LOCUS       NM_008491                853 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus lipocalin 2 (Lcn2), mRNA.
ACCESSION   NM_008491
VERSION     NM_008491.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 853)
  AUTHORS   Cho,J.Y., Woo,H.E., Yeom,J., An,M., Ma,S., Yim,D.J., Kim,S.H. and
            Lim,Y.H.
  TITLE     Microbial chaperonin 60 inhibits osteoclast differentiation by
            interfering with RANK/RANKL binding and overexpression of
            lipocalin2
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119850 (2024)
   PUBMED   39303785
  REMARK    GeneRIF: Microbial chaperonin 60 inhibits osteoclast
            differentiation by interfering with RANK/RANKL binding and
            overexpression of lipocalin2.
REFERENCE   2  (bases 1 to 853)
  AUTHORS   Wang,X., Zhu,Z., Zhang,Z., Liang,Z., Li,K., Ma,Y., Zhou,J., Wu,T.,
            Wang,Z. and Hu,X.
  TITLE     Astrocyte-derived lipocalin 2 promotes inflammation and scarring
            after spinal cord injury by activating SMAD in mice
  JOURNAL   Exp Neurol 380, 114915 (2024)
   PUBMED   39122167
  REMARK    GeneRIF: Astrocyte-derived lipocalin 2 promotes inflammation and
            scarring after spinal cord injury by activating SMAD in mice.
REFERENCE   3  (bases 1 to 853)
  AUTHORS   Fei,X., Dou,Y., Yang,Y., Zheng,B., Luo,P., Dai,S., Zhang,J.,
            Peng,K., Jiang,X., Yu,Y. and Wei,J.
  TITLE     Lipocalin-2 inhibition alleviates neural injury by microglia
            ferroptosis suppression after experimental intracerebral hemorrhage
            in mice via enhancing ferritin light chain expression
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167435 (2024)
   PUBMED   39067535
  REMARK    GeneRIF: Lipocalin-2 inhibition alleviates neural injury by
            microglia ferroptosis suppression after experimental intracerebral
            hemorrhage in mice via enhancing ferritin light chain expression.
REFERENCE   4  (bases 1 to 853)
  AUTHORS   Garcia,S.J., Mike,E.V., Zhang,J., Cuda,C.M. and Putterman,C.
  TITLE     Lipocalin-2 drives neuropsychiatric and cutaneous disease in
            MRL/lpr mice
  JOURNAL   Front Immunol 15, 1466868 (2024)
   PUBMED   39399497
  REMARK    GeneRIF: Lipocalin-2 drives neuropsychiatric and cutaneous disease
            in MRL/lpr mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 853)
  AUTHORS   Huang,Q., Xing,J., Li,G., Liu,M., Gao,M., Wang,J., Tang,F., Ren,J.,
            Zhao,C., Wang,X., Zhou,X., Luo,H., Yu,Y., Zeng,D., Dai,J. and
            Xue,F.
  TITLE     LCN2 regulates the gut microbiota and metabolic profile in mice
            infected with Mycobacterium bovis
  JOURNAL   mSystems 9 (8), e0050124 (2024)
   PUBMED   39051782
  REMARK    GeneRIF: LCN2 regulates the gut microbiota and metabolic profile in
            mice infected with Mycobacterium bovis.
REFERENCE   6  (bases 1 to 853)
  AUTHORS   Kasik,J.W. and Rice,E.J.
  TITLE     An increase in expression of the lipocalin 24p3 is found in mouse
            uterus coincident with birth
  JOURNAL   Am J Obstet Gynecol 173 (2), 613-617 (1995)
   PUBMED   7544071
REFERENCE   7  (bases 1 to 853)
  AUTHORS   Salier,J.P., Chan,P., Raguenez,G., Zwingman,T. and Erickson,R.P.
  TITLE     Developmentally regulated transcription of the four liver-specific
            genes for inter-alpha-inhibitor family in mouse
  JOURNAL   Biochem J 296 (Pt 1) (Pt 1), 85-91 (1993)
   PUBMED   7504460
REFERENCE   8  (bases 1 to 853)
  AUTHORS   Flower,D.R., North,A.C. and Attwood,T.K.
  TITLE     Mouse oncogene protein 24p3 is a member of the lipocalin protein
            family
  JOURNAL   Biochem Biophys Res Commun 180 (1), 69-74 (1991)
   PUBMED   1834059
REFERENCE   9  (bases 1 to 853)
  AUTHORS   Peitsch,M.C. and Boguski,M.S.
