LOCUS       NM_010690               7222 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus large tumor suppressor (Lats1), transcript variant 1,
            mRNA.
ACCESSION   NM_010690 XM_618738 XM_906240
VERSION     NM_010690.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7222)
  AUTHORS   Dang,K., Singh,A., Chen,X., Cotton,J.L., Guo,S., Hu,X., Tao,Z.,
            Liu,H., Zhu,L.J., Ip,Y.T., Wu,X. and Mao,J.
  TITLE     Mesenchymal Hippo signaling regulates intestinal homeostasis in
            adult mice
  JOURNAL   iScience 28 (2), 111847 (2025)
   PUBMED   39981512
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7222)
  AUTHORS   Nie,L., Fei,C., Fan,Y., Dang,F., Zhao,Z., Zhu,T., Wu,X., Dai,T.,
            Balasubramanian,A., Pan,J., Hu,Y., Luo,H.R., Wei,W. and Chen,J.
  TITLE     Consecutive palmitoylation and phosphorylation orchestrates NLRP3
            membrane trafficking and inflammasome activation
  JOURNAL   Mol Cell 84 (17), 3336-3353 (2024)
   PUBMED   39173637
REFERENCE   3  (bases 1 to 7222)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   4  (bases 1 to 7222)
  AUTHORS   Choi,S., Kang,J.G., Tran,Y.T.H., Jeong,S.H., Park,K.Y., Shin,H.,
            Kim,Y.H., Park,M., Nahmgoong,H., Seol,T., Jeon,H., Kim,Y., Park,S.,
            Kim,H.J., Kim,M.S., Li,X., Bou Sleiman,M., Lee,E., Choi,J.,
            Eisenbarth,D., Lee,S.H., Cho,S., Moore,D.D., Auwerx,J., Kim,I.Y.,
            Kim,J.B., Park,J.E., Lim,D.S. and Suh,J.M.
  TITLE     Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy
            balance by uncoupling leptin expression from fat mass
  JOURNAL   Nat Metab 6 (5), 847-860 (2024)
   PUBMED   38811804
REFERENCE   5  (bases 1 to 7222)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 7222)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   7  (bases 1 to 7222)
  AUTHORS   Turenchalk,G.S., St John,M.A., Tao,W. and Xu,T.
  TITLE     The role of lats in cell cycle regulation and tumorigenesis
  JOURNAL   Biochim Biophys Acta 1424 (2-3), M9-M16 (1999)
   PUBMED   10528150
  REMARK    Review article
REFERENCE   8  (bases 1 to 7222)
  AUTHORS   St John,M.A., Tao,W., Fei,X., Fukumoto,R., Carcangiu,M.L.,
            Brownstein,D.G., Parlow,A.F., McGrath,J. and Xu,T.
  TITLE     Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian
            tumours and pituitary dysfunction
  JOURNAL   Nat Genet 21 (2), 182-186 (1999)
   PUBMED   9988269
REFERENCE   9  (bases 1 to 7222)
  AUTHORS   Tao,W., Zhang,S., Turenchalk,G.S., Stewart,R.A., St John,M.A.,
            Chen,W. and Xu,T.
  TITLE     Human homologue of the Drosophila melanogaster lats tumour
            suppressor modulates CDC2 activity
  JOURNAL   Nat Genet 21 (2), 177-181 (1999)
   PUBMED   9988268
REFERENCE   10 (bases 1 to 7222)
  AUTHORS   Xu,T., Wang,W., Zhang,S., Stewart,R.A. and Yu,W.
  TITLE     Identifying tumor suppressors in genetic mosaics: the Drosophila
            lats gene encodes a putative protein kinase
  JOURNAL   Development 121 (4), 1053-1063 (1995)
   PUBMED   7743921
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK038612.1, AF104414.1, CO045800.1, AC156391.6 and AW744536.1.
