LOCUS       NM_010691               2524 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ladybird homeobox 1 (Lbx1), mRNA.
ACCESSION   NM_010691 XM_006526722
VERSION     NM_010691.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2524)
  AUTHORS   Yin,G., Duan,K., Dong,D., Du,F., Guo,C., Zhang,C., Liu,X., Sun,Y.,
            Huang,T., Cui,G. and Cheng,L.
  TITLE     Central control of opioid-induced mechanical hypersensitivity and
            tolerance in mice
  JOURNAL   Neuron 112 (23), 3897-3923 (2024)
   PUBMED   39406237
REFERENCE   2  (bases 1 to 2524)
  AUTHORS   Cui,K., Xia,Y., Patnaik,A., Salivara,A., Lowenstein,E.D.,
            Isik,E.G., Knorz,A.L., Airaghi,L., Crotti,M., Garratt,A.N.,
            Meng,F., Schmitz,D., Studer,M., Rijli,F.M., Nothwang,H.G.,
            Rost,B.R., Strauss,U. and Hernandez-Miranda,L.R.
  TITLE     Genetic identification of medullary neurons underlying congenital
            hypoventilation
  JOURNAL   Sci Adv 10 (25), eadj0720 (2024)
   PUBMED   38896627
REFERENCE   3  (bases 1 to 2524)
  AUTHORS   Zhang,D., Turecek,J., Choi,S., Delisle,M., Pamplona,C.L.,
            Meltzer,S. and Ginty,D.D.
  TITLE     C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway
  JOURNAL   bioRxiv (2024)
   PUBMED   38915692
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2524)
  AUTHORS   Gradwell,M.A., Ozeri-Engelhard,N., Eisdorfer,J.T., Laflamme,O.D.,
            Gonzalez,M., Upadhyay,A., Medlock,L., Shrier,T., Patel,K.R.,
            Aoki,A., Gandhi,M., Abbas-Zadeh,G., Oputa,O., Thackray,J.K.,
            Ricci,M., George,A., Yusuf,N., Keating,J., Imtiaz,Z., Alomary,S.A.,
            Bohic,M., Haas,M., Hernandez,Y., Prescott,S.A., Akay,T. and
            Abraira,V.E.
  TITLE     Multimodal sensory control of motor performance by glycinergic
            interneurons of the mouse spinal cord deep dorsal horn
  JOURNAL   Neuron 112 (8), 1302-1327 (2024)
   PUBMED   38452762
REFERENCE   5  (bases 1 to 2524)
  AUTHORS   Rankin,G., Chirila,A.M., Emanuel,A.J., Zhang,Z., Woolf,C.J.,
            Drugowitsch,J. and Ginty,D.D.
  TITLE     Nerve injury disrupts temporal processing in the spinal cord dorsal
            horn through alterations in PV+ interneurons
  JOURNAL   Cell Rep 43 (2), 113718 (2024)
   PUBMED   38294904
REFERENCE   6  (bases 1 to 2524)
  AUTHORS   Mankoo,B.S., Collins,N.S., Ashby,P., Grigorieva,E., Pevny,L.H.,
            Candia,A., Wright,C.V., Rigby,P.W. and Pachnis,V.
  TITLE     Mox2 is a component of the genetic hierarchy controlling limb
            muscle development
  JOURNAL   Nature 400 (6739), 69-73 (1999)
   PUBMED   10403250
REFERENCE   7  (bases 1 to 2524)
  AUTHORS   Chen,F., Liu,K.C. and Epstein,J.A.
  TITLE     Lbx2, a novel murine homeobox gene related to the Drosophila
            ladybird genes is expressed in the developing urogenital system,
            eye and brain
  JOURNAL   Mech Dev 84 (1-2), 181-184 (1999)
   PUBMED   10473138
REFERENCE   8  (bases 1 to 2524)
  AUTHORS   Dietrich,S., Abou-Rebyeh,F., Brohmann,H., Bladt,F.,
            Sonnenberg-Riethmacher,E., Yamaai,T., Lumsden,A., Brand-Saberi,B.
            and Birchmeier,C.
