LOCUS       NM_133815               3568 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus lamin B receptor (Lbr), mRNA.
ACCESSION   NM_133815
VERSION     NM_133815.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3568)
  AUTHORS   Lee JY, Davis I, Youth EHH, Kim J, Churchill G, Godwin J, Korstanje
            R and Beck S.
  TITLE     Misexpression of genes lacking CpG islands drives degenerative
            changes during aging
  JOURNAL   Sci Adv 7 (51), eabj9111 (2021)
   PUBMED   34910517
REFERENCE   2  (bases 1 to 3568)
  AUTHORS   Norrie JL, Lupo MS, Xu B, Al Diri I, Valentine M, Putnam D,
            Griffiths L, Zhang J, Johnson D, Easton J, Shao Y, Honnell V, Frase
            S, Miller S, Stewart V, Zhou X, Chen X and Dyer MA.
  TITLE     Nucleome Dynamics during Retinal Development
  JOURNAL   Neuron 104 (3), 512-528 (2019)
   PUBMED   31493975
REFERENCE   3  (bases 1 to 3568)
  AUTHORS   Hause F, Schlote D, Simm A, Hoffmann K and Santos AN.
  TITLE     Accumulation of glycated proteins suggesting premature ageing in
            lamin B receptor deficient mice
  JOURNAL   Biogerontology 19 (1), 95-100 (2018)
   PUBMED   29081010
  REMARK    GeneRIF: Lbr deficiency could be related to Premature Ageing
            reflected by enhanced accumulation of protein glycation as a
            biomarker for ageing.
REFERENCE   4  (bases 1 to 3568)
  AUTHORS   Giannios I, Chatzantonaki E and Georgatos S.
  TITLE     Dynamics and Structure-Function Relationships of the Lamin B
            Receptor (LBR)
  JOURNAL   PLoS One 12 (1), e0169626 (2017)
   PUBMED   28118363
  REMARK    GeneRIF: The diffusional mobility of full-length LBR shows
            significant regional variation along the nuclear envelope,
            consistent with the existence of discrete LBR microdomains and the
            occurrence of multiple, asymmetrically-spaced anastomoses along the
            nuclear envelope-endoplasmic reticulum interface.  Native LBR may
            be 'configured' by long-range interactions between adjacent
            transmembrane domains and parts of the NH2 region.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3568)
  AUTHORS   Kurogi S, Sekimoto T, Funamoto T, Ota T, Nakamura S, Nagai T,
            Nakahara M, Yoshinobu K, Araki K, Araki M and Chosa E.
  TITLE     Development of an efficient screening system to identify novel bone
            metabolism-related genes using the exchangeable gene trap
            mutagenesis mouse models
  JOURNAL   Sci Rep 7, 40692 (2017)
   PUBMED   28106071
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3568)
  AUTHORS   Goldowitz,D. and Mullen,R.J.
  TITLE     Nuclear morphology of ichthyosis mutant mice as a cell marker in
            chimeric brain
  JOURNAL   Dev Biol 89 (1), 261-267 (1982)
   PUBMED   7054010
REFERENCE   7  (bases 1 to 3568)
  AUTHORS   Jensen,J.E. and Esterly,N.B.
  TITLE     The ichthyosis mouse: histologic, histochemical, ultrastructural,
            and autoradiographic studies of interfollicular epidermis
  JOURNAL   J Invest Dermatol 68 (1), 23-31 (1977)
   PUBMED   830768
REFERENCE   8  (bases 1 to 3568)
  AUTHORS   Green,M.C., Shultz,L.D. and Nedzi,L.A.
  TITLE     Abnormal nuclear morphology of leukocytes in the mouse mutant
            ichthyosis
  JOURNAL   Transplantation 20 (2), 172-175 (1975)
   PUBMED   1101484
REFERENCE   9  (bases 1 to 3568)
  AUTHORS   Green,M.C., Alpert,B.N. and Mayer,T.C.
  TITLE     The site of action of the ichthyosis locus (ic) in the mouse, as
            determined by dermal-epidermal recombinations
  JOURNAL   J Embryol Exp Morphol 32 (3), 715-721 (1974)
   PUBMED   4463225
REFERENCE   10 (bases 1 to 3568)
  AUTHORS   Gruneberg,H.
  TITLE     Exocrine glands and the Chievitz organ of some mouse mutants
  JOURNAL   J Embryol Exp Morphol 25 (2), 247-261 (1971)
   PUBMED   5088022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB849128.1, AK167157.1 and BE991506.1.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_133815.3.
