LOCUS       NM_001001492            3164 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Leber congenital amaurosis 5-like (Lca5l), transcript
            variant 1, mRNA.
ACCESSION   NM_001001492 XM_358892
VERSION     NM_001001492.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3164)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164647.3.
            
            On Jun 17, 2022 this sequence version replaced NM_001001492.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029554.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC164647.3         25087-25149
            64-222              AC164647.3         31408-31566
            223-298             AC164647.3         37217-37292
            299-630             AC164647.3         38399-38730
            631-1145            AC164647.3         41070-41584
            1146-1283           AC164647.3         43467-43604
            1284-1368           AC164647.3         53337-53421
            1369-1472           AC164647.3         54675-54778
            1473-1590           AC164647.3         55237-55354
            1591-1701           AC164647.3         55896-56006
            1702-3164           AC164647.3         57470-58932
FEATURES             Location/Qualifiers
     source          1..3164
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 56.84 cM"
     gene            1..3164
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /note="Leber congenital amaurosis 5-like"
                     /db_xref="GeneID:385668"
                     /db_xref="MGI:MGI:3041157"
     exon            1..63
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /inference="alignment:Splign:2.1.0"
     exon            64..222
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /inference="alignment:Splign:2.1.0"
     exon            223..298
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..2501
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lebercilin-like protein; leber congenital amaurosis 5-like
                     protein"
                     /codon_start=1
                     /product="lebercilin-like protein isoform 1"
                     /protein_id="NP_001001492.2"
                     /db_xref="CCDS:CCDS37413.1"
                     /db_xref="GeneID:385668"
                     /db_xref="MGI:MGI:3041157"
                     /translation="MRLWTMSLADTTEAHTNEHFPSLALGSNKKSTEGKRSPGAGGQS
                     QNSQASNGSVDYSRSQCSCTSLTSHYDYSEDFLSDCSETAVRRLQSEKPLAKAKEKRK
                     YNAGKLPQPRGQKDIPAEKKQFWNASLISSQIQTIAKRRDTMTHRILSARLHKIKELK
                     NELADVHRKLEASAIENQFLKQLQLRHLKAIGKYVNSQNNLPQITAKHQNEVKNLRQL
                     LRKSQEKERAVSRKLRETDGELLRTKDVLQALQRLSEDKNLAEREELTDRLTDLTAKM
                     EANDKKIQNLEKQLRLNNRSYSRQLAKENRKTLAAQTATKTLQAEVRQLQQKLKEKDR
                     ELEIKNIYTNRILKNLNDKEDYPKVSSTKSVQADRKSLPSVNMRHQETQKSDVPFWIT
                     KGKRGKGNIAHKEKSTETNHDIPYYVCKLPKQEESKRKYEANLTVLKSMPSPPASWGL
                     VATEQICAFHLECHSCTHTADLSKEVEHRKPQTSLETPRRPKENKEDQEKRAIPAEAE
                     PTAKESEAHKDAEDKALTRAAGNAGDAGDAGDAGNDREVVGEHKVVGAQEVVGAQELP
                     GADEADEVHGAGEAPRDVEPGRGRRKTPRKHYSFTEATENLHHGLPTSCRQVSGSPHC
                     RCRHDMGKHRSEQELRLEPAGYEPSFGKGAGARARARARATAFRDRKSSLMEELFGAG
                     FAGRAGSSDSEAVSKSPQTGPQASAGNAFGDSRATVAGSIQASPTEANRKTVV"
     exon            299..630
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /inference="alignment:Splign:2.1.0"
     exon            631..1145
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1283
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1368
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1472
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1590
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1701
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..3164
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2636..2641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /note="hexamer: AATAAA"
     polyA_site      2654
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /note="major polyA site"
     regulatory      3139..3144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /note="hexamer: TATAAA"
