LOCUS       NM_010688               3557 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus LIM and SH3 protein 1 (Lasp1), transcript variant 2,
            mRNA.
ACCESSION   NM_010688
VERSION     NM_010688.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3557)
  AUTHORS   Butt,E., Gunder,T., Sturzebecher,P., Kowalski,I., Schneider,P.,
            Buschmann,N., Schafer,S., Bender,A., Hermanns,H.M. and Zernecke,A.
  TITLE     Cholesterol uptake in the intestine is regulated by the
            LASP1-AKT-NPC1L1 signaling pathway
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 327 (1), G25-G35 (2024)
   PUBMED   38713618
  REMARK    GeneRIF: Cholesterol uptake in the intestine is regulated by the
            LASP1-AKT-NPC1L1 signaling pathway.
REFERENCE   2  (bases 1 to 3557)
  AUTHORS   Ren,L., Cheng,S.G., Kang,P.C., Li,T.F., Li,X., Xiao,J.Z. and
            Jiang,D.
  TITLE     Silenced LASP1 interacts with DNMT1 to promote TJP2 expression and
            attenuate articular cartilage injury in mice by suppressing TJP2
            methylation
  JOURNAL   Kaohsiung J Med Sci 39 (11), 1096-1105 (2023)
   PUBMED   37578083
  REMARK    GeneRIF: Silenced LASP1 interacts with DNMT1 to promote TJP2
            expression and attenuate articular cartilage injury in mice by
            suppressing TJP2 methylation.
REFERENCE   3  (bases 1 to 3557)
  AUTHORS   Beckmann,D., Romer-Hillmann,A., Krause,A., Hansen,U., Wehmeyer,C.,
            Intemann,J., de Gorter,D.J.J., Dankbar,B., Hillen,J., Heitzmann,M.,
            Begemann,I., Galic,M., Weinhage,T., Foell,D., Ai,R.,
            Kremerskothen,J., Kiener,H.P., Muller,S., Kamradt,T., Schroder,C.,
            Leitao,E., Horsthemke,B., Rosenstiel,P., Nordstrom,K.,
            Gasparoni,G., Gasparoni,N., Walter,J., Li,N., Yang,X., Chung,H.R.,
            Pavenstadt,H., Lindemann,N., Schnittler,H.J., Wang,W.,
            Firestein,G.S., Pap,T. and Korb-Pap,A.
  TITLE     Lasp1 regulates adherens junction dynamics and fibroblast
            transformation in destructive arthritis
  JOURNAL   Nat Commun 12 (1), 3624 (2021)
   PUBMED   34131132
  REMARK    GeneRIF: Lasp1 regulates adherens junction dynamics and fibroblast
            transformation in destructive arthritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3557)
  AUTHORS   Cui,Y.H., Fu,A., Wang,X.Q., Tu,B.X., Chen,K.Z., Wang,Y.K., Hu,Q.G.,
            Wang,L.F., Hu,Z.L., Pan,P.H., Li,F., Bi,F.F. and Li,C.Q.
  TITLE     Hippocampal LASP1 ameliorates chronic stress-mediated behavioral
            responses in a mouse model of unpredictable chronic mild stress
  JOURNAL   Neuropharmacology 184, 108410 (2021)
   PUBMED   33242526
  REMARK    GeneRIF: Hippocampal LASP1 ameliorates chronic stress-mediated
            behavioral responses in a mouse model of unpredictable chronic mild
            stress.
REFERENCE   5  (bases 1 to 3557)
  AUTHORS   Tan,J., Chen,X.J., Shen,C.L., Zhang,H.X., Tang,L.Y., Lu,S.Y.,
            Wu,W.T., Kuang,Y., Fei,J. and Wang,Z.G.
  TITLE     Lacking of palladin leads to multiple cellular events changes which
            contribute to NTD
  JOURNAL   Neural Dev 12 (1), 4 (2017)
   PUBMED   28340616
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3557)
  AUTHORS   Zhou,Q., Zhao,J., Wiedmer,T. and Sims,P.J.
