlptadvqpp tvgaqlpaad vqlptvdvqi stvdtqlstv geqpledicd dprkertsle
      721 ggdedtssak khqeaevcls lreqdpsssp rpgetttssp acllptllpn dnmsevpegs
      781 ivvspptesv lsfqeqdqpp asqlgpeemq aqechlvpta gstpftsred sedllcrpqs
      841 spktsirees spcsedegst valdpplgle lsehdqstst eaetrdipge tlllddslpl
      901 lessivtden psemeegeat sgtghleahd ndtkysaend psepnsdspe envdkkkkar
      961 kfpeasdrcl rsqlgdpsss drypgsqgld ssaacseikv sknpavkhsk regdsgrvts
     1021 egpvidsihp dnledpedsg vsehssdeet kqetegvgvi trqtvknmla keikreeggt
     1081 ypnsdpatvg qplpgdnlet hvwskiderd ahvpsesipc krdpeqvken pghlaiqdte
     1141 aaamsevdpe dthhkddagl apcsssgisa shsdgadgpp ksvtrpkrlp sstynlrhah
     1201 csnaldtakm tsekqgtqvn paakeggase saepldeede dsvveeqpkf igwcaeeenq
     1261 eliasfnahy lrvqkgwiql ekeaqptara rsksdklkei wkskkrarkc rgslevqkfs
     1321 pvqmlfmtnf klsnickwfl ettetrslvi vkklntrlpg diplvkhplq kfppstmyps
     1381 slqaerlkkh lkkfpgaipa rnnwktqklw aklrenpdli esedgsdisf gpssedsvee
     1441 vregrhshpp tnlptpastr ilrkysnirg klraqrldss lcgasemkqg rksvcinplm
     1501 spklalqvga dgfpvnpkra erskgrrgkq mpetllkveg qnkrkraegs gtqdgkdkgp
     1561 atkvsrglsa kklaakdran qlskkmtlka nkvrvcrkgp grsclssrke kenanrrpgh
     1621 paaasealtk pskqrgarea sskppkvrrr nrklssgrgh arplakspen rtaprkrklk
     1681 akldssqgkr rrleak
//
