LOCUS       NM_010689               1281 bp    mRNA    linear   ROD 10-OCT-2024
DEFINITION  Mus musculus linker for activation of T cells (Lat), mRNA.
ACCESSION   NM_010689
VERSION     NM_010689.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1281)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1281)
  AUTHORS   Lo,W.L., Kuhlmann,M., Rizzuto,G., Ekiz,H.A., Kolawole,E.M.,
            Revelo,M.P., Andargachew,R., Li,Z., Tsai,Y.L., Marson,A.,
            Evavold,B.D., Zehn,D. and Weiss,A.
  TITLE     A single-amino acid substitution in the adaptor LAT accelerates TCR
            proofreading kinetics and alters T-cell selection, maintenance and
            function
  JOURNAL   Nat Immunol 24 (4), 676-689 (2023)
   PUBMED   36914891
REFERENCE   3  (bases 1 to 1281)
  AUTHORS   Arbulo-Echevarria,M.M., Vico-Barranco,I., Zhang,F.,
            Fernandez-Aguilar,L.M., Chotomska,M., Narbona-Sanchez,I., Zhang,L.,
            Malissen,B., Liang,Y. and Aguado,E.
  TITLE     Mutation of the glycine residue preceding the sixth tyrosine of the
            LAT adaptor severely alters T cell development and activation
  JOURNAL   Front Immunol 13, 1054920 (2022)
   PUBMED   36569841
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1281)
  AUTHORS   Gregoire,C., Spinelli,L., Villazala-Merino,S., Gil,L.,
            Holgado,M.P., Moussa,M., Dong,C., Zarubica,A., Fallet,M.,
            Navarro,J.M., Malissen,B., Milpied,P. and Gaya,M.
  TITLE     Viral infection engenders bona fide and bystander subsets of
            lung-resident memory B cells through a permissive mechanism
  JOURNAL   Immunity 55 (7), 1216-1233 (2022)
   PUBMED   35768001
REFERENCE   5  (bases 1 to 1281)
  AUTHORS   Imbert,A., Rompais,M., Selloum,M., Castelli,F., Mouton-Barbosa,E.,
            Brandolini-Bunlon,M., Chu-Van,E., Joly,C., Hirschler,A., Roger,P.,
            Burger,T., Leblanc,S., Sorg,T., Ouzia,S., Vandenbrouck,Y.,
            Medigue,C., Junot,C., Ferro,M., Pujos-Guillot,E., de Peredo,A.G.,
            Fenaille,F., Carapito,C., Herault,Y. and Thevenot,E.A.
  TITLE     ProMetIS, deep phenotyping of mouse models by combined proteomics
            and metabolomics analysis
  JOURNAL   Sci Data 8 (1), 311 (2021)
   PUBMED   34862403
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1281)
  AUTHORS   Saitoh,S., Arudchandran,R., Manetz,T.S., Zhang,W., Sommers,C.L.,
            Love,P.E., Rivera,J. and Samelson,L.E.
  TITLE     LAT is essential for Fc(epsilon)RI-mediated mast cell activation
  JOURNAL   Immunity 12 (5), 525-535 (2000)
   PUBMED   10843385
REFERENCE   7  (bases 1 to 1281)
  AUTHORS   Pivniouk,V.I. and Geha,R.S.
  TITLE     The role of SLP-76 and LAT in lymphocyte development
  JOURNAL   Curr Opin Immunol 12 (2), 173-178 (2000)
   PUBMED   10712938
  REMARK    Review article
REFERENCE   8  (bases 1 to 1281)
  AUTHORS   Zhang,W., Sommers,C.L., Burshtyn,D.N., Stebbins,C.C.,
            DeJarnette,J.B., Trible,R.P., Grinberg,A., Tsay,H.C., Jacobs,H.M.,
            Kessler,C.M., Long,E.O., Love,P.E. and Samelson,L.E.
  TITLE     Essential role of LAT in T cell development
  JOURNAL   Immunity 10 (3), 323-332 (1999)
   PUBMED   10204488
REFERENCE   9  (bases 1 to 1281)
  AUTHORS   Zhang,W., Trible,R.P. and Samelson,L.E.
  TITLE     LAT palmitoylation: its essential role in membrane microdomain
            targeting and tyrosine phosphorylation during T cell activation
  JOURNAL   Immunity 9 (2), 239-246 (1998)
   PUBMED   9729044
REFERENCE   10 (bases 1 to 1281)
  AUTHORS   Zhang,W., Sloan-Lancaster,J., Kitchen,J., Trible,R.P. and
            Samelson,L.E.
