LOCUS       NM_026235               2308 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus La ribonucleoprotein 6, translational regulator
            (Larp6), mRNA.
ACCESSION   NM_026235
VERSION     NM_026235.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2308)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2308)
  AUTHORS   Zuo,S., Wang,B., Liu,J., Kong,D., Cui,H., Jia,Y., Wang,C., Xu,X.,
            Chen,G., Wang,Y., Yang,L., Zhang,K., Ai,D., Du,J., Shen,Y. and
            Yu,Y.
  TITLE     ER-anchored CRTH2 antagonizes collagen biosynthesis and organ
            fibrosis via binding LARP6
  JOURNAL   EMBO J 40 (16), e107403 (2021)
   PUBMED   34223653
REFERENCE   3  (bases 1 to 2308)
  AUTHORS   Sabik,O.L., Medrano,J.F. and Farber,C.R.
  TITLE     Genetic Dissection of a QTL Affecting Bone Geometry
  JOURNAL   G3 (Bethesda) 7 (3), 865-870 (2017)
   PUBMED   28082324
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2308)
  AUTHORS   Guo,Y., Tang,C.Y., Man,X.F., Tang,H.N., Tang,J., Zhou,C.L.,
            Tan,S.W., Wang,M., Feng,Y.Z. and Zhou,H.D.
  TITLE     Insulin-like growth factor-1 promotes osteogenic differentiation
            and collagen I alpha 2 synthesis via induction of mRNA-binding
            protein LARP6 expression
  JOURNAL   Dev Growth Differ 59 (2), 94-103 (2017)
   PUBMED   28211947
  REMARK    GeneRIF: Data indicate that insulin-like growth factor 1 (IGF1)
            could promote collagen I alpha 2 (COL1A2) expression and osteoblast
            differentiation in primary pre-osteoblasts by increasing La
            ribonucleoprotein domain family member 6 (Larp6) expression via a
            posttranscriptional mechanism.
REFERENCE   5  (bases 1 to 2308)
  AUTHORS   Blackstock,C.D., Higashi,Y., Sukhanov,S., Shai,S.Y., Stefanovic,B.,
            Tabony,A.M., Yoshida,T. and Delafontaine,P.
  TITLE     Insulin-like growth factor-1 increases synthesis of collagen type I
            via induction of the mRNA-binding protein LARP6 expression and
            binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA
  JOURNAL   J Biol Chem 289 (11), 7264-7274 (2014)
   PUBMED   24469459
  REMARK    GeneRIF: LARP6 is a critical mediator by which IGF-1 augments
            synthesis of collagen type I in vascular smooth muscle
REFERENCE   6  (bases 1 to 2308)
  AUTHORS   Shao,R., Scully,S.J. Jr., Yan,W., Bentley,B., Mueller,J., Brown,C.,
            Bigelow,C. and Schwartz,L.M.
  TITLE     The novel lupus antigen related protein acheron enhances the
            development of human breast cancer
  JOURNAL   Int J Cancer 130 (3), 544-554 (2012)
   PUBMED   21387291
  REMARK    GeneRIF: Achn enhances human breast tumor growth and
            vascularization and that this activity is dependent on nuclear
            localization.
REFERENCE   7  (bases 1 to 2308)
  AUTHORS   Wang,Z., Glenn,H., Brown,C., Valavanis,C., Liu,J.X., Seth,A.,
            Thomas,J.E., Karlstrom,R.O. and Schwartz,L.M.
  TITLE     Regulation of muscle differentiation and survival by Acheron
  JOURNAL   Mech Dev 126 (8-9), 700-709 (2009)
   PUBMED   19481601
  REMARK    GeneRIF: achn plays key roles in the processes of differentiation
            and self-renewal
REFERENCE   8  (bases 1 to 2308)
  AUTHORS   Weng,H., Kim,C., Valavanis,C., Wang,Z. and Schwartz,L.M.