            
            On or before Dec 3, 2007 this sequence version replaced
            XM_906240.2, XM_618738.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158123.1, SRR10662773.748139.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2181              AK038612.1         2-2182
            2182-3192           AF104414.1         1307-2317
            3193-3623           CO045800.1         256-686
            3624-6690           AC156391.6         60454-63520         c
            6691-7222           AW744536.1         1-532               c
FEATURES             Location/Qualifiers
     source          1..7222
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 2.29 cM"
     gene            1..7222
                     /gene="Lats1"
                     /note="large tumor suppressor"
                     /db_xref="GeneID:16798"
                     /db_xref="MGI:MGI:1333883"
     exon            1..242
                     /gene="Lats1"
                     /inference="alignment:Splign:2.1.0"
     exon            243..722
                     /gene="Lats1"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..3764
                     /gene="Lats1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase LATS1; large tumor
                     supressor, homolog 1; WARTS protein kinase; large tumor
                     suppressor homolog 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase LATS1 isoform 1"
                     /protein_id="NP_034820.1"
                     /db_xref="CCDS:CCDS48494.1"
                     /db_xref="GeneID:16798"
                     /db_xref="MGI:MGI:1333883"
                     /translation="MKRGEKPEGYRQMRPKTFPASNYPGSSRQMLQEIRESLRNLSKP
                     SDASKAEHNLNKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETSSSRSPSEVN
                     PQMFQDLQAAGFDEDMVIQALQKTNNRSIEAAVEFISKMSYQDPRREQMSAAAARPIN
                     ATMKPGNVQHSINRKQSWKGSKESLVPQRHGPSLGENVVYRSESPNSQADVGRPLSGS
                     GIAAFAQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPSSQTKR
                     YSGNMEYVISRISPVPPGAWQEGYPPPPLTTSPMNPPSQAQRAISSVPVGRQPIIMQS
                     TSKFNFTPGRPGVQNGGGQSDFIVHQNVPTGSVTRQPPPPYPLTPANGQSPSALQTGA
                     SAAPPSFANGNVPQSMMVPNRNSHNMELYNINVPGLQTAWPQSSSAPAQSSPSGGHEI
                     PTWQPNIPVRSNSFNNPLGSRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQ
                     TALAPTHPSWMPQPVQTVQPTPFSEGTASSVPVIPPVAEAPSYQGPPPPYPKHLLHQN
                     PSVPPYESVSKPCKDEQPSLPKEDDSEKSADSGDSGDKEKKQITTSPITVRKNKKDEE
                     RRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRK
                     MLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDV
                     LLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGI
                     FPENLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTH
                     DSKYYQSGDHPRQDSMDFSNEWGDPSNCRCGDRLKPLERRAARQHQRCLAHSLVGTPN
                     YIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPP
                     QAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKIT
                     HPTDTSNFDPVDPDKLWSDGSEEENISDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGY
                     PYNYPKPIEYEYIHSQGSEQQSDEDDQHTSSDGNNRDLVYV"
     exon            723..870
                     /gene="Lats1"