  TITLE     The first lipocalin with enzymatic activity
  JOURNAL   Trends Biochem Sci 16 (10), 363 (1991)
   PUBMED   1723819
REFERENCE   10 (bases 1 to 853)
  AUTHORS   Hraba-Renevey,S., Turler,H., Kress,M., Salomon,C. and Weil,R.
  TITLE     SV40-induced expression of mouse gene 24p3 involves a
            post-transcriptional mechanism
  JOURNAL   Oncogene 4 (5), 601-608 (1989)
   PUBMED   2542864
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X14607.1.
            
            [WARNING] On Jan 24, 2025 this sequence was replaced by
            NM_008491.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X14607.1, BC020275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="Swiss"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..853
                     /gene="Lcn2"
                     /gene_synonym="24p3; NRL; Sip24"
                     /note="lipocalin 2"
                     /db_xref="GeneID:16819"
                     /db_xref="MGI:MGI:96757"
     exon            1..160
                     /gene="Lcn2"
                     /gene_synonym="24p3; NRL; Sip24"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..625
                     /gene="Lcn2"
                     /gene_synonym="24p3; NRL; Sip24"
                     /note="secreted inducible protein 24; neutrophil
                     gelatinase-associated lipocalin; p25; SV-40-induced 24P3
                     protein; siderocalin LCN2; neu-related lipocalin; oncogene
                     24p3"
                     /codon_start=1
                     /product="neutrophil gelatinase-associated lipocalin
                     precursor"
                     /protein_id="NP_032517.1"
                     /db_xref="CCDS:CCDS15913.1"
                     /db_xref="GeneID:16819"
                     /db_xref="MGI:MGI:96757"
                     /translation="MALSVMCLGLALLGVLQSQAQDSTQNLIPAPSLLTVPLQPDFRS
                     DQFRGRWYVVGLAGNAVQKKTEGSFTMYSTIYELQENNSYNVTSILVRDQDQGCRYWI
                     RTFVPSSRAGQFTLGNMHRYPQVQSYNVQVATTDYNQFAMVFFRKTSENKQYFKITLY
                     GRTKELSPELKERFTRFAKSLGLKDDNIIFSVPTDQCIDN"
     exon            161..297
                     /gene="Lcn2"
                     /gene_synonym="24p3; NRL; Sip24"
                     /inference="alignment:Splign:2.1.0"
     exon            298..383
                     /gene="Lcn2"
                     /gene_synonym="24p3; NRL; Sip24"
                     /inference="alignment:Splign:2.1.0"
     exon            384..503
                     /gene="Lcn2"
                     /gene_synonym="24p3; NRL; Sip24"
                     /inference="alignment:Splign:2.1.0"
     exon            504..605
                     /gene="Lcn2"
                     /gene_synonym="24p3; NRL; Sip24"
                     /inference="alignment:Splign:2.1.0"
     exon            606..853
                     /gene="Lcn2"
                     /gene_synonym="24p3; NRL; Sip24"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      853
                     /gene="Lcn2"
                     /gene_synonym="24p3; NRL; Sip24"
                     /note="polyA site"
ORIGIN      
        1 agacctagta gctgtggaaa ccatggccct gagtgtcatg tgtctgggcc ttgccctgct
       61 tggggtcctg cagagccagg cccaggactc aactcagaac ttgatccctg ccccatctct
      121 gctcactgtc cccctgcagc cagacttccg gagcgatcag ttccggggca ggtggtacgt
      181 tgtgggcctg gcaggcaatg cggtccagaa aaaaacagaa ggcagcttta cgatgtacag
      241 caccatctat gagctacaag agaacaatag ctacaatgtc acctccatcc tggtcaggga
      301 ccaggaccag ggctgtcgct actggatcag aacatttgtt ccaagctcca gggctggcca
      361 gttcactctg ggaaatatgc acaggtatcc tcaggtacag agctacaatg tgcaagtggc
      421 caccacggac tacaaccagt tcgccatggt atttttccga aagacttctg aaaacaagca
      481 atacttcaaa attaccctgt atggaagaac caaggagctg tcccctgaac tgaaggaacg
      541 tttcacccgc tttgccaagt ctctgggcct caaggacgac aacatcatct tctctgtccc
      601 caccgaccaa tgcattgaca actgaatggg tggtgagtgt ggctgactgg gatgcgcaga
      661 gacccaatgg ttcaggcgct gcctgtctgt ctgccactcc atctttcctg ttgccagaga
      721 gccacctggc tgccccacca gccaccatac caaggagcat ctggagcctc ttcttatttg
      781 gccagcactc cccatccacc tgtcttaaca ccaccaatgg cgtccccttt ctgctgaata
      841 aatacatgcc ccc
//