  TITLE     The role of SF/HGF and c-Met in the development of skeletal muscle
  JOURNAL   Development 126 (8), 1621-1629 (1999)
   PUBMED   10079225
REFERENCE   9  (bases 1 to 2524)
  AUTHORS   Mennerich,D., Schafer,K. and Braun,T.
  TITLE     Pax-3 is necessary but not sufficient for lbx1 expression in
            myogenic precursor cells of the limb
  JOURNAL   Mech Dev 73 (2), 147-158 (1998)
   PUBMED   9622616
REFERENCE   10 (bases 1 to 2524)
  AUTHORS   Jagla,K., Dolle,P., Mattei,M.G., Jagla,T., Schuhbaur,B.,
            Dretzen,G., Bellard,F. and Bellard,M.
  TITLE     Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene
            family related to the Drosophila lady bird genes
  JOURNAL   Mech Dev 53 (3), 345-356 (1995)
   PUBMED   8645601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123058.3.
            
            On or before Jul 21, 2018 this sequence version replaced
            XM_006526722.3, NM_010691.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4283669.1,
                                           SRR7652917.1049810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AC123058.3         22677-22887         c
            212-950             AC123058.3         20949-21687         c
            951-2524            AC123058.3         18730-20303         c
FEATURES             Location/Qualifiers
     source          1..2524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.61 cM"
     gene            1..2524
                     /gene="Lbx1"
                     /gene_synonym="Lbx1h"
                     /note="ladybird homeobox 1"
                     /db_xref="GeneID:16814"
                     /db_xref="MGI:MGI:104867"
     exon            1..211
                     /gene="Lbx1"
                     /gene_synonym="Lbx1h"
                     /inference="alignment:Splign:2.1.0"
     exon            212..950
                     /gene="Lbx1"
                     /gene_synonym="Lbx1h"
                     /inference="alignment:Splign:2.1.0"
     CDS             626..1474
                     /gene="Lbx1"
                     /gene_synonym="Lbx1h"
                     /note="ladybird homeobox protein homolog 1; lady bird-like
                     homeobox 1 homolog"
                     /codon_start=1
                     /product="transcription factor LBX1"
                     /protein_id="NP_034821.2"
                     /db_xref="CCDS:CCDS29859.1"
                     /db_xref="GeneID:16814"
                     /db_xref="MGI:MGI:104867"
                     /translation="MTSKEDGKAAPGEERRRSPLDHLPPPANSNKPLTPFSIEDILNK
                     PSVRRSYSLCGAAHLLAAADKHAPGGLPLAGRALLSQTSPLCALEELASKTFKGLEVS
                     VLQAAEGRDGMTIFGQRQTPKKRRKSRTAFTNHQIYELEKRFLYQKYLSPADRDQIAQ
                     QLGLTNAQVITWFQNRRAKLKRDLEEMKADVESAKKLGPSGQMDIVALAELEQNSEAS
                     GGGGGGGCGRAKSRPGSPALPPGAPQAPGGGPLQLSPASPLTDQRASSQDCSEDEEDE
                     EIDVDD"
     exon            951..2524
                     /gene="Lbx1"
                     /gene_synonym="Lbx1h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2498..2503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lbx1"
                     /gene_synonym="Lbx1h"
                     /note="hexamer: AATAAA"
     polyA_site      2524
                     /gene="Lbx1"