  TITLE     Acheron, an novel LA antigen family member, binds to CASK and forms
            a complex with Id transcription factors
  JOURNAL   Cell Mol Biol Lett 14 (2), 273-287 (2009)
   PUBMED   19096764
  REMARK    Erratum:[Cell Mol Biol Lett. 2009 Jan 28;14(2):288. doi:
            10.2478/s11658-009-0005-5.. Dosage error in article text. PMID:
            30534160]
REFERENCE   9  (bases 1 to 2308)
  AUTHORS   Valavanis,C., Wang,Z., Sun,D., Vaine,M. and Schwartz,L.M.
  TITLE     Acheron, a novel member of the Lupus Antigen family, is induced
            during the programmed cell death of skeletal muscles in the moth
            Manduca sexta
  JOURNAL   Gene 393 (1-2), 101-109 (2007)
   PUBMED   17383118
  REMARK    GeneRIF: These data define Achn as a newly discovered regulatory
            molecule that presumably mediates a variety of developmental and
            homeostatic processes in animals.
REFERENCE   10 (bases 1 to 2308)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC156940.1.
            
            On Apr 29, 2007 this sequence version replaced NM_026235.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087521.1, AK042616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AC156940.1         116594-116878       c
            286-496             AC156940.1         105642-105852       c
            497-2308            AC156940.1         91198-93009         c
FEATURES             Location/Qualifiers
     source          1..2308
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 32.87 cM"
     gene            1..2308
                     /gene="Larp6"
                     /gene_synonym="5430431G03Rik; Achn"
                     /note="La ribonucleoprotein 6, translational regulator"
                     /db_xref="GeneID:67557"
                     /db_xref="MGI:MGI:1914807"
     exon            1..285
                     /gene="Larp6"
                     /gene_synonym="5430431G03Rik; Achn"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1564
                     /gene="Larp6"
                     /gene_synonym="5430431G03Rik; Achn"
                     /note="acheron; La ribonucleoprotein domain family, member
                     6"
                     /codon_start=1
                     /product="la-related protein 6"
                     /protein_id="NP_080511.2"
                     /db_xref="CCDS:CCDS23258.1"
                     /db_xref="GeneID:67557"
                     /db_xref="MGI:MGI:1914807"
                     /translation="MAQLGEQTLPGPETTVQIRVAIQEAEDLEDLEEEDEGTSARAAG
                     DPARYLSPGWGSASEEEPSRGHSSATTSGGENDREDLEPEWRPPDEELIRKLVDQIEF
                     YFSDENLEKDAFLLKHVRRNKLGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSVTLEL
                     NEDHRKVRRTTPVPLFPNENLPSKMLLVYDLHLSPKLWALATPQKNGRVQEKVMEHLL
                     KLFGTFGVISSVRILKPGRELPPDIRRISSRYSQVGTQECAIVEFEEVDAAIKAHEFM
                     VTESQSKENMKAVLIGMKPPKKKPLKDKNHDDEATAGTHLSRSLNKRVEELQYMGDES
                     SANSSSDPESNPTSPMAGRRHAASNKLSPSGHQNIFLSPNASPCSSPWSSPLAQRKGV
                     SRKSPLAEEGRLNFSTSPEIFRKCMDYSSDSSITPSGSPWVRRRRQAEMGTQEKSPGA
                     SPLLSRRMQTADGLPVGVLRLPRGPDNTRGFHGGHERGRACV"
     exon            286..496
                     /gene="Larp6"
                     /gene_synonym="5430431G03Rik; Achn"
                     /inference="alignment:Splign:2.1.0"
     exon            497..2308
                     /gene="Larp6"
                     /gene_synonym="5430431G03Rik; Achn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2023..2028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Larp6"