  TITLE     Normal hemostasis but defective hematopoietic response to growth
            factors in mice deficient in phospholipid scramblase 1
  JOURNAL   Blood 99 (11), 4030-4038 (2002)
   PUBMED   12010804
REFERENCE   7  (bases 1 to 3557)
  AUTHORS   Kleiter,N., Artner,I., Gmachl,N., Ghaffari-Tabrizi,N. and
            Kratochwil,K.
  TITLE     Mutagenic transgene insertion into a region of high gene density
            and multiple linkage disruptions on mouse chromosome 11
  JOURNAL   Cytogenet Genome Res 97 (1-2), 100-105 (2002)
   PUBMED   12438746
REFERENCE   8  (bases 1 to 3557)
  AUTHORS   Hotfilder,M., Baxendale,S., Cross,M.A. and Sablitzky,F.
  TITLE     Def-2, -3, -6 and -8, novel mouse genes differentially expressed in
            the haemopoietic system
  JOURNAL   Br J Haematol 106 (2), 335-344 (1999)
   PUBMED   10460589
REFERENCE   9  (bases 1 to 3557)
  AUTHORS   Schreiber,V., Masson,R., Linares,J.L., Mattei,M.G., Tomasetto,C.
            and Rio,M.C.
  TITLE     Chromosomal assignment and expression pattern of the murine Lasp-1
            gene
  JOURNAL   Gene 207 (2), 171-175 (1998)
   PUBMED   9511759
REFERENCE   10 (bases 1 to 3557)
  AUTHORS   Sparks,A.B., Hoffman,N.G., McConnell,S.J., Fowlkes,D.M. and
            Kay,B.K.
  TITLE     Cloning of ligand targets: systematic isolation of SH3
            domain-containing proteins
  JOURNAL   Nat Biotechnol 14 (6), 741-744 (1996)
   PUBMED   9630982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596446.11 and BE955478.1.
            
            On Feb 15, 2018 this sequence version replaced NM_010688.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034404.1, AK078445.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               AL596446.11        78081-78378
            299-393             AL596446.11        85341-85435
            394-478             AL596446.11        94214-94298
            479-586             AL596446.11        103358-103465
            587-743             AL596446.11        112062-112218
            744-847             AL596446.11        112600-112703
            848-3076            AL596446.11        114588-116816
            3077-3557           BE955478.1         1-481               c
FEATURES             Location/Qualifiers
     source          1..3557
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.1 cM"
     gene            1..3557
                     /gene="Lasp1"
                     /gene_synonym="Def-4; LASP-1; MLN 50; SH3P6;
                     Tg(Col1a1-lacZ)1Ngma"
                     /note="LIM and SH3 protein 1"
                     /db_xref="GeneID:16796"
                     /db_xref="MGI:MGI:109656"
     exon            1..298
                     /gene="Lasp1"
                     /gene_synonym="Def-4; LASP-1; MLN 50; SH3P6;
                     Tg(Col1a1-lacZ)1Ngma"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1021
                     /gene="Lasp1"
                     /gene_synonym="Def-4; LASP-1; MLN 50; SH3P6;
                     Tg(Col1a1-lacZ)1Ngma"
                     /note="metastatic lymph node gene 50 protein;
                     Tg(11Col1a1)NG"
                     /codon_start=1
                     /product="LIM and SH3 domain protein 1"
                     /protein_id="NP_034818.1"
                     /db_xref="CCDS:CCDS25332.1"
                     /db_xref="GeneID:16796"
