LOCUS       NM_001162432            2069 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus lymphocyte protein tyrosine kinase (Lck), transcript
            variant 1, mRNA.
ACCESSION   NM_001162432
VERSION     NM_001162432.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2069)
  AUTHORS   Lui,V.G., Hoenig,M., Cabrera-Martinez,B., Baxter,R.M.,
            Garcia-Perez,J.E., Bailey,O., Acharya,A., Lundquist,K., Capera,J.,
            Matusewicz,P., Hartl,F.A., D'Abramo,M., Alba,J., Jacobsen,E.M.,
            Niewolik,D., Lorenz,M., Pannicke,U., Schulz,A.S., Debatin,K.M.,
            Schamel,W.W., Minguet,S., Gumbart,J.C., Dustin,M.L., Cambier,J.C.,
            Schwarz,K. and Hsieh,E.W.Y.
  TITLE     A partial human LCK defect causes a T cell immunodeficiency with
            intestinal inflammation
  JOURNAL   J Exp Med 221 (1) (2024)
   PUBMED   37962568
REFERENCE   2  (bases 1 to 2069)
  AUTHORS   Zhao,H., Zhu,H., Zhang,Y., Ding,Y., Feng,R., Li,J., Ma,T. and
            Huang,C.
  TITLE     Lymphocyte-Specific Protein Tyrosine Kinase Contributes to
            Spontaneous Regression of Liver Fibrosis may by Interacting with
            Suppressor of Cytokine Signaling 1
  JOURNAL   Inflammation 46 (5), 1653-1669 (2023)
   PUBMED   37233920
  REMARK    GeneRIF: Lymphocyte-Specific Protein Tyrosine Kinase Contributes to
            Spontaneous Regression of Liver Fibrosis may by Interacting with
            Suppressor of Cytokine Signaling 1.
REFERENCE   3  (bases 1 to 2069)
  AUTHORS   Dey,G., Bharti,R., Braley,C., Alluri,R., Esakov,E., Crean-Tate,K.,
            McCrae,K., Joehlin-Price,A., Rose,P.G., Lathia,J., Gong,Z. and
            Reizes,O.
  TITLE     LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in
            the nucleus of chemoresistant ovarian cancer
  JOURNAL   J Ovarian Res 16 (1), 122 (2023)
   PUBMED   37370140
  REMARK    GeneRIF: LCK facilitates DNA damage repair by stabilizing RAD51 and
            BRCA1 in the nucleus of chemoresistant ovarian cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2069)
  AUTHORS   Hivroz,C.
  TITLE     [LAG3 intracytoplasmic acidic environment locally disrupts the
            association of the Lck kinase to CD4 and CD8, two co-receptors of
            the TCR]
  JOURNAL   Med Sci (Paris) 38 (12), 1068-1071 (2022)
   PUBMED   36692275
  REMARK    GeneRIF: [LAG3 intracytoplasmic acidic environment locally disrupts
            the association of the Lck kinase to CD4 and CD8, two co-receptors
            of the TCR].
REFERENCE   5  (bases 1 to 2069)
  AUTHORS   Hwang,S.M., Ha,Y.J., Koo,G.B., Noh,H.J., Lee,A.Y., Kim,B.J.,
            Hong,S.M., Morgan,M.J., Eyun,S.I., Lee,D., Roe,J.S., Lee,Y. and
            Kim,Y.S.
  TITLE     LCK-Mediated RIPK3 Activation Controls Double-Positive Thymocyte
            Proliferation and Restrains Thymic Lymphoma by Regulating the
            PP2A-ERK Axis
  JOURNAL   Adv Sci (Weinh) 9 (32), e2204522 (2022)
   PUBMED   36161785
  REMARK    GeneRIF: LCK-Mediated RIPK3 Activation Controls Double-Positive
            Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating
            the PP2A-ERK Axis.
REFERENCE   6  (bases 1 to 2069)
  AUTHORS   Hurley,T.R., Amrein,K.E. and Sefton,B.M.
  TITLE     Creation and characterization of temperature-sensitive mutants of
            the lck tyrosine protein kinase
  JOURNAL   J Virol 66 (12), 7406-7413 (1992)
   PUBMED   1279202
REFERENCE   7  (bases 1 to 2069)
  AUTHORS   Beier,D.R., Dushkin,H. and Sussman,D.J.
  TITLE     Mapping genes in the mouse using single-strand conformation
            polymorphism analysis of recombinant inbred strains and
            interspecific crosses
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9102-9106 (1992)
   PUBMED   1409609
REFERENCE   8  (bases 1 to 2069)
  AUTHORS   Straus,D.B. and Weiss,A.
  TITLE     Genetic evidence for the involvement of the lck tyrosine kinase in
            signal transduction through the T cell antigen receptor
  JOURNAL   Cell 70 (4), 585-593 (1992)
   PUBMED   1505025
REFERENCE   9  (bases 1 to 2069)
  AUTHORS   Mori,T., Gou,M.W., Yoshida,H., Saito,S. and Mori,E.
  TITLE     Expression of the signal transducing regions of CD4-like and lck
            genes in murine egg
  JOURNAL   Biochem Biophys Res Commun 182 (2), 527-533 (1992)
   PUBMED   1370884
REFERENCE   10 (bases 1 to 2069)
  AUTHORS   Haefliger,J.A., Bruzzone,R., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Paul,D.L.
  TITLE     Four novel members of the connexin family of gap junction proteins.
            Molecular cloning, expression, and chromosome mapping
  JOURNAL   J Biol Chem 267 (3), 2057-2064 (1992)
   PUBMED   1370487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606921.6.
            
            On Jan 4, 2023 this sequence version replaced NM_001162432.1.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longer isoform (a).
