LOCUS       NM_010694                719 bp    mRNA    linear   ROD 03-AUG-2024
DEFINITION  Mus musculus lipocalin 3 (Lcn3), mRNA.
ACCESSION   NM_010694
VERSION     NM_010694.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 719)
  AUTHORS   Choi,J.H., Zhong,X., McAlpine,W., Liao,T.C., Zhang,D., Fang,B.,
            Russell,J., Ludwig,S., Nair-Gill,E., Zhang,Z., Wang,K.W.,
            Misawa,T., Zhan,X., Choi,M., Wang,T., Li,X., Tang,M., Sun,Q.,
            Yu,L., Murray,A.R., Moresco,E.M.Y. and Beutler,B.
  TITLE     LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling
  JOURNAL   Science 364 (6440) (2019)
   PUBMED   31073040
REFERENCE   2  (bases 1 to 719)
  AUTHORS   Charkoftaki,G., Wang,Y., McAndrews,M., Bruford,E.A., Thompson,D.C.,
            Vasiliou,V. and Nebert,D.W.
  TITLE     Update on the human and mouse lipocalin (LCN) gene family,
            including evidence the mouse Mup cluster is result of an
            'evolutionary bloom'
  JOURNAL   Hum Genomics 13 (1), 11 (2019)
   PUBMED   30782214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 719)
  AUTHORS   Suzuki,K., Lareyre,J.J., Sanchez,D., Gutierrez,G., Araki,Y.,
            Matusik,R.J. and Orgebin-Crist,M.C.
  TITLE     Molecular evolution of epididymal lipocalin genes localized on
            mouse chromosome 2
  JOURNAL   Gene 339, 49-59 (2004)
   PUBMED   15363845
REFERENCE   4  (bases 1 to 719)
  AUTHORS   Kasik,J.W. and Rice,E.J.
  TITLE     An increase in expression of the lipocalin 24p3 is found in mouse
            uterus coincident with birth
  JOURNAL   Am J Obstet Gynecol 173 (2), 613-617 (1995)
   PUBMED   7544071
REFERENCE   5  (bases 1 to 719)
  AUTHORS   Miyawaki,A., Matsushita,F., Ryo,Y. and Mikoshiba,K.
  TITLE     Possible pheromone-carrier function of two lipocalin proteins in
            the vomeronasal organ
  JOURNAL   EMBO J 13 (24), 5835-5842 (1994)
   PUBMED   7813422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX649340.3.
            
            On Feb 14, 2019 this sequence version replaced NM_010694.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D38580.1, BC116816.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               BX649340.3         63114-63258
            146-267             BX649340.3         63621-63742
            268-338             BX649340.3         63918-63988
            339-449             BX649340.3         64215-64325
            450-551             BX649340.3         65090-65191
            552-578             BX649340.3         65367-65393
            579-719             BX649340.3         65539-65679
FEATURES             Location/Qualifiers
     source          1..719
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.99 cM"
     gene            1..719
                     /gene="Lcn3"
                     /gene_synonym="Vnsp1"
                     /note="lipocalin 3"
                     /db_xref="GeneID:16820"
                     /db_xref="MGI:MGI:102669"
     exon            1..145
                     /gene="Lcn3"
                     /gene_synonym="Vnsp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..604
                     /gene="Lcn3"
                     /gene_synonym="Vnsp1"
                     /note="vomeronasal secretory protein 1; VNSP I;
                     vomeronasal secretory protein I"
                     /codon_start=1
                     /product="vomeronasal secretory protein 1 precursor"
                     /protein_id="NP_034824.2"
                     /db_xref="CCDS:CCDS15790.1"
                     /db_xref="GeneID:16820"
                     /db_xref="MGI:MGI:102669"
                     /translation="MRALLLIISFCLVAVLQAQDSSFLAFNNGNFSGKWFLKALVSED
                     DIPINKVSPMLILVLNNGDIELSITHMIYDQCLEVTTILEKTDVPGQYLAFEGKTHLQ
                     VQLSSVKGHYMLYCDGEIEGMRFLMTQLIGRDPQENLEALEEFKVFTQIKGLVAENLV
                     ILEQMEKCEPESFYELPSRPSE"
     exon            146..267
                     /gene="Lcn3"
                     /gene_synonym="Vnsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            268..338
                     /gene="Lcn3"
                     /gene_synonym="Vnsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            339..449
                     /gene="Lcn3"
                     /gene_synonym="Vnsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..551
                     /gene="Lcn3"
                     /gene_synonym="Vnsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            552..578
                     /gene="Lcn3"
                     /gene_synonym="Vnsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..719
                     /gene="Lcn3"
                     /gene_synonym="Vnsp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      701..706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lcn3"
                     /gene_synonym="Vnsp1"
                     /note="hexamer: AATAAA"
     polyA_site      719
                     /gene="Lcn3"
                     /gene_synonym="Vnsp1"
                     /note="major polyA site"
ORIGIN      
        1 atagcctctc ctgttcctgc tacctgttgg ttggctgtga atgcagaccc tagagatgag
       61 ggctctgctc ctgatcatta gcttctgtct ggttgctgtc ctgcaggccc aggactcttc
      121 attcctggct ttcaataatg ggaatttttc cggaaaatgg ttcctgaagg ccttggtgtc
      181 agaagacgac atcccaataa acaaggtctc tcccatgtta atcttggtgc tgaacaatgg
      241 ggacatagag ctttctatca cacatatgat ctatgatcag tgtcttgaag tgaccaccat
      301 cttggagaaa acagatgtgc ctggccagta ccttgccttt gagggtaaga cccacctgca
      361 ggtgcagctg tcttctgtga agggccacta catgctctac tgtgatggag agatagaggg
      421 gatgagattc ttgatgacac agctcatagg tagggacccc caggaaaatt tggaggcctt
      481 ggaggaattt aaggtgttca cacagataaa gggacttgta gcagagaacc tggtcatact
      541 tgagcagatg gaaaaatgtg aaccagagag tttctacgag ctcccaagcc gcccaagtga
      601 gtgagtgccg ccagcatgtc tgtcccatgg gaggtggaaa gagtggcctg ctggatcctc
      661 cgactcccct tctctctttc ctcacccccc ccagcttctc aataaagagc ttcagcagt
//
