LOCUS       NM_134137               3927 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus leucyl-tRNA synthetase 1 (Lars1), mRNA.
ACCESSION   NM_134137 XM_619533 XM_901168 XM_901173 XM_901177 XM_901182
            XM_901187 XM_913429 XM_922755 XM_922767 XM_922771 XM_922775
            XM_922782 XM_922785 XM_989215
VERSION     NM_134137.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3927)
  AUTHORS   You,J.S., Karaman,K., Reyes-Ordonez,A., Lee,S., Kim,Y., Bashir,R.
            and Chen,J.
  TITLE     Leucyl-tRNA Synthetase Contributes to Muscle Weakness through
            Mammalian Target of Rapamycin Complex 1 Activation and Autophagy
            Suppression in a Mouse Model of Duchenne Muscular Dystrophy
  JOURNAL   Am J Pathol 194 (8), 1571-1580 (2024)
   PUBMED   38762116
  REMARK    GeneRIF: Leucyl-tRNA Synthetase Contributes to Muscle Weakness
            through Mammalian Target of Rapamycin Complex 1 Activation and
            Autophagy Suppression in a Mouse Model of Duchenne Muscular
            Dystrophy.
REFERENCE   2  (bases 1 to 3927)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3927)
  AUTHORS   Passarelli,M.C., Pinzaru,A.M., Asgharian,H., Liberti,M.V.,
            Heissel,S., Molina,H., Goodarzi,H. and Tavazoie,S.F.
  TITLE     Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and
            regulates codon-dependent translation dynamics
  JOURNAL   Nat Cell Biol 24 (3), 307-315 (2022)
   PUBMED   35288656
REFERENCE   4  (bases 1 to 3927)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3927)
  AUTHORS   Menendez-Montes,I., Escobar,B., Gomez,M.J., Albendea-Gomez,T.,
            Palacios,B., Bonzon-Kulichenko,E., Izquierdo-Garcia,J.L.,
            Alonso,A.V., Ferrarini,A., Jimenez-Borreguero,L.J.,
            Ruiz-Cabello,J., Vazquez,J. and Martin-Puig,S.
  TITLE     Activation of amino acid metabolic program in cardiac
            HIF1-alpha-deficient mice
  JOURNAL   iScience 24 (2), 102124 (2021)
   PUBMED   33665549
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3927)
  AUTHORS   Yoon,I., Nam,M., Kim,H.K., Moon,H.S., Kim,S., Jang,J., Song,J.A.,
            Jeong,S.J., Kim,S.B., Cho,S., Kim,Y., Lee,J., Yang,W.S., Yoo,H.C.,
            Kim,K., Kim,M.S., Yang,A., Cho,K., Park,H.S., Hwang,G.S.,
            Hwang,K.Y., Han,J.M., Kim,J.H. and Kim,S.
  TITLE     Glucose-dependent control of leucine metabolism by leucyl-tRNA
            synthetase 1
  JOURNAL   Science 367 (6474), 205-210 (2020)
   PUBMED   31780625
  REMARK    GeneRIF: this study provides evidence for a role of leucyl-tRNA
            synthetase 1 (LARS1) in glucose-dependent control of leucine usage
REFERENCE   7  (bases 1 to 3927)
  AUTHORS   Li,B., Wang,Z., Chen,R., Hong,J., Wu,Q., Hu,J., Hu,Z. and Zhang,M.
  TITLE     Up regulation of isoleucyl-tRNA synthetase promotes vascular smooth
            muscle cells dysfunction via p38 MAPK/PI3K signaling pathways
  JOURNAL   Life Sci 224, 51-57 (2019)
   PUBMED   30905780
  REMARK    GeneRIF: High LARS expression is associated with abdominal aortic
            aneurysm.
REFERENCE   8  (bases 1 to 3927)
  AUTHORS   Son,K., You,J.S., Yoon,M.S., Dai,C., Kim,J.H., Khanna,N.,
            Banerjee,A., Martinis,S.A., Han,G., Han,J.M., Kim,S. and Chen,J.
