LOCUS       NM_008490               1370 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus lecithin cholesterol acyltransferase (Lcat), mRNA.
ACCESSION   NM_008490
VERSION     NM_008490.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1370)
  AUTHORS   Hommes,J.W., Kratofil,R.M., Wahlen,S., de Haas,C.J.C.,
            Hildebrand,R.B., Hovingh,G.K., Otto,M., van Eck,M., Hoekstra,M.,
            Korporaal,S.J.A. and Surewaard,B.G.J.
  TITLE     High density lipoproteins mediate in vivo protection against
            staphylococcal phenol-soluble modulins
  JOURNAL   Sci Rep 11 (1), 15357 (2021)
   PUBMED   34321507
  REMARK    GeneRIF: High density lipoproteins mediate in vivo protection
            against staphylococcal phenol-soluble modulins.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1370)
  AUTHORS   Tsujita,M., Vaisman,B., Chengyu,L., Vickers,K.C., Okuhira,K.I.,
            Braesch-Andersen,S. and Remaley,A.T.
  TITLE     Apolipoprotein A-I in mouse cerebrospinal fluid derives from the
            liver and intestine via plasma high-density lipoproteins assembled
            by ABCA1 and LCAT
  JOURNAL   FEBS Lett 595 (6), 773-788 (2021)
   PUBMED   33020907
  REMARK    GeneRIF: Apolipoprotein A-I in mouse cerebrospinal fluid derives
            from the liver and intestine via plasma high-density lipoproteins
            assembled by ABCA1 and LCAT.
REFERENCE   3  (bases 1 to 1370)
  AUTHORS   Abe,A., Hiraoka,M., Matsuzawa,F., Aikawa,S.I. and Niimura,Y.
  TITLE     Esterification of side-chain oxysterols by lysosomal phospholipase
            A2
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1865 (10), 158787 (2020)
   PUBMED   32777483
  REMARK    GeneRIF: Esterification of side-chain oxysterols by lysosomal
            phospholipase A2.
REFERENCE   4  (bases 1 to 1370)
  AUTHORS   Neufeld,E.B., Sato,M., Gordon,S.M., Durbhakula,V., Francone,N.,
            Aponte,A., Yilmaz,G., Sviridov,D., Sampson,M., Tang,J., Pryor,M.
            and Remaley,A.T.
  TITLE     ApoA-I-Mediated Lipoprotein Remodeling Monitored with a Fluorescent
            Phospholipid
  JOURNAL   Biology (Basel) 8 (3), 53 (2019)
   PUBMED   31336888
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1370)
  AUTHORS   Xepapadaki,E., Maulucci,G., Constantinou,C., Karavia,E.A.,
            Zvintzou,E., Daniel,B., Sasson,S. and Kypreos,K.E.
  TITLE     Impact of apolipoprotein A1- or lecithin:cholesterol
            acyltransferase-deficiency on white adipose tissue metabolic
            activity and glucose homeostasis in mice
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (6), 1351-1360 (2019)
   PUBMED   30742993
  REMARK    GeneRIF: It has been reported that universal deletion of Apoa1 or
            Lcat expression in mice fed western-type diet results in increased
            sensitivity to body-weight gain compared to control C57BL/6 group.
REFERENCE   6  (bases 1 to 1370)
  AUTHORS   Roghani,A., Welch,C., Xia,Y., Liu,Y., Peter,D., Finn,J.P.,
            Edwards,R.H. and Lusis,A.J.
  TITLE     Assignment of the mouse vesicular monoamine transporter genes,
            Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis
  JOURNAL   Mamm Genome 7 (5), 393-394 (1996)
   PUBMED   8661734
REFERENCE   7  (bases 1 to 1370)
  AUTHORS   Parks,J.S., Li,H., Gebre,A.K., Smith,T.L. and Maeda,N.
  TITLE     Effect of apolipoprotein A-I deficiency on lecithin:cholesterol
            acyltransferase activation in mouse plasma
  JOURNAL   J Lipid Res 36 (2), 349-355 (1995)
   PUBMED   7751823
REFERENCE   8  (bases 1 to 1370)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
REFERENCE   9  (bases 1 to 1370)
  AUTHORS   Warden,C.H., Langner,C.A., Gordon,J.I., Taylor,B.A., McLean,J.W.
            and Lusis,A.J.
  TITLE     Tissue-specific expression, developmental regulation, and
            chromosomal mapping of the lecithin: cholesterol acyltransferase
            gene. Evidence for expression in brain and testes as well as liver
  JOURNAL   J Biol Chem 264 (36), 21573-21581 (1989)
   PUBMED   2600083
REFERENCE   10 (bases 1 to 1370)
  AUTHORS   Scherer,G., Bausch,E., Gaa,A. and von Deimling,O.
  TITLE     Gene mapping on mouse chromosome 8 by interspecific crosses: new
            data on a linkage group conserved on human chromosome 16q
  JOURNAL   Genomics 5 (2), 275-282 (1989)
   PUBMED   2571576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI574112.1, AK149476.1 and AI046659.1.
