LOCUS       NM_001355725             874 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus late cornified envelope 1M (Lce1m), transcript variant
            1, mRNA.
ACCESSION   NM_001355725 XM_006501877
VERSION     NM_001355725.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 874)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 874)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 874)
  AUTHORS   Henry,J., Toulza,E., Hsu,C.Y., Pellerin,L., Balica,S.,
            Mazereeuw-Hautier,J., Paul,C., Serre,G., Jonca,N. and Simon,M.
  TITLE     Update on the epidermal differentiation complex
  JOURNAL   Front Biosci (Landmark Ed) 17 (4), 1517-1532 (2012)
   PUBMED   22201818
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 874)
  AUTHORS   Ezhkova,E., Pasolli,H.A., Parker,J.S., Stokes,N., Su,I.H.,
            Hannon,G., Tarakhovsky,A. and Fuchs,E.
  TITLE     Ezh2 orchestrates gene expression for the stepwise differentiation
            of tissue-specific stem cells
  JOURNAL   Cell 136 (6), 1122-1135 (2009)
   PUBMED   19303854
REFERENCE   5  (bases 1 to 874)
  AUTHORS   Brown,S.J., Tilli,C.M., Jackson,B., Avilion,A.A., MacLeod,M.C.,
            Maltais,L.J., Lovering,R.C. and Byrne,C.
  TITLE     Rodent Lce gene clusters; new nomenclature, gene organization, and
            divergence of human and rodent genes
  JOURNAL   J Invest Dermatol 127 (7), 1782-1786 (2007)
   PUBMED   17410201
REFERENCE   6  (bases 1 to 874)
  AUTHORS   Jackson,B., Tilli,C.M., Hardman,M.J., Avilion,A.A., MacLeod,M.C.,
            Ashcroft,G.S. and Byrne,C.
  TITLE     Late cornified envelope family in differentiating
            epithelia--response to calcium and ultraviolet irradiation
  JOURNAL   J Invest Dermatol 124 (5), 1062-1070 (2005)
   PUBMED   15854049
REFERENCE   7  (bases 1 to 874)
  AUTHORS   Marshall,D., Hardman,M.J., Nield,K.M. and Byrne,C.
  TITLE     Differentially expressed late constituents of the epidermal
            cornified envelope
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13031-13036 (2001)
   PUBMED   11698679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135289.3 and BY704085.1.
            
            On Sep 26, 2017 this sequence version replaced XM_006501877.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003825.1, BC109181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC135289.3         151666-151667
            3-818               BY704085.1         2-817
            819-874             AC135289.3         152865-152920
FEATURES             Location/Qualifiers
     source          1..874
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     gene            1..874
                     /gene="Lce1m"
                     /gene_synonym="1110059L13Rik; Lce5a; Sprrl10"
                     /note="late cornified envelope 1M"
                     /db_xref="GeneID:66203"
                     /db_xref="MGI:MGI:1913453"
     exon            1..41
                     /gene="Lce1m"
                     /gene_synonym="1110059L13Rik; Lce5a; Sprrl10"
                     /inference="alignment:Splign:2.1.0"
     exon            42..874
                     /gene="Lce1m"
                     /gene_synonym="1110059L13Rik; Lce5a; Sprrl10"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..601
                     /gene="Lce1m"
                     /gene_synonym="1110059L13Rik; Lce5a; Sprrl10"
                     /note="small proline rich-like 10; late cornified envelope
                     5A"
                     /codon_start=1
                     /product="late cornified envelope protein 5A"
                     /protein_id="NP_001342654.1"
                     /db_xref="CCDS:CCDS17579.1"
                     /db_xref="GeneID:66203"
                     /db_xref="MGI:MGI:1913453"
                     /translation="MSCQQSQQQCQPPPKCKTPKCPPTSSCCSLGSGGCCGSSSGGCC
                     SSGCGGCCLSHHKPRFSLRRRRHSSGCCSSGGSSCCGSSGGSSCCGSSGGSSGGSSGG
                     SSGGSSCCGSSGGSSGGSSCCGSSSGGSSCCGSSSGGSSGGSSGGSSCCGSSGGSSGG
                     SSSGSNSHQQSGGSSCCSGGCC"
     regulatory      852..857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lce1m"
                     /gene_synonym="1110059L13Rik; Lce5a; Sprrl10"
                     /note="hexamer: AATAAA"
     polyA_site      872
                     /gene="Lce1m"
                     /gene_synonym="1110059L13Rik; Lce5a; Sprrl10"
                     /note="major polyA site"
ORIGIN      
        1 tcaatccatt actcgctgag tgatctactc cagtgcctga gttcctttgg agatgtcctg
       61 tcagcagagc cagcaacagt gccagccccc tcccaaatgc aagaccccaa agtgccctcc
      121 aacctcttcc tgctgtagcc tgggttctgg gggctgctgt ggttccagct ccgggggctg
      181 ctgcagctct ggatgtggtg gctgctgtct gagccaccac aagccccgat tctctctccg
      241 tcgccgacgt cacagctctg gatgctgtag cagcggtggc agcagttgct gtggcagcag
      301 cggtggcagc agttgctgtg gcagcagcgg tggcagcagc ggtggcagca gcggtggcag
      361 cagcggtggc agcagttgct gtggcagcag cggtggcagc agcggtggca gcagttgctg
      421 tggcagcagc agcggtggca gcagttgctg tggcagcagc agtggtggca gtagcggtgg
      481 cagtagcggt ggcagcagct gctgtggtag cagtgggggc agcagtggtg gcagcagcag
      541 tggcagcaac agccatcagc agtctggggg ctctagctgc tgctctggag gttgctgctg
      601 acctggccac gaagaacatg gaaagcagca ttgactgaag acctgcaagc ctagggtctc
      661 ctcttctctg gttttcccgc agaagtactt agaactctct gtacgtcctc ttcatctccc
      721 taaagctcat ctaccacgag gtcttcaggt cccagctctg agatgcattg gctttgcttt
      781 ttttctctga cacaactaat tgagaatgag atattgaaaa attagctttg aaaaatcttt
      841 ttctgggcaa taataaagct tttgattcct gaca
//