                     /inference="alignment:Splign:2.1.0"
     exon            871..2381
                     /gene="Lats1"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2964
                     /gene="Lats1"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3147
                     /gene="Lats1"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3254
                     /gene="Lats1"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..7215
                     /gene="Lats1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6828..6833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lats1"
                     /note="hexamer: AATAAA"
     polyA_site      6860
                     /gene="Lats1"
     regulatory      7184..7189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lats1"
                     /note="hexamer: AATAAA"
     polyA_site      7214
                     /gene="Lats1"
                     /note="major polyA site"
ORIGIN      
        1 gacacggagt ggaaggcaaa atggcggcgg cagcgatggc ctggtgctga ggggagagcc
       61 aggtcctcgc gaccccgcgt cgggccgcgc tggccggccg cagccccccg gcgtgtgtcc
      121 ccgccctgcc ccatcccgaa cccggagcga cgctaggggc cctgggggac gggctccggg
      181 ccgccgcggc gccggccctc gggcccgcag cggctgtcca gaagcctcac cgtcccctgc
      241 aggttagtta cttccactgt aaaggatttt aacattcctg ggacttcccc tttcaccttg
      301 gctcagaaga agctctgagt ctttgagtta gctccttaag aagtgctttg caggggccac
      361 atatagatgc tttcatgaag aggggtgaaa agccagaagg gtacagacag atgaggccta
      421 agacctttcc tgccagcaac taccctggca gcagccgaca gatgctgcag gagatccgag
      481 aatccctgag gaatttatca aaaccatctg atgcttcgaa ggccgagcat aacctgaata
      541 agatgtcgac tgaagatccc aggcaggtga gaaatccacc caaatttggc acacatcata
      601 aagccttgca agaaattcga aactctctac taccatttgc aaatgaaaca agttcttccc
      661 ggagcccttc agaagttaat ccacagatgt ttcaggattt gcaggctgct ggctttgatg
      721 aggacatggt tattcaagct cttcagaaaa ccaataacag aagcatagaa gccgctgttg
      781 aattcattag taaaatgagt taccaagacc ctcgtcgaga gcagatgtct gcagcagctg
      841 ccaggcctat taatgccacc atgaaaccag gaaatgtgca acattcaatt aaccgaaaac
      901 aaagctggaa aggttctaaa gagtctctag ttcctcagag acacggccca tctctaggag
      961 aaaatgtggt ttatcgttct gaaagcccca actcacaggc ggatgtagga agacctctgt
     1021 ctggatccgg cattgcagca tttgctcaag ctcacccaag caatggacag agagtgaacc
     1081 ccccaccacc acctcaagtt aggagtgtta ctcctccacc acctccgaga ggccagaccc
     1141 cacctccccg aggcaccact ccccctcccc cctcatggga accaagctct cagacaaagc
     1201 gctactctgg gaacatggag tacgtaatct cccgaatctc ccctgttcca cctggggcgt
     1261 ggcaggaggg ctaccctcca ccacctctta ccacttctcc catgaatccc cctagccagg
     1321 ctcagagggc cattagttct gttccagttg gtagacaacc catcatcatg cagagtacta
     1381 gcaaatttaa ctttacacca gggcgacctg gagttcagaa tggtggtggt cagtctgatt
     1441 ttatcgtgca ccaaaatgtc cccactggtt ctgtgactcg gcagccacca cctccatatc
     1501 ctctgacccc agctaatgga caaagcccct ctgctttaca aacaggggct tctgctgctc
     1561 caccatcatt cgccaatgga aacgttcctc agtcgatgat ggtgcccaac aggaacagtc
     1621 ataacatgga gctttataat attaatgtcc ctggactgca aacagcctgg ccccagtcgt
     1681 cttctgctcc tgcgcagtca tccccaagcg gtgggcatga aattcctaca tggcaaccta
     1741 acataccagt gaggtcaaat tcttttaata acccattagg aagtagagca agtcactctg
     1801 ctaattctca gccttctgcc actacagtca ctgccatcac acccgctcct attcaacagc
     1861 ccgtgaaaag catgcgcgtc ctgaaaccag agctgcagac tgctttagcc ccaacccatc
