LOCUS       NM_029999               3068 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus limb-bud and heart (Lbh), mRNA.
ACCESSION   NM_029999 XM_979734 XM_980498
VERSION     NM_029999.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3068)
  AUTHORS   Dai,W., Guo,Y., Shen,Z., Wang,J., Lu,L., Dong,H. and Cai,X.
  TITLE     Identification of LBH and SPP1 involved in hepatic stellate cell
            activation during liver fibrogenesis
  JOURNAL   Hum Cell 36 (3), 1054-1067 (2023)
   PUBMED   36917392
  REMARK    GeneRIF: Identification of LBH and SPP1 involved in hepatic
            stellate cell activation during liver fibrogenesis.
REFERENCE   2  (bases 1 to 3068)
  AUTHORS   Wu,A., Luo,N., Xu,Y., Du,N., Li,L. and Liu,Q.
  TITLE     Exosomal LBH inhibits epithelial-mesenchymal transition and
            angiogenesis in nasopharyngeal carcinoma via downregulating VEGFA
            signaling
  JOURNAL   Int J Biol Sci 18 (1), 242-260 (2022)
   PUBMED   34975330
  REMARK    GeneRIF: Exosomal LBH inhibits epithelial-mesenchymal transition
            and angiogenesis in nasopharyngeal carcinoma via downregulating
            VEGFA signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3068)
  AUTHORS   Liu,H., Giffen,K.P., Grati,M., Morrill,S.W., Li,Y., Liu,X.,
            Briegel,K.J. and He,D.Z.
  TITLE     Transcription co-factor LBH is necessary for the survival of
            cochlear hair cells
  JOURNAL   J Cell Sci 134 (7) (2021)
   PUBMED   33674448
  REMARK    GeneRIF: Transcription co-factor LBH is necessary for the survival
            of cochlear hair cells.
REFERENCE   4  (bases 1 to 3068)
  AUTHORS   Wang,Y., Shi,Y., Zhang,X., Fu,J. and Chen,F.
  TITLE     Overexpression of Limb Bud and Heart Alleviates Sepsis-Induced
            Acute Lung Injury via Inhibiting the NLRP3 Inflammasome
  JOURNAL   Biomed Res Int 2021, 4084371 (2021)
   PUBMED   33553423
  REMARK    GeneRIF: Overexpression of Limb Bud and Heart Alleviates
            Sepsis-Induced Acute Lung Injury via Inhibiting the NLRP3
            Inflammasome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3068)
  AUTHORS   Ashad-Bishop,K., Garikapati,K., Lindley,L.E., Jorda,M. and
            Briegel,K.J.
  TITLE     Loss of Limb-Bud-and-Heart (LBH) attenuates mammary hyperplasia and
            tumor development in MMTV-Wnt1 transgenic mice
  JOURNAL   Biochem Biophys Res Commun 508 (2), 536-542 (2019)
   PUBMED   30509497
  REMARK    GeneRIF: LBH plays an essential role in WNT-induced mammary
            tumorigenesis by promoting hyperplastic growth and tumor formation.
REFERENCE   6  (bases 1 to 3068)
  AUTHORS   Conen,K.L., Nishimori,S., Provot,S. and Kronenberg,H.M.
  TITLE     The transcriptional cofactor Lbh regulates angiogenesis and
            endochondral bone formation during fetal bone development
  JOURNAL   Dev Biol 333 (2), 348-358 (2009)
   PUBMED   19607824
  REMARK    GeneRIF: during endochondral bone formation, Lbh may negatively
            regulate vascular invasion and formation of the early ossification
            center at least in part by interfering with Runx2 and/or VEGF
            expression
REFERENCE   7  (bases 1 to 3068)
  AUTHORS   Hoogaars,W.M., Engel,A., Brons,J.F., Verkerk,A.O., de Lange,F.J.,
            Wong,L.Y., Bakker,M.L., Clout,D.E., Wakker,V., Barnett,P.,
            Ravesloot,J.H., Moorman,A.F., Verheijck,E.E. and Christoffels,V.M.
