LOCUS       NM_001284523            6543 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus La ribonucleoprotein 4 (Larp4), transcript variant 5,
            mRNA.
ACCESSION   NM_001284523
VERSION     NM_001284523.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6543)
  AUTHORS   Tian,Y., Zeng,Z., Li,X., Wang,Y., Chen,R., Mattijssen,S.,
            Gaidamakov,S., Wu,Y., Maraia,R.J., Peng,W. and Zhu,J.
  TITLE     Transcriptome-wide stability analysis uncovers LARP4-mediated
            NFkappaB1 mRNA stabilization during T cell activation
  JOURNAL   Nucleic Acids Res 48 (15), 8724-8739 (2020)
   PUBMED   32735645
  REMARK    GeneRIF: Transcriptome-wide stability analysis uncovers
            LARP4-mediated NFkappaB1 mRNA stabilization during T cell
            activation.
REFERENCE   2  (bases 1 to 6543)
  AUTHORS   Mattijssen,S., Arimbasseri,A.G., Iben,J.R., Gaidamakov,S., Lee,J.,
            Hafner,M. and Maraia,R.J.
  TITLE     LARP4 mRNA codon-tRNA match contributes to LARP4 activity for
            ribosomal protein mRNA poly(A) tail length protection
  JOURNAL   Elife 6, e28889 (2017)
   PUBMED   28895529
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6543)
  AUTHORS   Mattijssen,S. and Maraia,R.J.
  TITLE     LARP4 Is Regulated by Tumor Necrosis Factor Alpha in a
            Tristetraprolin-Dependent Manner
  JOURNAL   Mol Cell Biol 36 (4), 574-584 (2015)
   PUBMED   26644407
  REMARK    GeneRIF: Mouse LARP4 is regulated by TNF-alpha in a TTP-dependent
            manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6543)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   5  (bases 1 to 6543)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   6  (bases 1 to 6543)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ080411.1, AK139636.1, AK139909.1, AK141743.1, AK052358.1,
            BE951991.1 and AI853685.1.
            
            Transcript Variant: This variant (5) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. The
            encoded isoform (5) is longer, compared to isoform 1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               CJ080411.1         2-205
            205-729             AK139636.1         208-732
            730-2523            AK139909.1         578-2371
            2524-3754           AK141743.1         313-1543
            3755-5626           AK052358.1         13-1884
            5627-6179           BE951991.1         156-708
            6180-6543           AI853685.1         1-364               c
FEATURES             Location/Qualifiers
     source          1..6543
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.13 cM"
     gene            1..6543
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="La ribonucleoprotein 4"
                     /db_xref="GeneID:207214"
                     /db_xref="MGI:MGI:2443114"
     exon            1..204
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..2349
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="isoform 5 is encoded by transcript variant 5;
                     la-related protein 4; La ribonucleoprotein domain family,
                     member 4"
                     /codon_start=1
                     /product="la-related protein 4 isoform 5"
                     /protein_id="NP_001271452.1"
                     /db_xref="GeneID:207214"
                     /db_xref="MGI:MGI:2443114"
                     /translation="MLLFVEQVTSKGTGLNPNAKVWQEIPSGNPDGTPVTEPSWHETA
                     ATSGSHPEGHTELSEDMCKEYEVMYSPSCETTRNTADVEESADGMILGPEDLSYQLYD
                     VSGESSSAISTEDLKECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEEI
                     KKLTTNTDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPVEEVKALFKN
                     ENCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFA
                     KNGYRLMDSSMYTQPIQTPTQYPSPVFMQPVYNPQQYSVYSLVPQSWSPSPAPYFETP
                     LAPFPNGSFVNGFSSPGSYKTNAAAMNMGRPFPKNRVKPHFRSSSGSEHSTEGSVSLG
                     DGPLSRSSSRIFLSERHNPTVTGQQEQTYLPKEAPILQMEQNGDFGRGRRTLFRGRRR
                     RDDDRIPRPQPAATEAKAPTPKFDLLATNFPPLPGSSSRVPDELGLENRMSDVVKGVC
                     REKDSEDVRVSCPVPAEDGQTDCTSAPLSISPSPPCTAEPPVLSTTQQEQDQMEDSAV
                     PKDTLNPVAVPVSSPTATKPSPANTASPCTSNINPPRAVALQEPRKLSYAEVCQKPPK
                     EPSPVLVQPLRELRSNAVSPTRNEENGAPEKPVEKPHEKPETRASKDHSGFRGNTIPR
                     GAAGKIREQRRQFSHRATPQGVTRRNGKEQYVPPRSPK"
     exon            205..343
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            344..499
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            500..575
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            576..712
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            713..816
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            817..927
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            928..981
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1191
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1295
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1508
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1557
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1719
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1841
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2010
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..6533
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4504..4509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="hexamer: AATAAA"
     polyA_site      4523
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="major polyA site"
     regulatory      6423..6428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="hexamer: CATAAA"
     polyA_site      6440
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
ORIGIN      
        1 agttgttgct tcccgggagg agggactggg cgggtcaggg cgcagcggct gacggcgggg
       61 gaggagccgg gtccactgcc gggtggaggg gcaaggcgag tgtccttatc ctaccgaccg
      121 gggcccgggc ctgggagcca gttggagtcg cggcagcgtg aacgatcggg ccgagcggaa
      181 gcagacatgt tgctcttcgt tgagcaggtg acatctaaag gcactggttt aaatcctaat
      241 gccaaagtat ggcaagaaat tccttctgga aatccggatg gcactcctgt aactgaaccc
      301 tcttggcatg aaactgcagc cacatctgga tctcaccctg agggccatac agaactttca
      361 gaagatatgt gtaaggaata tgaagtaatg tattctccat cttgtgaaac cacaaggaat
      421 actgcagatg ttgaagagtc agctgatgga atgatcttag gaccggaaga cctgagttac
      481 caactctatg atgtttctgg agaaagcagt tcagcaattt ctacagaaga tttaaaagaa
      541 tgtctgaaaa aacaattgga attctgtttc tcacgagaaa atttatcaaa ggacctttac
      601 ttgatatctc aaatggatag tgatcagttc gtcccaatat ggacggttgc caacatggaa
      661 gaaattaaaa aattgactac aaatacagat ttaattcttg aagtattgag atcttcccct
      721 atggtacaag ttgatgagaa gggagaaaag gtgagaccaa gtcataagcg atgtattgtg
      781 attctcagag agattcctga gacaacgcct gtagaggaag tgaaagcttt gtttaaaaat
      841 gaaaactgcc ccaaagtgat aagctgtgag tttgcgcaca acagcaactg gtacatcact
      901 ttccagtcag acacagatgc acagcaggct tttaaatact taagagaaga agttaaaaca
