LOCUS       NM_033145                653 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus lipocalin 8 (Lcn8), mRNA.
ACCESSION   NM_033145
VERSION     NM_033145.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 653)
  AUTHORS   Gong,Q.Q., Dou,Z.L., Wang,X., Zhang,K.Y., Chen,H., Gao,J.G. and
            Sun,X.Y.
  TITLE     Epididymal initial segment-specific Cre recombinase activity in
            Lcn8-Cre knock-in mice
  JOURNAL   Mol Biol Rep 48 (8), 6015-6023 (2021)
   PUBMED   34328598
  REMARK    GeneRIF: Epididymal initial segment-specific Cre recombinase
            activity in Lcn8-Cre knock-in mice.
REFERENCE   2  (bases 1 to 653)
  AUTHORS   Wen,Z., Liu,D., Zhu,H., Sun,X., Xiao,Y., Lin,Z., Zhang,A., Ye,C.
            and Gao,J.
  TITLE     Deficiency for Lcn8 causes epididymal sperm maturation defects in
            mice
  JOURNAL   Biochem Biophys Res Commun 548, 7-13 (2021)
   PUBMED   33631677
  REMARK    GeneRIF: Deficiency for Lcn8 causes epididymal sperm maturation
            defects in mice.
REFERENCE   3  (bases 1 to 653)
  AUTHORS   Charkoftaki,G., Wang,Y., McAndrews,M., Bruford,E.A., Thompson,D.C.,
            Vasiliou,V. and Nebert,D.W.
  TITLE     Update on the human and mouse lipocalin (LCN) gene family,
            including evidence the mouse Mup cluster is result of an
            'evolutionary bloom'
  JOURNAL   Hum Genomics 13 (1), 11 (2019)
   PUBMED   30782214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 653)
  AUTHORS   Suzuki,K., Lareyre,J.J., Sanchez,D., Gutierrez,G., Araki,Y.,
            Matusik,R.J. and Orgebin-Crist,M.C.
  TITLE     Molecular evolution of epididymal lipocalin genes localized on
            mouse chromosome 2
  JOURNAL   Gene 339, 49-59 (2004)
   PUBMED   15363845
REFERENCE   5  (bases 1 to 653)
  AUTHORS   Fouchecourt,S., Lareyre,J.J., Chaurand,P., DaGue,B.B., Suzuki,K.,
            Ong,D.E., Olson,G.E., Matusik,R.J., Caprioli,R.M. and
            Orgebin-Crist,M.C.
  TITLE     Identification, immunolocalization, regulation, and postnatal
            development of the lipocalin EP17 (epididymal protein of 17
            kilodaltons) in the mouse and rat epididymis
  JOURNAL   Endocrinology 144 (3), 887-900 (2003)
   PUBMED   12586765
  REMARK    GeneRIF: data demonstrate that lipocalin EP17 (mEP17) spatial
            expression, regulation, and fate are different from that of the
            highly related mouse epididymal retinoic acid binding protein
REFERENCE   6  (bases 1 to 653)
  AUTHORS   Suzuki,K., Araki,Y., Zhu,M.Y., Lareyre,J.J., Matusik,R.J. and
            Orgebin-Crist,M.C.
  TITLE     The 5'-flanking region of the murine epididymal protein of 17
            kilodaltons gene targets transgene expression in the epididymis
  JOURNAL   Endocrinology 144 (3), 877-886 (2003)
   PUBMED   12586764
  REMARK    GeneRIF: results suggest that the 5.3mEP17(murine epididymal
            protein of 17 kilodaltons) fragment contains all the information
            required for spatial and temporal expression in the mouse
            epididymis
REFERENCE   7  (bases 1 to 653)
  AUTHORS   Lareyre,J.J., Winfrey,V.P., Kasper,S., Ong,D.E., Matusik,R.J.,
            Olson,G.E. and Orgebin-Crist,M.C.