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422590.229357.1,
                                           SRR13862062.156947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AL606921.6         159904-159988       c
            86-195              AL606921.6         159697-159806       c
            196-277             AL606921.6         159242-159323       c
            278-368             AL606921.6         158981-159071       c
            369-467             AL606921.6         158650-158748       c
            468-571             AL606921.6         158260-158363       c
            572-721             AL606921.6         157904-158053       c
            722-874             AL606921.6         157469-157621       c
            875-1054            AL606921.6         157155-157334       c
            1055-1131           AL606921.6         153564-153640       c
            1132-1285           AL606921.6         153333-153486       c
            1286-1417           AL606921.6         153121-153252       c
            1418-2069           AL606921.6         149965-150616       c
FEATURES             Location/Qualifiers
     source          1..2069
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.26 cM"
     gene            1..2069
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /note="lymphocyte protein tyrosine kinase"
                     /db_xref="GeneID:16818"
                     /db_xref="MGI:MGI:96756"
     exon            1..85
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /inference="alignment:Splign:2.1.0"
     exon            86..195
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /inference="alignment:Splign:2.1.0"
     exon            196..277
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /inference="alignment:Splign:2.1.0"
     exon            278..368
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /inference="alignment:Splign:2.1.0"
     exon            369..467
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /inference="alignment:Splign:2.1.0"
     exon            468..571
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /inference="alignment:Splign:2.1.0"
     exon            572..721
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /inference="alignment:Splign:2.1.0"
     exon            722..874
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1054
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1131
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1285
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1417
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..2069
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2042..2047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /note="hexamer: AATAAA"
     polyA_site      2069
                     /gene="Lck"
                     /gene_synonym="Hck-3; Lsk; Lskt; p56<lck>; p56Lck"
                     /note="major polyA site"
ORIGIN      
        1 agagggaacc cagtcaggag cttgaatccc acgattcagc gcttctgtct gcggccaatg
       61 ggggcctctg agctgacgat ctcggggatc atgggctgtg tctgcagctc aaaccctgaa
      121 gatgactgga tggagaacat tgacgtgtgt gaaaactgcc actatcccat agtcccactg
      181 gacagcaaga tctcgctgcc catccggaat ggctctgaag tgcgggaccc actggtcacc
      241 tatgagggat ctctcccacc agcatccccg ctgcaagaca acctggttat cgccctgcac
      301 agttatgagc cctcccatga tggagacttg ggctttgaga agggtgaaca gctccgaatc
      361 ctggagcaga gcggtgagtg gtggaaggct cagtccctga cgactggcca agaaggcttc
      421 attcccttca acttcgtggc gaaagcaaac agcctggagc ctgaaccttg gttcttcaag
      481 aatctgagcc gtaaggacgc cgagcggcag cttttggcgc ccgggaacac gcatggatcc
      541 ttcctgatcc gggaaagcga aagcactgcg gggtcctttt ccctgtcggt cagagacttc
      601 gaccagaacc agggagaagt ggtgaaacat tacaagatcc gtaacctaga caacggtggc
      661 ttctacatct cccctcgtat cacttttccc ggattgcacg atctagtccg ccattacacc
      721 aacgcctctg atgggctgtg cacaaagttg agccgtcctt gccagaccca gaagccccag
      781 aaaccatggt gggaggacga atgggaagtt cccagggaaa cactgaagtt ggtggagcgg
      841 ctgggagctg gccagttcgg ggaagtgtgg atggggtact acaacggaca cacgaaggtg
      901 gcggtgaaga gtctgaaaca agggagcatg tcccccgacg ccttcctggc tgaggctaac
      961 ctcatgaagc agctgcagca cccgcggcta gtccggcttt atgcagtggt cacccaggaa
     1021 cccatctaca tcatcacgga atacatggag aacgggagcc tagtagattt tctcaagact
     1081 ccctcgggca tcaagttgaa tgtcaacaaa cttttggaca tggcagccca gattgcagag
     1141 ggcatggcgt tcatcgaaga acagaattac atccatcggg acctgcgcgc cgccaacatc
     1201 ctggtgtctg acacgctgag ctgcaagatt gcagactttg gcctggcgcg cctcattgag
     1261 gacaatgagt acacggcccg ggagggggcc aaatttccca ttaagtggac agcaccagaa
     1321 gccattaact atgggacctt caccatcaag tcagacgtgt ggtccttcgg gatcttgctt
     1381 acagagatcg tcacccacgg tcgaatccct tacccaggaa tgaccaaccc tgaagtcatt
     1441 cagaacctgg agagaggcta ccgcatggtg agacctgaca actgtccgga agagctgtac
     1501 cacctcatga tgctgtgctg gaaggagcgc ccagaggacc ggcccacgtt tgactacctt
     1561 cggagtgttc tggatgactt cttcacagcc acagagggcc agtaccagcc ccagccttga
     1621 taggcctttc ggtcccaaga tcctcccaac cactgtgccc tggctagggc agatggaatt
     1681 cctgtgccat atctgtgtgg cctgtgcaca catggactct gactctgtac atgaaacctg
     1741 tgcgtgtgtc acacataatg cagtttctgt cttgtacaca catctgtagt tatgtgggtt
     1801 ctacacatgt gtcttatacc tgtggagcac gtgagtctaa gccttggata cctcctaaga
     1861 tgtctcttcc tataccgttc catttcctga agccatagag aggagaaggt ctgcgattga
     1921 tgcgtgtctc tgtctaccac tgcctttcag agggtctcca ggaaggccct ccttgtgggc
     1981 tgccatccaa tctcatgtct ctgtgtgttc tgtcctggtg cctagcacac accaggagct
     2041 caataaaagt ctgttgaatt aaggttgta
//