     1921 cttcttggat gccacagcca gttcagactg ttcagcctac ccctttttct gagggtacag
     1981 cttcaagtgt gcctgtcatc ccacctgttg ctgaagctcc aagctatcaa ggtccaccac
     2041 cgccttatcc aaaacatctg ctacaccaaa acccatctgt ccctccatat gagtcagtaa
     2101 gtaagccctg caaagatgaa cagcctagct tacccaagga agatgatagt gagaagagtg
     2161 cggacagtgg tgactctggg gataaagaaa agaaacagat tacaacttca cctatcactg
     2221 ttcggaaaaa caagaaagat gaagaacgaa gagagtctcg gattcagagt tactccccac
     2281 aggcctttaa gttcttcatg gagcagcacg tagagaacgt cctgaagtct catcagcagc
     2341 gtctgcatcg gaagaagcag ctagaaaatg aaatgatgcg ggttggatta tctcaagatg
     2401 cccaggatca aatgagaaag atgctttgcc agaaagagtc taactatatt cgtcttaaaa
     2461 gggctaaaat ggacaagtct atgtttgtaa agataaagac attaggaata ggagcgtttg
     2521 gtgaagtctg tctagcaaga aaagtcgata ctaaagcttt gtatgcaaca aagactcttc
     2581 gaaagaaaga cgttctgctc cgaaatcagg tggctcatgt gaaagcggag agggatatcc
     2641 tagcagaagc cgacaatgag tgggtggtcc gcctgtacta ctctttccag gacaaggaca
     2701 acttgtactt tgtgatggac tacattcctg ggggggatat gatgagccta ttaattagaa
     2761 tgggcatctt tcctgaaaat ctggcacgat tctacatagc agaacttacc tgtgcagttg
     2821 aaagtgttca taaaatgggt tttattcata gagatattaa acctgataac attttgattg
     2881 accgtgatgg ccatattaaa ttgactgact ttggcttgtg cactggcttc agatggacac
     2941 atgactccaa gtactaccag agtggggatc acccacggca agatagcatg gatttcagta
     3001 acgaatgggg agatccttcc aattgtcggt gtggggacag actgaagcca ctggagcgga
     3061 gagctgctcg ccagcaccag cgatgtctag cccattctct ggttgggact cccaattata
     3121 ttgcacctga agtgctactg cgaacaggat atacacagct gtgtgactgg tggagtgttg
     3181 gtgttattct ttttgaaatg ttggtgggac aacctccttt cttggcacaa accccattag
     3241 aaacacaaat gaaggttatc aactggcaaa cttctcttca catccctcct caagctaagc
     3301 tgagtcctga agcctctgac ctcattatca aactttgtcg aggaccagaa gaccgcctcg
     3361 gcaagaacgg tgctgatgag ataaaggctc atccattttt taagaccatc gatttctcta
     3421 gtgatctgag acagcagtct gcttcataca tccctaaaat cacgcatcca acagatacat
     3481 ccaatttcga ccctgttgat cctgataaat tgtggagcga tggcagcgag gaggaaaata
     3541 tcagtgacac tctgaacgga tggtataaaa atgggaagca ccccgagcac gctttctatg
     3601 agttcacctt tcggaggttt tttgatgaca atggctaccc atataattat ccaaagccta
     3661 ttgagtatga atacattcat tcacagggct cagaacaaca gtctgatgaa gatgatcaac
     3721 acacaagctc cgatggaaac aaccgagatc tagtgtatgt ttaataaact aggagatcat
     3781 tgtaagaatt tgcaagaggc ctgaagtgca ggggtttttg aagttttgag aaaattatgc
     3841 aaatgtgaca gagtttgtgt gctctgtgta caatatttta ttttcctaag ttatgggaaa
     3901 ttgttttaaa atgttaattt attccaccct tttaattcag taatttagaa aaaattgtta
     3961 taaggaaagt aaattatgaa ctgagtatta tagtcaattc ttggtactta aagtacttaa
     4021 aaaatagtgc tctgtttaaa aagagaagcc tggtatcttt tgtatatatg ataaataatt
     4081 ttaaaattca agaatttttg aagatttttg aaagacagtt ttatcttgct ttaaccaaat
     4141 atgaaatata accatatttc ccttgtaact ttgggtttag ttcccaatac gctaaagaaa
     4201 tcaagccgtt gttttagaag gtaaggtgtt cctagagtaa ttttaatctt gaagtcatat
     4261 cctgtaatca caaatacaga gcaaaaacaa tatgttcact agaaataatg cagcttaccc
     4321 cttccctccc cagaagtctt caacctaacc tagcattttt ctttcagata ccggctttaa
     4381 agaagccaga gcactgctag ttttgtttcc agattggtat taatgctgct tccagttttt
     4441 gttttattgg gatttttgtt ttggtttggt tttgggtttt ttttcgaggg gtgggggtat
     4501 tgttttgttt tgattttttt ttttttgttt tggtttggtt ttttgggggg caggggattg
