LOCUS       NM_008489               2528 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus lipopolysaccharide binding protein (Lbp), mRNA.
ACCESSION   NM_008489
VERSION     NM_008489.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2528)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2528)
  AUTHORS   Chen,J., Zhang,X., DeLaughter,D.M., Trembley,M.A., Saifee,S.,
            Xiao,F., Chen,J., Zhou,P., Seidman,C.E., Seidman,J.G. and Pu,W.T.
  TITLE     Molecular and Spatial Signatures of Mouse Embryonic Endothelial
            Cells at Single-Cell Resolution
  JOURNAL   Circ Res 134 (5), 529-546 (2024)
   PUBMED   38348657
REFERENCE   3  (bases 1 to 2528)
  AUTHORS   Chen,H.J., Galley,J.D., Verosky,B.G., Yang,F.T., Rajasekera,T.A.,
            Bailey,M.T. and Gur,T.L.
  TITLE     Fetal CCL2 signaling mediates offspring social behavior and
            recapitulates effects of prenatal stress
  JOURNAL   Brain Behav Immun 115, 308-318 (2024)
   PUBMED   37914098
REFERENCE   4  (bases 1 to 2528)
  AUTHORS   Xie,L., Qiu,S., Lu,C., Gu,C., Wang,J., Lv,J., Fang,L., Chen,Z.,
            Li,Y., Jiang,T., Xia,Y., Wang,W., Li,B. and Xu,Z.
  TITLE     Gastric cancer-derived LBP promotes liver metastasis by driving
            intrahepatic fibrotic pre-metastatic niche formation
  JOURNAL   J Exp Clin Cancer Res 42 (1), 258 (2023)
   PUBMED   37789385
  REMARK    GeneRIF: Gastric cancer-derived LBP promotes liver metastasis by
            driving intrahepatic fibrotic pre-metastatic niche formation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2528)
  AUTHORS   Yin,X., Xu,Z., Zhang,X., Wu,J. and Lu,W.
  TITLE     Deficiency of lipopolysaccharide binding protein facilitates
            adipose browning, glucose uptake and oxygen consumption in mouse
            embryonic fibroblasts via activating PI3K/Akt/mTOR pathway and
            inhibiting autophagy
  JOURNAL   Cell Cycle 22 (8), 967-985 (2023)
   PUBMED   36710409
  REMARK    GeneRIF: Deficiency of lipopolysaccharide binding protein
            facilitates adipose browning, glucose uptake and oxygen consumption
            in mouse embryonic fibroblasts via activating PI3K/Akt/mTOR pathway
            and inhibiting autophagy.
REFERENCE   6  (bases 1 to 2528)
  AUTHORS   Lengacher,S., Reed,D., Heumann,D. and Jongeneel,C.V.
  TITLE     Genomic organization and chromosomal localization of the mouse
            lipopolysaccharide binding protein gene
  JOURNAL   Immunogenetics 49 (6), 553-556 (1999)
   PUBMED   10380702
REFERENCE   7  (bases 1 to 2528)
  AUTHORS   Ulevitch,R.J. and Tobias,P.S.
  TITLE     Recognition of gram-negative bacteria and endotoxin by the innate
            immune system
  JOURNAL   Curr Opin Immunol 11 (1), 19-22 (1999)
   PUBMED   10047547
  REMARK    Review article
REFERENCE   8  (bases 1 to 2528)
  AUTHORS   Wurfel,M.M., Monks,B.G., Ingalls,R.R., Dedrick,R.L., Delude,R.,
            Zhou,D., Lamping,N., Schumann,R.R., Thieringer,R., Fenton,M.J.,
            Wright,S.D. and Golenbock,D.
  TITLE     Targeted deletion of the lipopolysaccharide (LPS)-binding protein
            gene leads to profound suppression of LPS responses ex vivo,
            whereas in vivo responses remain intact
  JOURNAL   J Exp Med 186 (12), 2051-2056 (1997)
   PUBMED   9396775
REFERENCE   9  (bases 1 to 2528)
  AUTHORS   Jack,R.S., Fan,X., Bernheiden,M., Rune,G., Ehlers,M., Weber,A.,
            Kirsch,G., Mentel,R., Furll,B., Freudenberg,M., Schmitz,G.,
            Stelter,F. and Schutt,C.
