LOCUS       NM_178036               1106 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus lipocalin 10 (Lcn10), mRNA.
ACCESSION   NM_178036
VERSION     NM_178036.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1106)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1106)
  AUTHORS   Zhao,H., Wang,P., Wang,X., Du,W., Yang,H.H., Liu,Y., Cui,S.N.,
            Huang,W., Peng,T., Chen,J., Gao,C., Wang,Y., Sadayappan,S., Ma,C.,
            Fan,Y., Wang,C. and Fan,G.C.
  TITLE     Lipocalin 10 is essential for protection against
            inflammation-triggered vascular leakage by activating LDL
            receptor-related protein 2-slingshot homologue 1 signalling pathway
  JOURNAL   Cardiovasc Res 119 (10), 1981-1996 (2023)
   PUBMED   37392461
  REMARK    GeneRIF: Lipocalin 10 is essential for protection against
            inflammation-triggered vascular leakage by activating LDL
            receptor-related protein 2-slingshot homologue 1 signalling
            pathway.
REFERENCE   3  (bases 1 to 1106)
  AUTHORS   Li,Q., Li,Y., Huang,W., Wang,X., Liu,Z., Chen,J., Fan,Y., Peng,T.,
            Sadayappan,S., Wang,Y. and Fan,G.C.
  TITLE     Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy
            via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in
            Macrophages
  JOURNAL   Front Immunol 13, 930397 (2022)
   PUBMED   35757735
  REMARK    GeneRIF: Loss of Lipocalin 10 Exacerbates Diabetes-Induced
            Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory
            Response in Macrophages.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1106)
  AUTHORS   Charkoftaki,G., Wang,Y., McAndrews,M., Bruford,E.A., Thompson,D.C.,
            Vasiliou,V. and Nebert,D.W.
  TITLE     Update on the human and mouse lipocalin (LCN) gene family,
            including evidence the mouse Mup cluster is result of an
            'evolutionary bloom'
  JOURNAL   Hum Genomics 13 (1), 11 (2019)
   PUBMED   30782214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1106)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1106)
  AUTHORS   Suzuki,K., Lareyre,J.J., Sanchez,D., Gutierrez,G., Araki,Y.,
            Matusik,R.J. and Orgebin-Crist,M.C.
  TITLE     Molecular evolution of epididymal lipocalin genes localized on
            mouse chromosome 2
  JOURNAL   Gene 339, 49-59 (2004)
   PUBMED   15363845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732590.7.
            
            On Jun 6, 2014 this sequence version replaced NM_178036.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF435737.1, BC119103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AL732590.7         177363-177524
            163-302             AL732590.7         178152-178291
            303-373             AL732590.7         178666-178736
            374-481             AL732590.7         178933-179040
            482-580             AL732590.7         179680-179778
            581-1106            AL732590.7         180193-180718
FEATURES             Location/Qualifiers
     source          1..1106
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.75 cM"
     gene            1..1106
                     /gene="Lcn10"
                     /gene_synonym="9230112J07Rik"
                     /note="lipocalin 10"
                     /db_xref="GeneID:332578"
                     /db_xref="MGI:MGI:1925000"
     exon            1..162
                     /gene="Lcn10"
                     /gene_synonym="9230112J07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..609
                     /gene="Lcn10"
                     /gene_synonym="9230112J07Rik"
                     /note="epididymal-specific lipocalin-10"
                     /codon_start=1
                     /product="epididymal-specific lipocalin-10 precursor"
                     /protein_id="NP_828875.1"
                     /db_xref="CCDS:CCDS15787.1"
                     /db_xref="GeneID:332578"
                     /db_xref="MGI:MGI:1925000"
                     /translation="MKLEMALSIALALAVVSWTQEFFPKEAQTLNWSKFSGFWYIIAI
                     ATDTQGFLPARDKRKLGASVVKVHKTGQLRVVIAFSRPRGCQSREVTLKKDRKRPVFR
                     NTLKGVKGFHVLSTDYTYGLVYLRLGRGGSNYKSLLLFNRQNISSFLSLREFLDTCHI
                     LQLTKQATILPKDDSCAHTILP"
     exon            163..302
                     /gene="Lcn10"
                     /gene_synonym="9230112J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            303..373
                     /gene="Lcn10"
                     /gene_synonym="9230112J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            374..481
                     /gene="Lcn10"
                     /gene_synonym="9230112J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            482..580
                     /gene="Lcn10"
                     /gene_synonym="9230112J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            581..1106
                     /gene="Lcn10"
                     /gene_synonym="9230112J07Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accctacaac aggacagata cagtgagata caggtttaaa ctgacctgcc cgagctaagg
       61 atgaagttag agatggccct atccatagct ctagccctgg ctgtggtgtc ctggacgcag
      121 gagtttttcc ctaaggaggc ccagactctc aactggagca agttttcagg cttctggtac
      181 attattgcca tcgccacaga cacccagggg ttcctaccgg ctagagacaa gaggaagctg
      241 ggggcatctg tggtcaaggt gcacaaaaca ggccagctca gggtggtcat cgccttcagc
      301 aggcctcggg gctgccagtc cagggaggtg actctgaaga aggacaggaa gagacctgtg
      361 ttcaggaata ccctcaaggg agtaaagggc ttccatgtgc tgtccacgga ctacacgtac
      421 ggcctggtat acctccgcct ggggcgtgga ggcagcaact acaagagcct gctgcttttc
      481 aacagacaga acatctctag cttcctgagt ctgcgagaat ttctggacac atgtcatatt
      541 ctgcagctca ccaaacaggc caccatcctt ccgaaagacg attcctgtgc acatacgatc
      601 ctgccttgac agccagcctc ctgcttagcc ctttggcttg agaggtcctc cagaccctgg
      661 acattcagtg gctggctggc tgcagagagc ctgagccgtg gttgctgcct ttgcatcttc
      721 cgatcccaga aaacttcctc tgggctgtgc tcatggcttt ctcttcggtc tacctgccct
      781 gcaggttccc ggacttcact ggaggctgag tctcaccatc acttcaccct ggggaggtca
      841 acactgactt cagcctcact ctgctcccat ttccttcttt tattttaaaa gggctttctt
      901 tattttgtgg cctagagatg gcttagtagt tagagagtgt attgttgagg actcaattca
      961 gtccccagca cccatattgt gtggcaaacg atcgcctgta actccagctc aaggggatcc
     1021 aacagcctct ctggcctttg tggccactgc acacacatgt acaacctgcc acacatacat
     1081 aaaattaaaa ataaaaatct tttaaa
//
