LOCUS       NM_020044               1672 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus linker for activation of T cells family, member 2
            (Lat2), transcript variant 1, mRNA.
ACCESSION   NM_020044 XM_622911
VERSION     NM_020044.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1672)
  AUTHORS   Halova,I., Bambouskova,M., Draberova,L., Bugajev,V. and Draber,P.
  TITLE     The transmembrane adaptor protein NTAL limits mast cell chemotaxis
            toward prostaglandin E2
  JOURNAL   Sci Signal 11 (556) (2018)
   PUBMED   30425164
  REMARK    GeneRIF: NTAL is a key inhibitor of mast cell chemotaxis toward
            PGE2, which may act through the RHOA/ERM/beta1-integrin and
            PI3K/AKT axes
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1672)
  AUTHORS   Freund,J., May,R.M., Yang,E., Li,H., McCullen,M., Zhang,B.,
            Lenvik,T., Cichocki,F., Anderson,S.K. and Kambayashi,T.
  TITLE     Activating Receptor Signals Drive Receptor Diversity in Developing
            Natural Killer Cells
  JOURNAL   PLoS Biol 14 (8), e1002526 (2016)
   PUBMED   27500644
  REMARK    Erratum:[PLoS Biol. 2016 Dec 29;14(12):e1002590. doi:
            10.1371/journal.pbio.1002590.. PMID: 28033606]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1672)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   4  (bases 1 to 1672)
  AUTHORS   Polakovicova,I., Draberova,L., Simicek,M. and Draber,P.
  TITLE     Multiple regulatory roles of the mouse transmembrane adaptor
            protein NTAL in gene transcription and mast cell physiology
  JOURNAL   PLoS One 9 (8), e105539 (2014)
   PUBMED   25153696
  REMARK    GeneRIF: NTAL is a negative regulator of FcepsilonRI activation
            events in murine bone marrow-derived mast cells, independently of
            possible compensatory developmental alterations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1672)
  AUTHORS   Nunez,B., Martinez de Mena,R., Obregon,M.J., Font-Llitjos,M.,
            Nunes,V., Palacin,M., Dumitrescu,A.M., Morte,B. and Bernal,J.
  TITLE     Cerebral cortex hyperthyroidism of newborn mct8-deficient mice
            transiently suppressed by lat2 inactivation
  JOURNAL   PLoS One 9 (5), e96915 (2014)
   PUBMED   24819605
  REMARK    GeneRIF: Cerebral cortex hyperthyroidism of newborn mct8-deficient
            mice transiently suppressed by lat2 inactivation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1672)
  AUTHORS   Volna,P., Lebduska,P., Draberova,L., Simova,S., Heneberg,P.,
            Boubelik,M., Bugajev,V., Malissen,B., Wilson,B.S., Horejsi,V.,
            Malissen,M. and Draber,P.
  TITLE     Negative regulation of mast cell signaling and function by the
            adaptor LAB/NTAL
  JOURNAL   J Exp Med 200 (8), 1001-1013 (2004)
   PUBMED   15477348
  REMARK    GeneRIF: NTAL negatively regulates Fc-epsilon receptor I-mediated
            signaling events in bone marrow-derived mast cells.
REFERENCE   7  (bases 1 to 1672)
  AUTHORS   Janssen,E., Zhu,M., Zhang,W., Koonpaew,S. and Zhang,W.
  TITLE     LAB: a new membrane-associated adaptor molecule in B cell
            activation
  JOURNAL   Nat Immunol 4 (2), 117-123 (2003)
   PUBMED   12514734
REFERENCE   8  (bases 1 to 1672)
  AUTHORS   DeSilva,U., Elnitski,L., Idol,J.R., Doyle,J.L., Gan,W.,
            Thomas,J.W., Schwartz,S., Dietrich,N.L., Beckstrom-Sternberg,S.M.,
            McDowell,J.C., Blakesley,R.W., Bouffard,G.G., Thomas,P.J.,
            Touchman,J.W., Miller,W. and Green,E.D.
  TITLE     Generation and comparative analysis of approximately 3.3 Mb of
            mouse genomic sequence orthologous to the region of human
            chromosome 7q11.23 implicated in Williams syndrome
  JOURNAL   Genome Res 12 (1), 3-15 (2002)
   PUBMED   11779826
REFERENCE   9  (bases 1 to 1672)
  AUTHORS   Martindale,D.W., Wilson,M.D., Wang,D., Burke,R.D., Chen,X.,
            Duronio,V. and Koop,B.F.
  TITLE     Comparative genomic sequence analysis of the Williams syndrome
            region (LIMK1-RFC2) of human chromosome 7q11.23
  JOURNAL   Mamm Genome 11 (10), 890-898 (2000)
   PUBMED   11003705
REFERENCE   10 (bases 1 to 1672)
  AUTHORS   Doyle,J.L., DeSilva,U., Miller,W. and Green,E.D.
  TITLE     Divergent human and mouse orthologs of a novel gene
            (WBSCR15/Wbscr15) reside within the genomic interval commonly
            deleted in Williams syndrome
  JOURNAL   Cytogenet Cell Genet 90 (3-4), 285-290 (2000)
   PUBMED   11124535
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143533.1 and AK138953.1.