      961 tttcagggca agccaatcat ggcaaggata aaagccatca atacattttt tgctaagaat
     1021 ggttatcgat taatggattc tagtatgtat actcaaccta ttcagactcc tacccaatat
     1081 ccctcaccag tcttcatgca accagtgtat aatcctcagc agtactcagt gtatagtctt
     1141 gtgcctcagt cttggtctcc aagtcctgca ccttactttg aaacaccact ggctcccttt
     1201 cccaatggta gttttgtgaa tggctttagt tcaccaggat cttacaaaac aaatgctgct
     1261 gctatgaata tgggccgacc attcccaaaa aatcgtgtga agcctcattt taggtcatcc
     1321 agtggttcag aacactcaac agagggctcc gtgtcattgg gggatggacc actgagcaga
     1381 tctagttcaa ggatctttct ttctgaacgg cataacccaa cagtaacagg gcagcaggaa
     1441 caaacttatc ttccaaagga ggctcccatt ttacagatgg aacagaatgg ggactttgga
     1501 agaggcaggc gaactctctt cagaggccga aggcgaaggg atgatgacag gatcccaaga
     1561 ccccaacctg cagcaactga agccaaggct ccaactccga agtttgattt gcttgctaca
     1621 aatttccctc ctttacctgg aagctcatcg agagtgccag atgaacttgg tttggagaac
     1681 agaatgtctg atgtcgttaa aggtgtctgc agagaaaagg acagcgagga cgtgcgagtt
     1741 agttgcccag tgcctgcaga ggacggacag acagactgca cttctgcgcc gctcagcata
     1801 agtcctagtc ctccgtgtac agctgagcct cctgtgttaa gcacgactca gcaagagcag
     1861 gatcagatgg aggactctgc tgttccaaag gacactctca acccagtagc tgtgccagtg
     1921 tcttctccaa ctgccacaaa gccatccccg gcaaacacgg cttcaccttg cactagtaac
     1981 ataaacccac cgagagctgt ggccctgcag gaacctcgaa agttaagcta tgctgaagtg
     2041 tgccagaagc ctcctaaaga gccatctcca gttctcgtac agccgctgcg ggaactccgg
     2101 tctaatgcag tatcccccac cagaaatgaa gagaacggag ctcccgagaa gcctgttgag
     2161 aagccgcatg agaaaccaga aacaagggct agtaaggatc attctggctt ccgaggcaac
     2221 actattccca ggggagcggc tggaaaaatc agggaacaga gacgccagtt cagccatagg
     2281 gctacacctc agggagtgac tcgacgtaat gggaaagagc aatacgtgcc acccagatca
     2341 ccaaagtaaa aacaaagcct acaaaaacta ctcagaagct tctcttccca ctaaacttga
     2401 gcctctgttg aactgttttg gaggggagga agtagccagg aaagaatggg aagtaagccc
     2461 taaatatgac ggatttttga aattgcgagt aggaagagcc caaaattcat ctctaaatga
     2521 ttttcaaatg ctggaggatt ccaatcagta taaatatata taaatatata tatatacaca
     2581 catatatata taaatataat ttttctattt ttgtttttga ttttaatttg caggaatttt
     2641 ctgcctggaa tcaattttga gggttcagat ttagcttggg agagaaaaca aaaaacatta
     2701 tacatccttc agtataggag atgagggagt gagagaaaat attttttgaa gaaacatttc
     2761 tgtaaaaatt agaaattact ttttttaatc tatttaaagt ttggcttgaa gaatgctatc
     2821 tctgactaaa tggccttgtg ttgcagagta gatgagtggc tagggagtct gttctgggtc
     2881 cgagtgtgtg caaaagtgat ttaagccaaa tctgttgtca tggtagtaaa tgatttcaaa
     2941 gctgaatgta atacttgagt agattttctt tgtagtttgg aatttagttg tttttgtttt
     3001 ttgacattac taatactgta ttgtatgaac aagctataaa gctctgattg tgtgtgaagc
     3061 tgtgactacc aatcagtttg atattcaagg aaagaatgga gattattcaa aaaaaatatt
     3121 gaaaattctg ttttagacct gaatactgga taggtcaaat agattgcaga ggtttaaact
     3181 gccctgtgac cttttttttt cctttttaat tttttttctg attgtttgtt agtctctgtt
     3241 cttagactgt cttcccccca aaagcaatat gactaactgt ttactggaca gtatgtttct
     3301 tactactttg accagtttaa tcaaattata taactattct aagctacata atggaatatt
     3361 gaaagatttt tattcaatta gaattttagg tcccaggatg gtactgacct gccagtaatt
     3421 tatttgtatt ggtgttaaaa aaatgaaata gtgcttctgg ctgtgcgggc ataaatctcc
     3481 aaccctggcc tccagaggtg tggcaggtgg atctcagtcc cagtccatcc agggctctac
     3541 ctctcactag tttctgtcta aagaaagaaa aggaaaagga aagaaagatg aaaccgtgta
     3601 actgactttt taaatggtct aacggaaaaa ttcaaacatt aatttgggga attttgttgt
     3661 ttacaatgtt tatcatcttt ctttggcttg cccccaaaag tacagtttag catttgcaga
     3721 ctaaaaatag caagtcaagg attttttttt ttttgagata aagcgaaaaa gtggttgaag
