LOCUS       NM_001159649            2371 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus lymphocyte transmembrane adaptor 1 (Lax1), transcript
            variant 1, mRNA.
ACCESSION   NM_001159649
VERSION     NM_001159649.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2371)
  AUTHORS   Arndt,B., Kalinski,T., Reinhold,D., Thielitz,A., Roessner,A.,
            Schraven,B. and Simeoni,L.
  TITLE     Cooperative immunoregulatory function of the transmembrane adaptor
            proteins SIT and LAX
  JOURNAL   J Leukoc Biol 93 (3), 353-362 (2013)
   PUBMED   23307938
  REMARK    GeneRIF: SIT and LAX are important negative regulators of immune
            responses that functionally cooperate.
REFERENCE   2  (bases 1 to 2371)
  AUTHORS   Sancho-Shimizu,V., Khan,R., Mostowy,S., Lariviere,L., Wilkinson,R.,
            Riendeau,N., Behr,M. and Malo,D.
  TITLE     Molecular genetic analysis of two loci (Ity2 and Ity3) involved in
            the host response to infection with Salmonella typhimurium using
            congenic mice and expression profiling
  JOURNAL   Genetics 177 (2), 1125-1139 (2007)
   PUBMED   17660555
REFERENCE   3  (bases 1 to 2371)
  AUTHORS   Zhu,M., Rhee,I., Liu,Y. and Zhang,W.
  TITLE     Negative regulation of Fc epsilonRI-mediated signaling and mast
            cell function by the adaptor protein LAX
  JOURNAL   J Biol Chem 281 (27), 18408-18413 (2006)
   PUBMED   16672218
  REMARK    GeneRIF: LAX negatively regulates mast cell function
REFERENCE   4  (bases 1 to 2371)
  AUTHORS   Zhu,M., Granillo,O., Wen,R., Yang,K., Dai,X., Wang,D. and Zhang,W.
  TITLE     Negative regulation of lymphocyte activation by the adaptor protein
            LAX
  JOURNAL   J Immunol 174 (9), 5612-5619 (2005)
   PUBMED   15843560
  REMARK    GeneRIF: Upon T or B cell activation, the LAX protein is
            up-regulated dramatically. This in vivo study of LAX-deficient mice
            demonstrates that LAX functions as a negative regulator in
            lymphocyte signaling.
REFERENCE   5  (bases 1 to 2371)
  AUTHORS   Zhu,M., Janssen,E., Leung,K. and Zhang,W.
  TITLE     Molecular cloning of a novel gene encoding a membrane-associated
            adaptor protein (LAX) in lymphocyte signaling
  JOURNAL   J Biol Chem 277 (48), 46151-46158 (2002)
   PUBMED   12359715
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124338.11 and AY090785.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040834.1, AK088503.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               AC124338.11        28934-29233
            301-380             AC124338.11        30038-30117
            381-1768            AY090785.1         9-1396
            1769-2371           AC124338.11        39411-40013
FEATURES             Location/Qualifiers
     source          1..2371
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.95 cM"
     gene            1..2371
                     /gene="Lax1"
                     /gene_synonym="A530029E09; E430019B13Rik"
                     /note="lymphocyte transmembrane adaptor 1"
                     /db_xref="GeneID:240754"
                     /db_xref="MGI:MGI:2443362"
     exon            1..300
                     /gene="Lax1"
                     /gene_synonym="A530029E09; E430019B13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            301..484
                     /gene="Lax1"
                     /gene_synonym="A530029E09; E430019B13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             399..1622
                     /gene="Lax1"
                     /gene_synonym="A530029E09; E430019B13Rik"
                     /note="linker for activation of X cells;
                     membrane-associated adapter protein LAX"
                     /codon_start=1
                     /product="lymphocyte transmembrane adapter 1"
                     /protein_id="NP_001153121.1"
                     /db_xref="CCDS:CCDS35711.1"
                     /db_xref="GeneID:240754"
                     /db_xref="MGI:MGI:2443362"
                     /translation="MYSTPAPPEVTRRNSEPSTRQGTLGSLQGEKGQIIFPGFVVLLT
