LOCUS       NM_138593               2135 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus La ribonucleoprotein 7, transcriptional regulator
            (Larp7), mRNA.
ACCESSION   NM_138593 NM_001037823
VERSION     NM_138593.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2135)
  AUTHORS   Wang,M., Liu,X., Fang,Y. and Li,Q.
  TITLE     Extra-cerebral recombination activity of Emx1-Cre and nestin-Cre in
            the kidney
  JOURNAL   Front Cell Dev Biol 12, 1480217 (2024)
   PUBMED   39479517
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2135)
  AUTHORS   Yang,P., Wu,S., Li,Y., Lou,Y., Xiong,J., Wang,Y., Geng,Z. and
            Zhang,B.
  TITLE     LARP7 overexpression alleviates aortic senescence and
            atherosclerosis
  JOURNAL   J Cell Mol Med 28 (11), e18388 (2024)
   PUBMED   38818612
  REMARK    GeneRIF: LARP7 overexpression alleviates aortic senescence and
            atherosclerosis.
REFERENCE   3  (bases 1 to 2135)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2135)
  AUTHORS   Li,N. and Liu,Y.
  TITLE     LARP7 upregulates SIRT1 deacetylase activity and inhibits Th1/Th17
            cytokine response in psoriatic mice
  JOURNAL   Allergol Immunopathol (Madr) 51 (6), 16-22 (2023)
   PUBMED   37937491
  REMARK    GeneRIF: LARP7 upregulates SIRT1 deacetylase activity and inhibits
            Th1/Th17 cytokine response in psoriatic mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2135)
  AUTHORS   Li,N. and Liu,Y.
  TITLE     LARP7 alleviates psoriasis symptoms in mice by regulating the
            SIRT1/NF-kappaB signaling pathway
  JOURNAL   Allergol Immunopathol (Madr) 51 (1), 140-145 (2023)
   PUBMED   36617833
  REMARK    GeneRIF: LARP7 alleviates psoriasis symptoms in mice by regulating
            the SIRT1/NF-kappaB signaling pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2135)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2135)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2135)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2135)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   10 (bases 1 to 2135)
  AUTHORS   Kerr,S.M., Taggart,M.H., Lee,M. and Cooke,H.J.
  TITLE     Ott, a mouse X-linked multigene family expressed specifically
            during meiosis
  JOURNAL   Hum Mol Genet 5 (8), 1139-1148 (1996)
   PUBMED   8842733
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY269910.1, AK162147.1, AK082815.1, BM946683.1 and BU701061.1.
            
            On or before Jul 25, 2006 this sequence version replaced
            NM_001037823.1, NM_138593.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164140,
                              SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                BY269910.1         1-85
            86-1082             AK162147.1         3-999
            1083-1231           AK082815.1         1082-1230
            1232-1810           BM946683.1         100-678
            1811-2135           BU701061.1         1-325               c
FEATURES             Location/Qualifiers
     source          1..2135
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 56.54 cM"
     gene            1..2135
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /note="La ribonucleoprotein 7, transcriptional regulator"
                     /db_xref="GeneID:28036"
                     /db_xref="MGI:MGI:107634"
     exon            1..167
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /inference="alignment:Splign:2.1.0"
     exon            168..352
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1881
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /note="La ribonucleoprotein domain family, member 7"
                     /codon_start=1
                     /product="la-related protein 7"
                     /protein_id="NP_613059.2"
                     /db_xref="CCDS:CCDS38626.1"
                     /db_xref="GeneID:28036"
                     /db_xref="MGI:MGI:107634"
                     /translation="METENQKTMEESTKRKEEKKKRSRVKQVLADIAKQVDFWFGDAN
                     LHKDKFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALKSSSVVELDLEGTR
                     IRRKKPLGERPKDEEERTVYVELLPKNVTHSWIERVFGKCGNVVYISIPHYKSTGDPK
                     GFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPSLRVAEEKKKKKKK
                     KGRIKKEESVQAKESAVDSSSSGVCKATKRPRTASEGSEAETPEAPKQPAKKKKKRDK
                     VEASSLPEARAGKRERCSAEDEDCLPPRPKAKKRAQKDGVGQAASEVSKESRDLEFCS
                     TEEEKETDRKGDSLSKVKRKHKKKHKERHKMGEEVIPLRVLSKTEWMDLKKEYLALQK
                     ASMASLKKTISQIKLESEMETDCKAPTAGSGQECSTQEKVSAQGPQFVTGVIVKIVSG
                     EPLPGRKQVKDILATISEVVYIDLLEGDTECHARFKTPEDAQAVMNAQTEIRKKHSWN
                     LEVLSGDHEQRYWQKILVDRQAKLNQPREKKRGTEKLITKAEKIRLAKTQQASQHIRF
                     SEYD"
     exon            353..453
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /inference="alignment:Splign:2.1.0"
     exon            454..537
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /inference="alignment:Splign:2.1.0"
     exon            538..702
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /inference="alignment:Splign:2.1.0"
     exon            703..796
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1153
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1298
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1423
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1548
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1708
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1800
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..2121
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2100..2105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /note="hexamer: AATAAA"
     polyA_site      2121
                     /gene="Larp7"
                     /gene_synonym="C330027G06Rik; D3Wsu161e"
                     /note="major polyA site"
ORIGIN      
        1 tatgacgtca gcaacgaacc ctgggcctcg gacccgtctt tccgtagcgg gctgagagaa
       61 gcgcgtcgct actcgaatga cgcaaatttc cgccgaccgc aggggtcggg agaaggaaag
      121 cgtgggagaa cacaagcgct gaccgtggat ctggggacga gcacggaaat ggaaactgaa
      181 aaccaaaaaa ctatggaaga aagcactaag agaaaagaag aaaaaaagaa gcgctcccgg
      241 gttaaacagg tgcttgcaga tattgctaag caggtggact tctggtttgg agatgcaaac
      301 cttcacaagg acaagtttct gcgagagcaa attgaaaagt ctagagatgg atatgtggac
      361 atttctctcc tggtgtcttt taacaaaatg aagaagctga caactgatgg gaagctaata
      421 gccagagcat tgaaaagctc atctgttgta gagttggact tagaagggac cagaatcagg
      481 aggaaaaaac ccctaggtga gagaccaaag gacgaggagg aacgcacggt atatgtggag
      541 ttgctcccca aaaatgttac tcatagctgg attgagagag tatttgggaa atgtggcaat
      601 gtggtttaca taagtattcc acattacaag tctactgggg atcctaaggg atttgccttt
      661 gtggaatttg aaacaaaaga gcaagcagca aaagccattg agtttctgaa caacccacca
      721 gaagaagcac ctagaaagcc tggtatattt cccaagacag tgaaaaacaa gcccatccct
      781 tccttacgag tagcagaaga gaagaaaaag aagaaaaaga aaaaaggcag aataaagaag
      841 gaagagagtg tgcaggccaa agagtcggcc gtggacagca gcagctcggg cgtgtgtaaa
      901 gccacgaaga gaccaaggac ggcctctgag ggctccgaag cagaaacccc ggaagctcca
      961 aagcaacctg caaagaaaaa gaagaagcgg gacaaggtgg aagcatccag cttacctgaa
     1021 gccagggcag ggaagaggga gaggtgcagc gccgaggacg aagactgcct ccccccaagg
     1081 ccaaaagcta agaaaagggc tcagaaggat ggcgtcggcc aagcagcttc cgaggtctcc
     1141 aaggagagca gagacttaga attctgctct actgaggagg agaaggagac agacagaaaa
     1201 ggtgactcac tctcaaaggt gaagaggaag cataagaaga aacacaagga gagacataag
     1261 atgggcgagg aggttatacc attgagagtg ctgtccaaga ctgaatggat ggatttgaag
     1321 aaagagtatt tggcactgca aaaagctagc atggcttctc taaaaaaaac aatatctcaa
     1381 atcaaattgg aatcagaaat ggaaacagac tgtaaagcgc ctacagcagg cagtggtcaa
     1441 gagtgttcca cccaggagaa ggtcagtgca caaggcccac agtttgtgac tggagtgatt
     1501 gtgaagattg tgagcggaga gcctctaccg ggcaggaaac aagtcaagga tattttggcc
     1561 acaatctcag aagttgttta cattgatttg ctagaaggag atactgaatg ccatgcccga
     1621 tttaaaaccc ccgaggatgc tcaggcagta atgaatgcac agactgaaat tagaaagaag
     1681 cacagttgga acctcgaggt cctttctggg gatcatgagc agaggtactg gcagaagatt
     1741 ttggtagata gacaggccaa acttaatcaa cctcgggaaa agaaaagagg cacagaaaag
     1801 ctaatcacca aagctgagaa gattagactg gctaagactc agcaagccag tcagcacatc
     1861 cgtttctctg agtatgactg agaagatgac gacttttggg cctcccttgc tgaagtgttc
     1921 ttactgctgg gctgcctcat gactgttgtg ttgagatctg catgagaaaa gaaaaggaaa
     1981 aaaccttggc tcctcaatgt gtcaataaga cttttctaat aacaagtgca tgtttgtcag
     2041 attttttcaa tgaacaccct tacttttgaa tttacgcaaa tgcaacttca gatttcataa
     2101 ataaatgtgt tttgaacata aaaaaaaaaa aaaaa
//