     4561 agacagggtt tctctgtgta gccctggctg tcctggaact cgctctgtga ccaggctggc
     4621 ctcagactca gaggttcacc agactctgcc tcccccgaga gctggaatta aaagtgtgtg
     4681 ccaccacacc cagctgtttc cagttttaaa agggaacaaa gttgccatga attgaatttt
     4741 caaactgaaa ctaagatctg taatatttgt atcttaaaat tagaagaaaa atttccatct
     4801 cctaagtaaa gaaattattt tcagtttgta attttttttt ttaatttacg tgtatgtact
     4861 cactaagaaa gtacattttc taggggctaa ggatatggct cagtggtaga gcacttgcct
     4921 aacatacaca aagccttggg ttcagtccct agcccctgcc acataaaggt acctttgttg
     4981 tacagtgacc aatcttgatt gtgtcattga tgctatagat ttcctttttc agaacagtgc
     5041 tacaatacaa attgttggca aaggaaatgt aactatttgg cactattata cctaagagta
     5101 gattaattgg ttaaaaataa ttattaatta actcttaatt gggatgagca tccctaatta
     5161 gatacatagt agtttagaaa gtgaaaactt cctaagttat ttaagattaa tgtcctattt
     5221 atataatgtt taggttctaa ggaagaattg tggatcccta acaaacatct taggaacatc
     5281 ttttaggaag aagaatgggg ctgtactctg accttagtaa agtttgtatg tatattattt
     5341 cattttttca aggtttattg acatgaattg ctttatcaga cttaatgttt gtggctagga
     5401 atgatgttta cctatctagc tttcttataa aagataattt gtttaaaacc atatgtatag
     5461 taaaattaaa agcaaagcta tttgtttgaa ttggggagag agaaaaacat tattagctta
     5521 cactttcatg ttgagcttgg aacctgtcac gtgtacaagt gagccttcag accatagatc
     5581 attttgagat aaagactatg tgaactcagg ccctactgaa aaaaagtgtg tatccacaca
     5641 tacattagaa agtgttgcat gcactctcaa gagaccctgg gtgtgataaa acttcccaga
     5701 cagcaggtta aagacctaca tcctgtgagt caattgctat atcaaagtaa gacctttgat
     5761 atcctttgac tttattgcac agcgctcaga tgagcacgtt tgtaaacaag taatgatctg
     5821 ctcttggaat gagcccgtga aagcaacaca gcacagacat gtctataaca tgaaagcagc
     5881 acaacacaga catgtctata acactgttct aacggcactg gtgtcttgtg attctgaggg
     5941 ctcctgatga gagctgtcac cagacagtct tcacagcatg gagcgtctga agtctgaagg
     6001 ccctatgcaa agcatgcatt gagggaggtt tggcctgggt ccctcccaca ggtcagaaag
     6061 acagccctct gaccttcggg ctcttcactc agactgacat tttcatttag tggttttaca
     6121 cctggatcat gttcacaacg caggactgct aaggtgctgc ccctccccac gaccatggtg
     6181 cctcagaatg taaacactaa ttctacgtcc ttctttgctt ccctcggaca gtataagctt
     6241 ctagcgtttg tctgaggcag tatacaagga ttcggtatct gcaattttag tattttgttc
     6301 acaattttaa cattttggat gctcatgttg gttattttac ccctgactac acccagttct
     6361 cccagcatag gagttgctgc tttctgagca aacaatgagc acagcataga aaacatagac
     6421 acttaattaa aacggcaaag acgctgctct ccagctctcc cctagaaccc gccgtctcct
     6481 gtgcgtgccc cttcagtgtg tatcagtggt atttataaaa tgtgctctat aattatgtgc
     6541 ttgtacatac tggtatatgt tgtgcagtga tgtcctgagg caggccctgt tgctgtatct
     6601 gtcctacctt cctatttgta atagaaacta tagaatgtat gactaagaag tcactttgag
     6661 attgactttt ataaaaagtt atttaccttc tgctgttgag aagtgcaaaa ctgtgagtgg
     6721 aaatgtttta ttctgattta ataatatgtt agaaattaga aacccagtgg gaggagtttt
     6781 tagatatgct gctgctgtta cccaaggtac tttagaaatt ttcctttaat aaaaaaattc
     6841 ctttgatatt taaagtaaaa cagtctgttt ttgaatctaa aactgtaatt tgggtcaaca
     6901 tattggtcta tttgtaaagt gccttagtat attcctttgt ggagggcact acccagttta
     6961 cttttatatt gtcttatgta tataagggtt ttatattaca atggaatcaa tggcaacact
     7021 accattttat aaaacagtgc tttgctagga aaaattacag ctttgcaata taacaactgt
     7081 ttttggatat ttctgaatgt actagaacaa ataatcagtc tgtttttaat gaatctattt
     7141 gtattttccc aatcattccc tctagtgtaa tatttgctgg gataataaaa aaggcaaact
     7201 tcaaattttt tcaataaaaa aa
//