            
            On May 8, 2009 this sequence version replaced NM_133815.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151798.1, AK088179.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                BB849128.1         2-59
            59-3511             AK167157.1         4-3456
            3512-3568           BE991506.1         1-57                c
FEATURES             Location/Qualifiers
     source          1..3568
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.89 cM"
     gene            1..3568
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /note="lamin B receptor"
                     /db_xref="GeneID:98386"
                     /db_xref="MGI:MGI:2138281"
     exon            1..114
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /inference="alignment:Splign:2.1.0"
     exon            115..293
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..2009
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /EC_number="1.3.1.70"
                     /note="integral nuclear envelope inner membrane protein;
                     ichthyosis; delta-14-SR; sterol C14-reductase; C-14 sterol
                     reductase; 3-beta-hydroxysterol Delta (14)-reductase"
                     /codon_start=1
                     /product="delta(14)-sterol reductase LBR"
                     /protein_id="NP_598576.2"
                     /db_xref="CCDS:CCDS15584.1"
                     /db_xref="GeneID:98386"
                     /db_xref="MGI:MGI:2138281"
                     /translation="MPSRKFVEGEVVRGRWPGSSLYYEVEILSHDNKSQLYTVKYKDG
                     TELELKESDIKPLKSFKQRKSGSISSSPSRRRGSRSRSRSRSRSRSPGRAPKGSRRSV
                     SASHEGDVKEKKEKEMRREILQVKLTPLVLKPFGNSVSVYNGEPEHMEKNATPYKDKQ
                     ERIILSTEDRYIVTQYSLRPRREEVKAKEIESEEQNLVTKGPAPLGTFQVTTPQRKDL
                     EFGGVPGAVLIMLGLPACVLLLLLQCRQKDPGLLHFPPPLPALHELWEPRVCGVYLLW
                     FFVQALFHLLPVGKVAEGTPLVDGRRLQYRLNGLYAFILTSAALGAAVFWGVELCYLY
                     THFLQLALAATGFSVLLSAYLYVRSLRAPREELSPASSGNAVYDFFIGRELNPRLGAF
                     DLKFFCELRPGLIGWVVINLVMLLMEMKIQERAAPSLAMILVNSFQLLYVVDALWNEE
                     ALLTSMDIMHDGFGFMLAFGDLVWVPFTYSLQAFYLVSHPHDLSWPLASVIIALKLCG
                     YVIFRCANSQKNAFRKNPTDPKLAHLKTIHTSTGKSLLVSGWWGFVRHPNYLGDLIMA
                     LAWSLPCGFNHLLPYFYIIYFTALLIHREARDEHQCRRKYGLAWEKYCQRVPYRIFPY
                     IY"
     exon            294..524
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /inference="alignment:Splign:2.1.0"
     exon            525..608
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /inference="alignment:Splign:2.1.0"
     exon            609..801
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /inference="alignment:Splign:2.1.0"
     exon            802..998
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1053
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1245
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1349
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1475
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1644
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1725
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1848
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..3552
                     /gene="Lbr"
                     /gene_synonym="C14SR; ic"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggggcggga cctcgggggc gcgagagcgc ggccggctgt gtcgcgcgcg gagtcgccgc
       61 tggctgctgg tgactgtcct ggagtggctg gagttcccgc cggagcgcgg ccagactaat
      121 tttagaaaat gccaagtagg aagtttgttg agggtgaagt ggtcagaggc cgatggcctg
      181 ggagctccct ttattatgaa gtagagattc tgagccacga caacaaatcc cagctctaca
      241 ctgtaaaata caaagatggc accgaactgg aactgaagga gagtgatatc aagcctttaa
      301 aatcctttaa gcaaagaaaa agtggctcga tttccagctc tccctctcga cgccgtggca
      361 gccgcagccg cagccgctca agatcacgtt cccgatcccc gggcagagca ccgaaaggct