  TITLE     Tbx3 controls the sinoatrial node gene program and imposes
            pacemaker function on the atria
  JOURNAL   Genes Dev 21 (9), 1098-1112 (2007)
   PUBMED   17473172
REFERENCE   8  (bases 1 to 3068)
  AUTHORS   Briegel,K.J., Baldwin,H.S., Epstein,J.A. and Joyner,A.L.
  TITLE     Congenital heart disease reminiscent of partial trisomy 2p syndrome
            in mice transgenic for the transcription factor Lbh
  JOURNAL   Development 132 (14), 3305-3316 (2005)
   PUBMED   15958514
  REMARK    Erratum:[Development. 2005 Sep;132(17):4015]
REFERENCE   9  (bases 1 to 3068)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   10 (bases 1 to 3068)
  AUTHORS   Briegel,K.J. and Joyner,A.L.
  TITLE     Identification and characterization of Lbh, a novel conserved
            nuclear protein expressed during early limb and heart development
  JOURNAL   Dev Biol 233 (2), 291-304 (2001)
   PUBMED   11336496
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK020110.1, BC052470.1 and AK007400.1.
            
            On Jun 13, 2009 this sequence version replaced NM_029999.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK020110.1, BC052470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-691               AK020110.1         1-691
            692-2768            BC052470.1         672-2748
            2769-3068           AK007400.1         1233-1532
FEATURES             Location/Qualifiers
     source          1..3068
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 44.73 cM"
     gene            1..3068
                     /gene="Lbh"
                     /gene_synonym="1810009F10Rik; 6720416L16Rik"
                     /note="limb-bud and heart"
                     /db_xref="GeneID:77889"
                     /db_xref="MGI:MGI:1925139"
     exon            1..274
                     /gene="Lbh"
                     /gene_synonym="1810009F10Rik; 6720416L16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..566
                     /gene="Lbh"
                     /gene_synonym="1810009F10Rik; 6720416L16Rik"
                     /note="limb bud and heart-expressed protein"
                     /codon_start=1
                     /product="protein LBH"
                     /protein_id="NP_084275.3"
                     /db_xref="CCDS:CCDS28964.1"
                     /db_xref="GeneID:77889"
                     /db_xref="MGI:MGI:1925139"
                     /translation="MSVYFPIHCSDYLRSAEMTEVMMNAPSMEEIGLSPRKDGLSYQI
                     FPDPSDFDRCCKLKDRLPSIVVEPTEGEVESGELRWPPEEFLVQEDEQDNCEETTNEK
                     KDQ"
     exon            275..377
                     /gene="Lbh"
                     /gene_synonym="1810009F10Rik; 6720416L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            378..3068
                     /gene="Lbh"
                     /gene_synonym="1810009F10Rik; 6720416L16Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacccggag atcggtggag agcggagagc ttggtctgca ctgcctacgc cgttggcagc
       61 gaggctgtct ccggaaggcg gaccggcgct agcccagtac ccgctctcgg ctgcccgctg
      121 ctctcctctg cgcccctgcc aatctcattc aggactcagt gactggtttt tttttgtttg
      181 tttgtttgtt ttgttttgtt ttgtttttct taatcacaag ggcgtgggtc agcctcccct
      241 aggacttcat gtctgtatat ttccccattc actgctctga ctatctgaga tcggctgaga
      301 tgaccgaggt gatgatgaac gctccatcca tggaagagat tggtctcagc ccccgcaagg
