LOCUS       NM_177840                744 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus lipocalin 6 (Lcn6), transcript variant 2, mRNA.
ACCESSION   NM_177840 XM_885099 XM_913732
VERSION     NM_177840.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 744)
  AUTHORS   Charkoftaki G, Wang Y, McAndrews M, Bruford EA, Thompson DC,
            Vasiliou V and Nebert DW.
  TITLE     Update on the human and mouse lipocalin (LCN) gene family,
            including evidence the mouse Mup cluster is result of an
            'evolutionary bloom'
  JOURNAL   Hum Genomics 13 (1), 11 (2019)
   PUBMED   30782214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 744)
  AUTHORS   Yin Q, Shen J, Wan X, Liu Q, Zhou Y and Zhang Y.
  TITLE     Impaired sperm maturation in conditional Lcn6 knockout mice
  JOURNAL   Biol Reprod 98 (1), 28-41 (2018)
   PUBMED   29045572
REFERENCE   3  (bases 1 to 744)
  AUTHORS   Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M,
            Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice
            DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson
            A, Zambrowicz BP and de Sauvage FJ.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB584268.1 and FJ465143.1.
            
            On Feb 13, 2013 this sequence version replaced NM_177840.3.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, which results in a frameshift, compared to
            variant 1. The encoded isoform (2) is shorter and has a distinct
            C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ465143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BB584268.1         2-24
            24-744              FJ465143.1         1-721
FEATURES             Location/Qualifiers
     source          1..744
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.73 cM"
     gene            1..744
                     /gene="Lcn6"
                     /gene_synonym="9230101D24Rik"
                     /note="lipocalin 6"
                     /db_xref="GeneID:620709"
                     /db_xref="MGI:MGI:3045364"
     exon            1..123
                     /gene="Lcn6"
                     /gene_synonym="9230101D24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..576
                     /gene="Lcn6"
                     /gene_synonym="9230101D24Rik"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="epididymal-specific lipocalin-6 isoform 2
                     precursor"
                     /protein_id="NP_808508.2"
                     /db_xref="CCDS:CCDS50535.1"
                     /db_xref="GeneID:620709"
                     /db_xref="MGI:MGI:3045364"
                     /translation="MKVILLTAALLALVSIPWLQAVWLGRLDPKQLLGPWYVLAVASR
                     AKDFMVEKDMKNVEGVVVTLTPDNKLRVESSRHGPGGCHQSTVELLKQESRWVFENPS
                     LGILDYRVLGTNFKDYAVVFTQLEFGDEVFNTVSLYSRTEMASHEAMQLFTKWSQGLG
                     FLSQQQAQLQKDLTCAHKILQ"
     exon            124..263
                     /gene="Lcn6"
                     /gene_synonym="9230101D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            264..334
                     /gene="Lcn6"
                     /gene_synonym="9230101D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            335..445
                     /gene="Lcn6"
                     /gene_synonym="9230101D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            446..547
                     /gene="Lcn6"
                     /gene_synonym="9230101D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            548..573
                     /gene="Lcn6"
                     /gene_synonym="9230101D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            574..729
                     /gene="Lcn6"
                     /gene_synonym="9230101D24Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcctgtagt gtgcctgtac ctctcggaga atgaaggtga tccttctgac tgctgctctt
       61 cttgctttgg tctctattcc ctggttgcag gcagtgtggc tgggaaggct ggaccctaag
      121 cagctcctcg gtccctggta tgtcctggct gtggcctccc gtgcaaagga cttcatggtg
      181 gagaaggaca tgaagaatgt ggaaggtgtc gtggtgactc ttactccaga taacaaattg
      241 agagttgagt cctctcggca tgggccaggc ggatgtcatc agagcaccgt ggagctgctg
      301 aagcaagagt cccgatgggt gtttgagaat ccctctctgg gtatattgga ttatcgggta
      361 ctgggcacta acttcaaaga ctacgctgtc gtcttcacac agctggaatt tggggatgag
      421 gtcttcaaca cagtgtcgtt gtacagtcgg acagagatgg ctagccacga agccatgcag
      481 ctattcacca aatggagcca ggggctgggc ttcttgtctc aacagcaggc tcagctgcag
      541 aaggacctca cttgtgcaca caagatcctc cagtgagtgc cacaccctgg atatagcacc
      601 acagcatcct ggcatcctgg tggaggtggg caggcacggt ctttgcacag tggctggtgg
      661 tactggcgct gattggctgc tctcctaggc tcttgcttgg gttcaaaata aaatgatttc
      721 acaagtaaaa aaaaaaaaaa aaaa
//