  TITLE     Lipopolysaccharide-binding protein is required to combat a murine
            gram-negative bacterial infection
  JOURNAL   Nature 389 (6652), 742-745 (1997)
   PUBMED   9338787
REFERENCE   10 (bases 1 to 2528)
  AUTHORS   Lengacher,S., Jongeneel,C.V., Le Roy,D., Lee,J.D., Kravchenko,V.,
            Ulevitch,R.J., Glauser,M.P. and Heumann,D.
  TITLE     Reactivity of murine and human recombinant LPS-binding protein
            (LBP) within LPS and gram negative bacteria
  JOURNAL   J Inflamm 47 (4), 165-172 (1995)
   PUBMED   9144073
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143562.1, AA207419.1, BQ176753.1, AL663063.14 and AI643881.1.
            
            On Sep 1, 2006 this sequence version replaced NM_008489.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X99347.1, BC004795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1098              AK143562.1         2-1099
            1099-1394           AA207419.1         74-369
            1395-1828           BQ176753.1         177-610             c
            1829-2477           AL663063.14        184495-185143
            2478-2528           AI643881.1         1-51                c
FEATURES             Location/Qualifiers
     source          1..2528
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.72 cM"
     gene            1..2528
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /note="lipopolysaccharide binding protein"
                     /db_xref="GeneID:16803"
                     /db_xref="MGI:MGI:1098776"
     exon            1..301
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1623
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /codon_start=1
                     /product="lipopolysaccharide-binding protein precursor"
                     /protein_id="NP_032515.2"
                     /db_xref="CCDS:CCDS16988.1"
                     /db_xref="GeneID:16803"
                     /db_xref="MGI:MGI:1098776"
                     /translation="MKAGTGPLLSTLLGLLFLSIQGTGGVNPGVVARITDKGLAYAAK
                     EGLVALQRELYKITLPDFSGDFKIKAVGRGQYEFHSLEIQNCELRGSSLKLLPGQGLS
                     LAISDSSIGVRGKWKVRKSFLKLHGSFDLDVKGVTISVDLLLGMDPSGRPTVSASGCS
                     SRICDLDVHISGNVGWLLNLFHNQIESKLQKVLENKVCEMIQKSVTSDLQPYLQTLPV
                     TAEIDNVLGIDYSLVAAPQAKAQVLDVMFKGEIFNRNHRSPVATPTPTMSLPEDSKQM
                     VYFAISDYAFNIASRVYHQAGYLNFSITDDMLPHDSGIRLNTKAFRPFTPQIYKKYPD
                     MKLELLGTVVSAPILNVSPGNLSLAPQMEIEGFVILPTSAREPVFRLGVVTNVFASLT
                     FNNSKVTGMLHPDKAQVRLIESKVGMFNVNLFQAFLNYYLLNSLYPDVNAELAQGFPL
                     PLPRHIQLHDLDFQIRKDFLYLGANVQYMRV"
     exon            302..416
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /inference="alignment:Splign:2.1.0"
     exon            417..545
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /inference="alignment:Splign:2.1.0"
     exon            546..701
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /inference="alignment:Splign:2.1.0"
     exon            702..765
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /inference="alignment:Splign:2.1.0"
     exon            766..829
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /inference="alignment:Splign:2.1.0"
     exon            830..921
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1098
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1158
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1326
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1394
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1437
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1501
