LOCUS       NM_025304               1369 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus leucine carboxyl methyltransferase 1 (Lcmt1),
            transcript variant 1, mRNA.
ACCESSION   NM_025304 XM_355938
VERSION     NM_025304.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1369)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1369)
  AUTHORS   Mo,J., Wang,X., Liang,N., Zhang,N., Li,Y., Zheng,Z., Ao,Q., Wu,Y.,
            Tang,T., Liao,S., Lei,Y., Ding,H., Du,B., Feng,M., Chen,C., Shi,Q.,
            Wei,L., Huang,Y., Lu,C., Tang,S. and Li,X.
  TITLE     Hepatic leucine carboxyl methyltransferase 1 (LCMT1) contributes to
            high fat diet-induced glucose intolerance through regulation of
            glycogen metabolism
  JOURNAL   J Nutr Biochem 117, 109321 (2023)
   PUBMED   36963730
  REMARK    GeneRIF: Hepatic leucine carboxyl methyltransferase 1 (LCMT1)
            contributes to high fat diet-induced glucose intolerance through
            regulation of glycogen metabolism.
REFERENCE   3  (bases 1 to 1369)
  AUTHORS   Gnanaprakash,M., Staniszewski,A., Zhang,H., Pitstick,R.,
            Kavanaugh,M.P., Arancio,O. and Nicholls,R.E.
  TITLE     Leucine Carboxyl Methyltransferase 1 Overexpression Protects
            Against Cognitive and Electrophysiological Impairments in Tg2576
            APP Transgenic Mice
  JOURNAL   J Alzheimers Dis 79 (4), 1813-1829 (2021)
   PUBMED   33459709
  REMARK    GeneRIF: Leucine Carboxyl Methyltransferase 1 Overexpression
            Protects Against Cognitive and Electrophysiological Impairments in
            Tg2576 APP Transgenic Mice.
REFERENCE   4  (bases 1 to 1369)
  AUTHORS   Staniszewski,A., Zhang,H., Asam,K., Pitstick,R., Kavanaugh,M.P.,
            Arancio,O. and Nicholls,R.E.
  TITLE     Reduced Expression of the PP2A Methylesterase, PME-1, or the PP2A
            Methyltransferase, LCMT-1, Alters Sensitivity to
            Beta-Amyloid-Induced Cognitive and Electrophysiological Impairments
            in Mice
  JOURNAL   J Neurosci 40 (23), 4596-4608 (2020)
   PUBMED   32341098
  REMARK    GeneRIF: Reduced Expression of the PP2A Methylesterase, PME-1, or
            the PP2A Methyltransferase, LCMT-1, Alters Sensitivity to
            Beta-Amyloid-Induced Cognitive and Electrophysiological Impairments
            in Mice.
REFERENCE   5  (bases 1 to 1369)
  AUTHORS   Lee,J.A., Wang,Z., Sambo,D., Bunting,K.D. and Pallas,D.C.
  TITLE     Global loss of leucine carboxyl methyltransferase-1 causes severe
            defects in fetal liver hematopoiesis
  JOURNAL   J Biol Chem 293 (25), 9636-9650 (2018)
   PUBMED   29735529
  REMARK    GeneRIF: Loss of Lcmt1 expression is associated with severe defects
            in fetal liver hematopoiesis.
REFERENCE   6  (bases 1 to 1369)
  AUTHORS   Sontag,J.M., Nunbhakdi-Craig,V., Mitterhuber,M., Ogris,E. and
            Sontag,E.
  TITLE     Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1
            plays a critical role in differentiation of neuroblastoma cells
  JOURNAL   J Neurochem 115 (6), 1455-1465 (2010)
   PUBMED   21044074
  REMARK    GeneRIF: Enhanced expression of LCMT1 in cultured neuroblastoma
            cells, which increases endogenous methylated catalytic C subunit
            and Balpha levels, induces changes in F-actin organization.
REFERENCE   7  (bases 1 to 1369)
  AUTHORS   Lee,J.A. and Pallas,D.C.
  TITLE     Leucine carboxyl methyltransferase-1 is necessary for normal
            progression through mitosis in mammalian cells
  JOURNAL   J Biol Chem 282 (42), 30974-30984 (2007)
   PUBMED   17724024
  REMARK    GeneRIF: LCMT-1 is important for normal progression through mitosis
            and cell survival and is essential for embryonic development
REFERENCE   8  (bases 1 to 1369)
  AUTHORS   Nord,A.S., Chang,P.J., Conklin,B.R., Cox,A.V., Harper,C.A.,
            Hicks,G.G., Huang,C.C., Johns,S.J., Kawamoto,M., Liu,S., Meng,E.C.,
            Morris,J.H., Rossant,J., Ruiz,P., Skarnes,W.C., Soriano,P.,
            Stanford,W.L., Stryke,D., von Melchner,H., Wurst,W., Yamamura,K.,
            Young,S.G., Babbitt,P.C. and Ferrin,T.E.