                     /db_xref="MGI:MGI:109656"
                     /translation="MNPNCARCGKIVYPTEKVNCLDKYWHKACFHCETCKMTLNMKNY
                     KGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVA
                     DTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGVEPERREAQDSSSYRRPTEQQQ
                     PQPHHIPTSAPVYQQPQQQQMTSSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAA
                     DEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVEAI"
     exon            299..393
                     /gene="Lasp1"
                     /gene_synonym="Def-4; LASP-1; MLN 50; SH3P6;
                     Tg(Col1a1-lacZ)1Ngma"
                     /inference="alignment:Splign:2.1.0"
     exon            394..478
                     /gene="Lasp1"
                     /gene_synonym="Def-4; LASP-1; MLN 50; SH3P6;
                     Tg(Col1a1-lacZ)1Ngma"
                     /inference="alignment:Splign:2.1.0"
     exon            479..586
                     /gene="Lasp1"
                     /gene_synonym="Def-4; LASP-1; MLN 50; SH3P6;
                     Tg(Col1a1-lacZ)1Ngma"
                     /inference="alignment:Splign:2.1.0"
     exon            587..743
                     /gene="Lasp1"
                     /gene_synonym="Def-4; LASP-1; MLN 50; SH3P6;
                     Tg(Col1a1-lacZ)1Ngma"
                     /inference="alignment:Splign:2.1.0"
     exon            744..847
                     /gene="Lasp1"
                     /gene_synonym="Def-4; LASP-1; MLN 50; SH3P6;
                     Tg(Col1a1-lacZ)1Ngma"
                     /inference="alignment:Splign:2.1.0"
     exon            848..3541
                     /gene="Lasp1"
                     /gene_synonym="Def-4; LASP-1; MLN 50; SH3P6;
                     Tg(Col1a1-lacZ)1Ngma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3515..3520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lasp1"
                     /gene_synonym="Def-4; LASP-1; MLN 50; SH3P6;
                     Tg(Col1a1-lacZ)1Ngma"
                     /note="hexamer: AATAAA"
     polyA_site      3541
                     /gene="Lasp1"
                     /gene_synonym="Def-4; LASP-1; MLN 50; SH3P6;
                     Tg(Col1a1-lacZ)1Ngma"
                     /note="major polyA site"
ORIGIN      
        1 tggtcgcgcg cgcctctttc cgcgcccgag gcgcgtcccc gccctagcca gtgcagcccc
       61 tcctccccac tgtgtttatt aggggaagga gggcggaggc ggaggccagt tccccagttc
      121 cagtcgccgt cgcctgcaca gttgcagccg ccgcctccca ccagctcgcc caaggaaaag
      181 ggaacgcgcg cgaatacggg cgtccccgcc ccagtctttc cccggaacca tgaaccctaa
      241 ctgtgcccgg tgcggcaaga tcgtgtaccc cacggagaag gtgaactgtc tggataagta
      301 ctggcataaa gcatgctttc actgcgagac ctgcaagatg accctgaaca tgaagaacta
      361 caagggttat gagaagaagc cttactgcaa tgcacactat cccaagcagt ccttcaccat
      421 ggtggccgac actccggaaa atctccgcct caagcaacag agcgagctgc agagtcaggt
      481 gcgctacaag gaggaatttg agaagaataa gggcaaaggt ttcagcgtgg tggcagacac
      541 gcctgagctg cagagaatca agaagaccca ggaccagatc agcaatatca aataccatga
      601 ggagtttgag aagagccgca tggggcccag tggaggagaa ggggtggaac cagagcgccg
      661 agaagcccag gacagcagca gctaccggag gcccacagag cagcagcagc cgcagcctca
      721 ccatatcccg accagtgccc ccgtgtacca gcagccccag cagcagcaga tgacctcgtc
      781 ctatggtggg tacaaggagc cagcagcccc tgtctccata cagcgcagtg ccccaggtgg
      841 cggtgggaaa cggtaccgtg cagtgtatga ctacagcgct gccgacgagg acgaggtctc
