LOCUS       NM_001033534            1786 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus layilin (Layn), mRNA.
ACCESSION   NM_001033534 XM_146887 XM_917279
VERSION     NM_001033534.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1786)
  AUTHORS   Mehta,P., Gouirand,V., Boda,D.P., Zhang,J., Gearty,S.V., Zirak,B.,
            Lowe,M.M., Clancy,S., Boothby,I., Mahuron,K.M., Fries,A.,
            Krummel,M.F., Mankoo,P., Chang,H.W., Liu,J., Moreau,J.M.,
            Scharschmidt,T.C., Daud,A., Kim,E., Neuhaus,I.M., Harris,H.W.,
            Liao,W. and Rosenblum,M.D.
  TITLE     Layilin Anchors Regulatory T Cells in Skin
  JOURNAL   J Immunol 207 (7), 1763-1775 (2021)
   PUBMED   34470859
  REMARK    GeneRIF: Layilin Anchors Regulatory T Cells in Skin.
REFERENCE   2  (bases 1 to 1786)
  AUTHORS   Mahuron,K.M., Moreau,J.M., Glasgow,J.E., Boda,D.P., Pauli,M.L.,
            Gouirand,V., Panjabi,L., Grewal,R., Luber,J.M., Mathur,A.N.,
            Feldman,R.M., Shifrut,E., Mehta,P., Lowe,M.M., Alvarado,M.D.,
            Marson,A., Singer,M., Wells,J., Jupp,R., Daud,A.I. and
            Rosenblum,M.D.
  TITLE     Layilin augments integrin activation to promote antitumor immunity
  JOURNAL   J Exp Med 217 (9) (2020)
   PUBMED   32539073
  REMARK    GeneRIF: Layilin augments integrin activation to promote antitumor
            immunity.
REFERENCE   3  (bases 1 to 1786)
  AUTHORS   Kim,Y., West,G.A., Ray,G., Kessler,S.P., Petrey,A.C., Fiocchi,C.,
            McDonald,C., Longworth,M.S., Nagy,L.E. and de la Motte,C.A.
  TITLE     Layilin is critical for mediating hyaluronan 35kDa-induced
            intestinal epithelial tight junction protein ZO-1 in vitro and in
            vivo
  JOURNAL   Matrix Biol 66, 93-109 (2018)
   PUBMED   28978412
REFERENCE   4  (bases 1 to 1786)
  AUTHORS   Adachi,T., Arito,M., Suematsu,N., Kamijo-Ikemori,A., Omoteyama,K.,
            Sato,T., Kurokawa,M.S., Okamoto,K., Kimura,K., Shibagaki,Y. and
            Kato,T.
  TITLE     Roles of layilin in TNF-alpha-induced epithelial-mesenchymal
            transformation of renal tubular epithelial cells
  JOURNAL   Biochem Biophys Res Commun 467 (1), 63-69 (2015)
   PUBMED   26410531
  REMARK    GeneRIF: LAYN is involved in the TNF-alpha-induced
            epithelial-mesenchymal transformation (EMT) of renal tubular
            epithelial cells.
REFERENCE   5  (bases 1 to 1786)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 1786)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   7  (bases 1 to 1786)
  AUTHORS   Wegener,K.L., Basran,J., Bagshaw,C.R., Campbell,I.D., Roberts,G.C.,
            Critchley,D.R. and Barsukov,I.L.
  TITLE     Structural basis for the interaction between the cytoplasmic domain
            of the hyaluronate receptor layilin and the talin F3 subdomain
  JOURNAL   J Mol Biol 382 (1), 112-126 (2008)
   PUBMED   18638481
  REMARK    GeneRIF: The structure of the talin/layilin complex, which shows
            that talin binds integrins, PIPK1gamma and layilin in similar
            although subtly different ways, is reported.
REFERENCE   8  (bases 1 to 1786)
  AUTHORS   Bono,P., Cordero,E., Johnson,K., Borowsky,M., Ramesh,V., Jacks,T.
            and Hynes,R.O.
  TITLE     Layilin, a cell surface hyaluronan receptor, interacts with merlin
            and radixin
  JOURNAL   Exp Cell Res 308 (1), 177-187 (2005)
   PUBMED   15913605
REFERENCE   9  (bases 1 to 1786)
  AUTHORS   Borowsky,M.L. and Hynes,R.O.
  TITLE     Layilin, a novel talin-binding transmembrane protein homologous
            with C-type lectins, is localized in membrane ruffles
  JOURNAL   J Cell Biol 143 (2), 429-442 (1998)
   PUBMED   9786953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119831.6.