  TITLE     The International Gene Trap Consortium Website: a portal to all
            publicly available gene trap cell lines in mouse
  JOURNAL   Nucleic Acids Res 34 (Database issue), D642-D648 (2006)
   PUBMED   16381950
REFERENCE   9  (bases 1 to 1369)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1369)
  AUTHORS   De Baere,I., Derua,R., Janssens,V., Van Hoof,C., Waelkens,E.,
            Merlevede,W. and Goris,J.
  TITLE     Purification of porcine brain protein phosphatase 2A leucine
            carboxyl methyltransferase and cloning of the human homologue
  JOURNAL   Biochemistry 38 (50), 16539-16547 (1999)
   PUBMED   10600115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU571243.1, AK003424.1 and BB686087.1.
            
            On or before Mar 23, 2004 this sequence version replaced
            XM_355938.1, NM_025304.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.249183.1, AK003424.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-565               BU571243.1         4-568
            566-1355            AK003424.1         491-1280
            1356-1369           BB686087.1         400-413
FEATURES             Location/Qualifiers
     source          1..1369
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 67.42 cM"
     gene            1..1369
                     /gene="Lcmt1"
                     /gene_synonym="Lcmt; LCMT-1"
                     /note="leucine carboxyl methyltransferase 1"
                     /db_xref="GeneID:30949"
                     /db_xref="MGI:MGI:1353593"
     exon            1..274
                     /gene="Lcmt1"
                     /gene_synonym="Lcmt; LCMT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..366
                     /gene="Lcmt1"
                     /gene_synonym="Lcmt; LCMT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..488
                     /gene="Lcmt1"
                     /gene_synonym="Lcmt; LCMT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..565
                     /gene="Lcmt1"
                     /gene_synonym="Lcmt; LCMT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..627
                     /gene="Lcmt1"
                     /gene_synonym="Lcmt; LCMT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..730
                     /gene="Lcmt1"
                     /gene_synonym="Lcmt; LCMT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..851
                     /gene="Lcmt1"
                     /gene_synonym="Lcmt; LCMT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..953
                     /gene="Lcmt1"
                     /gene_synonym="Lcmt; LCMT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1045
                     /gene="Lcmt1"
                     /gene_synonym="Lcmt; LCMT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1143
                     /gene="Lcmt1"
                     /gene_synonym="Lcmt; LCMT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1369
                     /gene="Lcmt1"
                     /gene_synonym="Lcmt; LCMT-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1334..1339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lcmt1"
                     /gene_synonym="Lcmt; LCMT-1"
                     /note="hexamer: AATAAA"
     polyA_site      1360
                     /gene="Lcmt1"
                     /gene_synonym="Lcmt; LCMT-1"
                     /note="major polyA site"
ORIGIN      
        1 gaaaggtggg tgggcggtgc gggggcggcg tcactgagca gcgcccgcct atcgcgcctt
       61 atctttgcag ctttagtcgg tgcctgtttc ttgcctcttt cccccactgc tcgtttcccc
      121 gtttccatgt ccctggtggg tgccgcaccc cagaacatcc cacgcacatg gcctccagct
      181 cgagggagtc ctcgttctct tcctgctcgt cgagctgtga cttggacgac gagggagtgc
      241 gcggcacctg cgaagatgct tctctctgca agaggtttgc ggtgagcatt ggctactggc
      301 atgatccgta catcgagcat cttgtaaggc agtctaaaga gaggaaggcc cccgaaatta
      361 acagaggata ttttgcccga gttcatggtg tcagtcagct tattaaagct tttctccgaa
      421 agacagaatg ccattgccaa attctcaacc ttggggctgg gatggatacc accttctgga
      481 aattaaagga tgaaggtctt ctcccaaata aatattttga agtcgacttt ccaatgatag
      541 tcacaagaaa gctgctcacc atcaaaagca agccgctttt attcagaccc atcatggagt
      601 tacacccaga ggacacgctt caaatggata gtcacatgct ggattcaaaa agatatgcca
      661 tcattggagc agatctccga gacctttctg agctggaaga gaaactaaag aaatgtaaca
      721 tgaatacaca attgccaaca ctcctgataa ctgaatgtgt gctggtttac atgactccag
      781 agcagtcagc caacctcctg aaatgggcag ccagcagttt tgagacagcc atgttcataa
      841 actatgagca ggtcaacatg gacgaccggt ttgggcagat catgattgaa aacctccgga
      901 ggcgaagttg tgacctggca ggagtggaaa cctgcaaatc actggagtcc cagaaggaac
      961 ggctgctgtt gaatgggtgg gagacagcgt ctgcagtgaa catgatggag ctgtacagtg
     1021 ggctacctcg ggcagaggta aacagaatag aatccctcga gttcctggat gagatggagc
     1081 tcctggagca gctcatgcgc cattactgcc tgtgctgggc cacccgcggc ggccaggagc
     1141 ttggtttgaa ggagataacc tattgatctg ctgaaggctc gtgctggggt ggaaggtgaa
     1201 ggctctagct aagggagtgc cagggcctcc tgagagatgt gcagcctcac tttgttggtc
     1261 ctgctgcaca tccggaaccc gtggttacaa aggtggtcac accagatcct gttcctgtca
     1321 gtatcattgt ttaaataaat ctcacttgcc atttgtgtca gactctgct
//