     3781 aaaataaatg cataatttct cagtgaataa agttgtagct gtcagacatt aaataggcaa
     3841 agttacatgc tgatatttag aaaacagctc aaatatgaaa aaccatgttt cattaatctg
     3901 tttaagtcag gccattttta tagttttatg tagggtggtt tatttttctt agggacagtt
     3961 tacaatagta agagctgtct ctcatattaa gtgagttact tatgtacaaa ttgaaactgt
     4021 aaattgtaaa cactggaacg caccattgtg acataaacat cgtagtaata tattaaaatg
     4081 aatgtaaatg gaagttaaaa ttacattact gtgaaactta ccttccagct gttaagtgtc
     4141 agagatttgt gttagtgggt aattcttaaa gagctttgaa aacactgcat aatccgtgta
     4201 acccagaatt attatttctt tgtaacttat tattcagctt ggcgagcgct tttgatttgg
     4261 cagattgata acatggtata tttacttagt tggaaacaat tatttctaca tacttttaaa
     4321 aaaatatctg ctagatgaaa catacaataa aactacctgt actaaaattt gggagaactt
     4381 taggtccttt aaaaagtatt aatcattatt agcaacatct atgataaaag tgtttattct
     4441 ggtttactta gaaatgataa acatttaaag tgttaacatc ttatgaatgc agtgaattaa
     4501 tagaataaac attttgcaaa aaatcacttg ataaggatta gaaactttat ttttgcactt
     4561 aaaatgaaaa ataactttgt tttctctaaa tgtgtcacag atgtagtttc cgatttcttg
     4621 ctactttgtg tgactttctg ataatccatt actacaggtt ggtttttttg aacagttctt
     4681 cccttgaaac cagggccgta gacagacccc atgagtgtta caacactgag ctatacctcc
     4741 aacttctaaa ggtctgactg aaatccaaga aaaatttcct cttaaagcaa gtatattctt
     4801 ggtttttttt ttctccaaat actgagtgta gagttttttt aaagcatagg atttttattt
     4861 caattttcct cagtatttct aaacagctcc catttgatgg gggtgtatgt ggggaggggt
     4921 aatgaatgtg aatgtgtaat atatatttgc agtgtgtatt tggccgttat tttattgcag
     4981 cgtgtgtaaa tgatgcctgt gagttatgtg aaaccggctt ttccccatca tcattactca
     5041 agtcaattgg gtgggtgttc attgtacttc aactatttat tggttctgta gatgggggaa
     5101 ttttaaacgt cagagtgtgt tcttcacctt atggcttgct tcattgaagg ccaagagtag
     5161 ataacgtgat gcttattgtg tcctacagta gtgcatcgtg gttcccactg catgaagaga
     5221 gcagaactca cacaagttca tcatgttgtg cttcatagag aaggtgctta gaggggctgg
     5281 catggcaaaa ccttctcatc tctgtcttga tgatatctag tctttaatct gaatactcac
     5341 tctcagtttt gccaaagact cagtggcgtt taaaagcgtt ctatctacgt tcttacccac
     5401 ctatgttttg gagacagatg aaaccttcca gggatagggg tttgttgtct tacctgcata
     5461 tctttacata taatcaaatg atatgcagaa ttttaattta tttttagttc ctaaagttaa
     5521 ggtagcttca atattatttc acattccttt ttctctttaa attgccagat ttgcttttca
     5581 aagacttagg ggcagaatta agttagtatc tttcacttag agtaaagaga acaagacaat
     5641 attatttaag agttaggagc actttgtcta gttctgttag ttatgtatgg ccttaataat
     5701 cagtctcttg gcttaagtgt tcactggttt cactttgaca cagttgaaca gcactggggt
     5761 tcagttcctg atgcttgtgt tggcaatata tattaaccat attttaagag tatcattctg
     5821 gctttttatg gaaaagatga aaatcaaaca gtatattcct tttgagggtt tttttaatac
     5881 gtaaatatat ataaatataa tatatgatgg attttttcta attttttata tttccttaca
     5941 atttggtgac tattactcta actttagact ctttggcata tactaagtag ctagtctggg
     6001 ctttaaaaat atgcatggac atttcagttt gttttagctg aatgaggaca ttttgaattc
     6061 tcttaaaagt cacctgatta ttaaataaca atgtttattt ttaaaactaa caatgtgttg
     6121 tgtcttatta cacattacac agtcctaaag gtgcggctct gatgtctgtg agctgtgggc
     6181 caagtattct gttttcagtt ctatagcaca gaacagtgat tagaaatgta aagagatacc
     6241 cacatcaact ttctgttttt gtttttccaa ctgattcagg tgtccattga atgacgtatc
     6301 tcttaaatgt tgggggagtg gtgtgtcaga accagttacc tggcttctgt tttgtccata
     6361 gcttagattt gttccgttgt caaaactgtc ccccccccca aattgtgtga cacatattca
     6421 tgcataaact gttaaaacga gcatctttgt atttgtattg ttttcaacat tgccaaggtg
     6481 ctatgggaaa ttaaaattac aaaattagaa aaaaataaaa ttattgaaaa acaaaaaaaa
     6541 aaa
//