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1578
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..2525
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1966..1971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /note="hexamer: AATAAA"
     polyA_site      1992
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /note="major polyA site"
ORIGIN      
        1 gtggtgtcgc aagagggttc cagtcagtgg gcctctcttt ccctgggcct ctctttcctg
       61 ctcccaggag cccgccctcc ctcaagaacc gccccctagc cctgggcctt gactagttaa
      121 gaacaccaga gccagcccac tctgtcacag tcctcactcc cccacggagc atccaggatg
      181 aaggctggga ctggacctct gctctctaca ttgctggggc tgctgttcct gtccatacag
      241 ggaactggcg gtgtcaaccc cggtgtggtg gccaggatca ccgacaaggg cctggcctac
      301 gcggccaagg aggggctggt ggctctgcag agagagctgt acaagatcac actaccggac
      361 ttcagcgggg acttcaagat caaggccgtg ggtcgtgggc agtacgagtt tcatagcctg
      421 gagattcaga actgtgagct gcgtggctcc tctctgaagc tgctcccagg ccagggcctg
      481 agtctcgcca tctctgactc ttccatcggt gtccgaggca aatggaaggt gcgcaaatcc
      541 ttcctgaaac ttcatggctc ctttgacctg gatgtcaaag gtgtcaccat ttcagtggac
      601 ctcctcctgg gcatggatcc ctcagggcgg cccacagtct ctgcctctgg gtgcagcagc
      661 cgcatttgtg atttggatgt gcacatatca ggaaatgtgg ggtggctgct gaatctcttc
      721 cacaaccaga tcgagtcgaa gctccagaaa gtactggaga ataaggtttg tgagatgatc
      781 cagaagtctg tgacctctga cctgcagcct tatctccaga ctctgccagt cacagcagag
      841 atcgacaatg tcctgggcat tgactacagt ttggtggcgg ctccccaagc gaaggcccag
      901 gtgctggatg tcatgtttaa gggtgaaatt tttaatcgga atcaccgctc tccagttgct
      961 acccccactc cgaccatgag cctacctgag gacagtaagc aaatggtcta ctttgccatc
     1021 tcagattatg ccttcaacat agccagccgg gtttatcacc aggctgggta cctgaatttt
     1081 tccatcacag atgacatgtt accacatgac tccggcatcc ggttgaacac caaggccttc
     1141 cgtcccttca ctccccagat atacaaaaag tatcccgaca tgaaattgga gctccttgga
     1201 acagtggtct ctgccccgat tctgaatgtc agtcctggga atctgtcctt ggccccacag
     1261 atggagatcg aaggctttgt gatcctgccc acctccgccc gggaacctgt cttccggctt
     1321 ggcgtggtca ctaatgtatt tgcctcatta actttcaaca acagcaaggt taccgggatg
     1381 ctgcatccag acaaggcaca agtgagactg atcgaatcca aagtcggcat gttcaatgtg
     1441 aacctgttcc aggcattcct taactactac cttctcaaca gcctctaccc tgatgtcaat
     1501 gctgagctgg cccagggctt ccccctccct ctgccaaggc atattcagct ccacgacctc
     1561 gacttccaga tccgcaagga cttcttatac ttgggtgcca atgtccagta tatgagagtc
     1621 tgaggacaag aagaaagatg ggtctcagtg gccacagctg gaccggccat ttgtaattcc
     1681 agatgtacag cacatctctg gagagtctca aaatacaaag atgtttctgc tcctggctcg
     1741 ggtgggccct gaccccagag tcctcttcag caggtgcacc cttgacctgg acttgactcc
     1801 gtcccatcct ccaggaaggg cccctcccct cactgacttc tccaggaagg gccctctcca
     1861 acactgggtg ggagacctgg aatcacttta agagcgggca ctgtggtttt aaattcacca
     1921 tctgaccttc atgtttgaca gggtgctggc actttgtagg tcctcaataa atatttatag
     1981 aatatcacaa catcccagct gaacctcttt attgctcttc catctggtct gagccagtct
     2041 tagatgcttg ccggagctgt ggtctctaag gctagaccta ggcctccttt tttctcctgt
     2101 tggccctgct atgagggcct caacaaggga gtggtggact acacacacac acacacacac
     2161 acacacacac acacacacac acacacacac cgcccttccc cagcacttgg cctggtgttc
     2221 atcactaggc ccttatcctg tctaggctcc tagctttgtt tccacaggta tctcttccat
     2281 ggttgctgtt tgctgcagac aacaggccca gaacaaaagc aaaatggcag gctcccacga
     2341 ctgtccccat ggaggcctgt gtaagtgagc aagagatgga tccaaggaag gttttggttg
     2401 gacccaaatc aaaaactcat cggactgctg ttcacgagcc acatgcctgc gaggagagac
     2461 cgtgatttct aactactgaa caataagcct ttgatcagac ttaataaaga gtcatttccg
     2521 tgttaaaa
//