                     IILVIIAACILWSWKKQKKRPVPYFQVAPSLTLPPPRHRAKNIYDFLPRQQTELGRHQ
                     LSGFSTESLLSRASDSPEPEAPQANGSLQMHRVSVHTVEYSVNIYDNGTVPQMCRHLA
                     SSTHHVCVRTSRSNPSISSKESNDYVNIPTVEDTCETLTRIESTPENHLGLPSALRLE
                     FAEGGHAGCGNATDHDGFWAPGPKCSDSLSDGDDLSQTSNDYVNMTGLDLENIQENRP
                     RGAFQCCRDYENVPWVDTNESQLPTLEEVASSTVDHREPVWRTLSSVYHMAFQPSAQS
                     EDSAMVHREEQSSEDSSDYETVLVAELEGRDWKQGPGTQHPSDEGTPGDLAGKLCEVV
                     YPAGSLATETSDEDA"
     exon            485..588
                     /gene="Lax1"
                     /gene_synonym="A530029E09; E430019B13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            589..693
                     /gene="Lax1"
                     /gene_synonym="A530029E09; E430019B13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            694..764
                     /gene="Lax1"
                     /gene_synonym="A530029E09; E430019B13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            765..2371
                     /gene="Lax1"
                     /gene_synonym="A530029E09; E430019B13Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagcgact ttccattctg ccagagtggt ttgctgtttt cacactgccc tgggggttgg
       61 aggaagaaga ttttctcacg aaaacgctgg gcctcttgac agtcgcctcc ctactccccc
      121 acaggcccct catgtttcca tcaactggca gaaactagag agtggcccta ctgcttcaca
      181 ctgggagcac agacagctgg gtgagaaaga gcacggctcc tgcagtgggc attgtggcca
      241 cctccagtag accaactctg atgaaccttc taccaactca gcctggaatt tcaggtgaag
      301 caacttagaa agagctaaga aaagtggaag ccatactggc tagtcagtca cgacactgaa
      361 aaggcttaga agctgcaaag cccctcagag gtccagtgat gtacagcacc ccggcccctc
      421 cagaggtcac aagaaggaac tcagagccca gcactcggca ggggactctt ggcagcctgc
      481 agggagagaa aggccagatc atcttccctg gctttgtcgt gctcctgacc atcatcctgg
      541 tcatcatagc tgcctgtatc ctgtggagct ggaagaaaca gaagaagcgg cctgttcctt
      601 acttccaagt agctccatcg ttgactctgc ctccacccag acatcgagcc aaaaatattt
      661 atgacttctt gccccggcag cagacagagc tggggagaca tcagttgagt ggtttcagta
      721 ccgagagcct cctctccaga gcatctgaca gccctgagcc tgaggccccc caagccaatg
      781 gttcccttca gatgcataga gtgtccgttc atactgtgga gtattcagta aacatctatg
      841 acaatggcac agtgccccag atgtgcaggc acctggcctc ctcaacacat catgtctgtg
      901 tcagaacttc cagaagtaac cccagcattt cttccaagga gtcaaatgat tatgtcaata
      961 tccccacagt agaggacacc tgtgagactc taactcgcat agaaagcact cctgaaaatc
     1021 accttggtct tccaagtgcc ctgcggctgg agtttgctga aggagggcat gcaggctgtg
     1081 ggaatgccac ggaccacgat ggtttttggg ctccaggacc caagtgcagt gattcactca
     1141 gcgacggaga cgatttatct cagacttcaa atgactacgt caatatgaca gggttggatc
     1201 ttgagaacat ccaagagaat cgacccaggg gagcttttca gtgctgcaga gattatgaaa
     1261 atgtcccatg ggtagatacc aatgagagcc agctgccgac tctggaagaa gtggcatcgt
     1321 caactgtaga ccacagggaa cctgtctgga ggaccctctc ttcagtgtat catatggcat
     1381 ttcagccgtc ggcacagagt gaggacagtg ccatggtcca tagagaagag cagtcaagcg
     1441 aagactccag tgactatgag actgtgctgg ttgctgagtt agaaggcagg gactggaagc
     1501 agggacctgg tactcagcat ccttctgatg aaggaacacc aggcgaccta gctggaaagc
     1561 tctgtgaggt ggtctaccct gctgggtctt tagccaccga aacatctgat gaagatgcct
     1621 gaatgcccta gcatctcggg actcacttgc tgaggggaag gaggccaaga ggaactgggc
     1681 actagcaggc ttccccaaag caaaagttta ggaagtccag agaatccttc ctgagcaaga
     1741 ttgctgttag ctctcaggcc aactgaagaa agttagcgac actatgttat ggggatgttg
     1801 gggataaaaa ggcacatagc acttagagtg gaagcatgac gtgatagaaa gtaatcaggg
     1861 tcacaaactc cagctggcta ccaagcagct gtggccccgg gcaggccaaa aggaggatca
     1921 ggctggggta gtgggagatt tccagcttga gaagagctgg tgagggtgta gaacgacagg
     1981 agccctgttg atgctggtgg attacagatc agatacctgc cgttggagcc gtccatctca
     2041 cccttaggat gtgaaactac tttcaatgtg tacaaataag ttagtctatt gtagataagg
     2101 aggggcaggt tccctttaag ctgtttttac tttattaacc tgagtgatat atggtcactt
     2161 tctttttttt taaacttttg attctctgtg aatttcacat catgtacccc aatctcattc
     2221 atctccccat gcctttctat ctgccctcca cccttgcaat ctccctcagc aaaagaaaat
     2281 aaaaataaat taattaaatt aaaaaaaaac cacctcgttc tggttccaca gtatacccct
     2341 cagcaaaaga aaataaaaat aaattaatta a
//