      361 atggcctttc ctatcagatc tttccggacc catcagactt tgaccgttgc tgcaagctga
      421 aggaccgcct gccctccata gtggtggaac ccactgaagg ggaggtggaa agcggggagc
      481 tccggtggcc tcctgaggaa ttcctggtcc aggaggatga gcaagacaac tgtgaagaga
      541 caacaaatga aaagaaggac cagtagagtc cacgcaggct cgcctgggtc atgccagcca
      601 gcacacctga actgtttttc ccatggtgat ggaagaagag aatgagccac agtcattgtg
      661 aaaatgtcaa acgaggcttc cgttttgcac ctgaaaatca ccgagtcggt tttcttttct
      721 tcttcttttt tttttttttt tttttttttg gtttgttttt aaattcgttg agcaatggag
      781 ccctctgaca acttgcaagg ctgagaaagg aagttgctga gaacaggggt ggaggggggg
      841 gtggggggaa ggggtgctgc ttcgaagatc cctatctgaa ctctagtgcc agaggcagtg
      901 cgtgcacatg tgtgtgtgtg ggggggggtg cagttcgggc tgagggggtg agcaaatgag
      961 caagaaagat tttggattag aagaagaaca acaacaacaa caaaacaaaa caaaacaaac
     1021 tctacacttt taaagagaac tacagccagg aagtgctgct ctttccagca tttgtcctgg
     1081 ctactggggc atctgacaac caagtcctta tctcctgctc tgttgctcac agccaccagc
     1141 ctttgttttc atttcaagtg tgtttggtca cccacagaga agtcgggcca ggtaaactgc
     1201 ctaggaagcc agatggaggg atacagagga aaggaagact ccaccaccat tccccagatg
     1261 cttcaggctg tcagagtccc cagggacctg ggaggcttta agacatagta cttttgagtt
     1321 tttctcccta tttaccccct tctgcctccc agtatataag gggaacagcc agagcacttc
     1381 ctgcccttgt gaggcactcc aaggctgcag cctgaatagg gagtgcctcc tcccacggtg
     1441 gatctcccaa gaattcttat gtaatctcta tggagcagga gggtagaagt gtcggctttc
     1501 tcaggcctgc ccttcctttc tcctttggcc acagcagtca ggtggacggt ccccagctat
     1561 gctgtggcct gtcactgttc atctgacctg cagcagggcc actccaatgg gtttcccagc
     1621 ccggcttcca tgggcgctaa aagcagagtg tgcttcttgg ttgggaagct ggctagcggg
     1681 cttccatgca ggggcctggg tggtgccgca ttgattccca tgtgggaatc agccctccag
     1741 tggagcagct gtggcatcca gtttgagaca gtagctgttg tgagatcacg gcttctcctc
     1801 ttgttgctcc tgagcacagg ttgggagaag atacagggtg tgctggagta tccttgtaga
     1861 atagcagcct ttattccttc cccactttac ctgtctctgg aaagggcagc agttgcatgg
     1921 ggaaattaac atttggattt agctctgatc atagctcaga accttctgga atagcgggtt
     1981 agaggacaga atttttagag cagggctgtt tggtcaagag gtggacttaa agccttcctt
     2041 aggcttcact tagccaacca aggcactcac aaatgtcccc tcacgtctct tgtcagtcca
     2101 ggttgacccc cgtctttgga ctcgtttgtc tggttctatt taatacctca aagtcagtgt
     2161 ggctctgggc cacgttgggg caagagcgtg gggggtgtgc tgttgacacg gcattcagca
     2221 aggtttggtt ctgggatgcc gatggtcacc ccctcccccg tctcttccct ctgtcgtctg
     2281 cctgtgatac acaccgatgg caataacttt tttccggctc cttgcagaag tgggagaggg
     2341 ctgcagccaa ccctgcaacc agagagcttc tctctctctt gcttccactc tgctctgttt
     2401 tggctacaga gatctgttca tcccactcct gttcccccgc agcgtttctc atccctcgcc
     2461 tccctttatg gacaggtgtc tggcctttta aattcccgtg ttgtggtgtc ttctcatccc
     2521 taccccagtt atctgtcttg gtcttgccgt gtgatgggat gtgcttgtaa atccagtatc
     2581 aaatcagctt tgtgtatatg tgtgtctctg gggtggcttc ttccttttgc tggtcactag
     2641 actgtgttga acaaccatgt gctgtctgag caggtcaggg gctgaccgct acaggcccct
     2701 cagcggttga gcctgttggg gggacccagc tgctcttgga caagtggctg agctcctgtc
     2761 tggcctcctc ttttcctcct cctcctcctc ctcctcctcc tcctcctcct cctcctcctc
     2821 ctcctcttcc tcttccttct cttcttcctt gtcttcctcc tcctctttct ttaagtaatt
     2881 tgtgtgtatt tctaactgat cgtattgaaa aaaaaatcct agtatttcag tgacatgcct
     2941 gttgtgagat gaacctcctg tgacttctgt ctgttctgta ttgaggctca gggagaaact
     3001 agcatttttt tttccaaact actttttgtc actgtgacag ttgtaaataa agtttgaaaa
     3061 tgctttcc
//
