LOCUS       NP_032515                481 aa            linear   ROD 11-FEB-2025
DEFINITION  lipopolysaccharide-binding protein precursor [Mus musculus].
ACCESSION   NP_032515
VERSION     NP_032515.2
DBSOURCE    REFSEQ: accession NM_008489.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 481)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 481)
  AUTHORS   Chen,J., Zhang,X., DeLaughter,D.M., Trembley,M.A., Saifee,S.,
            Xiao,F., Chen,J., Zhou,P., Seidman,C.E., Seidman,J.G. and Pu,W.T.
  TITLE     Molecular and Spatial Signatures of Mouse Embryonic Endothelial
            Cells at Single-Cell Resolution
  JOURNAL   Circ Res 134 (5), 529-546 (2024)
   PUBMED   38348657
REFERENCE   3  (residues 1 to 481)
  AUTHORS   Chen,H.J., Galley,J.D., Verosky,B.G., Yang,F.T., Rajasekera,T.A.,
            Bailey,M.T. and Gur,T.L.
  TITLE     Fetal CCL2 signaling mediates offspring social behavior and
            recapitulates effects of prenatal stress
  JOURNAL   Brain Behav Immun 115, 308-318 (2024)
   PUBMED   37914098
REFERENCE   4  (residues 1 to 481)
  AUTHORS   Xie,L., Qiu,S., Lu,C., Gu,C., Wang,J., Lv,J., Fang,L., Chen,Z.,
            Li,Y., Jiang,T., Xia,Y., Wang,W., Li,B. and Xu,Z.
  TITLE     Gastric cancer-derived LBP promotes liver metastasis by driving
            intrahepatic fibrotic pre-metastatic niche formation
  JOURNAL   J Exp Clin Cancer Res 42 (1), 258 (2023)
   PUBMED   37789385
  REMARK    GeneRIF: Gastric cancer-derived LBP promotes liver metastasis by
            driving intrahepatic fibrotic pre-metastatic niche formation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 481)
  AUTHORS   Yin,X., Xu,Z., Zhang,X., Wu,J. and Lu,W.
  TITLE     Deficiency of lipopolysaccharide binding protein facilitates
            adipose browning, glucose uptake and oxygen consumption in mouse
            embryonic fibroblasts via activating PI3K/Akt/mTOR pathway and
            inhibiting autophagy
  JOURNAL   Cell Cycle 22 (8), 967-985 (2023)
   PUBMED   36710409
  REMARK    GeneRIF: Deficiency of lipopolysaccharide binding protein
            facilitates adipose browning, glucose uptake and oxygen consumption
            in mouse embryonic fibroblasts via activating PI3K/Akt/mTOR pathway
            and inhibiting autophagy.
REFERENCE   6  (residues 1 to 481)
  AUTHORS   Lengacher,S., Reed,D., Heumann,D. and Jongeneel,C.V.
  TITLE     Genomic organization and chromosomal localization of the mouse
            lipopolysaccharide binding protein gene
  JOURNAL   Immunogenetics 49 (6), 553-556 (1999)
   PUBMED   10380702
REFERENCE   7  (residues 1 to 481)
  AUTHORS   Ulevitch,R.J. and Tobias,P.S.
  TITLE     Recognition of gram-negative bacteria and endotoxin by the innate
            immune system
  JOURNAL   Curr Opin Immunol 11 (1), 19-22 (1999)
   PUBMED   10047547
  REMARK    Review article
REFERENCE   8  (residues 1 to 481)
  AUTHORS   Wurfel,M.M., Monks,B.G., Ingalls,R.R., Dedrick,R.L., Delude,R.,
            Zhou,D., Lamping,N., Schumann,R.R., Thieringer,R., Fenton,M.J.,
            Wright,S.D. and Golenbock,D.
  TITLE     Targeted deletion of the lipopolysaccharide (LPS)-binding protein
            gene leads to profound suppression of LPS responses ex vivo,
            whereas in vivo responses remain intact
  JOURNAL   J Exp Med 186 (12), 2051-2056 (1997)
   PUBMED   9396775
REFERENCE   9  (residues 1 to 481)
  AUTHORS   Jack,R.S., Fan,X., Bernheiden,M., Rune,G., Ehlers,M., Weber,A.,
            Kirsch,G., Mentel,R., Furll,B., Freudenberg,M., Schmitz,G.,
            Stelter,F. and Schutt,C.