  TITLE     Nontranslational function of leucyl-tRNA synthetase regulates
            myogenic differentiation and skeletal muscle regeneration
  JOURNAL   J Clin Invest 129 (5), 2088-2093 (2019)
   PUBMED   30985292
  REMARK    GeneRIF: leucyl-tRNA synthetase has a nontranslational function in
            regulating myogenic differentiation and skeletal muscle
            regeneration
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3927)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3927)
  AUTHORS   Kim,J.Y., Kang,Y.S., Lee,J.W., Kim,H.J., Ahn,Y.H., Park,H., Ko,Y.G.
            and Kim,S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB652360.1, BC052715.1 and BE989557.1.
            
            On Jul 20, 2018 this sequence version replaced NM_134137.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.5804.1, BC052715.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BB652360.1         3-56
            55-3860             BC052715.1         1-3806
            3861-3927           BE989557.1         1-67                c
FEATURES             Location/Qualifiers
     source          1..3927
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 22.37 cM"
     gene            1..3927
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /note="leucyl-tRNA synthetase 1"
                     /db_xref="GeneID:107045"
                     /db_xref="MGI:MGI:1913808"
     exon            1..165
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..3696
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /EC_number="6.1.1.4"
                     /note="leucyl-tRNA synthetase, cytoplasmic"
                     /codon_start=1
                     /product="leucine--tRNA ligase, cytoplasmic"
                     /protein_id="NP_598898.2"
                     /db_xref="CCDS:CCDS37796.1"
                     /db_xref="GeneID:107045"
                     /db_xref="MGI:MGI:1913808"
                     /translation="MAGRKGTAKVDFLKEIEKEAQQKWEAEKVFEVSASRLEKQKQSS
                     KGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLFPFGLHCTGMPIKAC
                     ADKLKREIELYGCPPDFPEEEEEEEESSAKPGDIVVRDKAKGKKSKAAAKAGSSKYQW
                     DIMKSLGLSDDDIVKFSEAEHWLDYFPPLAVQDLKTIGLKVDWRRSFITTDVNPYYDS
                     FVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLVKLKVLEP
                     YPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETANGDIFICTQRAAR
                     NMSYQGFTKHNGVVPVVKELMGEEILGASLSAPLTCYKVVYVLPMLTIKEDKGTGVVT
                     SVPSDSPDDLAALRDLKKKQALRTKFGIRDDMVLPFEPVPVLEIPGIGNLPAVTVCDE
                     LKIQSQNDREKLAEAKEKLYLRGFYDGVMLVDGFKGQKIQHVKKTIQKNMIDAGDALI
                     YMEPEKQVMSRSADECVVALCDQWYLDYGDENWKKQTFQCLKNMETFCEESRKNFEAS
                     LDWLQEHACSRTYGLGTRLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGDLNGQAESP
                     LGIRPQQMTKDVWDYVFFKDAPFPKTQIPKEKLDQLKQEFEFWYPVDLRASGKDLIPN
                     HLSYYIYNHVAMWPEQSDKWPVSVRANGHLLLNSEKMSKSTGNFLTLSQAVDKFSADG
                     MRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMLASCSSLRSGPADSFNDRV
                     FASEMNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELATEGMHRELVFRFIEV
                     QTILLTPFCPHLCEHIWTLLGKPDSIMHASWPVAGPVDESLIRSSQYLMEVAHDLRLR
                     LKNYMMPAKGKKTDKQPAQRPSHCTIYVAKNYPVWQHITLTTLRSHFEANNGKLPDNK
                     VIASELGSLPELKKYMKKVMPFVAMIKENMEKKGPRVLDLELEFDEQAVLMENIVYLT
                     NSLELEHIEVKFASEAEDKVREECCPGKPLNVFRTEPGVPVSLVNPQPSSGHFSTKID
                     IRQGDSCESIIRRLMKTDRGIKDLSKVKLMRFDDPLLGPRRVPVLGREHSEKTLISEN
                     AVFHVDLVSKKVHLTENGLRTDIGDTMVYLVH"
     exon            166..290