      901 cttccaggat ggggacacca tcgtcaatgt gcagcagatc gatgacggct ggatgtacgg
      961 gaccgtagag cgcaccggtg acacggggat gctgccagcc aactacgtgg aggccatctg
     1021 aaccctgtgc cgccccgccc tgtcttcaat gcattccatg gcatcacatc tgtcctgggg
     1081 cctgacccgt ccacccttca gtgtctctgt cttttaagat cttcaactgc ttctttatcc
     1141 ccgcccctcc agcttatttt accatcccaa gccttgttct gcccctgtca tgggctcctt
     1201 cctctggcag gttttccctt ggaccaatca actgattgat ttttctctct ggatggaaca
     1261 ggctgggcac tctggggagg gcaggattgt tctgagctag gtagactccc agggctgggc
     1321 tgaactagga gacccactaa ggagatcagt ttagactggg tgcagtggca aacaccctta
     1381 atcccagcga agggaggcag aggcaggcag atctgtgact ttgaagccag cctggtctac
     1441 atcgtgcgtt tcaggacagc cagagctatg tagtgaggcc ctgtctcgga ggaagagtgg
     1501 gggttggtta gctctcagct tcacttcctg ccttaggctc ctcagaaccc ctgacccagc
     1561 tcccccgact cccttcctcc tagagctggg gtgagctgtg tcctcctcat acctccaggt
     1621 gtggctccac acatccccag ggggtcggta ttaaggcctc gtgctgacct ttgccctagt
     1681 ccatcttcct gactctctgc ctcctcggga catccaaagg agagcagagt tcctgcttca
     1741 gactgaatcc ttgcccctct gtgcagtcct ccacataaca gagtgtgccc attctgcccc
     1801 cacacacacc tagggtggcc agggagcgcc ccagaaatcc cagcttgggt cagattcttg
     1861 ccttagttct aggggcagca gcagaaagga aggaacaggg cgctctccct ccctgggcct
     1921 gtttgctccc tgcctcctct ggccctcccg gggctctctt tatctccctg gctgggagcc
     1981 tgcagtgaag ggtagagcaa agggtgcctt tggggcctga ctgagctgtt tgttcctgct
     2041 tccctgggaa aaggtctccg cgtctctcct gtggccttcc ttccccagaa caaggctgga
     2101 ctggctgaga gctctgccaa gccagaaaat ggccagagtc ttctggagcc caggaggccc
     2161 tcccgcctcg ctggggaggt gggagaaggc ttctgggtta gacatgtgct tttctgtcgt
     2221 cgtgtctgag gctacagagc ccagtaccag aagggccgag tcacccacac tgtggttggt
     2281 acctctcacc tgaggctctc ctatccttga agcaaaggag agtccagggc ttcaaagctg
     2341 gcggcaccat ctctgggctg gtgctaaact caagttccct ctttgcctct ggggcctggg
     2401 acagtactca ctctgcttca ttcatctctg ggttttcttg tccctcctcc tgggtcccct
     2461 gattctcatc tttaccttga gtgagcctga tgtcaggttc ctttacatac tcagaccctg
     2521 ctacaggtga ggtttgaacc tgaagacttt gatcaggcca gcaacgtggt tgtcatgagg
     2581 gcttgctaga gtttgcctgc ctggtcaatc cctttacttc cgaccctcgc ctgagtgaag
     2641 gcagggcgtg gtctggtggg cagcatgggg aagagccttg tgggggcatc tcaggagcca
     2701 cggggtgggg ggaggtgcca gcccattcca tttcctctta tctcaaagca caatgtggtt
     2761 ctggggacca gagggagctt gctcttggag ggcctgtgtt caggaggtgc tgcgagcctc
     2821 ctggttcctc tcagctgaac ctcccttccc aacgtcaagt cagctgttct agtgccctag
     2881 aaatggggga gacttacaaa cacctgaaga ggggagagga actacctaag gtgctgaggg
     2941 ccccaagcct gctggagtcc atacttttcc agaaacatct acccctagaa gagcacagaa
     3001 tcccccaagc ccatagtctc ttcctctgta aaggtctttt cagccaatcc aaacccagga
     3061 aagaaggcac cttggctaga ctgtgaactt aacttttgtg gaccaacccc ataatgcaag
     3121 aagccccatg gtgagcgaca taggttctcc cccccgggct gcttcctgtt ctccctcctc
     3181 acgtcccttc ggggacattt tatttcctaa tagctggaca taagacaaaa agtaccaccc
     3241 cacagagcct atatttaaac agaaacagaa gtgaccctgt gaagtccgcc tctgtccaac
     3301 atttcatctg tgtatgaatg tgtgtgtgtg agagagagta tgtgtgcgtg tgtgtgtgtg
     3361 tgagaagcca cccactcatc ttttatatat cgggttgtca tctttctttg gtcccctccc
     3421 tcctggcctt gtccttggga tcatttcttt ctggcctgtt atgattttga acattgactt
     3481 gaaccacaaa gtgaatcttt atcctggtga gtcaaataaa aatgtaattt ttacctgcgg
     3541 aaaaaaaaaa aaaaaaa
//