                     /gene_synonym="Lbx1h"
                     /note="major polyA site"
ORIGIN      
        1 acactcaagc cctgtgcccg gctgggcggg gcgggcagcg gggccccggc cctggccggg
       61 gcagagagca gcggggaagc ccggaacccg cccgggtaac cccgacaccc ggccgagttt
      121 ccgtcagacg tccgtcatca gacatgtggt ggccctagct tgccccgaga gccacggcgg
      181 gaggaaagag tgtgcaagat tgcagaagga gtccgggatc ggcgccctcg cctcggttct
      241 tccaactgcc gccgccagga ccccgggcca ggagccgccg cggcggagcc acctgacacc
      301 tttaaatagc accggggctg gcgaaactgg agcccggcgc ggcgcttccc ggctccggcc
      361 cgggcttgct ggaaaccccg gcggtggcgg cggcggcggc ggtggcagtg gcggcgcccg
      421 cgtcagcgct ttcctcccgg ggccccgcgc cactccgctc gcccgggtcg ccgcgctaat
      481 cggccgcttg cccatccgcg ccctgcccgg cgcggcctcc tgcccgcctc tcgccttcct
      541 ctcgcaccgt ccagcgtccg agctgcccgc gggctgggtc cccccggccc gagccgcccc
      601 ggccgggccc ccaaacgagg ccgagatgac ttccaaggag gacggcaagg cggcgccagg
      661 ggaggagcgg cgacgcagcc ctctggacca cctgccgccg cccgccaact ccaacaagcc
      721 gctgacgccg ttcagcatcg aggacatcct caacaagccg tccgtgcgga gaagttactc
      781 gctgtgtggg gcggcgcacc tgctggcggc cgcggacaag cacgcgccgg gcggcttgcc
      841 cctggcgggc cgcgctctgc tctcgcagac ctcgcctctc tgcgccttgg aggagctcgc
      901 cagcaagacc tttaaggggc tggaggtcag cgtcctgcag gcagccgaag gccgcgatgg
      961 gatgaccatc tttgggcaga ggcagacgcc caagaaacgg cgaaaatcac gcacggcctt
     1021 caccaaccac cagatctacg agttggagaa acgctttcta taccagaagt acctgtcccc
     1081 ggcagatcgc gaccaaattg cgcagcagct gggcctcacc aatgcacagg tcatcacctg
     1141 gttccagaac cggcgcgcca agctcaagcg ggacctagag gagatgaagg ccgacgtgga
     1201 gtctgccaag aaactgggcc ccagcgggca gatggacatc gtggcgctgg ccgaactcga
     1261 gcagaactcg gaggcttcgg gcggtggcgg cggcggtggc tgcggcaggg ctaagtctag
     1321 gccgggttct cctgcgctgc ccccaggcgc cccgcaggcc ccgggcggag gacccttgca
     1381 gctctcgccc gcctctccac tcacggacca gcgggccagc agccaggact gctcagagga
     1441 tgaggaagat gaagagatcg acgtggacga ttgagctgcg ccctggacct cctgccgccc
     1501 gggcccccag tgcccgcatg cccgccgcct cccggatcgg accgctaagg ggagctggga
     1561 cctcctctgc acctcccgcc tccacccttg tcccggggcc gggcttggcc cctgatagcc
     1621 gcctcttcct tttcgaagca ataaatccgg gccggccggc ggggccggcc gccacacgag
     1681 gcctccgccg ccccggaagc cctcgccgtg caattctgta tggcttctgt ataaatattt
     1741 aagcctatat agtgggttcc tcccaccaca gcttgattat tttctttctt ttattatgat
     1801 tattattttt ttttaatctc agagatttcg atgttttcaa agcccgggtg ctgccgggtc
     1861 ggctgacggt gaggcggact cgagagcggc gaacactact aactcctgcg gtctagaagc
     1921 tgttttaatt tttttctgca tgtggcgaat gcaccggtcc gctcacctct ctcggcctat
     1981 tacagttgac ttttaatttc cttctgcctt tttttccctc cgtgagaagg ggggggggga
     2041 gccgggccct gacttgcaag tttcaaaatc gatcttttct ttccccagcg agagaagtct
     2101 gctttcgatg gcgtgtctgc ctcccgaggc ccactatttt ttaaaattcc tccaaatctt
     2161 cctgcatttt ctcggactga ttgctgaagt ctggctctta gggaaaaagc agggaagcac
     2221 ccaaccagtc atggaaaaca gaacccaaag ccctaggaat tattttttac tctttaaaat
     2281 ttttttcttt ttgcatgtga cagagaccta aagaaggatg acccaagcgc taaccctcac
     2341 ctcctctgta gctctgggtc cgtctgtcaa catctctctc ccgtctcaag ttggccattc
     2401 gagggtggcc cagggagggt gggttccggg tgccctttcc cagctcctgc cttgccctct
     2461 ctttcttcga ctgtacccaa ggcctcttcc tccgataaat aaagtctttg ccattttact
     2521 agaa
//