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            291..378
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            379..459
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            460..597
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            598..759
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            760..872
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            873..936
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1004
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1230
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1318
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1395
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1449
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1590
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1668
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1754
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1820
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1903
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2042
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2255
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2313
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2377
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2561
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2652
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2793
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2934
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3045
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3156
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3261
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3357
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3490
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     exon            3491..3911
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3840..3845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /note="hexamer: AATAAA"
     polyA_site      3860
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /note="major polyA site"
     regulatory      3890..3895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
                     /note="hexamer: AATAAA"
     polyA_site      3911
                     /gene="Lars1"
                     /gene_synonym="2310045K21Rik; 3110009L02Rik; Lars; leuRS"
ORIGIN      
        1 gtagtcagtg agctttgcga ttgcctcagc aagtgtgaag tgtgtgcttt ggtgtcttga
       61 gaggctagac ttccacgagt gggagggaaa agttggacct acatctctga ggggttcatt
      121 gggcaactgt actggatctt cagtcgtttg ggcggcgcca tggcgggaag aaaaggaact
      181 gctaaagtag acttcttgaa ggagatcgag aaagaggccc agcagaagtg ggaagctgag
      241 aaagtgtttg aagtcagtgc ctcccggctg gagaagcaga agcagagcag caagggcaaa
      301 tactttgtca ccttcccata tccatacatg aatggacgcc ttcatttggg acacacgttt
      361 tccttatcca agtgtgagtt tgcagtagga taccagagat taaaaggaaa aagctgtctg
      421 tttccctttg ggttgcactg tactggtatg cctattaagg catgcgctga caagctgaaa
      481 agagaaatag agctgtatgg ctgccctcct gattttcccg aggaagaaga ggaagaggaa
      541 gaaagcagtg ctaaacctgg agatatagta gtgagggata aagccaaagg gaaaaagagc
      601 aaagctgccg ccaaagcagg atcttctaag taccagtggg acattatgaa atcccttggg
      661 ctctctgatg acgacatagt gaagttttct gaagcagagc actggcttga ttatttccca
      721 ccactggccg ttcaggatct gaagactata ggtttgaagg tagactggcg gcgctccttc
      781 atcaccacgg acgtgaatcc ttactacgat tcctttgtca ggtggcagtt tttaacttta
      841 agagaaagaa ataaaattaa atttgggaag cggtacacta tttattcccc aaaagatgga
      901 cagccttgca tggatcatga cagacaaact ggagagggtg ttggacctca ggaatatact
      961 ctggtcaaac tgaaggtgct tgaaccatat ccatcaaaat taagcggcct gaaagggaaa