  TITLE     Gene duplication gives rise to a new 17-kilodalton lipocalin that
            shows epididymal region-specific expression and testicular
            factor(s) regulation
  JOURNAL   Endocrinology 142 (3), 1296-1308 (2001)
   PUBMED   11181548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF082221.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048433.1, CA464695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..653
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/SvJ"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.67 cM"
     gene            1..653
                     /gene="Lcn8"
                     /gene_synonym="9230106L18Rik; EP17; Lcn5; mEP17"
                     /note="lipocalin 8"
                     /db_xref="GeneID:78076"
                     /db_xref="MGI:MGI:2135945"
     exon            1..115
                     /gene="Lcn8"
                     /gene_synonym="9230106L18Rik; EP17; Lcn5; mEP17"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..550
                     /gene="Lcn8"
                     /gene_synonym="9230106L18Rik; EP17; Lcn5; mEP17"
                     /note="epididymal-specific lipocalin-8; epididymal 17 kDa
                     lipocalin; lipocalin 5"
                     /codon_start=1
                     /product="epididymal-specific lipocalin-8 precursor"
                     /protein_id="NP_149157.1"
                     /db_xref="CCDS:CCDS15786.1"
                     /db_xref="GeneID:78076"
                     /db_xref="MGI:MGI:2135945"
                     /translation="MEARLLSNVCGFFLVFLLQAESTRVELVPEKIAGFWKEVAVASD
                     QKLVLKAQRRVEGLFLTFSGGNVTVKAVYNSSGSCVTESSLGSERDTVGEFAFPGNRE
                     IHVLDTDYERYTILKLTLLWQGRNFHVLKYFTRSLENEDEPGFWLFREMTADQGLYML
                     ARHGRCAELLKEGLV"
     exon            116..246
                     /gene="Lcn8"
                     /gene_synonym="9230106L18Rik; EP17; Lcn5; mEP17"
                     /inference="alignment:Splign:2.1.0"
     exon            247..317
                     /gene="Lcn8"
                     /gene_synonym="9230106L18Rik; EP17; Lcn5; mEP17"
                     /inference="alignment:Splign:2.1.0"
     exon            318..422
                     /gene="Lcn8"
                     /gene_synonym="9230106L18Rik; EP17; Lcn5; mEP17"
                     /inference="alignment:Splign:2.1.0"
     exon            423..512
                     /gene="Lcn8"
                     /gene_synonym="9230106L18Rik; EP17; Lcn5; mEP17"
                     /inference="alignment:Splign:2.1.0"
     exon            513..538
                     /gene="Lcn8"
                     /gene_synonym="9230106L18Rik; EP17; Lcn5; mEP17"
                     /inference="alignment:Splign:2.1.0"
     exon            539..653
                     /gene="Lcn8"
                     /gene_synonym="9230106L18Rik; EP17; Lcn5; mEP17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagccacaag ccaggccctg agatggaagc taggctgctg agcaatgtct gcggattctt
       61 cctggtgttc ctgctacaag ctgagtctac cagggtggag cttgtaccag agaagattgc
      121 aggattctgg aaggaagtgg ctgttgcttc tgaccaaaaa ctggtgctga aggctcaaag
      181 gagggtagag ggcttgttcc tcaccttcag tggggggaat gtcactgtga aagccgtgta
      241 caacagctca ggaagttgtg tgacagaaag ttcactgggt tcagaaagag acactgtggg
      301 ggaatttgct tttcctggta acagggagat ccacgtgctg gacacggact atgagcgcta
      361 caccatcctg aagttgaccc tgctctggca gggtagaaac ttccatgtgc tcaagtactt
      421 cactcggagc cttgagaacg aggatgagcc aggcttctgg ctgttccggg aaatgacagc
      481 agaccaaggc ctttacatgt tggcccgaca tgggaggtgt gctgagctct tgaaagaggg
      541 actggtctga gtagctcctg cccaggcctg tggctgcagc cccatctacc tggcctctcc
      601 tgctcctgcc cgaagaacct ctgtatctgc tccaaataaa ttctgctgcc aaa
//