      421 ccagaagatc cgtctctgct tcccatgagg gtgacgtgaa ggagaagaag gagaaggaga
      481 tgaggaggga aattctgcaa gttaagctga ctccgcttgt gttgaagccg ttcggaaaca
      541 gcgtcagcgt gtacaacggg gagcccgaac acatggagaa gaacgctacg ccgtataaag
      601 acaagcagga aagaatcatt ttgtcaacag aagacagata tatagttaca cagtacagcc
      661 ttcgtcccag gagagaagag gtcaaagcca aagaaataga gtctgaggaa caaaaccttg
      721 tcaccaaagg acccgcacct ttgggaacct ttcaagtgac cactccacag aggaaggact
      781 tggagtttgg aggagtacct ggtgcggtcc tcatcatgct gggcctgccc gcctgcgtcc
      841 tcttgctgct gctgcagtgc aggcagaagg acccggggct gctccacttc cctccacctc
      901 tgccggctct ccacgagctg tgggaaccca gggtgtgcgg cgtttacctc ctctggtttt
      961 tcgttcaagc tctcttccac cttctaccag ttgggaaggt tgcagaagga acacctcttg
     1021 ttgatggaag aagactccag tatagactga atggattgta tgccttcatt ctgacatctg
     1081 cagccctggg agcagctgtc ttctggggtg ttgagctgtg ctacctgtac actcacttcc
     1141 tgcagttggc actggcagcc accgggttct ccgtgctcct gagtgcttac ctctatgttc
     1201 gctctctgcg agccccgagg gaggagctgt cgccagccag ttccggaaat gctgtctacg
     1261 acttcttcat tggccgagag ttaaacccgc gacttggtgc tttcgatctc aagttctttt
     1321 gtgagttgcg ccctggattg attggatggg tggttattaa cttagtgatg cttctgatgg
     1381 aaatgaaaat tcaggagcga gctgctccgt ccttggcaat gatcttggtt aacagtttcc
     1441 agctcttata tgtggtggac gccctctgga atgaggaagc actgctgacc tccatggaca
     1501 tcatgcacga cggctttggc ttcatgctgg cctttgggga tttagtgtgg gttccattta
     1561 cctacagcct ccaggccttt tacctggtca gccatcccca tgacttgtcc tggccattgg
     1621 cttctgtcat cattgctctg aaattgtgtg gatatgtaat cttccgttgt gcaaactctc
     1681 agaaaaatgc attccggaag aatcccactg atccaaagct tgcacatttg aagaccattc
     1741 atacttccac ggggaaaagt ctgcttgttt ccggatggtg gggctttgtt cgccatccca
     1801 attacttggg tgacctcatc atggctctgg cgtggtccct cccatgtggt ttcaaccacc
     1861 tcctgccata cttctacatt atctacttca ccgccttgct tatccatcga gaggcccggg
     1921 atgaacacca gtgcaggagg aagtacggcc tggcctggga gaagtactgc cagcgagtgc
     1981 cctaccgcat attcccctac atttactgac ctgtgctgct tgcctggcag ctcagacctc
     2041 tcccagaaac aagggaaagt ccaaatgaac taatgtgatg cactgacagg atctctaggt
     2101 ttgtttttga gtcaggacta tagagccaaa tagtacatct tttaatgtag ttaaatttat
     2161 tcttatggca gttaaggatg gtaaaatttg cttattagga aaattttaat ccctaaaaat
     2221 cttaactttt atttttgttg gttttttttt tttcaatttt ttttttcttt ttgccatttg
     2281 atttttctta attgaaaact cttattaaag tacatctacg tttcattgtg cttagaacag
     2341 aattctcttt aagtcagttt attagtctat aaatcaagca aaacccagcc caatattggt
     2401 gttatagctg aagaataagg gcagattact tgcaggacct gtttaaagga ccattcatag
     2461 cagtgactcc acttcagcct ttaaaagtgc atttggaaat ataaacacat agacgacttt
     2521 tatgtaatat atggtaactt ttgatttttc tgtacagttt ttgaatgtga gataattgtc
     2581 agaaactaag tagtttttta acagaatatt ttcagtgttt taaattaagt tttgtaaagt
     2641 aattacaatt catttaaagt taaaacatag gaaagttatt tttctttatc caaagtttgt
     2701 gaatttggct ttgctacctc aatttgcagg tgtgtgtttg cctttataaa atgttgcaaa
     2761 tagaaaaaaa aatatatatt ttttgagtaa cagcactatt taaacatttt tacacacatt
     2821 ggtgttggaa aaattgccat tttaggctac tatttttata tattttttga cttaaaattc
     2881 aacagtgttt ttgctactgt ttagctaata cagtttatat taatttgtat cctttatgtt
     2941 tttagaactc tctagaaagg agttctacct gatacaactt taagttttct ctctgtttaa
     3001 tggatgtgta taagctgttt gtagccttca gtactagtga ggttggatag tttcccagtc
     3061 actgtccctg agcaggacaa gtggcaagtt cactagactt ttttattcaa agctacattg
     3121 tcctcagagt aaacataagg atgcaataca tatagtgtgt acatttgggt ttctattaca
     3181 cataccacat gtgagctaga tgcaaaatat tcaggtcttc ctgctctgta gcttagagtg
     3241 tcaagtggct gtgcccgtct gatcatgccg tgctacgctc tgcattctgt cattctttac
     3301 tgttttacta gtcctaaggt gttcagcagg tggttttcta tcatgctttc tgctggaatc
     3361 aacatggtat gtgttaataa gcttacaagg aaacaacttt gggttctttg cctggttctg
     3421 aaagggcgga cagtgccaca gtatctggac attaggtgca agttgttttt aatttgatgt
     3481 ttggcaagct ttgtaataaa attttggttg gaaacaaaaa gttgaaaata aagagttgct
     3541 gttagagcct caaaaaaaaa aaaaaaaa
//