  TITLE     LAT: the ZAP-70 tyrosine kinase substrate that links T cell
            receptor to cellular activation
  JOURNAL   Cell 92 (1), 83-92 (1998)
   PUBMED   9489702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125322.4, AK134003.1 and BE947351.1.
            
            On Nov 24, 2015 this sequence version replaced NM_010689.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF036907.1, BC052340.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC125322.4         28050-28125         c
            77-1264             AK134003.1         2-1189
            1265-1281           BE947351.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1281
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.01 cM"
     gene            1..1281
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /note="linker for activation of T cells"
                     /db_xref="GeneID:16797"
                     /db_xref="MGI:MGI:1342293"
     exon            1..421
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..1047
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /note="linker protein; 36 kDa phospho-tyrosine adapter
                     protein; 36 kDa phosphotyrosine adapter protein"
                     /codon_start=1
                     /product="linker for activation of T-cells family member
                     1"
                     /protein_id="NP_034819.1"
                     /db_xref="CCDS:CCDS21825.1"
                     /db_xref="GeneID:16797"
                     /db_xref="MGI:MGI:1342293"
                     /translation="MEADALSPVGLGLLLLPFLVTLLAALCVRCRELPVSYDSTSTES
                     LYPRSILIKPPQITVPRTPAVSYPLVTSFPPLRQPDLLPIPRSPQPLGGSHRMPSSQQ
                     NSDDANSVASYENQEPACKNVDADEDEDDYPNGYLVVLPDSSPAAVPVVSSAPVPSNP
                     DLGDSAFSVESCEDYVNVPESEESAEASLDGSREYVNVSPEQQPVTRAELASVNSQEV
                     EDEGEEEGVDGEEAPDYENLQELN"
     exon            422..449
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            450..484
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            485..572
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            573..637
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            638..667
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            668..728
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            729..823
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            824..886
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            887..949
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1054
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1269
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1248..1253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /note="hexamer: AATAAA"
     polyA_site      1269
                     /gene="Lat"
                     /gene_synonym="p36-38; pp36"
                     /note="major polyA site"
ORIGIN      
        1 agcttcctgt cgcacgcggt ggtgagcagg agaggcaggc ggggagcaag aaaggggcag
       61 gtacagctgg gcacggggat cgtgcagctg gtagctgggg cacgggcccc agctctggct
      121 ctggggcgag cacctttcca gagccaacac tgctctcaac tcagtccagc aagagagggg
      181 agccatccag ccccgaaagg atacggctgc ctactgccgg gcggatccca ggctggagcc
      241 cgcttggtcc catacccctg ctgccactct gtctcgaggg gctgcagtgc agcagggcct
      301 gtggcaggtg ctctgcagat ggaagcagac gccttgagcc cggtggggct gggcctcctg
      361 ctgctgccct tcttggtcac gctcctggct gccctgtgcg tgcgctgccg tgagttgcca
      421 gtctcctatg acagcacttc cacagagagt ttgtacccaa gaagcatcct catcaagcca
      481 cctcaaataa ccgtcccccg aacacctgct gtttcctacc ctctagtcac ttccttccca
      541 cccctgaggc agccagacct gctccccatc ccgagatccc cacagcccct tgggggttcc
      601 catcggatgc catcttccca gcagaattca gatgatgcca acagtgtggc aagctacgag
      661 aaccaggagc cagcctgtaa gaatgtggat gcagatgagg atgaagacga ctatcccaac
      721 ggctacctag tggtgctgcc tgacagtagt cctgctgccg tccctgttgt ctcctctgct
      781 cctgtgccta gcaaccctga ccttggagac agtgccttct ctgtggagtc gtgtgaagat
      841 tacgtgaatg ttcctgagag tgaggagagc gcagaggcgt ctctggatgg gagccgggag
      901 tatgtgaatg tgtccccaga gcagcagcca gtgaccaggg ctgagctggc ctctgtgaac
      961 tcccaggagg tggaagacga aggagaagag gaaggggtgg atggagagga agctcctgac
     1021 tatgagaatc tgcaggagct taactgaaag cctactgcag ctgtctgtcc tgaaactgga
     1081 cttgctgggg tgtcgctaag aggatcccat ttgacctctg ccttgccaca gcctgagaat
     1141 cttcccctaa cttattgtca ctttggggtc cagtctgtgt ccccaatatt ctgtaccttc
     1201 tgataaagcc tgagaatgaa tctggttcca gccagaccat gtcatggaat aaaggccatg
     1261 tgacataaaa aaaaaaaaaa a
//