                     /gene_synonym="5430431G03Rik; Achn"
                     /note="hexamer: AATAAA"
     regulatory      2030..2035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Larp6"
                     /gene_synonym="5430431G03Rik; Achn"
                     /note="hexamer: AATAAA"
     polyA_site      2042
                     /gene="Larp6"
                     /gene_synonym="5430431G03Rik; Achn"
                     /note="major polyA site"
     polyA_site      2056
                     /gene="Larp6"
                     /gene_synonym="5430431G03Rik; Achn"
ORIGIN      
        1 gccgcgcgcg cgccgcccac gcgcgatcgt cgctatcgag ggctgccggc tggcctggcc
       61 tcgcgacacg gagaccctgc caaccatggc ccagctcggc gaacagactc tgcctgggcc
      121 cgagaccacg gtgcagatcc gtgtcgccat ccaggaggct gaggatctgg aggatctgga
      181 ggaggaggac gaggggacct cggcgcgggc agcgggggac ccagcccggt acctcagtcc
      241 cggctggggc agcgccagcg aggaggagcc gagccgcggg cacagtagtg ccacgacaag
      301 tgggggcgag aacgatcgcg aggacctgga gcctgagtgg aggcccccgg acgaggagct
      361 catcaggaag ctggtggatc agattgagtt ctacttttcg gacgagaacc tggagaagga
      421 cgccttcctg ctgaagcacg tgcggaggaa caagctgggc tacgtgagcg tcaagctgct
      481 cacctccttc aagaaggtga aacacctcac ccgggactgg aggaccacag cacacgcctt
      541 gaagtattca gtcaccctgg agttgaacga ggaccaccgg aaggttagga ggaccacccc
      601 tgtgccactg ttccccaatg agaacctccc cagcaagatg ctgctggtct atgacctaca
      661 cctgtcccct aagctctggg ccctggccac accccagaag aacggaaggg tgcaggagaa
      721 ggtgatggag catctgctca agctctttgg gacttttggc gtcatctcat cggtgcggat
      781 cctaaaacct gggagagagc tgccccctga catccggagg atcagcagcc gctacagcca
      841 ggtggggacc caagagtgcg ccattgtgga gttcgaggag gtggacgcgg ccattaaagc
      901 ccatgaattc atggtcactg aatctcagag caaagagaac atgaaggctg ttctgattgg
      961 gatgaagccg cccaaaaaga aacccctcaa agataagaac catgacgatg aggccacagc
     1021 aggtacccac ctaagcagat ccctgaacaa gagagtggag gaacttcagt acatggggga
     1081 tgagtcttcc gccaacagct cctctgaccc tgagagcaat cccacctctc ccatggccgg
     1141 ccggcggcac gcggccagca acaagctcag cccttcgggc caccagaata tttttctgag
     1201 ccccaatgcc tccccgtgct caagcccatg gagcagcccc ttggcacagc gcaagggtgt
     1261 ctccagaaaa tccccgctgg ctgaagaagg tagactgaac ttcagcacca gccctgagat
     1321 cttccgaaag tgcatggatt attcttccga cagcagcatc actccctcgg gcagcccctg
     1381 ggttcgcaga cgacgccagg ctgagatggg gactcaggag aaaagtccag gggcgagtcc
     1441 cctgctgtct cggaggatgc agaccgcaga tgggttacct gtgggggtgc tgaggctgcc
     1501 cagaggcccc gacaacacca ggggcttcca cggtggacat gagagaggca gagcctgtgt
     1561 ataatgcctt ctatttttta ataccagctc catcggaaac cgtctttgtt ttcgagatcc
     1621 tcactaatag ctagcatgac agagaatgga gttcagtccc cttagaaagc ttttgtatcc
     1681 atgtagacct cttaatttat atatttgtaa ggtatacaaa ctgtctggtg ggccatgggt
     1741 ttaggatcgt cttctggctg gggctgttgc tctcagcaag gccactgttc tgtcaatgct
     1801 tggcatgtgt tagtgtggtg gctctgaagg gctgtgggac agaggatctc tggaaagatc
     1861 tagtagtgtc ggaccgtttt tttcttacaa tgactgagct gtctttggca ggccgcgcaa
     1921 gggctcctct taagacctca aaggagatgt gctttatggt aaatcctaca gtcaatagca
     1981 tggtgtctca taggactgag tgtgtctgtt ccctgtcaag tgaataaata ataaaacacc
     2041 cactggaagt cctttatctg aggtcacaga gatgcctttt caagacagaa cccaacgggg
     2101 acatgttccc tctctctagc tcacggtgtc cctgcagggc agtcccggac tctcctggag
     2161 gcttctggca gcctgggagg tctgtcatct ctaggagtct cgctgaacag gcagcttaga
     2221 cagttcctgc tgtctccaca gcgttccaga ctaacagtgt ttgacatcac ctgagaactt
     2281 gcaagaaata aaagtttcta ggccccag
//
