LOCUS       NM_007947                699 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus lipocalin 5 (Lcn5), transcript variant 1, mRNA.
ACCESSION   NM_007947
VERSION     NM_007947.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 699)
  AUTHORS   Charkoftaki G, Wang Y, McAndrews M, Bruford EA, Thompson DC,
            Vasiliou V and Nebert DW.
  TITLE     Update on the human and mouse lipocalin (LCN) gene family,
            including evidence the mouse Mup cluster is result of an
            'evolutionary bloom'
  JOURNAL   Hum Genomics 13 (1), 11 (2019)
   PUBMED   30782214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 699)
  AUTHORS   Zhang YR, Zhao YQ and Huang JF.
  TITLE     Retinoid-binding proteins: similar protein architectures bind
            similar ligands via completely different ways
  JOURNAL   PLoS One 7 (5), e36772 (2012)
   PUBMED   22574224
REFERENCE   3  (bases 1 to 699)
  AUTHORS   Suzuki K, Yu X, Chaurand P, Araki Y, Lareyre JJ, Caprioli RM,
            Orgebin-Crist MC and Matusik RJ.
  TITLE     Epididymis-specific lipocalin promoters
  JOURNAL   Asian J Androl 9 (4), 515-521 (2007)
   PUBMED   17589789
  REMARK    Review article
REFERENCE   4  (bases 1 to 699)
  AUTHORS   Yu X, Suzuki K, Wang Y, Gupta A, Jin R, Orgebin-Crist MC and
            Matusik R.
  TITLE     The role of forkhead box A2 to restrict androgen-regulated gene
            expression of lipocalin 5 in the mouse epididymis
  JOURNAL   Mol Endocrinol 20 (10), 2418-2431 (2006)
   PUBMED   16740652
  REMARK    GeneRIF: Forkhead box A2 restricts androgen-regulated gene
            expression of lipocalin 5 in the mouse epididymis.
REFERENCE   5  (bases 1 to 699)
  AUTHORS   Lareyre JJ, Thomas TZ, Zheng WL, Kasper S, Ong DE, Orgebin-Crist MC
            and Matusik RJ.
  TITLE     A 5-kilobase pair promoter fragment of the murine epididymal
            retinoic acid-binding protein gene drives the tissue-specific,
            cell-specific, and androgen-regulated expression of a foreign gene
            in the epididymis of transgenic mice
  JOURNAL   J Biol Chem 274 (12), 8282-8290 (1999)
   PUBMED   10075734
REFERENCE   6  (bases 1 to 699)
  AUTHORS   Lareyre JJ, Mattei MG, Kasper S, Ong DE, Matusik RJ and
            Orgebin-Crist MC.
  TITLE     Genomic organization and chromosomal localization of the murine
            epididymal retinoic acid-binding protein (mE-RABP) gene
  JOURNAL   Mol Reprod Dev 50 (4), 387-395 (1998)
   PUBMED   9669522
REFERENCE   7  (bases 1 to 699)
  AUTHORS   Lareyre JJ, Zheng WL, Zhao GQ, Kasper S, Newcomer ME, Matusik RJ,
            Ong DE and Orgebin-Crist MC.
  TITLE     Molecular cloning and hormonal regulation of a murine epididymal
            retinoic acid-binding protein messenger ribonucleic acid
  JOURNAL   Endocrinology 139 (6), 2971-2981 (1998)
   PUBMED   9607808
REFERENCE   8  (bases 1 to 699)
  AUTHORS   Rankin TL, Ong DE and Orgebin-Crist MC.
  TITLE     The 18-kDa mouse epididymal protein (MEP 10) binds retinoic acid
  JOURNAL   Biol Reprod 46 (5), 767-771 (1992)
   PUBMED   1591333
REFERENCE   9  (bases 1 to 699)
  AUTHORS   Rankin TL, Tsuruta KJ, Holland MK, Griswold MD and Orgebin-Crist
            MC.
  TITLE     Isolation, immunolocalization, and sperm-association of three
            proteins of 18, 25, and 29 kilodaltons secreted by the mouse
            epididymis
  JOURNAL   Biol Reprod 46 (5), 747-766 (1992)
   PUBMED   1591332
REFERENCE   10 (bases 1 to 699)
  AUTHORS   Vreeburg JT, Holland MK, Cornwall GA and Orgebin-Crist MC.