            
            On Oct 19, 2013 this sequence version replaced NM_020044.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138953.1, AK144261.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AK143533.1         2-43
            43-1672             AK138953.1         2-1631
FEATURES             Location/Qualifiers
     source          1..1672
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 74.7 cM"
     gene            1..1672
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /note="linker for activation of T cells family, member 2"
                     /db_xref="GeneID:56743"
                     /db_xref="MGI:MGI:1926479"
     exon            1..137
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /inference="alignment:Splign:2.1.0"
     exon            138..260
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..775
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /note="isoform a is encoded by transcript variant 1; non-T
                     cell activation linker; linker for activation of B-cells;
                     membrane-associated adapter molecule; williams-Beuren
                     syndrome chromosomal region 15 protein homolog;
                     Williams-Beuren syndrome chromosome region 5 homolog"
                     /codon_start=1
                     /product="linker for activation of T-cells family member 2
                     isoform a"
                     /protein_id="NP_064428.1"
                     /db_xref="CCDS:CCDS39312.1"
                     /db_xref="GeneID:56743"
                     /db_xref="MGI:MGI:1926479"
                     /translation="MSAELELLWPVSGLLLLLLGATAWLCVHCSRPGVKRNEKIYEQR
                     NRQENAQSSAAAQTYSLARQVWPGPQMDTAPNKSFERKNKMLFSHLEGPESPRYQNFY
                     KGSNQEPDAAYVDPIPTNYYNWGCFQKPSEDDDSNSYENVLVCKPSTPESGVEDFEDY
                     QNSVSIHQWRESKRTMGAPMSLSGSPDEEPDYVNGDVAAAENI"
     exon            261..300
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /inference="alignment:Splign:2.1.0"
     exon            301..344
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /inference="alignment:Splign:2.1.0"
     exon            345..405
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /inference="alignment:Splign:2.1.0"
     exon            406..437
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /inference="alignment:Splign:2.1.0"
     exon            438..473
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /inference="alignment:Splign:2.1.0"
     exon            474..504
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /inference="alignment:Splign:2.1.0"
     exon            505..560
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /inference="alignment:Splign:2.1.0"
     exon            561..620
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /inference="alignment:Splign:2.1.0"
     exon            621..692
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /inference="alignment:Splign:2.1.0"
     exon            693..801
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1672
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1489..1494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /note="hexamer: AATAAA"
     polyA_site      1513
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
                     /note="major polyA site"
     polyA_site      1540
                     /gene="Lat2"
                     /gene_synonym="LAB; NTAL; Wbscr15; Wbscr5; WSCR5"
ORIGIN      
        1 gtagaggaga tgattcagta gtgacaggaa gccaactgcc ttgcccactg ctcaccagag
       61 tcagtggtgt tggcatcagc ttgggcaggt gtgcggcaca agatgaaggg gccatggtga
      121 ggagccctca ccctcagcct tacagcctct tccccaagcc aacatgagtg ccgagctgga
      181 gctgctgtgg ccggtgtcgg gattattgct gctgctgttg ggggccacag cctggctgtg
      241 tgtccactgc tcccgtccag gagtgaagag aaatgagaaa atctacgagc agaggaaccg
      301 gcaagaaaat gcacagagct cagctgcggc tcagacatac tccctggcca ggcaggtgtg
      361 gccaggaccc cagatggaca cagctccaaa caagtcattt gaaaggaaga acaagatgct
      421 gttctcccac cttgagggtc ctgagtcccc taggtaccag aacttctaca aaggaagtaa
      481 ccaggagcct gatgctgcct atgtagaccc catccctaca aactactaca actggggatg
      541 tttccagaag ccctcagaag acgacgattc caactcctac gagaatgtgc tcgtctgcaa
      601 gcccagcacc cccgagtcag gtgtcgagga ctttgaggat taccagaact cagtatccat
      661 ccatcagtgg cgagagtcca agaggactat gggtgcacca atgtccctat caggaagccc
      721 agatgaggag ccagactatg tgaatgggga tgtggccgca gcagagaaca tctaggagag
      781 aaccaatcaa tcggaaggaa gaagggcccg aggatggggg atctgagcgg gaactgaagc
      841 ctttactgcc tgctgaataa agcctgttct ccagggatgc tcaagtttca caccctggcc
      901 gtggctgctc cacagcctgg gagacactgg gcatcgccag agccccaacc ctcaagtgat
      961 gccctggact tctttggggg caaagcaagt gcccagagga tatagactgt gctgactgga
     1021 agcccaagac ctgaggcaag atgtgtcccc agtctcacat ctaaaatgag gcacaacagt
     1081 ggcatttgtg ggttttgttt ttgttttggc tgcaggatct cactaagtta ctcaggctga
     1141 tctcaaactt gtaaccctca gtcctagtgt tgggattgcg gcataccagt tttttttttt
     1201 cctttctttg tttggacctc agattactta tgtcgacttc taggactgtt gctatgactc
     1261 tttttgtggt taactgaagt tgctggagtc gtatttaata ttgtcaatgt cagggggttc
     1321 cctgtctcag agcattatgt gtactaactg tagcagagga atggggtgtg gggtaacctg
     1381 ggatcgcttt ggtttcttag tgggctccag tttgttctga tctttcattc ctgcggggac
     1441 cttgtgcgtc ggtgataggg aaataaaact gccccctcac caaacaccaa taaaccctgt
     1501 gagtgtgaga gcaggcgctg cacacatgcc tttgtttaaa caccttcccc tgtgtgttca
     1561 tagggctgaa tgtctctgtt gttgctctcc gttatttttt ttaagacagt cacactgtgt
     1621 agcccctggc taccctggaa cttgctttat aaaccggggt gaccctgatg ag
//