  TITLE     Lipopolysaccharide-binding protein is required to combat a murine
            gram-negative bacterial infection
  JOURNAL   Nature 389 (6652), 742-745 (1997)
   PUBMED   9338787
REFERENCE   10 (residues 1 to 481)
  AUTHORS   Lengacher,S., Jongeneel,C.V., Le Roy,D., Lee,J.D., Kravchenko,V.,
            Ulevitch,R.J., Glauser,M.P. and Heumann,D.
  TITLE     Reactivity of murine and human recombinant LPS-binding protein
            (LBP) within LPS and gram negative bacteria
  JOURNAL   J Inflamm 47 (4), 165-172 (1995)
   PUBMED   9144073
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143562.1, AA207419.1, BQ176753.1, AL663063.14 and AI643881.1.
            
            On Sep 1, 2006 this sequence version replaced NP_032515.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X99347.1, BC004795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.72 cM"
     Protein         1..481
                     /product="lipopolysaccharide-binding protein precursor"
                     /calculated_mol_wt=50685
     sig_peptide     1..24
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61805.2)"
                     /calculated_mol_wt=2389
     mat_peptide     25..481
                     /product="Lipopolysaccharide-binding protein.
                     /id=PRO_0000017159"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61805.2)"
                     /calculated_mol_wt=50685
     Region          29..252
                     /region_name="BPI1"
                     /note="BPI/LBP/CETP N-terminal domain; Bactericidal
                     permeability-increasing protein (BPI) /
                     Lipopolysaccharide-binding protein (LBP) / Cholesteryl
                     ester transfer protein (CETP) N-terminal domain; binds to
                     and neutralizes lipopolysaccharides from the outer...;
                     cd00025"
                     /db_xref="CDD:237992"
     Site            29..35
                     /site_type="other"
                     /note="BPI dimerizatation interface [polypeptide binding]"
                     /db_xref="CDD:237992"
     Site            order(34,39,42,46,49,101,142,144,154,201,205,209,243)
                     /site_type="active"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:237992"
     Region          241..478
                     /region_name="LBP_BPI_CETP_C"
                     /note="LBP / BPI / CETP family, C-terminal domain;
                     pfam02886"
                     /db_xref="CDD:397154"
     Site            order(277..281,461..466,472..477)
                     /site_type="other"
                     /note="BPI dimerization interface [polypeptide binding]"
                     /db_xref="CDD:237993"
     Site            order(281,286,289,293,296,356,389,391,400,436,440,444,448,
                     470)
                     /site_type="active"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:237993"
     Site            300
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61805.2)"
     Site            355
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61805.2)"
     CDS             1..481
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /coded_by="NM_008489.2:178..1623"
                     /db_xref="CCDS:CCDS16988.1"
                     /db_xref="GeneID:16803"
                     /db_xref="MGI:MGI:1098776"
ORIGIN      
        1 mkagtgplls tllgllflsi qgtggvnpgv varitdkgla yaakeglval qrelykitlp
       61 dfsgdfkika vgrgqyefhs leiqncelrg sslkllpgqg lslaisdssi gvrgkwkvrk
      121 sflklhgsfd ldvkgvtisv dlllgmdpsg rptvsasgcs sricdldvhi sgnvgwllnl
      181 fhnqiesklq kvlenkvcem iqksvtsdlq pylqtlpvta eidnvlgidy slvaapqaka
      241 qvldvmfkge ifnrnhrspv atptptmslp edskqmvyfa isdyafnias rvyhqagyln
      301 fsitddmlph dsgirlntka frpftpqiyk kypdmklell gtvvsapiln vspgnlslap
      361 qmeiegfvil ptsarepvfr lgvvtnvfas ltfnnskvtg mlhpdkaqvr lieskvgmfn
      421 vnlfqaflny yllnslypdv naelaqgfpl plprhiqlhd ldfqirkdfl ylganvqymr
      481 v
//