  TITLE     Secretion and transport of mouse epididymal proteins after
            injection of 35S-methionine
  JOURNAL   Biol Reprod 43 (1), 113-120 (1990)
   PUBMED   2393684
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK136629.1, AK021014.1 and
            AV379690.1.
            
            On Jan 17, 2013 this sequence version replaced NM_007947.2.
            
            Summary: This gene encodes a small secreted protein that is
            expressed in the epididymis and binds retinoic acid. The precursor
            protein is processed into both a longer major form and a shorter
            minor form. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U68546.1, AK021014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-569               AK136629.1         4-572
            570-604             AK021014.1         568-602
            605-698             AK136629.1         713-806
            699-699             AV379690.1         249-249
FEATURES             Location/Qualifiers
     source          1..699
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.68 cM"
     gene            1..699
                     /gene="Lcn5"
                     /gene_synonym="E-RABP; Erabp; MEP10"
                     /note="lipocalin 5"
                     /db_xref="GeneID:13863"
                     /db_xref="MGI:MGI:1277241"
     exon            1..146
                     /gene="Lcn5"
                     /gene_synonym="E-RABP; Erabp; MEP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..608
                     /gene="Lcn5"
                     /gene_synonym="E-RABP; Erabp; MEP10"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; epididymal-specific lipocalin-5; epididymal
                     retinoic acid binding protein; epididymal secretory
                     protein 10"
                     /codon_start=1
                     /product="epididymal-specific lipocalin-5 isoform a
                     precursor"
                     /protein_id="NP_031973.2"
                     /db_xref="CCDS:CCDS38079.1"
                     /db_xref="GeneID:13863"
                     /db_xref="MGI:MGI:1277241"
                     /translation="MCSVARHMESIMLFTLLGLCVGLAAGTEAAVVKDFDVNKFLGFW
                     YEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGS
                     AKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNF
                     QKIALKHGFSETDIHILKHDLTCVNALQSGQI"
     exon            147..283
                     /gene="Lcn5"
                     /gene_synonym="E-RABP; Erabp; MEP10"
                     /inference="alignment:Splign:2.1.0"
     exon            284..363
                     /gene="Lcn5"
                     /gene_synonym="E-RABP; Erabp; MEP10"
                     /inference="alignment:Splign:2.1.0"
     exon            364..468
                     /gene="Lcn5"
                     /gene_synonym="E-RABP; Erabp; MEP10"
                     /inference="alignment:Splign:2.1.0"
     exon            469..570
                     /gene="Lcn5"
                     /gene_synonym="E-RABP; Erabp; MEP10"
                     /inference="alignment:Splign:2.1.0"
     exon            571..596
                     /gene="Lcn5"
                     /gene_synonym="E-RABP; Erabp; MEP10"
                     /inference="alignment:Splign:2.1.0"
     exon            597..699
                     /gene="Lcn5"
                     /gene_synonym="E-RABP; Erabp; MEP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      678..683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lcn5"
                     /gene_synonym="E-RABP; Erabp; MEP10"
     polyA_site      699
                     /gene="Lcn5"
                     /gene_synonym="E-RABP; Erabp; MEP10"
ORIGIN      
        1 gctatggctt ctggtgggga gctgaaccca tgtgctcagt tgctaggcat atggagagca
       61 tcatgctctt caccttgctg ggactgtgtg tggggctggc agctggcaca gaggctgcag
      121 tggtgaagga cttcgacgta aacaagtttt taggcttctg gtatgaaatt gcccttgcct
      181 ccaagatggg tgcatacggc ttggcacaca aggaggagaa gatgggagcc atggtggttg
      241 agctgaaaga gaaccttctg gctctgacca ccacctatta caatgagggc cactgtgtgc
      301 tggagaaggt tgcagccact caggtggacg gttcagcgaa gtacaaggtc accagaatat
      361 caggagagaa agaagttgtt gttgtagcca cagactacat gacgtatact gtgattgata
      421 tcacctctct ggtggccggg gcagtacatc gagccatgaa actgtacagc cggagcttgg
      481 acaacaatgg ggaagctctg aataatttcc agaagatagc cttgaagcat gggttttcag
      541 aaacagacat acacattctc aagcatgact taacctgtgt gaacgcattg caatcgggac
      601 agatctgagg agaaagcaat atctctgcct acctggcctc tcctgcccct acccaagggg
      661 tccctgcacc tgtgtgaaat aaagcttgct gcaacatga
//