            
            On Jul 2, 2009 this sequence version replaced NM_008490.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028861.1, AK149476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AI574112.1         1-6
            7-1354              AK149476.1         4-1351
            1355-1370           AI046659.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..1370
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.06 cM"
     gene            1..1370
                     /gene="Lcat"
                     /gene_synonym="D8Wsu61e"
                     /note="lecithin cholesterol acyltransferase"
                     /db_xref="GeneID:16816"
                     /db_xref="MGI:MGI:96755"
     exon            1..178
                     /gene="Lcat"
                     /gene_synonym="D8Wsu61e"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1341
                     /gene="Lcat"
                     /gene_synonym="D8Wsu61e"
                     /EC_number="2.3.1.43"
                     /EC_number="3.1.1.47"
                     /note="phosphatidylcholine-sterol acyltransferase;
                     lecithin-cholesterol acyltransferase Lcat;
                     phospholipid-cholesterol acyltransferase; PAF
                     acetylhydrolase; platelet-activating factor
                     acetylhydrolase; 1-alkyl-2-acetylglycerophosphocholine
                     esterase"
                     /codon_start=1
                     /product="phosphatidylcholine-sterol acyltransferase
                     precursor"
                     /protein_id="NP_032516.2"
                     /db_xref="CCDS:CCDS22622.1"
                     /db_xref="GeneID:16816"
                     /db_xref="MGI:MGI:96755"
                     /translation="MGLPGSPWQRVLLLLGLLLPPATPFWLLNVLFPPHTTPKAELSN
                     HTRPVILVPGCLGNRLEAKLDKPDVVNWMCYRKTEDFFTIWLDFNLFLPLGVDCWIDN
                     TRIVYNHSSGRVSNAPGVQIRVPGFGKTESVEYVDDNKLAGYLHTLVQNLVNNGYVRD
                     ETVRAAPYDWRLAPHQQDEYYKKLAGLVEEMYAAYGKPVFLIGHSLGCLHVLHFLLRQ
                     PQSWKDHFIDGFISLGAPWGGSIKAMRILASGDNQGIPILSNIKLKEEQRITTTSPWM
                     LPAPHVWPEDHVFISTPNFNYTVQDFERFFTDLHFEEGWHMFLQSRDLLERLPAPGVE
                     VYCLYGVGRPTPHTYIYDHNFPYKDPVAALYEDGDDTVATRSTELCGQWQGRQSQPVH
                     LLPMNETDHLNMVFSNKTLEHINAILLGAYRTPKSPAASPSPPPPE"
     exon            179..335
                     /gene="Lcat"
                     /gene_synonym="D8Wsu61e"
                     /inference="alignment:Splign:2.1.0"
     exon            336..451
                     /gene="Lcat"
                     /gene_synonym="D8Wsu61e"
                     /inference="alignment:Splign:2.1.0"
     exon            452..547
                     /gene="Lcat"
                     /gene_synonym="D8Wsu61e"
                     /inference="alignment:Splign:2.1.0"
     exon            548..772
                     /gene="Lcat"
                     /gene_synonym="D8Wsu61e"
                     /inference="alignment:Splign:2.1.0"
     exon            773..1362
                     /gene="Lcat"
                     /gene_synonym="D8Wsu61e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1337..1342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lcat"
                     /gene_synonym="D8Wsu61e"
                     /note="hexamer: AATAAA"
     polyA_site      1362
                     /gene="Lcat"
                     /gene_synonym="D8Wsu61e"
                     /note="major polyA site"
ORIGIN      
        1 tctgtcagta ggcactgggc tgtgatgggg ctgcctggct ccccatggca gcgggtgctg
       61 ttgctgttgg ggctactgct ccctcctgcc acccccttct ggctcctcaa tgtgctcttc
      121 cccccgcaca ccacgcccaa ggctgaactc agtaaccaca cacggcctgt catcctcgtg
      181 cctggctgct tggggaatcg gctagaagcc aagctggata aaccagatgt ggtgaactgg
      241 atgtgctacc gtaagacaga ggacttcttc accatctggc tggatttcaa cttgtttctc
      301 cccctcgggg tggactgctg gattgataat accaggattg tctacaacca cagctctggg
      361 cgcgtgtcca atgcccctgg tgtccagatc cgtgtccctg gctttggcaa gaccgaatct
      421 gttgagtacg tggatgacaa caagctagca ggctacctgc acacactggt gcagaatctg
      481 gttaacaacg gatatgtgcg ggatgagaca gtgcgggccg caccctatga ctggcgtctg
      541 gcaccccacc agcaggatga atactacaag aagctggctg gcctggtaga ggagatgtat
      601 gccgcttatg ggaagcctgt cttcctcatt gggcatagcc ttggctgtct gcatgtgctc
      661 cacttcttac tgcggcagcc tcagtcctgg aaggaccact tcattgatgg ttttatctct
      721 ctcggggctc cgtggggtgg ttccatcaag gccatgcgga tcctggcctc aggtgacaac
      781 cagggcatcc ccatcctgtc caacataaag ctgaaagagg agcagcgcat aaccacgact
      841 tccccctgga tgctcccagc ccctcacgtg tggcctgaag accatgtgtt catttccaca
      901 ccaaacttca actacaccgt ccaagacttt gagcgttttt tcacagatct gcattttgaa
      961 gaaggctggc acatgtttct tcagtctcgt gacctactgg agcgcctccc cgcacctggt
     1021 gtagaagtat attgtctcta cggtgtgggc agacccacac cccacaccta catctatgac
     1081 cacaacttcc cctacaaaga ccccgtggct gcactctatg aagatgggga cgacaccgta
     1141 gccacccgca gcactgagct ctgtggccag tggcagggcc gccagtcgca gcccgtacat
     1201 ttgctgccca tgaacgagac agatcacctc aacatggtct tcagcaataa gacactggag
     1261 catatcaatg ccatcctact gggtgcctac cgcactccta agtcgccagc tgccagccca
     1321 agtcccccac cccctgaata aagacctagc tgttataaat aaaaaaaaaa
//