            
            On or before Apr 19, 2009 this sequence version replaced
            XM_917279.3, XM_146887.7.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.1329978.1,
                                           SRR17253012.3622919.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC119831.6         71708-71916         c
            210-233             AC119831.6         71144-71167         c
            234-531             AC119831.6         68670-68967         c
            532-689             AC119831.6         62861-63018         c
            690-725             AC119831.6         58059-58094         c
            726-809             AC119831.6         57005-57088         c
            810-909             AC119831.6         54279-54378         c
            910-1786            AC119831.6         51602-52478         c
FEATURES             Location/Qualifiers
     source          1..1786
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 27.79 cM"
     gene            1..1786
                     /gene="Layn"
                     /gene_synonym="E030012M19Rik; Gm511"
                     /note="layilin"
                     /db_xref="GeneID:244864"
                     /db_xref="MGI:MGI:2685357"
     exon            1..209
                     /gene="Layn"
                     /gene_synonym="E030012M19Rik; Gm511"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1270
                     /gene="Layn"
                     /gene_synonym="E030012M19Rik; Gm511"
                     /codon_start=1
                     /product="layilin precursor"
                     /protein_id="NP_001028706.1"
                     /db_xref="CCDS:CCDS52791.1"
                     /db_xref="GeneID:244864"
                     /db_xref="MGI:MGI:2685357"
                     /translation="MQPGAALQAMLLAVLLAKPRDSKGRLLSASDLDPRGGQLVCRGG
                     TRRPCYKVIYFHDAFQRLNFEEAKETCMEDGGQLVSIETEDEQRLIEKFIENLLASDG
                     DFWIGLKRLEEKQSNNTACQDLYAWTDGSTSQFRNWYVDEPSCGSEVCVVMYHQPSAP
                     PGIGGSYMFQWNDDRCNMKNNFICKYHDDKPSTTPSIWPGGEATEPATPLLPEETQKE
                     DTKETFKERREAALNLAYILIPSIPLFLLLVVTSAVCWVWICRRKREQTDPSTKEQHT
                     IWPTPRQENSPNLDVYNVIRKQSEADLAEPRPDLKNISFRVCSGEAMPDDMSCDYENI
                     AVNPSESGFVTLASMESGFVTNDIYEFSPDRMGRSKESGWVENEIYY"
     exon            210..233
                     /gene="Layn"
                     /gene_synonym="E030012M19Rik; Gm511"
                     /inference="alignment:Splign:2.1.0"
     exon            234..531
                     /gene="Layn"
                     /gene_synonym="E030012M19Rik; Gm511"
                     /inference="alignment:Splign:2.1.0"
     exon            532..689
                     /gene="Layn"
                     /gene_synonym="E030012M19Rik; Gm511"
                     /inference="alignment:Splign:2.1.0"
     exon            690..725
                     /gene="Layn"
                     /gene_synonym="E030012M19Rik; Gm511"
                     /inference="alignment:Splign:2.1.0"
     exon            726..809
                     /gene="Layn"
                     /gene_synonym="E030012M19Rik; Gm511"
                     /inference="alignment:Splign:2.1.0"
     exon            810..909
                     /gene="Layn"
                     /gene_synonym="E030012M19Rik; Gm511"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1786
                     /gene="Layn"
                     /gene_synonym="E030012M19Rik; Gm511"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1761..1766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Layn"
                     /gene_synonym="E030012M19Rik; Gm511"
                     /note="hexamer: AATAAA"
     polyA_site      1786
                     /gene="Layn"
                     /gene_synonym="E030012M19Rik; Gm511"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggggt ctgtggatcc ttgggagatg cagctgcctt ggttgcagtt gctcaaacgc
       61 agtcgtctac ttgcccactt ctctgcctta gtcccagggt gtcgggaggc actggagtcc
      121 agccatgcag ccgggagcag cgctgcaggc tatgttgctg gcggtgctgc tggccaaacc
      181 gagggattcg aagggtcgcc tgctgagcgc ctcggacttg gaccccagag gagggcagct
      241 ggtctgccga ggaggaacac ggaggccttg ctataaagtc atttatttcc atgacgcctt
      301 tcaaagactg aactttgagg aagccaaaga aacctgcatg gaggatgggg gacagctcgt
      361 cagcattgag acagaggatg agcagaggtt gatagaaaag ttcattgaaa acctcctggc
      421 atctgatggt gacttctgga ttggcctcaa gaggctggag gagaaacaga gcaataacac
      481 agcctgccag gacctttatg cttggacaga tggaagcaca tcacagttta ggaactggta
      541 tgtggatgag ccttcctgtg gcagtgaggt ctgcgtggtc atgtaccatc agccatcagc
      601 accacccggc atcgggggct cgtacatgtt ccagtggaat gatgaccggt gcaacatgaa
      661 gaacaatttc atttgcaaat atcatgacga taaaccaagt acaacaccct ctatttggcc
      721 tggaggtgaa gcaactgagc cagcaacacc cttacttcca gaagaaacac agaaagaaga
      781 caccaaagaa acatttaaag aacgaagaga ggctgctttg aatcttgcct acatcctaat
      841 tcccagtatt ccccttttcc tcctacttgt ggtcacttca gctgtatgtt gggtttggat
      901 ctgtagaaga aaacgagaac agacagaccc tagcacaaag gagcagcaca ccatttggcc
      961 cactcctcgc caagaaaaca gccccaacct agatgtttac aatgtcatca gaaaacaaag
     1021 tgaagctgat ttagctgagc cccggccaga cctgaagaac atctccttcc gggtgtgttc
     1081 tggggaagct atgcctgatg acatgtcttg tgactatgaa aacattgctg tgaacccttc
     1141 ggaaagtggg tttgtgactt tggcaagtat ggagagtgga tttgtgacca atgacatcta
     1201 tgaattctcc ccggaccgaa tggggaggag caaggagagt ggatgggtag aaaatgaaat
     1261 atattactaa gacacaggaa aaacctggca agaatgcaaa aggagaagca aaggcctccg
     1321 atttcttaca aggacaatat tcagaaagct tatgaaaatg cccagctcag tcttaggggc
     1381 aagcacagca tcacaagtcc ctactgggtc cccaagttct ggctgtactt cttatctgag
     1441 ggcctcatcc tgctgagcct tctgagaagg cactttgccc aggggctgct gcacagcaga
     1501 ctcagtgatt gtcagccagt ggcttctaac tgatatctga gggctggtgc tttcactgct
     1561 cagcatgaag ggctgaccag ggagcttgga aagcccacct ctaggttctg ttttccttgc
     1621 tctatacagc agcacaggca atcacaaaaa cacaaactgt ggaatcctct caaagcctct
     1681 gtatggatgc ctcaggctgg cctgcacatc aataattaat tcccaaacct gcacccccac
     1741 cccgcccctg aaaaatatcc aataaaaagc aggaagtaga atgtta
//