     polyA_site      3164
                     /gene="Lca5l"
                     /gene_synonym="4921526F01Rik; Lcca5l"
                     /note="major polyA site"
ORIGIN      
        1 atggcgacgc ccgcgcttcc ttaagtccag ggtggaggca gctgcgggag cagcgcggag
       61 cagggtttta tgaaatatag tctttgttta aaaaagagac tagaacatgt caaaaagtct
      121 taccttggaa acttcatgag tcccacagtg acgagtgctc cccatgcaac atacagttca
      181 tctccagaca ccttagggaa tgaatttgag aaagagcaac agaatcgaga gctgaatgaa
      241 aaagccatgc tttcaaaggc atctgagacg gactggtttg tctccttcta ctgatgaggt
      301 tgtggactat gtctttggct gatacaacag aagcacacac aaacgagcat ttccccagtc
      361 tggcactagg aagcaacaag aagtctacag aaggcaagcg tagccctggc gctggtggcc
      421 agtcccagaa cagccaggct tccaatggga gcgtggatta cagcaggtct cagtgctcct
      481 gcacaagcct gacttctcac tatgactact cagaagactt tctctctgac tgctctgaga
      541 cggccgtcag gagactccag tcagagaagc ctctggcaaa ggcgaaggag aaaaggaagt
      601 acaacgctgg taaactcccc cagcctagag gccagaagga catcccagct gagaaaaagc
      661 aattctggaa tgcttcgttg atcagttctc aaattcaaac gattgccaag agaagagaca
      721 ccatgacaca tcggatactg tcagccaggc ttcataagat caaagagctg aagaacgagc
      781 tggcagacgt acatcggaag ctggaagcct ctgccataga aaaccaattt ctgaagcagc
      841 ttcagcttag acacctgaaa gccataggga aatacgtgaa ctctcagaac aacctacctc
      901 aaatcacagc caagcaccag aatgaggtga agaaccttcg acagctcctc cggaaatccc
      961 aggagaagga gcgagctgtg tccaggaaac tccgagaaac cgacggcgag ttactgagga
     1021 ccaaagacgt cttgcaagcc ctgcagagac tctcagaaga caaaaacctt gcagagagag
     1081 aagaactgac tgacaggttg accgacctta cagccaaaat ggaagcaaat gataaaaaaa
     1141 tacagaactt ggaaaaacag ctgcgactga acaatcggtc ctacagtcga cagctggcca
     1201 aagaaaatcg gaagacgtta gcagctcaaa cagcaacaaa gactctgcag gcagaagtga
     1261 gacagctgca gcagaagctt aaggagaagg accgtgagct ggagatcaaa aacatctata
     1321 cgaatcgaat actcaaaaac ttaaatgata aggaagacta tccgaaagtt tcttcaacga
     1381 aatcagtgca agcggacagg aaaagcctgc catctgtaaa tatgagacac caggaaactc
     1441 aaaagtcaga tgtcccattt tggataacca agggtaaaag ggggaaagga aacattgctc
     1501 ataaagaaaa atcaacagaa acaaaccatg atattcctta ctatgtgtgt aagctaccaa
     1561 agcaagaaga gtctaagaga aaatatgaag ccaatctcac ggtcttaaag agcatgccat
     1621 ctcctccagc ttcctgggga ctggtggcca ctgagcagat ctgtgccttc catctggaat
     1681 gtcactcttg tacccataca gcagatttat caaaggaggt cgaacaccgg aaaccacaaa
     1741 cctctctgga aactcctagg aggccaaaag agaataagga agaccaagaa aagagagcca
     1801 tcccagcaga ggcagagcca actgcaaagg aaagcgaggc ccacaaggac gccgaggata
     1861 aggccctgac cagggcggcc ggcaatgcag gcgatgcagg cgatgcgggc gatgccggca
     1921 atgaccgcga ggtggtcggg gagcacaaag tggtcggagc gcaagaggtg gtcggggcac
     1981 aggagctgcc cggggcagat gaggcggacg aggtgcacgg ggcgggcgag gccccgcgcg
     2041 atgtcgagcc cgggcgcggc aggaggaaga ccccgcggaa gcactactcc ttcaccgagg
     2101 ccaccgaaaa cctgcaccac gggctgccca cctcctgcag gcaggtttcg ggcagcccgc
     2161 actgccgctg ccgccacgac atgggcaagc accgcagcga gcaggagctg cggctggagc
     2221 ctgccggcta cgagccctcg ttcggcaagg gggccggggc cagggccagg gccagggcca
     2281 gggcgacggc attccgcgac agaaagagca gcctcatgga ggagctgttc ggcgcgggct
     2341 tcgcgggcag ggcgggctcc agcgacagcg aggcagtcag caagtccccg cagacggggc
     2401 cccaggcctc tgccggcaac gccttcgggg actctagagc caccgtggcg gggtccatcc
     2461 aggcctcgcc caccgaagcc aacaggaaga ctgttgttta aatgcagcag tcacctgata
     2521 cattctggtt tatatactag ttatgtgcct ttaatcttat ttaccatgtg agggcttaca
     2581 tagtgtctgt tttagtactt gggtggactg tgggtaattt gcgtgatttc tatctaataa
     2641 aaaaatccac tgtaccttgg atgtcatatg gtaacatttt aaatacaaat ctacatcttt
     2701 attatgaagg cggaacatgc atgtccactc tttttaggaa gattgggttt attacatagc
     2761 ccggagatct gggactcagc gattcttggc cagcctaagg cgcataaatt ctgccagcaa
     2821 ggctgctggc cggcacaact gcacggaaga ggtactgatc agcaagacgg aaggccagca
     2881 gacacaacga cagtacaagg attcaagctt ggcctcgtga gtcatgtctg gtggtctctt
     2941 gctcagctga actgaaagca tctaagtggc ctgcctttgt gtgcccctgc gcctgtatag
     3001 aagtctgtat ttttttgtta ttgttgagat ttattatttt ttgttacaca atgaccgttt
     3061 ctcttaatct tgttctaaaa ataactgcat gttcaatctg gctgctcagg tctaattcta
     3121 acagtattct gttgggacta taaagggtct gtattcccag tcta
//