     1021 aatatcttcc tagtagctgc tacactcaga cctgagacta tgtttgggca gacaaattgt
     1081 tgggttcggc ctgatatgaa atacattggg tttgagacag caaatggaga catcttcatc
     1141 tgtacccaga gagcagccag gaatatgtca taccaaggct tcaccaagca caacggagtg
     1201 gtgccggttg tgaaggagtt aatgggagag gaaatccttg gggcttcact ttctgcaccc
     1261 ctgacgtgct ataaggtggt ctacgttctc cctatgctga ccattaaaga ggataaaggc
     1321 actggggtgg tcacgagcgt tccttctgat tccccggatg atcttgcagc actcagagac
     1381 ttgaagaaaa agcaagcctt acgaacaaag tttggaatta gggatgacat ggtcctgccg
     1441 tttgaaccgg tgccagtcct ggaaatccca gggattggaa atcttcctgc tgtgactgtt
     1501 tgtgatgagc tgaaaattca gagccagaat gaccgtgaaa aacttgcaga agcaaaggag
     1561 aaattgtatt taagaggatt ttatgatggt gtaatgctag tggatggctt taaaggacag
     1621 aagatccaac atgtaaagaa gactattcag aaaaacatga ttgatgctgg agatgcgctt
     1681 atctacatgg agccagaaaa acaagtgatg tcgaggtctg cagatgagtg cgtcgtggcc
     1741 ctgtgtgacc agtggtactt ggattatgga gatgagaact ggaagaaaca gacatttcag
     1801 tgcctgaaga acatggaaac attctgcgag gagagcagga agaattttga agcttcctta
     1861 gactggctac aagaacatgc ttgctcaaga acgtacggtt taggcactcg tctgccttgg
     1921 gatgaacagt ggttaatcga atctctctcg gattccacaa tttacatggc gttctacaca
     1981 gtggcacacc tgctgcaggg gggtgacctg aatgggcagg cggagtctcc actgggcatc
     2041 agaccccagc agatgacaaa ggacgtttgg gattatgtgt tcttcaagga tgctccattt
     2101 cctaagactc agatcccaaa ggagaagctg gatcagttga agcaggagtt tgagttttgg
     2161 tacccagtgg accttcgagc ctctggcaag gatctgattc caaatcatct ttcatattac
     2221 atttacaacc atgtggccat gtggccagag caaagtgaca agtggcccgt gtctgtccga
     2281 gcaaatggac acctgctgct caactcggag aagatgtcaa aatctacggg caacttcctc
     2341 actttgagcc aagctgttga caaattttca gctgacggaa tgcgcctggc tctggctgat
     2401 gctggtgaca ctgttgaaga tgctaacttt gtggaagcca tggcagacgc aggcatcctc
     2461 cgtctgtaca catgggtaga gtgggtcaaa gaaatgctcg ccagctgcag cagcctcaga
     2521 agtggacctg ccgactcatt caatgatcgt gtgtttgcca gtgaaatgaa tgcaggaatt
     2581 ataaaaacag atcaaaacta tgaaaagatg atgtttaaag aagctttgaa aacaggtttt
     2641 tttgagtttc aggctgcgaa agacaaatac cgtgaactgg ccacggaggg catgcacaga
     2701 gagcttgtgt tccgctttat tgaagttcag acaatccttc tgactccatt ctgtccacat
     2761 ttgtgtgagc acatctggac actgcttgga aagcctgatt caatcatgca tgcctcatgg
     2821 cctgtggcag gtcccgtgga tgagtccttg atccgttcct cacagtatct catggaagta
     2881 gcacatgacc ttagattacg gctcaagaat tacatgatgc cagctaaagg gaagaagact
     2941 gacaagcagc cagctcagag gccctcacac tgcaccatct atgtggcaaa gaactacccc
     3001 gtctggcagc acattaccct gacaaccctg cggagccact ttgaggccaa caatggaaag
     3061 ttgcctgata acaaagtcat tgctagtgaa ctaggcagtt tgccagagtt gaagaaatat
     3121 atgaagaaag tgatgccatt cgttgctatg attaaggaaa acatggagaa gaaagggccg
     3181 agagtcttgg atttagagct ggagtttgat gagcaggcag tgcttatgga gaatatagtc
     3241 tacctaacca attctctcga gctggaacac atagaagtca agtttgcctc tgaggctgaa
     3301 gataaagtca gggaggagtg ctgtcctggg aagccactta acgttttcag aacagaacct
     3361 ggtgtgccag tttccctagt aaatcctcag ccatcgagtg ggcacttctc caccaaaatc
     3421 gacatcaggc aaggagatag ctgtgagtcc ataatcagac gcttgatgaa aacggaccga
     3481 gggatcaaag atctttccaa agtgaagctg atgcggtttg atgatcctct gttggggcct
     3541 cggcgagttc cggtcctggg gagagagcac agtgagaaga cactcatttc cgagaacgcc
     3601 gttttccacg tggacctggt gagcaagaaa gtccacctca ccgagaacgg gctgcgcacg
     3661 gacatcggcg acaccatggt ctacctggtt cactgagctc atgcaaattg gagagtcggg
     3721 atggttttcg gatacttctg ctccgagaat ctcaagctgg ctctaactag acttcatttc
     3781 taactgctga gttctgtatg tagtcagaat tatcccaatt cttctttgat ttctaatcta
     3841 ataaacttgc atttttttca cctttgggcc atgttattta tttattttta ataaataatt
     3901 gctggtccct aaaaaaaaaa aaaaaaa
//
